{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T20:20:50Z","timestamp":1772569250962,"version":"3.50.1"},"reference-count":129,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LAETA","award":["50022\/2020"],"award-info":[{"award-number":["50022\/2020"]}]},{"name":"LAETA","award":["SFRH\/BD\/151362\/2021"],"award-info":[{"award-number":["SFRH\/BD\/151362\/2021"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["50022\/2020"],"award-info":[{"award-number":["50022\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["SFRH\/BD\/151362\/2021"],"award-info":[{"award-number":["SFRH\/BD\/151362\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Cellular materials have a wide range of applications, including structural optimization and biomedical applications. Due to their porous topology, which promotes cell adhesion and proliferation, cellular materials are particularly suited for tissue engineering and the development of new structural solutions for biomechanical applications. Furthermore, cellular materials can be effective in adjusting mechanical properties, which is especially important in the design of implants where low stiffness and high strength are required to avoid stress shielding and promote bone growth. The mechanical response of such scaffolds can be improved further by employing functional gradients of the scaffold\u2019s porosity and other approaches, including traditional structural optimization frameworks; modified algorithms; bio-inspired phenomena; and artificial intelligence via machine learning (or deep learning). Multiscale tools are also useful in the topological design of said materials. This paper provides a state-of-the-art review of the aforementioned techniques, aiming to identify current and future trends in orthopedic biomechanics research, specifically implant and scaffold design.<\/jats:p>","DOI":"10.3390\/ma16113946","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:30:06Z","timestamp":1684981806000},"page":"3946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3462-2102","authenticated-orcid":false,"given":"A.","family":"Pais","sequence":"first","affiliation":[{"name":"Institute of Science and Innovation in Mechanical and Industrial Engineering (INEGI), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-7057","authenticated-orcid":false,"given":"J.","family":"Belinha","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, ISEP, Polytechnic University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-9092","authenticated-orcid":false,"given":"J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Institute of Science and Innovation in Mechanical and Industrial Engineering (INEGI), 4200-465 Porto, Portugal"},{"name":"Department of Mechanical Engineering, FEUP, University of Porto, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104613","DOI":"10.1016\/j.jmbbm.2021.104613","article-title":"Structural optimization of 3D-printed patient-specific ceramic scaffolds for in vivo bone regeneration in load-bearing defects","volume":"121","year":"2021","journal-title":"J. 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