{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:27:53Z","timestamp":1775478473574,"version":"3.50.1"},"reference-count":145,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Traces of metal are required for fundamental biochemical processes, such as photosynthesis and respiration. Cyanobacteria metal homeostasis acquires an important role because the photosynthetic machinery imposes a high demand for metals, making them a limiting factor for cyanobacteria, especially in the open oceans. On the other hand, in the last two centuries, the metal concentrations in marine environments and lake sediments have increased as a result of several industrial activities. In all cases, cells have to tightly regulate uptake to maintain their intracellular concentrations below toxic levels. Mechanisms to obtain metal under limiting conditions and to protect cells from an excess of metals are present in cyanobacteria. Understanding metal homeostasis in cyanobacteria and the proteins involved will help to evaluate the use of these microorganisms in metal bioremediation. Furthermore, it will also help to understand how metal availability impacts primary production in the oceans. In this review, we will focus on copper, nickel, cobalt and arsenic (a toxic metalloid) metabolism, which has been mainly analyzed in model cyanobacterium Synechocystis sp. PCC 6803.<\/jats:p>","DOI":"10.3390\/life4040865","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T10:18:35Z","timestamp":1418120315000},"page":"865-886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Metals in Cyanobacteria: Analysis of the Copper, Nickel, Cobalt and Arsenic Homeostasis Mechanisms"],"prefix":"10.3390","volume":"4","author":[{"given":"Mar\u00eda","family":"Huertas","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Universidad de Sevilla-CSIC, Am\u00e9rico Vespucio 49, E-41092 Sevilla, Spain"}]},{"given":"Luis","family":"L\u00f3pez-Maury","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Universidad de Sevilla-CSIC, Am\u00e9rico Vespucio 49, E-41092 Sevilla, Spain"}]},{"given":"Joaqu\u00edn","family":"Giner-Lamia","sequence":"additional","affiliation":[{"name":"Systems Biology and Bioinformatics Laboratory, IBB-CBME, University of Algarve,  Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"given":"Ana","family":"S\u00e1nchez-Riego","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Universidad de Sevilla-CSIC, Am\u00e9rico Vespucio 49, E-41092 Sevilla, Spain"}]},{"given":"Francisco","family":"Florencio","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis, Universidad de Sevilla-CSIC, Am\u00e9rico Vespucio 49, E-41092 Sevilla, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrmicro2057","article-title":"How do bacterial cells ensure that metalloproteins get the correct metal?","volume":"7","author":"Waldron","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nature09265","article-title":"Microbial metalloproteomes are largely uncharacterized","volume":"466","author":"Cvetkovic","year":"2010","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"32504","DOI":"10.1074\/jbc.M110.153080","article-title":"Structure and metal loading of a soluble periplasm cuproprotein","volume":"285","author":"Waldron","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nature08300","article-title":"Metalloproteins and metal sensing","volume":"460","author":"Waldron","year":"2009","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jenvman.2005.01.023","article-title":"Assessing pollution levels in sediments of a harbour with two opposing entrances. Environmental implications","volume":"77","year":"2005","journal-title":"J. Environ. Manag."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jhazmat.2008.04.061","article-title":"The remediation of heavy metals contaminated sediment","volume":"161","author":"Peng","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1104\/pp.106.079251","article-title":"Metal Homeostasis in Cyanobacteria and Chloroplasts. Balancing Benefits and Risks to the Photosynthetic Apparatus","volume":"141","author":"Shcolnick","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jprot.2014.03.002","article-title":"Proteomic pattern alterations of the cyanobacterium Synechocystis sp. PCC 6803 in response to cadmium, nickel and cobalt","volume":"102","author":"Mehta","year":"2014","journal-title":"J. Proteomics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1099\/mic.0.041038-0","article-title":"Using extracellular polymeric substances (EPS)-producing cyanobacteria for the bioremediation of heavy metals: Do cations compete for the EPS functional groups and also accumulate inside the cell?","volume":"157","author":"Pereira","year":"2011","journal-title":"Microbiology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Burnat, M., Diestra, E., Esteve, I., and Sol\u00e9, A. (2009). In Situ Determination of the Effects of Lead and Copper on Cyanobacterial Populations in Microcosms. PLoS One, 4.","DOI":"10.1371\/journal.pone.0006204"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-398264-3.00002-4","article-title":"Chapter 2\u2014Elemental Economy: Microbial Strategies for Optimizing Growth in the Face of Nutrient Limitation","volume":"Volume 60","author":"Merchant","year":"2012","journal-title":"Advances in Microbial Physiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1104\/pp.125.1.33","article-title":"Photosynthetic Reaction Centers","volume":"125","author":"Hillier","year":"2001","journal-title":"Plant Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/35082000","article-title":"Three-dimensional structure of cyanobacterial photosystem I at 2.5 \u00c5 resolution","volume":"411","author":"Jordan","year":"2001","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Barnett, J.P., Millard, A., Ksibe, A., Scanlan, D.J., Schmid, R., and Blindauer, C.A. (2012). Mining genomes of cyanobacteria for elements of zinc homeostasis. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00142"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1128\/AEM.01739-12","article-title":"Genetic Identification of a High-Affinity Ni Transporter and the Transcriptional Response to Ni Deprivation in Synechococcus sp. Strain WH8102","volume":"78","author":"Dupont","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4319\/lo.2002.47.4.0976","article-title":"Copper toxicity and cyanobacteria ecology in the Sargasso Sea","volume":"47","author":"Mann","year":"2002","journal-title":"Limnol. Oceanogr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev-marine-121211-172322","article-title":"The trace metal composition of marine phytoplankton","volume":"5","author":"Twining","year":"2013","journal-title":"Ann. Rev. Mar. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01577326","article-title":"Isolation and purification of siderophores produced by cyanobacteria, Synechococcus sp. PCC 7942 and Anabaena variabilis ATCC 29413","volume":"24","author":"Trick","year":"1992","journal-title":"Curr. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1016\/S0040-4020(01)00934-6","article-title":"Two structural isomeric siderophores from the freshwater cyanobacterium Anabaena cylindrica (NIES-19)","volume":"57","author":"Itou","year":"2001","journal-title":"Tetrahedron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/A:1017590425924","article-title":"Exopolysaccharide-producing cyanobacteria and their possible exploitation: A review","volume":"13","author":"Sili","year":"2001","journal-title":"J. Appl. Phycol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Jittawuttipoka, T., Planchon, M., Spalla, O., Benzerara, K., Guyot, F., Cassier-Chauvat, C., and Chauvat, F. (2013). Multidisciplinary evidences that Synechocystis PCC 6803 exopolysaccharides operate in cell sedimentation and protection against salt and metal stresses. PLoS One, 8.","DOI":"10.1371\/journal.pone.0055564"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1128\/AEM.02212-07","article-title":"Sheathless mutant of Cyanobacterium Gloeothece sp. strain PCC 6909 with increased capacity to remove copper ions from aqueous solutions","volume":"74","author":"Micheletti","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2958.1993.tb01109.x","article-title":"Isolation of a prokaryotic metallothionein locus and analysis of transcriptional control by trace metal ions","volume":"7","author":"Huckle","year":"1993","journal-title":"Mol. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0065-2911(01)44014-8","article-title":"Microbial metallothioneins","volume":"44","author":"Robinson","year":"2001","journal-title":"Adv. Microb. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1016\/S0021-9258(18)53636-X","article-title":"Construction of Zn2+\/Cd2+ hypersensitive cyanobacterial mutants lacking a functional metallothionein locus","volume":"268","author":"Turner","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17810","DOI":"10.1074\/jbc.M310560200","article-title":"A novel cyanobacterial SmtB\/ArsR family repressor regulates the expression of a CPx-ATPase and a metallothionein in response to both Cu(I)\/Ag(I) and Zn(II)\/Cd(II)","volume":"279","author":"Liu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(03)00370-3","article-title":"A metallothionein and CPx-ATPase handle heavy-metal tolerance in the filamentous cyanobacterium Oscillatoria brevis","volume":"542","author":"Liu","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1128\/JB.182.6.1507-1514.2000","article-title":"A Gene Cluster Involved in Metal Homeostasis in the Cyanobacterium Synechocystis sp. Strain PCC 6803","volume":"182","author":"Florencio","year":"2000","journal-title":"J. Bacteriol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1104\/pp.112.200659","article-title":"The CopRS two-component system is responsible for resistance to copper in the cyanobacterium Synechocystis sp. PCC 6803","volume":"159","author":"Reyes","year":"2012","journal-title":"Plant Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1128\/JB.185.18.5363-5371.2003","article-title":"Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. strain PCC 6803","volume":"185","author":"Florencio","year":"2003","journal-title":"J. Bacteriol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"25827","DOI":"10.1074\/jbc.274.36.25827","article-title":"Cobalt-dependent transcriptional switching by a dual-effector MerR-like protein regulates a cobalt-exporting variant CPx-type ATPase","volume":"274","author":"Rutherford","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10728","DOI":"10.1073\/pnas.95.18.10728","article-title":"An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter","volume":"95","author":"Thelwell","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1021\/bi050450+","article-title":"A Zinc(II)\/Lead(II)\/Cadmium(II)-Inducible Operon from the Cyanobacterium Anabaena Is Regulated by AztR, an \u03b13N ArsR\/SmtB Metalloregulator","volume":"44","author":"Liu","year":"2005","journal-title":"Biochemistry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1128\/AEM.00271-09","article-title":"Coastal strains of marine Synechococcus species exhibit increased tolerance to copper shock and a distinctive transcriptional response relative to those of open-ocean strains","volume":"75","author":"Stuart","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3390\/md11082894","article-title":"Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory","volume":"11","author":"Yu","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/cbdv.200890183","article-title":"Zinc-Handling in Cyanobacteria: An Update","volume":"5","author":"Blindauer","year":"2008","journal-title":"Chem. Biodivers."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0168-6445(03)00049-4","article-title":"Escherichia coli mechanisms of copper homeostasis in a changing environment","volume":"27","author":"Rensing","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0065-2164(08)00608-4","article-title":"Copper homeostasis in bacteria","volume":"65","author":"Osman","year":"2008","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1099\/mic.0.058487-0","article-title":"Copper-responsive gene regulation in bacteria","volume":"158","author":"Rademacher","year":"2012","journal-title":"Microbiology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8344","DOI":"10.1073\/pnas.0812808106","article-title":"The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity","volume":"106","author":"Macomber","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1128\/JB.00058-10","article-title":"Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis","volume":"192","author":"Chillappagari","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1073\/pnas.1117515109","article-title":"Cyanobacterial metallochaperone inhibits deleterious side reactions of copper","volume":"109","author":"Tottey","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Giner-Lamia, J., L\u00f3pez-Maury, L., and Florencio, F.J. (2014). Global Transcriptional Profiles of the Copper Responses in the Cyanobacterium Synechocystis sp. PCC 6803. PLoS One, 9.","DOI":"10.1371\/journal.pone.0108912"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/JB.01357-06","article-title":"Intracellular copper does not catalyze the formation of oxidative DNA damage in Escherichia coli","volume":"189","author":"Macomber","year":"2007","journal-title":"J. Bacteriol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19999","DOI":"10.1074\/jbc.M011243200","article-title":"Two Menkes-type atpases supply copper for photosynthesis in Synechocystis. PCC 6803","volume":"276","author":"Tottey","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1074\/jbc.M105857200","article-title":"A copper metallochaperone for photosynthesis and respiration reveals metal-specific targets, interaction with an importer, and alternative sites for copper acquisition","volume":"277","author":"Tottey","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2958.1994.tb00430.x","article-title":"A copper-transporting P-type ATPase found in the thylakoid membrane of the cyanobacterium Synechococcus species PCC7942","volume":"13","author":"Kanamaru","year":"1994","journal-title":"Mol. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1365-2958.2010.07402.x","article-title":"Distinct functional roles of homologous Cu+ efflux ATPases in Pseudomonas aeruginosa","volume":"78","author":"Raimunda","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10534-010-9404-3","article-title":"The transport mechanism of bacterial Cu+-ATPases: Distinct efflux rates adapted to different function","volume":"24","author":"Raimunda","year":"2011","journal-title":"BioMetals"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1105\/tpc.111.093914","article-title":"Initial steps of photosystem II de novo assembly and preloading with manganese take place in biogenesis centers in Synechocystis","volume":"24","author":"Stengel","year":"2012","journal-title":"Plant Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1074\/jbc.M806116200","article-title":"Interaction of the periplasmic PratA factor and the PsbA (D1) protein during biogenesis of photosystem II in Synechocystis sp. PCC 6803","volume":"284","author":"Schottkowski","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21944","DOI":"10.1074\/jbc.M111.237867","article-title":"An intermediate membrane subfraction in cyanobacteria is involved in an assembly network for Photosystem II biogenesis","volume":"286","author":"Rengstl","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1074\/jbc.M609916200","article-title":"A periplasmic iron-binding protein contributes toward inward copper supply","volume":"282","author":"Waldron","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/jb.131.2.631-637.1977","article-title":"Role of a major outer membrane protein in Escherichia coli","volume":"131","author":"Lutkenhaus","year":"1977","journal-title":"J. Bacteriol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1128\/JB.00763-13","article-title":"Porins increase copper susceptibility of Mycobacterium tuberculosis","volume":"195","author":"Speer","year":"2013","journal-title":"J. Bacteriol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.bbamem.2010.07.008","article-title":"The interplay between siderophore secretion and coupled iron and copper transport in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120","volume":"1798","author":"Nicolaisen","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4319\/lo.1996.41.3.0388","article-title":"Production of strong, extracellular Cu chelators by marine cyanobacteria in response to Cu stress","volume":"41","author":"Moffett","year":"1996","journal-title":"Limnol. Oceanogr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10534-013-9644-0","article-title":"The response of the TonB-dependent transport network in Anabaena sp. PCC 7120 to cell density and metal availability","volume":"26","author":"Stevanovic","year":"2013","journal-title":"BioMetals"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1074\/jbc.M311565200","article-title":"The efficient functioning of photosynthesis and respiration in Synechocystis sp. PCC 6803 strictly requires the presence of either cytochrome c6 or plastocyanin","volume":"279","author":"Duran","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"19054","DOI":"10.1016\/S0021-9258(18)41739-5","article-title":"Copper-mediated regulation of cytochrome c553 and plastocyanin in the cyanobacterium Synechocystis 6803","volume":"267","author":"Zhang","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF00017837","article-title":"Copper-induced expression, cloning, and regulatory studies of the plastocyanin gene from the cyanobacterium Synechocystis sp. PCC 6803","volume":"15","author":"Briggs","year":"1990","journal-title":"Plant Mol. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5394(01)00136-0","article-title":"An evolutionary analysis of the reaction mechanisms of photosystem I reduction by cytochrome c6 and plastocyanin","volume":"55","author":"Navarro","year":"2002","journal-title":"Bioelectrochemistry"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Giner-Lamia, J., L\u00f3pez-Maury, L., and Florencio, F.J. (2014). CopM is a novel copper binding protein involved in copper resistance in Synechocystis sp. PCC 6803. MicrobiologyOpen, in press.","DOI":"10.1002\/mbo3.231"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.4161\/psb.22323","article-title":"Redox control of copper homeostasis in cyanobacteria","volume":"7","author":"Florencio","year":"2012","journal-title":"Plant Signal. Behav."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/dnares\/dsl010","article-title":"Nitrogen induction of sugar catabolic gene expression in Synechocystis sp. PCC 6803","volume":"13","author":"Osanai","year":"2006","journal-title":"DNA Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/ismej.2012.175","article-title":"Genomic island genes in a coastal marine Synechococcus strain confer enhanced tolerance to copper and oxidative stress","volume":"7","author":"Stuart","year":"2012","journal-title":"ISME J."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Rodriguez, I.B., and Ho, T.-Y. (2014). Diel nitrogen fixation pattern of Trichodesmium: The interactive control of light and Ni. Sci. Rep., 4.","DOI":"10.1038\/srep04445"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"18571","DOI":"10.1074\/jbc.R900020200","article-title":"Nickel-based Enzyme Systems","volume":"284","author":"Ragsdale","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1432-1327.1999.00186.x","article-title":"Cobalt proteins","volume":"261","author":"Kobayashi","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1099\/13500872-145-2-447","article-title":"The marine cyanobacterium Synechococcus sp. WH7805 requires urease (urea amiohydrolase, EC 3.5.1.5) to utilize urea as a nitrogen source: Molecular-Genetic and biochemical analysis of the enzyme","volume":"145","author":"Collier","year":"1999","journal-title":"Microbiology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JB.182.4.1008-1015.2000","article-title":"Arginine catabolism in the cyanobacterium Synechocystis sp. Strain PCC 6803 involves the urea cycle and arginase pathway","volume":"182","author":"Quintero","year":"2000","journal-title":"J. Bacteriol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s102010070025","article-title":"Urea degradation by picophytoplankton in the euphotic zone of Lake Biwa","volume":"1","author":"Mitamura","year":"2000","journal-title":"Limnology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1126\/science.1256450","article-title":"Multiple nutrient stresses at intersecting Pacific Ocean biomes detected by protein biomarkers","volume":"345","author":"Saito","year":"2014","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1046\/j.1365-2958.2002.02778.x","article-title":"An ABC-type, high-affinity urea permease identified in cyanobacteria","volume":"43","author":"Valladares","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11308","DOI":"10.1021\/ja203376y","article-title":"The [NiFe]-Hydrogenase of the Cyanobacterium Synechocystis sp. PCC 6803 Works Bidirectionally with a Bias to H2 Production","volume":"133","author":"McIntosh","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1016\/j.biortech.2011.03.103","article-title":"The role of the bidirectional hydrogenase in cyanobacteria","volume":"102","author":"Carrieri","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"43502","DOI":"10.1074\/jbc.M112.392407","article-title":"Genetic Analysis of the Hox Hydrogenase in the Cyanobacterium Synechocystis sp. PCC 6803 Reveals Subunit Roles in Association, Assembly, Maturation, and Function","volume":"287","author":"Eckert","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1074\/jbc.M113.526376","article-title":"The bidirectional NiFe-hydrogenase in Synechocystis sp. PCC 6803 is reduced by flavodoxin and ferredoxin and is essential under mixotrophic, nitrate-limiting conditions","volume":"289","author":"Gutekunst","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1128\/AEM.71.8.4567-4576.2005","article-title":"Analysis of the hupSL Operon of the Nonheterocystous Cyanobacterium Lyngbya majuscula CCAP 1446\/4: Regulation of Transcription and Expression under a Light-Dark Regimen","volume":"71","author":"Oxelfelt","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wunschiers, R., Batur, M., and Lindblad, P. (2003). Presence and expression of hydrogenase specific C-terminal endopeptidases in cyanobacteria. BMC Microbiol., 3.","DOI":"10.1186\/1471-2180-3-8"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1128\/JB.01248-13","article-title":"The Uptake Hydrogenase in the Unicellular Diazotrophic Cyanobacterium Cyanothece sp. Strain PCC 7822 Protects Nitrogenase from Oxygen Toxicity","volume":"196","author":"Zhang","year":"2014","journal-title":"J. Bacteriol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Khetkorn, W., Lindblad, P., and Incharoensakdi, A. (2012). Inactivation of uptake hydrogenase leads to enhanced and sustained hydrogen production with high nitrogenase activity under high light exposure in the cyanobacterium Anabaena siamensis TISTR 8012. J. Biol. Eng., 6.","DOI":"10.1186\/1754-1611-6-19"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1128\/JB.182.6.1624-1631.2000","article-title":"Transcriptional and Mutational Analysis of the Uptake Hydrogenase of the Filamentous Cyanobacterium Anabaena Variabilis ATCC 29413","volume":"182","author":"Happe","year":"2000","journal-title":"J. Bacteriol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/j.1462-2920.2008.01604.x","article-title":"Diversity, function and evolution of genes coding for putative Ni-containing superoxide dismutases","volume":"10","author":"Dupont","year":"2008","journal-title":"Environ. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"38367","DOI":"10.1074\/jbc.M111.251603","article-title":"Structural Variation in Bacterial Glyoxalase I Enzymes: Investigation of the metalloenzyme glyoxalase I from clostridium acetobutylicum","volume":"286","author":"Suttisansanee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Kaur, C., Vishnoi, A., Ariyadasa, T.U., Bhattacharya, A., Singla-Pareek, S.L., and Sopory, S.K. (2013). Episodes of horizontal gene-transfer and gene-fusion led to co-existence of different metal-ion specific glyoxalase I. Sci. Rep., 3.","DOI":"10.1038\/srep03076"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3177\/jnsv.55.518","article-title":"Occurrence of Pseudovitamin B12 and Its Possible Function as the Cofactor of Cobalamin-Dependent Methionine Synthase in a Cyanobacterium Synechocystis sp. PCC6803","volume":"55","author":"Tanioka","year":"2009","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.dsr.2009.12.014","article-title":"Nickel utilization in phytoplankton assemblages from contrasting oceanic regimes","volume":"57","author":"Dupont","year":"2010","journal-title":"Deep Sea Res. Part I Oceanogr. Res. Pap."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Rodionov, D., Gelfand, M., and Gladyshev, V. (2009). Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics, 10.","DOI":"10.1186\/1471-2164-10-78"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"41148","DOI":"10.1074\/jbc.M305837200","article-title":"Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes","volume":"278","author":"Rodionov","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1111\/j.1742-4658.2006.05460.x","article-title":"Mutagenesis of hydrogenase accessory genes of Synechocystis sp. PCC 6803","volume":"273","author":"Hoffmann","year":"2006","journal-title":"FEBS J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1574-6976.2010.00230.x","article-title":"Canonical and ECF-type ATP-binding cassette importers in prokaryotes: Diversity in modular organization and cellular functions","volume":"35","author":"Eitinger","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/JB.188.1.317-327.2006","article-title":"Comparative and Functional Genomic Analysis of Prokaryotic Nickel and Cobalt Uptake Transporters: Evidence for a Novel Group of ATP-Binding Cassette Transporters","volume":"188","author":"Rodionov","year":"2006","journal-title":"J. Bacteriol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/JB.00090-12","article-title":"Characterization of the response to zinc deficiency in the cyanobacterium Anabaena sp. strain PCC 7120","volume":"194","author":"Napolitano","year":"2012","journal-title":"J. Bacteriol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Mirus, O., Strauss, S., Nicolaisen, K., von Haeseler, A., and Schleiff, E. (2009). TonB-dependent transporters and their occurrence in cyanobacteria. BMC Biol., 7.","DOI":"10.1186\/1741-7007-7-68"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1093\/nar\/gkp198","article-title":"Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition","volume":"37","author":"An","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1039\/b906683g","article-title":"Coordinating intracellular nickel-metal-site structure-function relationships and the NikR and RcnR repressors","volume":"27","author":"Iwig","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-2958.2002.02741.x","article-title":"A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803","volume":"43","author":"Florencio","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1039\/c3mt20241k","article-title":"Co(ll)-detection does not follow Kco(ll) gradient: Channelling in Co(ll)-sensing","volume":"5","author":"Patterson","year":"2013","journal-title":"Metallomics"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.1074\/jbc.M111.338301","article-title":"Cytosolic Ni(II) Sensor in Cyanobacterium: Nickel Detection Follows Nickel Affinity Across Four Families of Metal Sensors","volume":"287","author":"Foster","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nchembio844","article-title":"CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator","volume":"3","author":"Liu","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/mmi.12594","article-title":"Metal-specificity of cyanobacterial nickel-responsive repressor InrS: Cells maintain zinc and copper below the detection-threshold for InrS","volume":"92","author":"Foster","year":"2014","journal-title":"Mol. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1126\/science.1072375","article-title":"Public health. Worldwide occurrences of arsenic in ground water","volume":"296","author":"Nordstrom","year":"2002","journal-title":"Science"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1021\/bi200002a","article-title":"Arsenate replacing phosphate: Alternative life chemistries and ion promiscuity","volume":"50","author":"Tawfik","year":"2011","journal-title":"Biochemistry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/cb2000023","article-title":"Kinetic Consequences of Replacing the Internucleotide Phosphorus Atoms in DNA with Arsenic","volume":"6","author":"Fekry","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583512000157","article-title":"Why nature really chose phosphate","volume":"46","author":"Kamerlin","year":"2013","journal-title":"Q. Rev. Biophys."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1126\/science.2434996","article-title":"Why Nature Chose Phosphates","volume":"235","author":"Westheimer","year":"1987","journal-title":"Science"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.1073\/pnas.092131899","article-title":"Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9","volume":"99","author":"Liu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"18334","DOI":"10.1074\/jbc.M400037200","article-title":"As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli","volume":"279","author":"Meng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1046\/j.1365-2958.2001.02485.x","article-title":"The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae","volume":"40","author":"Wysocki","year":"2001","journal-title":"Mol. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/109374000436355","article-title":"Molecular aspects of arsenic stress","volume":"3","author":"Bernstam","year":"2000","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.1110832","article-title":"A Microbial Arsenic Cycle in a Salt-Saturated, Extreme Environment","volume":"308","author":"Oremland","year":"2005","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1160799","article-title":"Arsenic(III) Fuels Anoxygenic Photosynthesis in Hot Spring Biofilms from Mono Lake, California","volume":"321","author":"Kulp","year":"2008","journal-title":"Science"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbabio.2012.08.007","article-title":"Arsenics as bioenergetic substrates","volume":"1827","author":"Nitschke","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tplants.2011.12.003","article-title":"Arsenic biomethylation by photosynthetic organisms","volume":"17","author":"Ye","year":"2012","journal-title":"Trends Plant Sci."},{"key":"ref_116","first-page":"3","article-title":"Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals","volume":"232","author":"Thomas","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Riego, A.M., L\u00f3pez-Maury, L., and Florencio, F.J. (2014). Genomic Responses to Arsenic in the Cyanobacterium Synechocystis sp. PCC 6803. PLoS One, 9.","DOI":"10.1371\/journal.pone.0096826"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/bi201904p","article-title":"ArsH from the cyanobacterium Synechocystis sp. PCC 6803 is an efficient NADPH-dependent quinone reductase","volume":"51","author":"Hervas","year":"2012","journal-title":"Biochemistry"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/1574-6968.12481","article-title":"ArsH from Synechocystis sp. PCC 6803 reduces chromate and ferric iron","volume":"356","author":"Xue","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1128\/JB.01798-08","article-title":"The glutathione\/glutaredoxin system is essential for arsenate reduction in Synechocystis sp. strain PCC 6803","volume":"191","author":"Reyes","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1104\/pp.111.178947","article-title":"Biotransformation and volatilization of arsenic by three photosynthetic cyanobacteria","volume":"156","author":"Yin","year":"2011","journal-title":"Plant Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jprot.2011.10.011","article-title":"Proteomics combines morphological, physiological and biochemical attributes to unravel the survival strategy of Anabaena sp. PCC7120 under arsenic stress","volume":"75","author":"Pandey","year":"2012","journal-title":"J. Proteomics"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10811-010-9617-4","article-title":"Response of cyanobacteria to arsenic toxicity","volume":"23","author":"Bhattacharya","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1128\/JB.185.23.6780-6789.2003","article-title":"An arsenate reductase from Synechocystis sp. strain PCC 6803 exhibits a novel combination of catalytic characteristics","volume":"185","author":"Li","year":"2003","journal-title":"J. Bacteriol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1074\/jbc.M900877200","article-title":"Arsenate reductase, mycothiol, and mycoredoxin concert thiol\/disulfide exchange","volume":"284","author":"Roos","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2006.07.002","article-title":"Arsenate reduction: Thiol cascade chemistry with convergent evolution","volume":"362","author":"Messens","year":"2006","journal-title":"J. Mol. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1128\/MMBR.00035-08","article-title":"Ecological genomics of marine picocyanobacteria","volume":"73","author":"Scanlan","year":"2009","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1104\/pp.111.4.1067","article-title":"The cyanobacterial thioredoxin gene is required for both photoautotrophic and heterotrophic growth","volume":"111","author":"Navarro","year":"1996","journal-title":"Plant Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1016\/S0021-9258(19)84953-0","article-title":"Thioredoxin is essential for photosynthetic growth. The thioredoxin m gene of Anacystis nidulans","volume":"264","author":"Muller","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0966-842X(99)01494-8","article-title":"Families of arsenic transporters","volume":"7","author":"Rosen","year":"1999","journal-title":"Trends Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/(SICI)1097-0061(199707)13:9<819::AID-YEA142>3.0.CO;2-Y","article-title":"Isolation of Three Contiguous Genes, ACR1, ACR2 and ACR3, Involved in Resistance to Arsenic Compounds in the Yeast Saccharomyces cerevisiae","volume":"13","author":"Bobrowicz","year":"1997","journal-title":"Yeast"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1105\/tpc.109.069773","article-title":"A Vacuolar Arsenite Transporter Necessary for Arsenic Tolerance in the Arsenic Hyperaccumulating Fern Pteris vittata is Missing in Flowering Plants","volume":"22","author":"Indriolo","year":"2010","journal-title":"Plant Cell Online"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"729","DOI":"10.4319\/lo.2013.58.2.0729","article-title":"Arsenic and phosphorus biogeochemistry in the ocean: Arsenic species as proxies for P-limitation","volume":"58","author":"Wurl","year":"2013","journal-title":"Limnol. Oceanogr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1021\/es403836g","article-title":"Cyanobacteria-Mediated Arsenic Redox Dynamics is Regulated by Phosphate in Aquatic Environments","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11270-011-0936-0","article-title":"Accumulation and Transformation of Arsenic in the Blue-Green Alga Synechocysis sp. PCC 6803","volume":"223","author":"Yin","year":"2012","journal-title":"Water Air Soil Pollut."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/JB.00258-10","article-title":"Functional characterization of Synechocystis sp. strain PCC 6803 pst1 and pst2 gene clusters reveals a novel strategy for phosphate uptake in a freshwater cyanobacterium","volume":"192","author":"Pitt","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Dyhrman, S.T., and Haley, S.T. (2011). Arsenate Resistance in the Unicellular Marine Diazotroph Crocosphaera watsonii. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00214"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/aoc.590040316","article-title":"Effects of phosphate on arsenate inhibition in a marine cyanobacterium, Phormidium sp.","volume":"4","author":"Takahashi","year":"1990","journal-title":"Appl. Organomet. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/aoc.144","article-title":"Some characteristics of arsenate transport in a marine cyanobacterium, Synechococcus sp.","volume":"15","author":"Takahashi","year":"2001","journal-title":"Appl. Organomet. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1128\/jb.170.3.1143-1147.1988","article-title":"Phosphate transport and arsenate resistance in the cyanobacterium Anabaena variabilis","volume":"170","author":"Thiel","year":"1988","journal-title":"J. Bacteriol."},{"key":"ref_141","unstructured":"Markley, C.T. (2004). Arsenate uptake, sequestration and reduction by a freshwater cyanobacterium: A potential biologic control of arsenic in South Texas. [Master\u2019s Thesis, Texas A&M University]."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nature11517","article-title":"The molecular basis of phosphate discrimination in arsenate-rich environments","volume":"491","author":"Elias","year":"2012","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0006-291X(03)00584-9","article-title":"Metalloid tolerance based on phytochelatins is not functionally equivalent to the arsenite transporter Acr3p","volume":"304","author":"Wysocki","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/j.phytochem.2004.09.017","article-title":"A cyanobacterial protein with similarity to phytochelatin synthases catalyzes the conversion of glutathione to gamma-glutamylcysteine and lacks phytochelatin synthase activity","volume":"65","author":"Harada","year":"2004","journal-title":"Phytochemistry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.1074\/jbc.M113.455105","article-title":"Zinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii","volume":"288","author":"Malasarn","year":"2013","journal-title":"J. Biol. Chem."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/4\/4\/865\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:10:43Z","timestamp":1760217043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/4\/4\/865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":145,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["life4040865"],"URL":"https:\/\/doi.org\/10.3390\/life4040865","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}