{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:09:49Z","timestamp":1773907789040,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031143"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031143"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["POCI-01-0145-FEDER-022122"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031143"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031143"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00511\/2020"],"award-info":[{"award-number":["UIDB\/00511\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIM\/04293\/2019"],"award-info":[{"award-number":["UID\/BIM\/04293\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/03908\/2017"],"award-info":[{"award-number":["CEECIND\/03908\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Nanographene oxide (GOn) constitutes a nanomaterial of high value in the biomedical field. However, large scale production of highly stable aqueous dispersions of GOn is yet to be achieved. In this work, we explored high-power ultrasonication as a method to reduce particle size of GO and characterized the impact of the process on the physicochemical properties of the material. GOn was obtained with lateral dimensions of 99 \u00b1 43 nm and surface charge of \u221239.9 \u00b1 2.2 mV. High-power ultrasonication enabled an improvement of stability features, particularly by resulting in a decrease of the average particle size, as well as zeta potential, in comparison to GO obtained by low-power exfoliation and centrifugation (287 \u00b1 139 nm; \u221229.7 \u00b1 1.2 mV). Remarkably, GOn aqueous dispersions were stable for up to 6 months of shelf-time, with a global process yield of 74%. This novel method enabled the production of large volumes of highly concentrated (7.5 mg mL\u22121) GOn aqueous dispersions. Chemical characterization of GOn allowed the identification of characteristic oxygen functional groups, supporting high-power ultrasonication as a fast, efficient, and productive process for reducing GO lateral size, while maintaining the material\u2019s chemical features.<\/jats:p>","DOI":"10.3390\/ma14081916","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"1916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High-Yield Production of Nano-Lateral Size Graphene Oxide by High-Power Ultrasonication"],"prefix":"10.3390","volume":"14","author":[{"given":"Lic\u00ednia","family":"Timochenco","sequence":"first","affiliation":[{"name":"LEPABE, Faculdade de Engenharia, Universidade do Porto, 4200-180 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-645X","authenticated-orcid":false,"given":"Raquel","family":"Costa-Almeida","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"INEB\u2014Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-180 Porto, Portugal"}]},{"given":"Diana","family":"Bogas","sequence":"additional","affiliation":[{"name":"LEPABE, Faculdade de Engenharia, Universidade do Porto, 4200-180 Porto, Portugal"}]},{"given":"Filipa A. L. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"INEB\u2014Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-180 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-0728","authenticated-orcid":false,"given":"Joana","family":"Silva","sequence":"additional","affiliation":[{"name":"IFIMUP and IN-Institute of Nanoscience and Nanotechnology, Departamento de F\u00edsica e Astronomia da Faculdade de Ci\u00eancias da Universidade do Porto, 4169-007 Porto, Portugal"},{"name":"CFP, Department of Physics Engineering, FEUP, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Pereira","sequence":"additional","affiliation":[{"name":"IFIMUP and IN-Institute of Nanoscience and Nanotechnology, Departamento de F\u00edsica e Astronomia da Faculdade de Ci\u00eancias da Universidade do Porto, 4169-007 Porto, Portugal"},{"name":"CFP, Department of Physics Engineering, FEUP, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-4473","authenticated-orcid":false,"given":"Fern\u00e3o D.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"LEPABE, Faculdade de Engenharia, Universidade do Porto, 4200-180 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-8254","authenticated-orcid":false,"given":"Artur M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"LEPABE, Faculdade de Engenharia, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"INEB\u2014Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-180 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1556-276X-9-86","article-title":"Facile and green reduction of covalently PEGylated nanographene oxide via a \u2018water-only\u2019 route for high-efficiency photothermal therapy","volume":"9","author":"Chen","year":"2014","journal-title":"Nanoscale Res. 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