{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:05:49Z","timestamp":1777338349689,"version":"3.51.4"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundacao para a Ciencia e Tecnologia","award":["LAETA project UID\/EMS\/50022\/2019"],"award-info":[{"award-number":["LAETA project UID\/EMS\/50022\/2019"]}]},{"name":"Fundacao para a Ciencia e Tecnologia","award":["PTDC\/BBB-BMC\/5655\/2014"],"award-info":[{"award-number":["PTDC\/BBB-BMC\/5655\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Scaffolds for bone tissue engineering are porous structures that serve as support for cellular growth and, therefore, new tissue formation. The present work assessed the influence of the porous architecture of triply periodic minimal surface (TPMS) scaffolds on their macroscopic permeability behavior, combining numerical and experimental methods. The TPMS scaffolds considered were Schwartz D, Schwartz P, and Gyroid, which have been previously studied for bone tissue engineering, with 70% porosity. On the experimental side, these scaffolds were produced by MultiJet 3D printing and tested for fluid passage to calculate their permeability through Darcy\u2019s Law. On the numerical side, finite element (FE) models of the scaffolds were simulated on ABAQUS\u00ae for fluid passage under compression to assess potential fluid concentration spots. The outcomes revealed that the design of the unit cell had a noticeable effect on both calculated permeability and FE computed fluid flow velocity, regardless of the identical porosity, with the Gyroid scaffold having higher permeability and the Schwartz P a lower probability of fluid trapping. Schwartz D had the worst outcomes in both testing modalities, so these scaffolds would most likely be the last choice for promoting cell differentiation onto bone cells. Gyroid and Schwartz P would be up for selection depending on the application and targeted bone tissue.<\/jats:p>","DOI":"10.3390\/ma12081313","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:02:53Z","timestamp":1555930973000},"page":"1313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Permeability versus Design in TPMS Scaffolds"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-0408","authenticated-orcid":false,"given":"A. P. G.","family":"Castro","sequence":"first","affiliation":[{"name":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-7049","authenticated-orcid":false,"given":"T.","family":"Pires","sequence":"additional","affiliation":[{"name":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]},{"given":"J. E.","family":"Santos","sequence":"additional","affiliation":[{"name":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]},{"given":"B. P.","family":"Gouveia","sequence":"additional","affiliation":[{"name":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-096X","authenticated-orcid":false,"given":"P. R.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"061014","DOI":"10.1115\/1.3128672","article-title":"Parametric finite element analysis of physical stimuli resulting from mechanical stimulation of tissue engineered cartilage","volume":"131","author":"Babalola","year":"2009","journal-title":"J. Biomech. 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