{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:28:32Z","timestamp":1766269712683,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:00:00Z","timestamp":1532736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Luminescent mesoporous silica nanoparticles, CdTeQDs@MNs@PEG1, SiQDs@Isoc@MNs and SiQDs@Isoc@MNs@PEG2, were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC\/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT\/NR\/ LDH) compared with the respective solvent and\/or coating controls, excepting for CdTeQDs@MNs@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC\/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin.<\/jats:p>","DOI":"10.3390\/ma11081310","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T11:55:08Z","timestamp":1532951708000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-085X","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Marcelo","sequence":"first","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-5161","authenticated-orcid":false,"given":"Jessica","family":"Ariana-Machado","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-5874","authenticated-orcid":false,"given":"Maria","family":"Enea","sequence":"additional","affiliation":[{"name":"UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy of the University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Helena","family":"Carmo","sequence":"additional","affiliation":[{"name":"UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy of the University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Benito","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Scientific and Technological Research Assistance Centre (CACTI), University of Vigo, 36310 Vigo, Spain"}]},{"given":"Jos\u00e9","family":"Luis Capelo","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-5446","authenticated-orcid":false,"given":"Carlos","family":"Lodeiro","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-4820","authenticated-orcid":false,"given":"Elisabete","family":"Oliveira","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1039\/C4TB01217H","article-title":"Preparation of 2D molecularly imprinted materials based on mesoporous silicas via click reaction","volume":"2","author":"Xu","year":"2014","journal-title":"J. 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