{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:23:37Z","timestamp":1771374217445,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculdade de Medicina da Universidade de Coimbra); FCT, Portugal","award":["Strategic Project PEst-C\/SAU\/UI3282\/2013 and UID\/NEU\/04539\/2013], COMPETE-FEDER."],"award-info":[{"award-number":["Strategic Project PEst-C\/SAU\/UI3282\/2013 and UID\/NEU\/04539\/2013], COMPETE-FEDER."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>(1) Background: Recently, tricalcium silicate cements, such as Biodentine\u2122, have emerged. This biomaterial has a calcium hydroxide base and characteristics like mineral aggregate trioxide cements, but has tightening times that are substantially more suitable for their application and other clinical advantages. (2) Methods: A retrospective clinical study was conducted with 20 patients, which included a clinical evaluation of the presence or absence of pulp inflammation compatible symptoms, radiographic evaluation of the periapical tissues, and structural alterations of the coronary restoration that supports pulp capping therapies with Biodentine\u2122 and WhiteProRoot\u00aeMTA. (3) Results: This clinical study revealed similar success rates between mineral trioxide cement and tricalcium silicates cements at 6 months, with 100% and 95% success rates, respectively. There were no statistically significant differences between both biomaterials and between these and the various clinical circumstances, namely the absolute isolation of the operating field, exposure size, the aetiology of exposure, and even the type of restorative material used. (4) Conclusions: Biodentine\u2122 demonstrated a therapeutic effect on the formation of a dentin bridge accompanied by slight inflammatory signs, with a high clinical success rate, indicating the possibility of its effective and safe use in dental pulp direct capping in humans, similar to the gold standard material.<\/jats:p>","DOI":"10.3390\/ma12203382","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T04:46:06Z","timestamp":1571287566000},"page":"3382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective Clinical Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-4173","authenticated-orcid":false,"given":"Anabela","family":"Paula","sequence":"first","affiliation":[{"name":"Institute of Integrated Clinical Practice, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-5557","authenticated-orcid":false,"given":"Eunice","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-6007","authenticated-orcid":false,"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Ana M.","family":"Abrantes","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Jo\u00e3o","family":"Casalta-Lopes","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Radiation Oncology Department, Coimbra University Hospital Centre, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Biophysics Institute, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI Consortium, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-5417","authenticated-orcid":false,"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[{"name":"Institute of Experimental Pathology, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-6161","authenticated-orcid":false,"given":"Manuel M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Institute of Endodontics, Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology (CIBB), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0972-0707.212243","article-title":"Clinical evaluation of mineral trioxide aggregate and biodentine as direct pulp capping agents in carious teeth","volume":"20","author":"Hegde","year":"2017","journal-title":"J. Conserv. Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.joen.2017.06.017","article-title":"Treatment Outcome Following Direct Pulp Capping Using Bioceramic Materials in Mature Permanent Teeth with Carious Exposure: A Pilot Retrospective Study","volume":"43","author":"Linu","year":"2017","journal-title":"J. Endod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jebdp.2018.02.002","article-title":"Direct pulp capping: What is the most effective therapy?\u2014Systematic review and meta-analysis","volume":"18","author":"Laranjo","year":"2018","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_4","first-page":"946","article-title":"Success rate of direct pulp capping with calcium hydroxide","volume":"113","author":"Auschill","year":"2003","journal-title":"Schweizer Monatsschrift fur."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004770-200009000-00010","article-title":"Pulp capping of carious exposures: Treatment outcome after 5 and 10 years: A retrospective study","volume":"26","author":"Barthel","year":"2000","journal-title":"J. Endod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1079-2104(03)00155-0","article-title":"Direct capping of human pulps with a dentin bonding system or with calcium hydroxide cement","volume":"96","author":"Vilkinis","year":"2003","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2591.2008.01485.x","article-title":"Evaluation of two mineral trioxide aggregate compounds as pulp-capping agents in human teeth","volume":"42","author":"Accorinte","year":"2009","journal-title":"Int. Endod. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2007.09.012","article-title":"Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth","volume":"34","author":"Holland","year":"2008","journal-title":"J. Endod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5395\/rde.2016.41.1.29","article-title":"Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry","volume":"41","author":"Kim","year":"2016","journal-title":"Restor. Dent. Endod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/iej.12719","article-title":"Capping carious exposures in adults: A randomized controlled trial investigating mineral trioxide aggregate versus calcium hydroxide","volume":"50","author":"Kundzina","year":"2017","journal-title":"Int. Endod. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1365-2591.2006.01135.x","article-title":"Mineral trioxide aggregate: A review of the constituents and biological properties of the material","volume":"39","author":"Camilleri","year":"2006","journal-title":"Int. Endod. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tripleo.2008.06.006","article-title":"A comparative study of histologic response to different pulp capping materials and a novel endodontic cement","volume":"106","author":"Asgary","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.joen.2008.05.006","article-title":"The Properties of a New Endodontic Material","volume":"34","author":"Asgary","year":"2008","journal-title":"J. Endod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2009.09.006","article-title":"Mineral Trioxide Aggregate: A Comprehensive Literature Review\u2014Part I: Chemical, Physical, and Antibacterial Properties","volume":"36","author":"Parirokh","year":"2010","journal-title":"J. Endod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"464280","DOI":"10.1155\/2009\/464280","article-title":"Reparative Dentinogenesis Induced by Mineral Trioxide Aggregate: A Review from the Biological and Physicochemical Points of View","volume":"2009","author":"Okiji","year":"2009","journal-title":"Int. J. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s40368-015-0191-y","article-title":"Pulp management after traumatic injuries with a tricalcium silicate-based cement (BiodentineTM): A report of two cases, up to 48 months follow-up","volume":"16","author":"Martens","year":"2015","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nikfarjam, F., Beyer, K., K\u00f6nig, A., Hofmann, M., Butting, M., Valesky, E., Kippenberger, S., Kaufmann, R., Heidemann, D., and Bernd, A. (2016). Influence of Biodentine\u00ae\u2014A Dentine Substitute\u2014On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167633"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00784-012-0701-9","article-title":"Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth\u2014A prospective study","volume":"17","author":"Koubi","year":"2013","journal-title":"Clin. Oral Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40368-014-0114-3","article-title":"BiodentineTM material characteristics and clinical applications: A review of the literature","volume":"15","author":"Rajasekharan","year":"2014","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.dental.2013.03.007","article-title":"Investigation of the hydration and bioactivity of radiopacified tricalcium silicate cement, Biodentine and MTA Angelus","volume":"29","author":"Camilleri","year":"2013","journal-title":"Dent. Mater."},{"key":"ref_21","unstructured":"The Council of European Dentists (2015). Manual of Dental Practice 2015, Cardiff University. 5.1."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.adaj.2016.07.011","article-title":"Laser use in direct pulp capping: A meta-analysis","volume":"147","author":"Deng","year":"2016","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jbm.a.35968","article-title":"Could the application of bioactive molecules improve vital pulp therapy success? A systematic review","volume":"105","author":"Piva","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14219\/jada.archive.2008.0160","article-title":"Direct pulp capping with mineral trioxide aggregate: An observational study","volume":"139","author":"Bogen","year":"2008","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.joen.2015.03.015","article-title":"A Randomized Controlled Study of the Use of ProRoot Mineral Trioxide Aggregate and Endocem as Direct Pulp Capping Materials: 3-month versus 1-year Outcomes","volume":"41","author":"Jang","year":"2015","journal-title":"J. Endod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.joen.2018.08.004","article-title":"Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine: A Prospective Randomized Clinical Trial","volume":"44","author":"Awawdeh","year":"2018","journal-title":"J. Endod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.joen.2017.10.012","article-title":"Outcomes of Direct Pulp Capping by Using Either ProRoot Mineral Trioxide Aggregate or Biodentine in Permanent Teeth with Carious Pulp Exposure in 6- to 18-Year-Old Patients: A Randomized Controlled Trial","volume":"44","author":"Parinyaprom","year":"2018","journal-title":"J. Endod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.joen.2017.06.031","article-title":"Direct Pulp Capping with Calcium Hydroxide, Mineral Trioxide Aggregate, and Biodentine in Permanent Young Teeth with Caries: A Randomized Clinical Trial","volume":"43","author":"Brizuela","year":"2017","journal-title":"J. Endod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/0976-237X.137967","article-title":"Direct pulp capping in an immature incisor using a new bioactive material","volume":"5","author":"Bhat","year":"2014","journal-title":"Contemp. Clin. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.joen.2016.11.026","article-title":"Comparative Analysis of 2 Calcium Silicate-based Cements (Biodentine and Mineral Trioxide Aggregate) as Direct Pulp-capping Agent in Young Permanent Molars: A Split Mouth Study","volume":"43","author":"Katge","year":"2017","journal-title":"J. Endod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joen.2013.01.005","article-title":"Response of Human Dental Pulp Capped with Biodentine and Mineral Trioxide Aggregate","volume":"39","author":"Nowicka","year":"2013","journal-title":"J. Endod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","article-title":"Vital pulp therapy in vital permanent teeth with cariously exposed pulp: A systematic review","volume":"37","author":"Aguilar","year":"2011","journal-title":"J. Endod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-9657.2011.01058.x","article-title":"Pulp and periodontal tissue repair\u2014Regeneration or tissue metaplasia after dental trauma. A review","volume":"28","author":"Andreasen","year":"2012","journal-title":"Dent. Traumatol."},{"key":"ref_34","first-page":"843","article-title":"Effects of hemostatic agents on the histomorphologic response of human dental pulp capped with calcium hydroxide","volume":"38","author":"Accorinte","year":"2007","journal-title":"Quintessence Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0039-1698891","article-title":"Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study","volume":"5","author":"Bal","year":"2011","journal-title":"Eur. J. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1365-2591.2001.00410.x","article-title":"In vitro antimicrobial activity of several concentrations of sodium hypochlorite and chlorhexidine gluconate in the elimination of Enterococcus faecalis","volume":"34","author":"Gomes","year":"2001","journal-title":"Int. Endod. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.joen.2010.11.006","article-title":"Comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: A molecular microbiology study","volume":"37","author":"Siqueira","year":"2011","journal-title":"J. Endod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2591.2006.01101.x","article-title":"The influence of haemostatic agents on healing of healthy human dental pulp tissue capped with calcium hydroxide","volume":"39","author":"Silva","year":"2006","journal-title":"Int. Endod. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jdent.2013.08.016","article-title":"Are there universal restorative composites for anterior and posterior teeth?","volume":"41","author":"Baldissera","year":"2013","journal-title":"J. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.joen.2010.08.024","article-title":"Histologic assessment of human pulp response to capping with mineral trioxide aggregate and a novel endodontic cement","volume":"36","author":"Zarrabi","year":"2010","journal-title":"J. Endod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"594950","DOI":"10.1155\/2013\/594950","article-title":"Comparison of the radiopacities of different root-end filling and repair materials","volume":"2013","author":"Tanalp","year":"2013","journal-title":"Sci. World J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13005-015-0074-9","article-title":"An in vitro study of different material properties of Biodentine compared to ProRoot MTA","volume":"11","author":"Kaup","year":"2015","journal-title":"Head Face Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.joen.2014.09.025","article-title":"Radiopacifier particle size impacts the physical properties of tricalcium silicate-based cements","volume":"41","author":"Saghiri","year":"2015","journal-title":"J. Endod."},{"key":"ref_44","first-page":"19","article-title":"Bond efficacy and interface morphology of self-etching adhesives to ground enamel","volume":"12","author":"Abdalla","year":"2010","journal-title":"J. Adhes. Dent."},{"key":"ref_45","first-page":"321","article-title":"Adhesive sealing of dentin surfaces in vitro: A review","volume":"28","author":"Nawareg","year":"2015","journal-title":"Am. J. Dent."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.dental.2014.07.007","article-title":"Clinical effectiveness of contemporary adhesives for the restoration of non-carious cervical lesions. A systematic review","volume":"30","author":"Peumans","year":"2014","journal-title":"Dent. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.dental.2015.06.001","article-title":"Does the adhesive strategy influence the post-operative sensitivity in adult patients with posterior resin composite restorations?: A systematic review and meta-analysis","volume":"31","author":"Reis","year":"2015","journal-title":"Dent. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/0022034512452143","article-title":"Distinct photopolymerization efficacy on dentin of self-etch adhesives","volume":"91","author":"Zhang","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jdent.2012.11.006","article-title":"Effect of application mode on interfacial morphology and chemistry between dentine and self-etch adhesives","volume":"41","author":"Zhang","year":"2013","journal-title":"J. Dent."},{"key":"ref_50","first-page":"ZE18","article-title":"Flowable Resin Composites: A Systematic Review and Clinical Considerations","volume":"9","author":"Baroudi","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.dental.2010.10.020","article-title":"Resin composite\u2014State of the art","volume":"27","author":"Ferracane","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0022034514544217","article-title":"Longevity of posterior composite restorations: A systematic review and meta-analysis","volume":"93","author":"Opdam","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"78S","DOI":"10.1177\/0022034513484337","article-title":"Patient risk factors\u2019 influence on survival of posterior composites","volume":"92","author":"Opdam","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_54","first-page":"ZE04","article-title":"Allergic Reactions to Dental Materials\u2014A Systematic Review","volume":"9","author":"Syed","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_55","first-page":"69","article-title":"Biocompatibility of a new pulp capping cement","volume":"5","author":"Poggio","year":"2014","journal-title":"Ann. Stomatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/181945","article-title":"Cytocompatibility and Antibacterial Properties of Capping Materials","volume":"2014","author":"Poggio","year":"2014","journal-title":"Sci. World J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.joen.2013.11.006","article-title":"Biodentine and mineral trioxide aggregate induce similar cellular responses in a fibroblast cell line","volume":"40","author":"Bosomworth","year":"2014","journal-title":"J. Endod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2591.2006.01116.x","article-title":"Formation of a hard tissue barrier after pulp cappings in humans. A systematic review","volume":"39","author":"Olsson","year":"2006","journal-title":"Int. Endod. J."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/12\/20\/3382\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:26:54Z","timestamp":1760189214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/12\/20\/3382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":58,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["ma12203382"],"URL":"https:\/\/doi.org\/10.3390\/ma12203382","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,16]]}}}