{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:29:29Z","timestamp":1760146169890,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coimbra Chemistry Centre","award":["UID\/QUI\/UI0313\/2013"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liquids"],"abstract":"<jats:p>In this work, we propose a comprehensive experimental study of the diffusion of isoniazid, one of the first-line anti-tuberculosis drugs, in combination with another drug (ethambutol dihydrochloride) and with different cyclodextrins as carrier molecules, for facilitated transport and enhanced solubility. For that, ternary mutual diffusion coefficients measured by the Taylor dispersion method (D11, D22, D12, and D21) are determined for aqueous solutions containing isoniazid and different cyclodextrins (that is, \u03b1\u2013CD, \u03b2\u2013CD, and \u03b3\u2013CD) at 298.15 K. From the significant effect of the presence of these carbohydrates on the diffusion of this drug, interactions between these components are suggested. Support for this arose from models, which shows that these effects may be due to the formation of 1:1 (CDs:isoniazid) complexes.<\/jats:p>","DOI":"10.3390\/liquids4040039","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:14:03Z","timestamp":1729156443000},"page":"702-709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["On the Diffusion of Anti-Tuberculosis Drugs in Cyclodextrin-Containing Aqueous Solutions"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-0843","authenticated-orcid":false,"given":"M. Melia","family":"Rodrigo","sequence":"first","affiliation":[{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-0028","authenticated-orcid":false,"given":"Ana M. T. D. P. V.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-3184","authenticated-orcid":false,"given":"S\u00f3nia I. G.","family":"Fangaia","sequence":"additional","affiliation":[{"name":"Institute of Implantology and Prosthodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal"}]},{"given":"Afonso C.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Institute of Molecular Sciences, Department of Chemistry, CQC, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-7686","authenticated-orcid":false,"given":"Artur J. M.","family":"Valente","sequence":"additional","affiliation":[{"name":"Institute of Molecular Sciences, Department of Chemistry, CQC, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-1963","authenticated-orcid":false,"given":"Ana C. F.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Institute of Molecular Sciences, Department of Chemistry, CQC, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-3999","authenticated-orcid":false,"given":"Miguel A.","family":"Esteso","sequence":"additional","affiliation":[{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Universidad Cat\u00f3lica de \u00c1vila, Calle Los Canteros s\/n, 05005 \u00c1vila, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mazurek, A.H., and Szeleszczuk, \u0141. (2023). A Review of Applications of Solid-State Nuclear Magnetic Resonance (SsNMR) for the Analysis of Cyclodextrin-Including Systems. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043648"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-M\u00e9ndez, I., Aguayo-Ortiz, R., Sorroza-Mart\u00ednez, K., Solano, J.D., Porcu, P., Rivera, E., and Dominguez, L. (2020). Conformational Analysis by NMR and Molecular Dynamics of Adamantane-Doxorubicin Prodrugs and Their Assemblies with \u03b2\u2013Cyclodextrin: A Focus on the Design of Platforms for Controlled Drug Delivery. Bioorganic Med. 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Polym."}],"container-title":["Liquids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-8015\/4\/4\/39\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:12:12Z","timestamp":1760112732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-8015\/4\/4\/39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["liquids4040039"],"URL":"https:\/\/doi.org\/10.3390\/liquids4040039","relation":{},"ISSN":["2673-8015"],"issn-type":[{"type":"electronic","value":"2673-8015"}],"subject":[],"published":{"date-parts":[[2024,10,12]]}}}