{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:23:40Z","timestamp":1777652620108,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["2021.07178.BD"],"award-info":[{"award-number":["2021.07178.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Center in Physical Activity, Health and Leisure (CIAFEL)\u2014Faculty of Sports\u2014University of Porto","award":["UID\/00617\/2025"],"award-info":[{"award-number":["UID\/00617\/2025"]}]},{"name":"Laboratory for Integrative and Translational Research in Population Health","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lymphatics"],"abstract":"<jats:p>The ADRENALINE pilot study explores the role of physical activity in health outcomes among patients with Chronic Lymphocytic Leukemia (CLL), focusing on disease markers, functional capacity, immune parameters, and quality of life. This baseline analysis includes treatment-na\u00efve participants enrolled between September 2023 and August 2024, prior to randomization. Eleven patients (aged 47\u201378 years) underwent assessments of body composition, cardiovascular fitness, muscular strength, and immune profiling. Quality of life was evaluated using validated questionnaires (FACIT-F, EORTC QLQ-30\/CLL17), and daily activity was objectively measured via accelerometry. Correlation analyses examined associations between physical activity, muscle strength, lean mass, and physical aptitude. Despite high self-reported physical function, participants demonstrated suboptimal body composition and cardiovascular fitness. Accelerometry revealed marked sedentary behavior, particularly among females, and overall activity levels were below current recommendations. Moderate-to-vigorous physical activity correlated positively with muscular strength and lean mass. Immune profiling identified a variability in key markers, warranting further investigation of their relationship with physical activity. These findings highlight the need for tailored interventions to increase activity and reduce sedentary time in CLL patients and support incorporating functional and immune monitoring into survivorship care.<\/jats:p>","DOI":"10.3390\/lymphatics3040045","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T09:02:50Z","timestamp":1765270970000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Daily Activity in Risk and Survival Outcomes for Chronic Lymphocytic Leukemia Patients: Baseline Insights from the ADRENALINE Pilot Study"],"prefix":"10.3390","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-2010","authenticated-orcid":false,"given":"Pedro","family":"Cunha","sequence":"first","affiliation":[{"name":"Research Centre for Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-857X","authenticated-orcid":false,"given":"Ricardo","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Clinical Academic Center, School of Medicine and Biomedical Sciences Porto Hospital Centre, 4050-313 Porto, Portugal"},{"name":"Health Sciences Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-5569","authenticated-orcid":false,"given":"Andreia","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Research Centre for Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-9181","authenticated-orcid":false,"given":"Jorge","family":"Mota","sequence":"additional","affiliation":[{"name":"Research Centre for Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4606","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Research Centre for Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ou, Y., Long, Y., Ji, L., Zhan, Y., Qiao, T., Wang, X., Chen, H., and Cheng, Y. (2022). Trends in Disease Burden of Chronic Lymphocytic Leukemia at the Global, Regional, and National Levels from 1990 to 2019, and Projections Until 2030: A Population-Based Epidemiologic Study. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.840616"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yao, Y., Lin, X., Li, F., Jin, J., and Wang, H. (2022). The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: Analysis based on the global burden of disease study 2019. Biomed. Eng. Online, 21.","DOI":"10.1186\/s12938-021-00973-6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1249\/01.mss.0000877004.38963.34","article-title":"Quality of Life Changes Following High-intensity Interval Training in Older Adults with Chronic Lymphocytic Leukemia","volume":"54","author":"Artese","year":"2022","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11764-013-0322-6","article-title":"Physical activity levels of cancer survivors in Canada: Findings from the Canadian Community Health Survey","volume":"8","author":"Neil","year":"2014","journal-title":"J. Cancer Surviv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/107327481201900105","article-title":"Treatment of relapsed or refractory chronic lymphocytic leukemia","volume":"19","author":"Veliz","year":"2012","journal-title":"Cancer Control"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2141.2007.06791.x","article-title":"Quality of life in chronic lymphocytic leukemia: An international survey of 1482 patients","volume":"139","author":"Shanafelt","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13643-025-02764-9","article-title":"High-intensity interval training and strength conditioning in patients with chronic lymphocytic leukemia: A systematic review","volume":"14","author":"Cunha","year":"2025","journal-title":"Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood-2018-99-117736","article-title":"Exercise and Chronic Lymphocytic Leukemia (CLL)\u2013Relationships Among Physical Activity, Fitness, & Inflammation, and Their Impacts on CLL Patients","volume":"132","author":"Sitlinger","year":"2018","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s40279-021-01466-1","article-title":"Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis","volume":"51","author":"Chastin","year":"2021","journal-title":"Sports Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.2174\/1381612822666160322145107","article-title":"The Immunomodulatory Effects of Physical Activity","volume":"22","author":"Mooren","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2017-09-806398","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","journal-title":"Blood"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.bjc.6604433","article-title":"Long-term follow-up after cancer rehabilitation using high-intensity resistance training: Persistent improvement of physical performance and quality of life","volume":"99","author":"Vreugdenhil","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.21037\/gs-23-126","article-title":"The effects of exercise on the quality of life of patients with breast cancer: A systematic review and meta-analysis based on the QLQ-C30 quality of life scale","volume":"12","author":"Chen","year":"2023","journal-title":"Gland Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine\u2014Evidence for prescribing exercise as therapy in 26 different chronic diseases","volume":"25","author":"Pedersen","year":"2015","journal-title":"Scand. J. Med. Sci. Sport."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jshs.2019.04.002","article-title":"Exercise as a prescription for patients with various diseases","volume":"8","author":"Luan","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1200\/JCO.2008.20.0634","article-title":"Randomized Controlled Trial of the Effects of Aerobic Exercise on Physical Functioning and Quality of Life in Lymphoma Patients","volume":"27","author":"Courneya","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_18","first-page":"1697","article-title":"A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients","volume":"24","author":"Furzer","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.jpainsymman.2019.07.005","article-title":"The Effect of Exercise on Quality of Life, Fatigue, Physical Function, and Safety in Advanced Solid Tumor Cancers: A Meta-analysis of Randomized Control Trials","volume":"58","author":"Nadler","year":"2019","journal-title":"J. Pain Symptom Manag."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"MacDonald, G., Sitlinger, A., Deal, M.A., Hanson, E.D., Ferraro, S., Pieper, C.F., Weinberg, J.B., Brander, D.M., and Bartlett, D.B. (2021). A pilot study of high-intensity interval training in older adults with treatment naive chronic lymphocytic leukemia. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-02352-6"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/ejh.13958","article-title":"Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study","volume":"110","author":"Crane","year":"2023","journal-title":"Eur. J. Haematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1182\/bloodadvances.2019001317","article-title":"Impact of exercise on the immune system and outcomes in hematologic malignancies","volume":"4","author":"Sitlinger","year":"2020","journal-title":"Blood Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12966-017-0498-7","article-title":"Correlates of meeting the combined and independent aerobic and strength exercise guidelines in hematologic cancer survivors","volume":"14","author":"Vallerand","year":"2017","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1249\/mss.0b013e31815a51b3","article-title":"Physical activity in the United States measured by accelerometer","volume":"40","author":"Troiano","year":"2008","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1479-5868-7-60","article-title":"Accelerometer profiles of physical activity and inactivity in normal weight, overweight, and obese US men and women","volume":"7","author":"Brashear","year":"2010","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Stevens, W.R., Anderson, A.M., and Tulchin-Francis, K. (2020). Validation of Accelerometry Data to Identify Movement Patterns During Agility Testing. Front. Sports Act. Living, 2.","DOI":"10.3389\/fspor.2020.563809"},{"key":"ref_27","unstructured":"Paiva, S., and Paul, S. (2020). A Comprehensive Framework of Usability Issues Related to the Wearable Devices. Convergence of ICT and Smart Devices for Emerging Applications, Springer International Publishing."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/1534735416684016","article-title":"Assessing the Correlation Between Physical Activity and Quality of Life in Advanced Lung Cancer","volume":"17","author":"Bade","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ejvs.2020.11.044","article-title":"Wearable Activity Monitors in Home Based Exercise Therapy for Patients with Intermittent Claudication: A Systematic Review","volume":"61","author":"Chan","year":"2021","journal-title":"Eur. J. Vasc. Endovasc."},{"key":"ref_30","first-page":"3915","article-title":"Self-monitoring physical activity with a smartphone application in cancer patients: A randomized feasibility study (SMART-trial)","volume":"26","author":"Ormel","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jpainsymman.2011.06.013","article-title":"Physical Activity Monitoring: A Responsive and Meaningful Patient-Centered Outcome for Surgery, Chemotherapy, or Radiotherapy?","volume":"43","author":"Ferriolli","year":"2012","journal-title":"J. Pain Symptom Manag."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2016.04.016","article-title":"Circadian regulation of human peripheral neutrophils","volume":"57","author":"Ella","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e001121","DOI":"10.1136\/bmjresp-2021-001121","article-title":"ARTP statement on cardiopulmonary exercise testing 2021","volume":"8","author":"Pritchard","year":"2021","journal-title":"BMJ Open Respir. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1901441","DOI":"10.1183\/13993003.01441-2019","article-title":"Standardisation of cardiopulmonary exercise testing in chronic lung diseases: Summary of key findings from the ERS task force","volume":"54","author":"Radtke","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0894-1130(12)80326-7","article-title":"Accuracy of the Jamar dynamometer","volume":"6","author":"Harkonen","year":"1993","journal-title":"J. Hand Ther."},{"key":"ref_36","unstructured":"National Institute for Health and Care Research (2014). Procedure for Measuring Hand Grip Strength Using The JAMAR Dynamometer, NIHR Southampton Biomedical Research Centre."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1055\/s-2007-1021104","article-title":"Isokinetic evaluation of muscular performance: Implications for muscle testing and rehabilitation","volume":"15","author":"Kannus","year":"1994","journal-title":"Int. J. Sports Med."},{"key":"ref_38","first-page":"1121","article-title":"A guide to assessing physical activity using accelerometry in cancer patients","volume":"22","author":"Broderick","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","article-title":"A New Prognostic Classification of Chronic Lymphocytic-Leukemia Derived from a Multivariate Survival Analysis","volume":"48","author":"Binet","year":"1981","journal-title":"Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical Staging of Chronic Lymphocytic Leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/bjc.1993.140","article-title":"Performance status assessment in cancer patients. An inter-observer variability study","volume":"67","author":"Sorensen","year":"1993","journal-title":"Br. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7525-1-79","article-title":"The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: Properties, applications, and interpretation","volume":"1","author":"Webster","year":"2003","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/bjh.18072","article-title":"International validation of the EORTC QLQ-CLL17 questionnaire for assessment of health-related quality of life for patients with chronic lymphocytic leukaemia","volume":"197","author":"Oerlemans","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_44","unstructured":"Joanna Briggs Institute (2020). Checklist for Analytical Cross-Sectional Studies, Joanna Briggs Institute."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3352\/jeehp.2021.18.17","article-title":"Sample size determination and power analysis using the G*Power software","volume":"18","author":"Kang","year":"2021","journal-title":"J. Educ. Eval. Health Prof."},{"key":"ref_46","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Routledge. [2nd ed.]."},{"key":"ref_47","first-page":"6305","article-title":"Paired exercise has superior effects on psychosocial health compared to individual exercise in female cancer patients","volume":"29","author":"Yamada","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1200\/JCO.2007.15.4963","article-title":"Randomized Controlled Trial of Resistance or Aerobic Exercise in Men Receiving Radiation Therapy for Prostate Cancer","volume":"27","author":"Segal","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10549-007-9602-z","article-title":"Effects of a combined aerobic and resistance exercise program in breast cancer survivors: A randomized controlled trial","volume":"108","author":"Milne","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_50","unstructured":"ACSM (2018). ACSM\u2019s Guidelines for Exercise Testing and Prescription, Wolters Kluwer Health. [10th ed.]."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zeng, X., Zhang, L., Zhang, Y., Jia, S., Lin, T., Zhao, X., and Huang, X. (2023). Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: A systematic review. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1308544"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41585-021-00476-y","article-title":"Exercise-induced myokines and their effect on prostate cancer","volume":"18","author":"Kim","year":"2021","journal-title":"Nat. Rev. Urol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/aje\/kwx345","article-title":"Does Strength-Promoting Exercise Confer Unique Health Benefits? A Pooled Analysis of Data on 11 Population Cohorts with All-Cause, Cancer, and Cardiovascular Mortality Endpoints","volume":"187","author":"Stamatakis","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Imboden, M.T., Swartz, A.M., Finch, H.W., Herber, M.P., and Kaminsky, L.A. (2017). Reference standards for lean mass measures using GE dual energy X-ray absorptiometry in Caucasian adults. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176161"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0609.2004.00233.x","article-title":"Quality of life of patients with chronic lymphocytic leukemia: Results of a longitudinal investigation over 1 yr","volume":"72","author":"Holzner","year":"2004","journal-title":"Eur. J. Haematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/ejh.13503","article-title":"Quality of life in patients of chronic lymphocytic leukemia using the EORTC QLQ-C30 and QLQ-CLL17 questionnaire","volume":"105","author":"Youron","year":"2020","journal-title":"Eur. J. Haematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101373","DOI":"10.1016\/j.jgo.2022.09.002","article-title":"Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study","volume":"14","author":"Artese","year":"2022","journal-title":"J. Geriatr. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Stein, M.J., Baurecht, H., Bohmann, P., Fervers, B., Fontvieille, E., Freisling, H., Friedenreich, C.M., Konzok, J., Peruchet-Noray, L., and Sedlmeier, A.M. (2024). Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank. BMC Med., 22.","DOI":"10.1186\/s12916-024-03632-4"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/eurjpc\/zwac239","article-title":"Setting your clock: Associations between timing of objective physical activity and cardiovascular disease risk in the general population","volume":"30","author":"Albalak","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.smhs.2021.05.001","article-title":"2020 WHO guidelines on physical activity and sedentary behavior","volume":"3","author":"Okely","year":"2021","journal-title":"Sports Med. Health Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Persoon, S., Chinapaw, M.J.M., Buffart, L.M., Liu, R.D.K., Wijermans, P., Koene, H.R., Minnema, M.C., Lugtenburg, P.J., Marijt, E.W.A., and Brug, J. (2017). Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181313"},{"key":"ref_62","unstructured":"Central Administration of the Health System, IP, Portugal (2025, March 05). VALORES LABORATORIAIS DE REFER\u00caNCIA (ADULTOS). Available online: https:\/\/www.acss.min-saude.pt\/wp-content\/uploads\/2018\/09\/Tabela_Final.pdf."}],"container-title":["Lymphatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2813-3307\/3\/4\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:22:19Z","timestamp":1765279339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2813-3307\/3\/4\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["lymphatics3040045"],"URL":"https:\/\/doi.org\/10.3390\/lymphatics3040045","relation":{},"ISSN":["2813-3307"],"issn-type":[{"value":"2813-3307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}