{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:14:04Z","timestamp":1775078044161,"version":"3.50.1"},"reference-count":103,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Romanian National Authority for Scientific Research and Innovation, CNCS UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-TE-2019-0463"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2019-0463"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Romanian National Authority for Scientific Research and Innovation, CNCS UEFISCDI","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Romanian National Authority for Scientific Research and Innovation, CNCS UEFISCDI","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Romanian National Authority for Scientific Research and Innovation, CNCS UEFISCDI","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FCT\/MCTES (PIDDAC)","award":["PN-III-P1-1.1-TE-2019-0463"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2019-0463"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>This work was devoted to the first multi-parametric unitary comparative analysis of a selection of sintered piezoceramic materials synthesised by solid-state reactions, aiming to delineate the most promising biocompatible piezoelectric material, to be further implemented into macro-porous ceramic scaffolds fabricated by 3D printing technologies. The piezoceramics under scrutiny were: KNbO3, LiNbO3, LiTaO3, BaTiO3, Zr-doped BaTiO3, and the (Ba0.85Ca0.15)(Ti0.9Zr0.1)O3 solid solution (BCTZ). The XRD analysis revealed the high crystallinity of all sintered ceramics, while the best densification was achieved for the BaTiO3-based materials via conventional sintering. Conjunctively, BCTZ yielded the best combination of functional properties\u2014piezoelectric response (in terms of longitudinal piezoelectric constant and planar electromechanical coupling factor) and mechanical and in vitro osteoblast cell compatibility. The selected piezoceramic was further used as a base material for the robocasting fabrication of 3D macro-porous scaffolds (porosity of ~50%), which yielded a promising compressive strength of ~20 MPa (higher than that of trabecular bone), excellent cell colonization capability, and noteworthy cytocompatibility in osteoblast cell cultures, analogous to the biological control. Thereby, good prospects for the possible development of a new generation of synthetic bone graft substitutes endowed with the piezoelectric effect as a stimulus for the enhancement of osteogenic capacity were settled.<\/jats:p>","DOI":"10.3390\/ma16030901","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:04:44Z","timestamp":1674011084000},"page":"901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multi-Parametric Exploration of a Selection of Piezoceramic Materials for Bone Graft Substitute Applications"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-590X","authenticated-orcid":false,"given":"Liviu","family":"Nedelcu","sequence":"first","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-2809","authenticated-orcid":false,"given":"Jos\u00e9 M. F.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramic Engineering, CICECO\u2014Aveiro Materials Institute, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Adrian-Claudiu","family":"Popa","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"given":"Lumini\u021ba","family":"Amarande","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-7273","authenticated-orcid":false,"given":"Bo","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramic Engineering, CICECO\u2014Aveiro Materials Institute, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-4836","authenticated-orcid":false,"given":"Liliana-Marinela","family":"B\u0103lescu","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"given":"Cezar Drago\u0219","family":"Geamba\u0219u","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"given":"Marius-Cristian","family":"Cioangher","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"given":"Lucia","family":"Leonat","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"given":"Mihai","family":"Grigoroscu\u021b\u0103","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3871-1436","authenticated-orcid":false,"given":"Daniel","family":"Cristea","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Faculty of Materials Science and Engineering, Transilvania University of Brasov, 500068 Brasov, Romania"}]},{"given":"Hermine","family":"Stroescu","sequence":"additional","affiliation":[{"name":"\u201cIlie Murgulescu\u201d Institute of Physical Chemistry of the Romanian Academy, 060021 Bucharest, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2333-0099","authenticated-orcid":false,"given":"Robert C\u0103t\u0103lin","family":"Ciocoiu","sequence":"additional","affiliation":[{"name":"Department of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 060042 Bucharest, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-8988","authenticated-orcid":false,"given":"George E.","family":"Stan","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 077125 Magurele, Romania"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2217\/rme-2016-0042","article-title":"The potential impact of bone tissue engineering in the clinic","volume":"11","author":"Mishra","year":"2016","journal-title":"Regen. 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