{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:24Z","timestamp":1760144244031,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Agency of the Slovakia VEGA","award":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"],"award-info":[{"award-number":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"]}]},{"name":"Agency of the Faculty of Agrobiology and Food Resources SUA in Nitra (Slovakia)","award":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"],"award-info":[{"award-number":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"]}]},{"name":"Operational Programme Integrated Infrastructure for the project: Long-term strategic research of prevention, intervention, and mechanisms of obesity and its comorbidities","award":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"],"award-info":[{"award-number":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"]}]},{"name":"European Regional Development Fund","award":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"],"award-info":[{"award-number":["1\/0698\/22","APVV-21-0168","4\/2024","IMTS 313011V344"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Risk elements in blood matrices can affect human health status through associations with biomarkers at multiple levels. The aim of this study was to analyze 15 macro- and microelements in the blood serum of women with overweight (BMI of \u226525 kg\/m2) and obesity (BMI of \u226530 kg\/m2) and to examine possible associations with biochemical, liver enzymatic parameters, and markers of oxidative stress. Based on the power calculation, the study involved women (in the postmenopausal stage) with overweight (n = 26) and obesity (n = 22), aged between 50\u201365 years. Multifrequency bioelectrical impedance analysis was used to measure body composition parameters. Concentrations of elements were determined by inductively coupled plasma optical emission spectrometry, and Hg was measured using cold-vapor atomic absorption spectroscopy. Individuals with obesity, as indicated by a higher BMI, percentage of body fat, and visceral fat area, had elevated serum levels of Ca, Mg, Fe, Al, Sr, Pb, and Hg. Concentrations of Al, Cu, K, Sb, Zn, and Pb significantly affected biochemical and liver function markers in women with overweight or obesity. Elements such as Cu and Al were associated with increased total cholesterol. The correlation analysis between total antioxidant status and Cu, Al, and Ni confirmed associations in both groups. Our findings underscore the importance of addressing excess body weight and obesity in relation to risk elements. The results of the research could be beneficial in identifying potential targets for the treatment or prevention of comorbidities in people with obesity.<\/jats:p>","DOI":"10.3390\/life14040465","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:58:31Z","timestamp":1712055511000},"page":"465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blood Concentration of Macro- and Microelements in Women Who Are Overweight\/Obesity and Their Associations with Serum Biochemistry"],"prefix":"10.3390","volume":"14","author":[{"given":"Zuzana","family":"Knazicka","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-3200","authenticated-orcid":false,"given":"Maros","family":"Bihari","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"given":"Ivona","family":"Janco","sequence":"additional","affiliation":[{"name":"AgroBioTech Research Center, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-9803","authenticated-orcid":false,"given":"Lubos","family":"Harangozo","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-8795","authenticated-orcid":false,"given":"Julius","family":"Arvay","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-1795","authenticated-orcid":false,"given":"Anton","family":"Kovacik","sequence":"additional","affiliation":[{"name":"Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-0948","authenticated-orcid":false,"given":"Peter","family":"Massanyi","sequence":"additional","affiliation":[{"name":"Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-7659","authenticated-orcid":false,"given":"Branislav","family":"Galik","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-6056","authenticated-orcid":false,"given":"Jorge M. A.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, Campus Universit\u00e1rio de Santiago, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-7161","authenticated-orcid":false,"given":"Marta","family":"Habanova","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.fct.2011.03.002","article-title":"Determination of some heavy metals in food and environmental samples by flame atomic absorption spectrometry after coprecipitation","volume":"49","author":"Soylak","year":"2011","journal-title":"Food Chem. 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