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treatments, which should be more efficient and much less invasive for the patient. Magnetic hyperthermia (MH) is an emerging cancer therapy using nanoparticles, which has proved to be effective when combined with chemotherapy, radiotherapy and\/or surgery, or even by itself, depending on the type and location of the tumor\u2019s cells. This article presents the results obtained by using a previously developed economic homemade hyperthermia device with different types of magnetite nanoparticles, with sizes ranging between 12 \u00b1 5 and 36 \u00b1 11 nm and presenting different shapes (spherical and cubic particles). These magnetic nanoparticles (MNPs) were synthesized by three different methods (co-precipitation, solvothermal and hydrothermal processes), with their final form being naked, or possessing different kinds of covering layers (polyethylene glycol (PEG) or citric acid (CA)). The parameters used to characterize the heating by magnetic hyperthermia, namely the Specific Absorption Rate (SAR) and the intrinsic loss power (ILP), have been obtained by two different methods. Among other results, these experiments allowed for the determination of which synthesized MNPs showed the best performance concerning hyperthermia. From the results, it may be concluded that, as expected, the shape of MNPs is an important factor, as well as the time that the MNPs can remain suspended in solution (which is directly related to the concentration and covering layer of the MNPs). The MNPs that gave the best results in terms of the SAR were the cubic particles covered with PEG, while in terms of total heating the spherical particles covered with citric acid proved to be better.<\/jats:p>","DOI":"10.3390\/ma17102279","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:28:25Z","timestamp":1715592505000},"page":"2279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Economic and Accessible Portable Homemade Magnetic Hyperthermia System: Influence of the Shape, Characteristics and Type of Nanoparticles in Its Effectiveness"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-0082","authenticated-orcid":false,"given":"Teresa","family":"Castelo-Grande","sequence":"first","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-4226","authenticated-orcid":false,"given":"Paulo A.","family":"Augusto","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC\/Universidad de Salamanca (GIR Cit\u00f3mica), 37001 Salamanca, Spain"},{"name":"CEADIR\u2014Centro de Estudios Ambientales y Dinamizaci\u00f3n Rural, Universidad de Salamanca, 37008 Salamanca, Spain"}]},{"given":"Lobinho","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Naturais, Engenharias e Tecnologias, Universidade Lus\u00f3fona do Porto, 4000-098 Porto, Portugal"}]},{"given":"Ana Rita Castro","family":"Lopes","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-7727","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"IFIMUP\u2014Institute of Physics for Advanced Materials, Nanotechnology and Photonics, Physics Department, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-9775","authenticated-orcid":false,"given":"Domingos","family":"Barbosa","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/j.gastro.2020.10.030","article-title":"Cancer Screening During the Coronavirus Disease-2019 Pandemic: A Perspective From the National Cancer Institute\u2019s PROSPR Consortium","volume":"160","author":"Corley","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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