{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:08:12Z","timestamp":1771038492465,"version":"3.50.1"},"reference-count":97,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the population worldwide, accounting for more than 843 million (M) individuals. The prevalence of CKD (844 M patients) is higher than that of diabetes mellitus (422 M patients), cancer (42 M patients), and HIV (37 M patients), but people are often less aware of it. Global expert groups predict reductions in the nephrology workforce in the next decade, with a declining interest in nephrology careers. Over time, KDIGO guidelines have also focused on topics related to the prevention or management of CKD patients in real-life settings. On these premises, a new educational program with international experts in the field of nephrology took place from November 2022 until March 2023 in Milan, Italy. This multinational masterclass provided an educational platform providing unbiased education on diagnosis and treatment by sharing the most recent research data on CKD and comorbidities, therefore creating a snowball effect to increase the implementation of best practices worldwide, using examples from \u2018real-life\u2019 patient outcomes. This paper provides an overview of the International Nephrology Masterclass (INM) concept, summarizing the key lectures and discussions, and giving an outline of future key developments.<\/jats:p>","DOI":"10.3390\/life14121668","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:46:02Z","timestamp":1734407162000},"page":"1668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["International Nephrology Masterclass in Chronic Kidney Disease: Rationale, Summary, and Future Perspectives"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-4226","authenticated-orcid":false,"given":"Francesco","family":"Pesce","sequence":"first","affiliation":[{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Division of Renal Medicine, Ospedale Isola Tiberina-Gemelli, 00816 Rome, Italy"}]},{"given":"Maria","family":"Vadal\u00e0","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Ospedale Isola Tiberina-Gemelli, 00816 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-4569","authenticated-orcid":false,"given":"Edgar","family":"Almeida","sequence":"additional","affiliation":[{"name":"Hospital da Luz, 1500-650 Lisboa, Portugal"}]},{"given":"Beatriz","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Hospital Fundaci\u00f2n Jimenez-Diaz, 28040 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-7199","authenticated-orcid":false,"given":"Denis","family":"Fouque","sequence":"additional","affiliation":[{"name":"University Claude Bernard Lyon, 69100 Villeurbanne, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-8171","authenticated-orcid":false,"given":"Jolanta","family":"Malyszko","sequence":"additional","affiliation":[{"name":"Medical University Warsaw, 02-091 Warszawa, Poland"}]},{"given":"Kai","family":"Schmidt-Ott","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-4820","authenticated-orcid":false,"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[{"name":"Karolinska Hospital, 171 76 Stockholm, Sweden"}]},{"given":"David C.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"University College London, London WC1E 6BT, UK"}]},{"given":"Samuel","family":"Seidu","sequence":"additional","affiliation":[{"name":"Leicester City Clinical Commissioning Group, Leicester LE1 6NB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-6370","authenticated-orcid":false,"given":"Ana","family":"Cebrian","sequence":"additional","affiliation":[{"name":"Cartagena Casco Health Center, 30201 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-9454","authenticated-orcid":false,"given":"Nikolay","family":"Dimov","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, University Hospital \u201cSv. Georgi\u201d, 4002 Plovdiv, Bulgaria"}]},{"given":"Marta Blanco","family":"Pardo","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n of Nephrology, A Coru\u00f1a University Hospital, 15006 A Coru\u00f1a, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-3252","authenticated-orcid":false,"given":"Ieva","family":"Ziedina","sequence":"additional","affiliation":[{"name":"Riga Stradins University, LV-1007 Riga, Latvia"}]},{"given":"Nayaf","family":"Habashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, HaEmeq Hospital Afula, Afula 1834111, Israel"}]},{"given":"Joaquin","family":"Manrique","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-7871","authenticated-orcid":false,"given":"Sofia Homem De Melo","family":"Marques","sequence":"additional","affiliation":[{"name":"Hemodialysis Clinic Hospital Agostinho Ribeiro, 4610-106 Felgueiras, Portugal"}]},{"given":"Marco Antonio Vaca","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Hospital Universitario La Paz, 28046 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-3517","authenticated-orcid":false,"given":"Larisa","family":"Shehaj","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Bezmialem Vakif University, Istanbul 34093, T\u00fcrkiye"}]},{"given":"Milena Krasimirova","family":"Nikolova Vlahova","sequence":"additional","affiliation":[{"name":"University Hospital St. Ivan Rilski, 1000 Sofia, Bulgaria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1951-3941","authenticated-orcid":false,"given":"Luis","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Research and Development\u2014Unic@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Sara","family":"Ksiazek","sequence":"additional","affiliation":[{"name":"6th Medical Department of Internal Medicine with Nephrology & Dialysis, Clinic Ottakring, 1160 Vienna, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-0294","authenticated-orcid":false,"given":"Pierangelo","family":"Veltri","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Modeling, Electronics and Systems Engineering, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7600-524X","authenticated-orcid":false,"given":"Giuseppe","family":"Pezzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy"}]},{"given":"Gemma","family":"Patella","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Azienda Sanitaria Provinciale, 87100 Cosenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-9172","authenticated-orcid":false,"given":"Greta","family":"Borelli","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplant Unit, IRCSS-Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-702X","authenticated-orcid":false,"given":"Michele","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-0911","authenticated-orcid":false,"given":"Loreto","family":"Gesualdo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70121 Bari, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: Reference and alternative scenarios for 2016\u201340 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"34","author":"Jager","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Younes, S., Mourad, N., Safwan, J., Dabbous, M., Rahal, M., Al Nabulsi, M., and Sakr, F. (2022). Chronic kidney disease awareness among the general population: Tool validation and knowledge assessment in a developing country. BMC Nephrol., 23.","DOI":"10.1186\/s12882-022-02889-2"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1111\/j.1523-1755.2005.09801.x","article-title":"Chronic renal diseases as a public health problem: Epidemiology, social, and economic implications","volume":"68","author":"Schieppati","year":"2005","journal-title":"Kidney Int. Suppl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13098-023-01083-0","article-title":"Contribution of CKD to mortality in middle-aged and elderly people with diabetes: The China Health and Retirement Longitudinal Study: CKD was a chronic stressor for diabetics","volume":"15","author":"Liao","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Stanifer, J.W., Maro, V., Egger, J., Karia, F., Thielman, N., Turner, E.L., Shimbi, D., Kilaweh, H., Matemu, O., and Patel, U.D. (2015). The epidemiology of chronic kidney disease in Northern Tanzania: A population-based survey. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124506"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2471\/BLT.17.206441","article-title":"The global burden of kidney disease and the sustainable development goals","volume":"96","author":"Luyckx","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Crews, D.C., Guti\u00e9rrez, O.M., Fedewa, S.A., Luthi, J.C., Shoham, D., Judd, S.E., Powe, N.R., and McClellan, W.M. (2014). Low income, community poverty and risk of end stage renal disease. BMC Nephrol., 15.","DOI":"10.1186\/1471-2369-15-192"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100545","DOI":"10.1016\/j.xkme.2022.100545","article-title":"Treatment Adherence in CKD and Support From Health care Providers: A Qualitative Study","volume":"4","author":"Rivera","year":"2022","journal-title":"Kidney Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ekir.2020.11.039","article-title":"Adherence to the Kidney Disease: Improving Global Outcomes CKD Guideline in Nephrology Practice Across Countries","volume":"6","author":"Stengel","year":"2020","journal-title":"Kidney Int. Rep."},{"key":"ref_11","unstructured":"Chen, T.C., Clark, J., Riddles, M.K., Mohadjer, L.K., and Fakhouri, T.H.I. (2020). National Health and Nutrition Examination Survey, 2015\u20132018: Sample Design and Estimation Procedures. Vital and Health Statistics, National Center for Health Statistics."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/aje\/kwt292","article-title":"Reallocating time to sleep, sedentary behaviors, or active behaviors: Associations with cardiovascular disease risk biomarkers, NHANES 2005\u20132006","volume":"179","author":"Buman","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jand.2021.12.005","article-title":"Differences in Dietary Quality by Sexual Orientation and Sex in the United States: NHANES 2011\u20132016","volume":"122","author":"Prestemon","year":"2022","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.amsu.2020.12.036","article-title":"Statin eligibility based on the ACC\/AHA guidelines among Middle Eastern patients with diabetes mellitus presenting with acute myocardial infarction","volume":"61","author":"Jarrah","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_15","unstructured":"Steinfeldt, L.C., Martin, C.L., Goldman, J.D., and Moshfegh, A.J. (2023). Meeting Dietary Guidelines Recommendations: Older Adults: What We Eat in America, NHANES 2013\u20132016. FSRG Dietary Data Briefs, United States Department of Agriculture (USDA). Dietary Data Brief No. 28."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"SPRINT Research Group, Wright, J.T., Williamson, J.D., Whelton, P.K., Snyder, J.K., Sink, K.M., Rocco, M.V., Reboussin, D.M., Rahman, M., and Oparil, S. (2015). A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N. Engl. J. Med., 373, 2103\u20132116. Erratum in N. Engl. J. Med. 2017, 377, 2506. https:\/\/doi.org\/10.1056\/NEJMx170008.","DOI":"10.1056\/NEJMoa1511939"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1681\/ASN.2017020148","article-title":"Effects of Intensive BP Control in CKD","volume":"28","author":"Cheung","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_18","first-page":"CD013165","article-title":"Potassium binders for chronic hyperkalaemia in people with chronic kidney disease","volume":"6","author":"Natale","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","unstructured":"Hashmi, M.F., Aeddula, N.R., Shaikh, H., and Rout, P. (2024). Anemia of Chronic Kidney Disease. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_20","first-page":"i3","article-title":"Iron treatment and the TREAT trial","volume":"4","author":"Locatelli","year":"2011","journal-title":"NDT Plus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00467-008-0900-4","article-title":"Calcimimetics in CKD-results from recent clinical studies","volume":"23","author":"Schlieper","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0140-6736(11)60739-3","article-title":"The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial","volume":"377","author":"Baigent","year":"2011","journal-title":"Lancet"},{"key":"ref_24","first-page":"1237","article-title":"Was ist gesichert in der Therapie der chronischen Nierenerkrankung? [What is confirmed in the treatment of chronic kidney disease?","volume":"63","author":"Greite","year":"2022","journal-title":"Inn. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/s41366-020-0540-8","article-title":"Effects of abdominal obesity on the association between air pollution and kidney function","volume":"44","author":"Jeong","year":"2020","journal-title":"Int. J. Obes."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2589-7500(21)00252-1","article-title":"Characteristics of publicly available skin cancer image datasets: A systematic review","volume":"4","author":"Wen","year":"2022","journal-title":"Lancet Digit. Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100535","DOI":"10.1016\/j.xkme.2022.100535","article-title":"Sex Differences in CKD-Associated Mortality From 1990 to 2019: Data From the Global Burden of Disease Study","volume":"4","author":"Hockham","year":"2022","journal-title":"Kidney Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"f324","DOI":"10.1136\/bmj.f324","article-title":"Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: A meta-analysis","volume":"346","author":"Nitsch","year":"2013","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Costa, D., G\u00f3mez-Salgado, J., Fagundo-Rivera, J., Mart\u00edn-Pereira, J., Prieto-Callejero, B., and Garc\u00eda-Iglesias, J.J. (2020). Alternatives to the Use of Mechanical Restraints in the Management of Agitation or Aggressions of Psychiatric Patients: A Scoping Review. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092791"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fernandez-Fernandez, B., Mahillo, I., Sanchez-Rodriguez, J., Carriazo, S., Sanz, A.B., Sanchez-Ni\u00f1o, M.D., and Ortiz, A. (2020). Gender, Albuminuria and Chronic Kidney Disease Progression in Treated Diabetic Kidney Disease. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061611"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ajcn\/nqab113","article-title":"Association of food insecurity with dietary intakes and nutritional biomarkers among US children, National Health and Nutrition Examination Survey (NHANES) 2011\u20132016","volume":"114","author":"Jun","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2021.01.002","article-title":"US Renal Data System 2020 Annual Data Report: Epidemiology of Kidney Disease in the United States","volume":"77","author":"Johansen","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/1753-0407.13211","article-title":"Presentations at the 81st scientific sessions of the American Diabetes Association (ADA), Part 1","volume":"13","author":"Bloomgarden","year":"2021","journal-title":"J. Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/ckj\/sfac019","article-title":"The 2021 European Society of Cardiology Cardiovascular Disease Prevention Guidelines: Adding albuminuria to the SCORE scale increases the prevalence of very high\/high cardiovascular risk among patients with chronic kidney disease","volume":"15","author":"Cebrian","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2024). KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int., 105, S117\u2013S314.","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jamda.2013.03.022","article-title":"Frailty consensus: A call to action","volume":"14","author":"Morley","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/imj.15759","article-title":"Frailty in chronic kidney disease: Challenges in nephrology practice. A review of current literature","volume":"53","author":"Kennard","year":"2023","journal-title":"Intern Med. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/ckj\/sfx134","article-title":"Frailty and chronic kidney disease: Current evidence and continuing uncertainties","volume":"11","author":"Nixon","year":"2018","journal-title":"Clin. Kidney J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11255-023-03720-z","article-title":"Prevalence and associated factors of frailty in patients with chronic kidney disease: A cross-sectional analysis of PEAKING study","volume":"56","author":"Yang","year":"2024","journal-title":"Int. Urol. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.archger.2016.10.007","article-title":"Frailty and chronic kidney disease: A systematic review","volume":"68","author":"Chowdhury","year":"2017","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12603-012-0084-2","article-title":"A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans","volume":"16","author":"Morley","year":"2012","journal-title":"J. Nutr. Health Aging."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"CMAJ"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-023-00784-z","article-title":"Differences in the epidemiology, management and outcomes of kidney disease in men and women","volume":"20","author":"Chesnaye","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"514","DOI":"10.21037\/atm.2020.01.23","article-title":"The role of gender disparities in kidney injury","volume":"8","author":"Harris","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.semnephrol.2022.04.001","article-title":"Sex and gender differences in chronic kidney disease and access to care around the globe","volume":"42","author":"Iyengar","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1681\/ASN.2014050459","article-title":"Risk of Adverse Pregnancy Outcomes in Women with CKD","volume":"26","author":"Piccoli","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1681\/ASN.2016070806","article-title":"Pregnancy Outcomes after Clinical Recovery from AKI","volume":"28","author":"Tangren","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Piccoli, G.B., Zakharova, E., Attini, R., Ibarra Hernandez, M., Orozco Guillien, A., Alrukhaimi, M., Liu, Z.H., Ashuntantang, G., Covella, B., and Cabiddu, G. (2018). Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases. J. Clin. Med., 7.","DOI":"10.3390\/jcm7110415"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s40620-017-0390-1","article-title":"Kidney and Pregnancy Study Group of Italian Society of Nephrology. A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: The Italian study group on kidney and pregnancy","volume":"30","author":"Piccoli","year":"2017","journal-title":"J. Nephrol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.kint.2019.03.033","article-title":"A systematic review and meta-analysis indicates long-term risk of chronic and end-stage kidney disease after preeclampsia","volume":"96","author":"Covella","year":"2019","journal-title":"Kidney Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1701-2163(15)30533-8","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: Executive summary","volume":"36","author":"Magee","year":"2014","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S2215-0366(16)30263-2","article-title":"Why is depression more common among women than among men?","volume":"4","author":"Kuehner","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2054358120985379","DOI":"10.1177\/2054358120985379","article-title":"Providing Care for Transgender Persons With Kidney Disease: A Narrative Review","volume":"8","author":"Collister","year":"2021","journal-title":"Can. J. Kidney Health Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1373\/clinchem.2018.292730","article-title":"Impact of hormone therapy on laboratory values in transgender patients","volume":"65","author":"SoRelle","year":"2019","journal-title":"Clin. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.semnephrol.2022.04.011","article-title":"Sex and Gender Differences in Kidney Transplantation","volume":"42","author":"Shah","year":"2022","journal-title":"Semin. Nephrol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/jamasurg.2018.4598","article-title":"Association of Surgical Risk With Exogenous Hormone Use in Transgender Patients: A Systematic Review","volume":"154","author":"Boskey","year":"2019","journal-title":"JAMA Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3945\/ajcn.2009.28047","article-title":"Longitudinal study of muscle strength, quality, and adipose tissue infiltration","volume":"90","author":"Delmonico","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/ndt\/gfy139","article-title":"Quality over quantity? Association of skeletal muscle myosteatosis and myofibrosis on physical function in chronic kidney disease","volume":"34","author":"Wilkinson","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.clnu.2016.09.029","article-title":"Reliability of bedside ultrasound for measurement of quadriceps muscle thickness in critically ill patients with acute kidney injury","volume":"36","author":"Sabatino","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3000605221136683","DOI":"10.1177\/03000605221136683","article-title":"Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women","volume":"50","author":"Chen","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1681\/ASN.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes","volume":"24","author":"Afkarian","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.kint.2022.06.013","article-title":"Executive summary of the KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease: An update based on rapidly emerging new evidence","volume":"102","author":"Rossing","year":"2022","journal-title":"Kidney Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2215\/CJN.18881220","article-title":"SGLT2 Inhibitors in Diabetic Kidney Disease","volume":"16","author":"Zoungas","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(05)67186-3","article-title":"Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)","volume":"366","author":"Poulter","year":"2005","journal-title":"Lancet"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/CIRCULATIONAHA.116.021887","article-title":"Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications","volume":"134","author":"Heerspink","year":"2016","journal-title":"Circulation"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa1812389","article-title":"Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes","volume":"380","author":"Wiviott","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in Patients with Chronic Kidney Disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"The EMPA-KIDNEY Collaborative Group, Herrington, W.G., Staplin, N., Wanner, C., Green, J.B., Hauske, S.J., Emberson, J.R., Preiss, D., Judge, P., and Mayne, K.J. (2023). Empagliflozin in Patients with Chronic Kidney Disease. N. Engl. J. Med., 388, 117\u2013127.","DOI":"10.1056\/NEJMoa2204233"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"sfad268","DOI":"10.1093\/ckj\/sfad268","article-title":"Kidney biopsy in diabetic kidney disease. Yes, but in very selected cases","volume":"17","author":"Zoccali","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"sfad266","DOI":"10.1093\/ckj\/sfad266","article-title":"Should we enlarge the indication for kidney biopsy in patients with diabetes? The pro part","volume":"17","author":"Gesualdo","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.febslet.2007.02.006","article-title":"Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53","volume":"581","author":"Tikoo","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3523","article-title":"The immune system and kidney disease: Basic concepts and clinical implications","volume":"13","author":"Kurts","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_77","first-page":"e25269","article-title":"Fasting Ramadan in Chronic Kidney Disease (CKD), Kidney Transplant and Dialysis Patients: Review and Update","volume":"14","author":"Habas","year":"2022","journal-title":"Cureus"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IJNRD.S343582","article-title":"Measurement of Blood Pressure in Chronic Kidney Disease: Time to Change Our Clinical Practice\u2014A Comprehensive Review","volume":"15","author":"Nagaraju","year":"2022","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD","volume":"63","author":"Inker","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/ndt\/gfac134","article-title":"Biopsy-proven CKD etiology and outcomes: The Chronic Kidney Disease Japan Cohort (CKD-JAC) study","volume":"38","author":"Hamano","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41581-022-00562-3","article-title":"Artificial intelligence-enabled decision support in nephrology","volume":"18","author":"Loftus","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1093\/ckj\/sfad182","article-title":"Artificial intelligence: A new field of knowledge for nephrologists?","volume":"16","author":"Viera","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.mayocp.2022.12.019","article-title":"Clinical Implementation of an Artificial Intelligence Algorithm for Magnetic Resonance-Derived Measurement of Total Kidney Volume","volume":"98","author":"Potretzke","year":"2023","journal-title":"Mayo Clin. Proc."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.kint.2017.06.018","article-title":"Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"92","author":"Bockenhauer","year":"2017","journal-title":"Kidney Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41581-024-00844-y","article-title":"Progression and outcomes of rare kidney diseases","volume":"20","author":"Allison","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Turgut, F., Awad, A.S., and Abdel-Rahman, E.M. (2023). Acute Kidney Injury: Medical Causes and Pathogenesis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12010375"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.cmet.2019.09.012","article-title":"Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease","volume":"30","author":"Torres","year":"2019","journal-title":"Cell Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/MNH.0000000000000734","article-title":"Emerging non-pharmacological interventions in ADPKD: An update on dietary advices for clinical practice","volume":"30","author":"Meijer","year":"2021","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"101283","DOI":"10.1016\/j.xcrm.2023.101283","article-title":"Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD-a randomized controlled trial","volume":"4","author":"Cukoski","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Haaskjold, Y.L., Bj\u00f8rneklett, R., Bostad, L., Bostad, L.S., Lura, N.G., and Knoop, T. (2022). Utilizing the MEST score for prognostic staging in IgA nephropathy. BMC Nephrol., 23.","DOI":"10.1186\/s12882-021-02653-y"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1523-1755.2004.00443.x","article-title":"International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis. The classification of glomerulonephritis in systemic lupus erythematosus revisited","volume":"65","author":"Weening","year":"2004","journal-title":"Kidney Int."},{"key":"ref_92","first-page":"e47129","article-title":"Alport Syndrome: A Comprehensive Review","volume":"15","author":"Adone","year":"2023","journal-title":"Cureus"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kataoka, H., Fukuoka, H., Makabe, S., Yoshida, R., Teraoka, A., Ushio, Y., Akihisa, T., Manabe, S., Sato, M., and Mitobe, M. (2020). Prediction of Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease Using PKD1\/PKD2 Mutations. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010146"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14797\/mdcvj.1150","article-title":"Amyloidosis of the Heart and Kidney","volume":"18","author":"Adrogue","year":"2022","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e0230020","DOI":"10.1371\/journal.pone.0230020","article-title":"Renal resistive index in chronic kidney disease patients: Possible determinants and risk profile","volume":"15","author":"Provenzano","year":"2020","journal-title":"PLoS ONE"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e0172241","DOI":"10.1371\/journal.pone.0172241","article-title":"Epidemiology of low-proteinuric chronic kidney disease in renal clinics","volume":"12","author":"Provenzano","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1097\/HJH.0000000000001825","article-title":"Short-term blood pressure variability in nondialysis chronic kidney disease patients: Correlates and prognostic role on the progression of renal disease","volume":"36","author":"Borrelli","year":"2018","journal-title":"J Hypertens."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/12\/1668\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:28Z","timestamp":1760115208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/12\/1668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":97,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["life14121668"],"URL":"https:\/\/doi.org\/10.3390\/life14121668","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}