{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:25:21Z","timestamp":1768735521129,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A growing market for novel antioxidants obtained from non-expensive sources justifies educated screening of microalgae for their potential antioxidant features. Characterization of the antioxidant profile of 18 species of cyanobacteria (prokaryotic microalgae) and 23 species of (eukaryotic) microalgae is accordingly reported in this paper. The total antioxidant capacity, accounted for by both water- and lipid-soluble antioxidants, was evaluated by the (radical cation) ABTS method. For complementary characterization  of cell extracts, a deoxyribose assay was carried out, as well as a bacteriophage P22\/Salmonella-mediated approach. The microalga Scenedesmus obliquus strain M2-1 exhibited the highest (p &gt; 0.05) total antioxidant capacity (149 \u00b1 47 AAU) of intracellular extracts. Its scavenger activity correlated well with its protective effects against DNA oxidative damage induced by copper(II)-ascorbic acid; and against decay in bacteriophage infection capacity induced by H2O2. Finally, performance of an Ames test revealed no mutagenic effects of the said extract.<\/jats:p>","DOI":"10.3390\/md11041256","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T12:13:38Z","timestamp":1366200818000},"page":"1256-1270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Evaluation of the Antioxidant Activity of Cell Extracts  from Microalgae"],"prefix":"10.3390","volume":"11","author":[{"given":"A.","family":"Guedes","sequence":"first","affiliation":[{"name":"CBQF\/Biotechnology College, Catholic University of Portugal, Rua Dr. Ant\u00f3nio Bernardino de Almeida, Porto P-4200-072, Portugal"},{"name":"CIMAR\/CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas n\u00ba 177, Porto P-4050-123, Portugal"}]},{"given":"Maria","family":"Gi\u00e3o","sequence":"additional","affiliation":[{"name":"CBQF\/Biotechnology College, Catholic University of Portugal, Rua Dr. Ant\u00f3nio Bernardino de Almeida, Porto P-4200-072, Portugal"}]},{"given":"Rui","family":"Seabra","sequence":"additional","affiliation":[{"name":"IBMC\u2014Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre  n\u00ba 823, Porto P-4150-180, Portugal"}]},{"given":"A.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CBQF\/Biotechnology College, Catholic University of Portugal, Rua Dr. Ant\u00f3nio Bernardino de Almeida, Porto P-4200-072, Portugal"}]},{"given":"Paula","family":"Tamagnini","sequence":"additional","affiliation":[{"name":"IBMC\u2014Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre  n\u00ba 823, Porto P-4150-180, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Edif\u00edcio FC4, Porto P-4169-007, Portugal"}]},{"given":"Pedro","family":"Moradas-Ferreira","sequence":"additional","affiliation":[{"name":"IBMC\u2014Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre  n\u00ba 823, Porto P-4150-180, Portugal"},{"name":"ICBAS\u2014Institute of Biomedical Sciences Abel Salazar, University of Porto, Largo Abel Salazar  n\u00ba 2, Porto P-4099-003, Portugal"}]},{"given":"F.","family":"Malcata","sequence":"additional","affiliation":[{"name":"CIMAR\/CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas n\u00ba 177, Porto P-4050-123, Portugal"},{"name":"Department of Chemical Engineering, University of Porto, Rua Dr. Roberto Frias,  Porto P-4200-465, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2013,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.foodchem.2005.10.026","article-title":"Accumulation and antioxidant activity of secondary carotenoids in the aerial microalga Coelastrella striolata var. multistriata","volume":"100","author":"Abe","year":"2005","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0167-7799(03)00078-7","article-title":"Haematococcus astaxanthin: Applications for human health and nutrition","volume":"21","author":"Guerin","year":"2003","journal-title":"Trends Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.procbio.2010.05.023","article-title":"Identification of anti-lung cancer extract from Chlorella vulgaris C-C by antioxidant property using supercritical carbon dioxide extraction","volume":"45","author":"Wang","year":"2010","journal-title":"Process Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/btpr.575","article-title":"Microalgae as sources of high added-value compounds\u2014A brief review of recent work","volume":"27","author":"Guedes","year":"2011","journal-title":"Biotechnol. 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