{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:07:20Z","timestamp":1768525640636,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing effects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be efficient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg\/mL. Similar behavior was observed for antioxidant activity, determined by the \u03b2-carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan\u2013buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.<\/jats:p>","DOI":"10.3390\/ma13081977","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T11:42:14Z","timestamp":1587728534000},"page":"1977","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Biocompatible Gels of Chitosan\u2013Buriti Oil for Potential Wound Healing Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria Onaira Gon\u00e7alves","family":"Ferreira","sequence":"first","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]},{"given":"Idglan S\u00e1","family":"Lima","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]},{"given":"Alessandra Braga","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, CBQF\u2013Centre of Biotechnology and Fine Chemistry\u2013Associate Laboratory, Catholic University of Portugal, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2544-0438","authenticated-orcid":false,"given":"Anderson O.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]},{"given":"Marcia S.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-3244","authenticated-orcid":false,"given":"Josy Anteveli","family":"Osajima","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]},{"given":"Leticia Miranda","family":"Estevinho","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Bragan\u00e7a, Agricultural College of Bragan\u00e7a, Campus Santa Apol\u00f3nia, 5301-855 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-2970","authenticated-orcid":false,"given":"Edson C.","family":"Silva-Filho","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Graduate Program, Federal University of Piau\u00ed, Campus Universit\u00e1rio Ministro Petr\u00f4nio Portella, Teresina, PI CEP 64049-550, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.actbio.2009.04.021","article-title":"Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone","volume":"5","author":"Moreira","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000348359","article-title":"Delivery of mesenchymal stem cells in Chitosan\/collagen microbeads for orthopedic tissue repair","volume":"197","author":"Wang","year":"2013","journal-title":"Cells Tissues Organs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jddst.2018.12.003","article-title":"Chitosan associated with chlorhexidine in gel form: Synthesis, characterization and healing wounds applications","volume":"49","author":"Ferreira","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.carbpol.2016.07.037","article-title":"Chitosan Hydrogel in combination with Nerolidol for healing wounds","volume":"152","author":"Ferreira","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jhazmat.2007.08.025","article-title":"The removal of Basic Blue 3 from aqueous solutions by chitosan-based adsorbent: Batch studies","volume":"153","author":"Crini","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijpharm.2009.06.020","article-title":"Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery","volume":"379","author":"Li","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_7","unstructured":"Assis, O.B.G., Leoni, A.M., and Novaes, A.P. (2007). Avalia\u00e7\u00e3o do Efeito Cicatrizante da Quitosana por Aplica\u00e7\u00e3o T\u00f3pica em Ratos. Embrapa, 1\u201316. Available online: https:\/\/www.infoteca.cnptia.embrapa.br\/bitstream\/doc\/30800\/1\/DOC292007.pdf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jbm.b.30000","article-title":"Chitosan membrane as a wound-healing dressing: Characterization and clinical application","volume":"69","author":"Azad","year":"2004","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0939-6411(03)00161-9","article-title":"Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications","volume":"57","author":"Berger","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biotechadv.2011.01.005","article-title":"Biomaterials based on chitin and chitosan in wound dressing applications","volume":"29","author":"Jayakumar","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.burns.2006.12.002","article-title":"Effects of chitosan and heparin on early extension of burns","volume":"33","author":"Jin","year":"2007","journal-title":"Burns"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.fitote.2009.03.007","article-title":"Effect of citral, eugenol, nerolidol and \u03b1-terpineol on the ultrastructural changes of Trichophyton mentagrophytes","volume":"80","author":"Park","year":"2009","journal-title":"Fitoterapia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/am300292v","article-title":"Flexible and microporous chitosan hydrogel\/nano ZnO composite bandages for wound dressing: In vitro and in vivo evaluation","volume":"4","author":"Lakshmanan","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.carbpol.2011.11.069","article-title":"Hydrogel sheets of chitosan, honey and gelatin as burn wound dressings","volume":"88","author":"Wang","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jbbm.2005.10.003","article-title":"Fluorescence probes used for detection of reactive oxygen species","volume":"65","author":"Gomes","year":"2005","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0167531","article-title":"Antioxidant, antimicrobial and cytotoxic properties as well as the phenolic content of the extract from Hancornia speciosa gomes","volume":"11","author":"Santos","year":"2016","journal-title":"PLoS ONE"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.fct.2012.02.097","article-title":"Antimicrobial activity, phenolic profile and role in the inflammation of propolis","volume":"50","author":"Silva","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijpharm.2016.06.003","article-title":"Novel chitin\/chitosan-glucan wound dressing: Isolation, characterization, antibacterial activity and wound healing properties","volume":"510","author":"Jancar","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_19","unstructured":"Pighinelli, L., and Gall, M.C. (2008). New Process for Obtaining Nanochitosan\/Buriti Oil (Mauritia Flexuosa) Biocomposite: A Biocomposite for Regenerative Medicine and Tissue Engineering. Atena, Available online: https:\/\/www.atenaeditora.com.br\/post-artigo\/9945."},{"key":"ref_20","first-page":"247","article-title":"Influence of fibre treatment on the characteristics of buriti and ramie polyester composites","volume":"25","author":"Lavoratti","year":"2017","journal-title":"Polym. Polym. Compos."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.carbpol.2015.04.072","article-title":"Chitosan\/arginine-chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration","volume":"130","author":"Antunes","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.foodres.2016.10.029","article-title":"Assessment of the antioxidant activity of Bifurcaria bifurcata aqueous extract on canola oil. Effect of extract concentration on the oxidation stability and volatile compound generation during oil storage","volume":"99","author":"Lorenzo","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.17660\/ActaHortic.2008.765.43","article-title":"Antioxidant activity of the essential oils of Thymbra capitata, Origanum vulgare, Thymus mastichina, and Calamintha baetica","volume":"765","author":"Galego","year":"2008","journal-title":"Acta Hortic."},{"key":"ref_24","first-page":"331","article-title":"Antimicrobial activity of fatty acid methyl esters of some members of chenopodiaceae","volume":"63","author":"Chandrasekaran","year":"2008","journal-title":"Z. Fur Nat. Sect. C J. Biosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1590\/S0037-86822011000600024","article-title":"In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis","volume":"44","author":"Lima","year":"2011","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijdevneu.2015.05.001","article-title":"Buriti oil (Mauritia flexuosa L.) negatively impacts somatic growth and reflex maturation and increases retinol deposition in young rats","volume":"46","author":"Medeiros","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_27","first-page":"53","article-title":"\u00c1cidos Graxos E Cicatriza\u00e7\u00e3o: Uma Revis\u00e3o","volume":"88","author":"Hatanaka","year":"2007","journal-title":"Rev Bras Farm."},{"key":"ref_28","first-page":"1","article-title":"Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential","volume":"14","author":"Mikov","year":"2014","journal-title":"Bmc Complement. Altern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.ijbiomac.2017.08.068","article-title":"Characterization of citrus pectin films integrated with clove bud essential oil: Physical, thermal, barrier, antioxidant and antibacterial properties","volume":"106","author":"Nisar","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_30","first-page":"86","article-title":"Atividade antimicrobiana de extratos vegetais sobre bact\u00e9rias patog\u00eanicas humanas","volume":"9","author":"Alvarenga","year":"2007","journal-title":"Rev. Bras. Plantas Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.5897\/AJMR2015.7889","article-title":"Vibrio cholerae non-O1 in bivalve mollusks harvesting area in Bahia, Brazil","volume":"10","author":"Irana","year":"2016","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.sajb.2019.07.013","article-title":"Antioxidant, anti-inflammatory and wound healing properties of medicinal plant extracts used to treat wounds and dermatological disorders","volume":"126","author":"Ghuman","year":"2019","journal-title":"South Afr. J. Bot."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.pathol.2017.05.008","article-title":"Phenotypic chlorhexidine and triclosan susceptibility in clinical Staphylococcus aureus isolates in Australia","volume":"49","author":"Hughes","year":"2017","journal-title":"Pathology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pca.611","article-title":"Screening of Plant Extracts for Antioxidant Activity: A Comparative Study on Three Testing Methods","volume":"13","author":"Koleva","year":"2002","journal-title":"Phytochem. Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.foodres.2013.01.039","article-title":"Antioxidant, antimicrobial activities and characterization of phenolic compounds from buriti (Mauritia flexuosa L. f.) by UPLC-ESI-MS\/MS","volume":"51","author":"Koolen","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3390\/molecules16075875","article-title":"Comparative properties of amazonian oils obtained by different extraction methods","volume":"16","author":"Ferreira","year":"2011","journal-title":"Molecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fct.2013.11.010","article-title":"Biological activities of commercial bee pollens: Antimicrobial, antimutagenic, antioxidant and anti-inflammatory","volume":"63","author":"Pascoal","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodres.2017.10.053","article-title":"Small Brazilian wild fruits: Nutrients, bioactive compounds, health-promotion properties and commercial interest","volume":"103","author":"Pereira","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.burns.2006.09.010","article-title":"The effect of chitosan hydrogel containing DMEM\/F12 medium on full-thickness skin defects after deep dermal burn","volume":"33","author":"Kiyozumi","year":"2007","journal-title":"Burns"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.burns.2012.05.021","article-title":"Evaluation of healing activity of PVA\/chitosan hydrogels on deep second degree burn: Pharmacological and toxicological tests","volume":"39","author":"Mahlous","year":"2013","journal-title":"Burns"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/aps.2010.125","article-title":"Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: Synthesis, in vitro and in vivo evaluation","volume":"31","author":"Yang","year":"2010","journal-title":"Acta Pharm. Sin."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2012.08.001","article-title":"In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application","volume":"437","author":"Li","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.carbpol.2014.04.093","article-title":"Thermoresponsive chitosan-agarose hydrogel for skin regeneration","volume":"111","author":"Miguel","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijpharm.2016.05.035","article-title":"Particulate systems based on pectin\/chitosan association for the delivery of manuka honey components and platelet lysate in chronic skin ulcers","volume":"509","author":"Tenci","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Tong, S., Xu, D.-P., Liu, Z.-M., Du, Y., and Wang, X.-K. (2016). Synthesis of and in vitro and in vivo evaluation of a novel TGF-\u03b21-SF-CS three-dimensional scaffold for bone tissue engineering. Int. J. Mol. Med., 367\u2013380.","DOI":"10.3892\/ijmm.2016.2651"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1524-475X.2012.00848.x","article-title":"A multifunctional in situforming hydrogel for wound healing","volume":"20","author":"Du","year":"2012","journal-title":"Wound Repair Regen."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/13\/8\/1977\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:09:10Z","timestamp":1760364550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/13\/8\/1977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,23]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["ma13081977"],"URL":"https:\/\/doi.org\/10.3390\/ma13081977","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,23]]}}}