{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:53:34Z","timestamp":1776203614335,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/FIS\/04650\/2013"],"award-info":[{"award-number":["UID\/FIS\/04650\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/FIS\/04650\/2019"],"award-info":[{"award-number":["UID\/FIS\/04650\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/NAN-MAT\/0098\/2020"],"award-info":[{"award-number":["PTDC\/NAN-MAT\/0098\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"E-Field\u201cElectric-Field Engineered Lattice Distortions (E-FiELD)","doi-asserted-by":"publisher","award":["UID\/FIS\/04650\/2013"],"award-info":[{"award-number":["UID\/FIS\/04650\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"E-Field\u201cElectric-Field Engineered Lattice Distortions (E-FiELD)","doi-asserted-by":"publisher","award":["UID\/FIS\/04650\/2019"],"award-info":[{"award-number":["UID\/FIS\/04650\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"E-Field\u201cElectric-Field Engineered Lattice Distortions (E-FiELD)","doi-asserted-by":"publisher","award":["PTDC\/NAN-MAT\/0098\/2020"],"award-info":[{"award-number":["PTDC\/NAN-MAT\/0098\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Nanostructured dipeptide self-assemblies exhibiting quantum confinement are of great interest due to their potential applications in the field of materials science as optoelectronic materials for energy harvesting devices. Cyclic dipeptides are an emerging outstanding group of ring-shaped dipeptides, which, because of multiple interactions, self-assemble in supramolecular structures with different morphologies showing quantum confinement and photoluminescence. Chiral cyclic dipeptides may also display piezoelectricity and pyroelectricity properties with potential applications in new sources of nano energy. Among those, aromatic cyclo-dipeptides containing the amino acid tryptophan are wide-band gap semiconductors displaying the high mechanical rigidity, photoluminescence and piezoelectric properties to be used in power generation. In this work, we report the fabrication of hybrid systems based on chiral cyclo-dipeptide L-Tryptophan-L-Tryptophan incorporated into biopolymer electrospun fibers. The micro\/nanofibers contain self-assembled nano-spheres embedded into the polymer matrix, are wide-band gap semiconductors with 4.0\u00a0eV band gap energy, and display blue photoluminescence as well as relevant piezoelectric and pyroelectric properties with coefficients as high as 57\u00a0CN\u22121 and \u00a035\u00d710\u22126\u00a0Cm\u22122K\u22121, respectively. Therefore, the fabricated hybrid mats are promising systems for future thermal sensing and energy harvesting applications.<\/jats:p>","DOI":"10.3390\/ma16062477","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T02:36:22Z","timestamp":1679366182000},"page":"2477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bioinspired Cyclic Dipeptide Functionalized Nanofibers for Thermal Sensing and Energy Harvesting"],"prefix":"10.3390","volume":"16","author":[{"given":"Daniela","family":"Santos","sequence":"first","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5380-9212","authenticated-orcid":false,"given":"Rosa M. F.","family":"Baptista","sequence":"additional","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Adelino","family":"Handa","sequence":"additional","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Bernardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-8808","authenticated-orcid":false,"given":"Pedro V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Institute for Polymers and Composites, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimaraes, Portugal"}]},{"given":"Ana R.","family":"Torres","sequence":"additional","affiliation":[{"name":"Institute for Polymers and Composites, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimaraes, Portugal"}]},{"given":"Ana","family":"Machado","sequence":"additional","affiliation":[{"name":"Institute for Polymers and Composites, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimaraes, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-5038","authenticated-orcid":false,"given":"Michael","family":"Belsley","sequence":"additional","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Etelvina","family":"de Matos Gomes","sequence":"additional","affiliation":[{"name":"Laboratory for materials and Emergent Technologies (LAPMET), Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19037","DOI":"10.1002\/anie.202008702","article-title":"Bioinspired Supramolecular Packing Enables High Thermo-Sustainability","volume":"59","author":"Tao","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mattod.2019.04.002","article-title":"Stable and optoelectronic dipeptide assemblies for power harvesting","volume":"30","author":"Tao","year":"2019","journal-title":"Mater. Today"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1807481","DOI":"10.1002\/adma.201807481","article-title":"Bioinspired Stable and Photoluminescent Assemblies for Power Generation","volume":"31","author":"Tao","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1039\/C9NA00464E","article-title":"Self-assembly of dipeptide Boc-diphenylalanine nanotubes inside electrospun polymeric fibers with strong piezoelectric response","volume":"1","author":"Baptista","year":"2019","journal-title":"Nanoscale Adv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1002\/smll.201100353","article-title":"Effects of Water Molecules on Photoluminescence from Hierarchical Peptide Nanotubes and Water Probing Capability","volume":"7","author":"Wang","year":"2011","journal-title":"Small"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/psc.963","article-title":"Controlled patterning of peptide nanotubes and nanospheres using inkjet printing technology","volume":"14","author":"Gazit","year":"2008","journal-title":"J. Pept. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1021\/acsnano.5b00623","article-title":"Controlled Rod Nanostructured Assembly of Diphenylalanine and Their Optical Waveguide Properties","volume":"9","author":"Li","year":"2015","journal-title":"ACS Nano"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1039\/D1MA01022K","article-title":"Self-assembly of Boc-p-nitro-l-phenylalanyl-p-nitro-l-phenylalanine and Boc-l-phenylalanyl-l-tyrosine in solution and into piezoelectric electrospun fibers","volume":"3","author":"Baptista","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1021\/jacs.5b11012","article-title":"Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures","volume":"138","author":"Pinotsi","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1039\/C1NR11068C","article-title":"Charge transport in vertically aligned, self-assembled peptide nanotube junctions","volume":"4","author":"Mizrahi","year":"2012","journal-title":"Nanoscale"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183707","DOI":"10.1063\/1.4921012","article-title":"Self-assembled peptide nanotubes as electronic materials: An evaluation from first-principles calculations","volume":"106","author":"Akdim","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1021\/acs.cgd.5b01121","article-title":"Cyclic Dipeptides as Building Units of Nano- and Microdevices: Synthesis, Properties, and Structural Studies","volume":"15","author":"Jeziorna","year":"2015","journal-title":"Cryst. Growth Des."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/10610270412331328943","article-title":"Self-organization of short peptide fragments: From amyloid fibrils to nanoscale supramolecular assemblies","volume":"17","author":"Gilead","year":"2005","journal-title":"Supramol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11186","DOI":"10.1002\/anie.201103941","article-title":"Uniaxially Oriented Peptide Crystals for Active Optical Waveguiding","volume":"50","author":"Yan","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e24202","DOI":"10.1002\/pep2.24202","article-title":"Cyclic dipeptides: Biological activities and self-assembled materials","volume":"113","author":"Zhao","year":"2021","journal-title":"Peptide Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Scarel, M., and Marchesan, S. (2021). Diketopiperazine gels: New horizons from the self-assembly of cyclic dipeptides. Molecules, 26.","DOI":"10.3390\/molecules26113376"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2174\/0929866527666200212123542","article-title":"Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials","volume":"27","author":"Chen","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mishra, A.K., Choi, J., Choi, S.-J., and Baek, K.-H. (2017). Cyclodipeptides: An overview of their biosynthesis and biological activity. Molecules, 22.","DOI":"10.3390\/molecules22101796"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cplu.201600450","article-title":"Molecular Self-Assembly of Cyclic Dipeptide Derivatives and Their Applications","volume":"82","author":"Manchineella","year":"2017","journal-title":"Chempluschem"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1038\/s41467-018-05568-9","article-title":"Quantum confined peptide assemblies with tunable visible to near-infrared spectral range","volume":"9","author":"Tao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16070","article-title":"Bioinspired reductionistic peptide engineering for exceptional mechanical properties","volume":"5","author":"Avinash","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1364\/JOSA.38.000448","article-title":"New Contributions to the Optics of Intensely Light-Scattering Materials. Part I","volume":"38","author":"Kubelka","year":"1948","journal-title":"J. Opt. Soc. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1021\/acs.jpclett.8b02892","article-title":"How to Correctly Determine the Band Gap Energy of Modified Semiconductor Photocatalysts Based on UV\u2013Vis Spectra","volume":"9","author":"Pacia","year":"2018","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1166\/jnn.2018.15458","article-title":"Role of particle-particle interaction towards effective interpretation of Z-average and particle size distributions from dynamic light scattering (DLS) analysis","volume":"18","author":"Yeap","year":"2018","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0378-5173(02)00040-6","article-title":"Buparvaquone mucoadhesive nanosuspension: Preparation, optimisation and long-term stability","volume":"237","author":"Jacobs","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref_26","first-page":"265","article-title":"Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 2)","volume":"12","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.compscitech.2011.11.009","article-title":"Electrospun aligned PLLA\/PCL\/functionalised multiwalled carbon nanotube composite fibrous membranes and their bio\/mechanical properties","volume":"72","author":"Liao","year":"2012","journal-title":"Compos. Sci. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.compositesb.2017.11.065","article-title":"Relation between fiber orientation and mechanical properties of nano-engineered poly (vinylidene fluoride) electrospun composite fiber mats","volume":"139","author":"Maciel","year":"2018","journal-title":"Compos. B Eng."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Baptista, R.M.F., Moreira, G., Silva, B., Oliveira, J., Almeida, B., Castro, C., Rodrigues, P.V., Machado, A., Belsley, M., and de Matos Gomes, E. (2022). Lead-Free MDABCO-NH4I3 Perovskite Crystals Embedded in Electrospun Nanofibers. Materials, 15.","DOI":"10.3390\/ma15238397"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Baptista, R.M.F., Silva, B., Oliveira, J., Isfahani, V.B., Almeida, B., Pereira, M.R., Cerca, N., Castro, C., Rodrigues, P.V., and Machado, A. (2022). High Piezoelectric Output Voltage from Blue Fluorescent N,N-Dimethyl-4-nitroaniline Nano Crystals in Poly-L-Lactic Acid Electrospun Fibers. Materials, 15.","DOI":"10.20944\/preprints202209.0421.v1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"261907","DOI":"10.1063\/1.3167354","article-title":"Self-assembled bioinspired quantum dots: Optical properties","volume":"94","author":"Amdursky","year":"2009","journal-title":"Appl. Phys. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15632","DOI":"10.1021\/ja104373e","article-title":"Elementary Building Blocks of Self-Assembled Peptide Nanotubes","volume":"132","author":"Amdursky","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"116474","DOI":"10.1016\/j.synthmet.2020.116474","article-title":"Anisotropic charge transport and optoelectronic properties of wide band gap organic semiconductors based on biphenyl derivatives: A computational study","volume":"267","author":"Khatua","year":"2020","journal-title":"Synthetic Met."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1600556","DOI":"10.1002\/aelm.201600556","article-title":"A Wide Band Gap Naphthalene Semiconductor for Thin-Film Transistors","volume":"3","author":"Yan","year":"2017","journal-title":"Adv. Electron. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1063\/1.4862437","article-title":"Energy harvesting from nanofibers of hybrid organic ferroelectric dabcoHReO(4)","volume":"104","author":"Isakov","year":"2014","journal-title":"Appl. Phys. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"084004","DOI":"10.1088\/1361-665X\/aac0b3","article-title":"A dynamic method for the measurement of pyroelectric properties of materials","volume":"27","author":"Kroener","year":"2018","journal-title":"Smart Mater. Struct."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1039\/C2TC00283C","article-title":"Pyroelectric and electrocaloric materials","volume":"1","author":"Li","year":"2013","journal-title":"J. Mater. Chem. C."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.nanoen.2018.11.020","article-title":"Standard and figure-of-merit for quantifying the performance of pyroelectric nanogenerators","volume":"55","author":"Zhang","year":"2019","journal-title":"Nano Energy"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Esin, A. (2016). Pyroelectric effect and polarization instability in self-assembled diphenylalanine microtubes. Appl. Phys. Lett., 109.","DOI":"10.1063\/1.4962652"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2100694","DOI":"10.1002\/marc.202100694","article-title":"Thermoactive Smart Electrospun Nanofibers","volume":"43","author":"Liguori","year":"2022","journal-title":"Macromol. Rapid Comm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1021\/acsnano.0c01654","article-title":"Diphenylalanine-Derivative Peptide Assemblies with Increased Aromaticity Exhibit Metal-like Rigidity and High Piezoelectricity","volume":"14","author":"Basavalingappa","year":"2020","journal-title":"ACS Nano"}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/6\/2477\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:48Z","timestamp":1760122788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/6\/2477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ma16062477"],"URL":"https:\/\/doi.org\/10.3390\/ma16062477","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,21]]}}}