{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:44:45Z","timestamp":1762674285994,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004493","name":"International Atomic Energy Agency","doi-asserted-by":"publisher","award":["CRP F23030, Contract number: 18202"],"award-info":[{"award-number":["CRP F23030, Contract number: 18202"]}],"id":[{"id":"10.13039\/501100004493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Several studies have shown that chitosan possesses characteristics favorable for promoting dermal regeneration and accelerated wound healing. In this work we have reported the work that has been done on the development and characterization of biocompatible and biodegradable chitosan based matrices to be used as skin scaffolds. Poly(vinylpyrrrolidone) (PVP) was used as copolymer and a two steps methodology of freeze-drying and gamma irradiation was used to obtain the porous matrices. The influence of PVP content, synthesis procedure and absorbed radiation dose on matrices\u2019 physical, chemical and structural properties was evaluated by ATR-FTIR, TGA, SEM, contact angle measurements and degradation behavior. The in vitro cellular viability and proliferation of HFFF2 fibroblast cell line was analyzed as a measure of matrices\u2019 biocompatibility and ability to assist skin regeneration. Results show that over the studied range values, gamma-radiation dose, copolymer concentration and synthesis procedure can be used to tailor the matrices\u2019 morphology in terms of porosity and surface roughness. Early results from biological assays evidence the biocompatibility of the prepared chitosan\/PVP matrices since cells adhered to the surface of all matrices (chitosan\/PVP (5%) \u03b3-irradiated at 10 kGy presents the higher cellular viability). These features show that the resultant matrices could be a potential suitable scaffold for skin tissue regeneration.<\/jats:p>","DOI":"10.3390\/ma11122535","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T03:58:17Z","timestamp":1544759897000},"page":"2535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chitosan\/Poly(vinylpyrrolidone) Matrices Obtained by Gamma-Irradiation for Skin Scaffolds: Characterization and Preliminary Cell Response Studies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-0686","authenticated-orcid":false,"given":"Maria Helena","family":"Casimiro","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares (C2TN), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal"}]},{"given":"Susana R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares (C2TN), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal"}]},{"given":"Gabriela","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro de Ecologia, Evolu\u00e7\u00e3o e Altera\u00e7\u00f5es Ambientais (cE3c) and Departamento de Biologia Animal, Faculdade de Ci\u00eancias, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-0107","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Leal","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares (C2TN), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural (CQE), Instituto Superior T\u00e9cnico, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal"}]},{"given":"Lu\u00eds M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares (C2TN), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.msec.2015.12.094","article-title":"The influence of topography on tissue engineering perspective","volume":"61","author":"Mansouri","year":"2016","journal-title":"Mater. 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