{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:07:42Z","timestamp":1775610462893,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/84226\/2012"],"award-info":[{"award-number":["SFRH\/BPD\/84226\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/CTM\/50011\/2013"],"award-info":[{"award-number":["UID\/CTM\/50011\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT UID\/QUI\/00062\/2013"],"award-info":[{"award-number":["FCT UID\/QUI\/00062\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/NEU\/04539\/2013"],"award-info":[{"award-number":["UID\/NEU\/04539\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/AGR\/00115\/2013"],"award-info":[{"award-number":["UID\/AGR\/00115\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/110717\/2015"],"award-info":[{"award-number":["SFRH\/BD\/110717\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SEACOLORS","award":["LIFE13 ENV\/ES\/000445"],"award-info":[{"award-number":["LIFE13 ENV\/ES\/000445"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012-HealthyAging2020"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Macroalgae have been seen as an alternative source of molecules with promising bioactivities to use in the prevention and treatment of current lifestyle diseases. In this vein, the lipophilic fraction of short-term (three weeks) cultivated Bifurcaria bifurcata was characterized in detail by gas chromatography\u2013mass spectrometry (GC-MS). B. bifurcata dichloromethane extract was composed mainly by diterpenes (1892.78 \u00b1 133.97 mg kg\u22121 dry weight (DW)), followed by fatty acids, both saturated (550.35 \u00b1 15.67 mg kg\u22121 DW) and unsaturated (397.06 \u00b1 18.44 mg kg\u22121 DW). Considerable amounts of sterols, namely fucosterol (317.68 \u00b1 26.11 mg kg\u22121 DW) were also found. In vitro tests demonstrated that the B. bifurcata lipophilic extract show antioxidant, anti-inflammatory and antibacterial activities (against both Gram-positive and Gram-negative bacteria), using low extract concentrations (in the order of \u00b5g mL\u22121). Enhancement of antibiotic activity of drug families of major clinical importance was observed by the use of B. bifurcata extract. This enhancement of antibiotic activity depends on the microbial strain and on the antibiotic. This work represents the first detailed phytochemical study of the lipophilic extract of B. bifurcata and is, therefore, an important contribution for the valorization of B. bifurcata macroalgae, with promising applications in functional foods, nutraceutical, cosmetic and biomedical fields.<\/jats:p>","DOI":"10.3390\/md15110340","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T16:01:19Z","timestamp":1509552079000},"page":"340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-7619","authenticated-orcid":false,"given":"S\u00f3nia","family":"Santos","sequence":"first","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Stephanie","family":"Trindade","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Catia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Paula","family":"Parreira","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia Agr\u00edcola e Agro-Alimentar do Alentejo (CEBAL)\/Instituto Polit\u00e9cnico de Beja (IPBeja), 7801-908 Beja, Portugal"}]},{"given":"Daniela","family":"Rosa","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia Agr\u00edcola e Agro-Alimentar do Alentejo (CEBAL)\/Instituto Polit\u00e9cnico de Beja (IPBeja), 7801-908 Beja, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-7784","authenticated-orcid":false,"given":"Maria","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia Agr\u00edcola e Agro-Alimentar do Alentejo (CEBAL)\/Instituto Polit\u00e9cnico de Beja (IPBeja), 7801-908 Beja, Portugal"},{"name":"ICAAM\u2014Instituto de Ci\u00eancias Agr\u00e1rias e Ambientais Mediterr\u00e2nicas, Universidade de \u00c9vora, P\u00f3lo da Mitra, 7006-554 \u00c9vora, Portugal"}]},{"given":"Isabel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"FFUC\u2014Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Maria","family":"Cruz","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"FFUC\u2014Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-423X","authenticated-orcid":false,"given":"Andreia","family":"Rego","sequence":"additional","affiliation":[{"name":"ALGAplus\u2014Prod. e Comerc. De Algas e Seus Derivados, Lda., 3830-196 \u00cdlhavo, Portugal"}]},{"given":"Maria","family":"Abreu","sequence":"additional","affiliation":[{"name":"ALGAplus\u2014Prod. e Comerc. De Algas e Seus Derivados, Lda., 3830-196 \u00cdlhavo, Portugal"}]},{"given":"Silvia","family":"Rocha","sequence":"additional","affiliation":[{"name":"QOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-8416","authenticated-orcid":false,"given":"Armando","family":"Silvestre","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: How are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. 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