{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:26:00Z","timestamp":1778336760663,"version":"3.51.4"},"reference-count":165,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Seaweeds are well-known for their exceptional capacity to accumulate essential minerals and trace elements needed for human nutrition, although their levels are commonly very variable depending on their morphological features, environmental conditions, and geographic location. Despite this variability, accumulation of Mg, and especially Fe, seems to be prevalent in Chlorophyta, while Rhodophyta and Phaeophyta accumulate higher concentrations of Mn and I, respectively. Both red and brown seaweeds also tend to accumulate higher concentrations of Na, K, and Zn than green seaweeds. Their valuable mineral content grants them great potential for application in the food industry as new ingredients for the development of numerous functional food products. Indeed, many studies have already shown that seaweeds can be used as NaCl replacers in common foods while increasing their content in elements that are oftentimes deficient in European population. In turn, high concentrations of some elements, such as I, need to be carefully addressed when evaluating seaweed consumption, since excessive intake of this element was proven to have negative impacts on health. In this regard, studies point out that although very bioaccessible, I bioavailability seems to be low, contrarily to other elements, such as Na, K, and Fe. Another weakness of seaweed consumption is their capacity to accumulate several toxic metals, which can pose some health risks. Therefore, considering the current great expansion of seaweed consumption by the Western population, specific regulations on this subject should be laid down. This review presents an overview of the mineral content of prevalent edible European macroalgae, highlighting the main factors interfering in their accumulation. Furthermore, the impact of using these marine vegetables as functional ingredients or NaCl replacers in foods will be discussed. Finally, the relationship between macroalgae\u2019s toxic metals content and the lack of European legislation to regulate them will be addressed.<\/jats:p>","DOI":"10.3390\/md16110400","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:59:40Z","timestamp":1540349980000},"page":"400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":299,"title":["Minerals from Macroalgae Origin: Health Benefits and Risks for Consumers"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-3114","authenticated-orcid":false,"given":"Ana R.","family":"Circuncis\u00e3o","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Organic Chemistry, Natural Products and Food Stuffs Research Unit (QOPNA), University of Aveiro, Aveiro 3810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-7975","authenticated-orcid":false,"given":"Marcelo D.","family":"Catarino","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Organic Chemistry, Natural Products and Food Stuffs Research Unit (QOPNA), University of Aveiro, Aveiro 3810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-737X","authenticated-orcid":false,"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Organic Chemistry, Natural Products and Food Stuffs Research Unit (QOPNA), University of Aveiro, Aveiro 3810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Organic Chemistry, Natural Products and Food Stuffs Research Unit (QOPNA), University of Aveiro, Aveiro 3810-193, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.foodres.2018.07.021","article-title":"Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on \u03b1-amylase, \u03b1-glucosidase, pancreatic lipase and tyrosinase","volume":"113","author":"Yuan","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.3390\/md10091920","article-title":"Polyunsaturated fatty acids of marine macroalgae: Potential for nutritional and pharmaceutical applications","volume":"10","author":"Pereira","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1007\/s10811-017-1152-0","article-title":"Antidiabetic and antioxidant activities of brown and red macroalgae from the Persian Gulf","volume":"29","author":"Pirian","year":"2017","journal-title":"J. Appl. Phycol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1753-4887.2007.tb00278.x","article-title":"Nutritional value of edible seaweeds","volume":"65","author":"MacArtain","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/jmf.2008.0151","article-title":"Characteristics and nutritional and cardiovascular-health properties of seaweeds","volume":"12","author":"Bocanegra","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0308-8146(02)00171-1","article-title":"Mineral content of edible marine seaweeds","volume":"79","author":"Ruperez","year":"2002","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11906-014-0465-5","article-title":"Sodium, potassium, blood pressure, and cardiovascular disease in humans","volume":"16","author":"Whelton","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1056\/NEJMoa1304127","article-title":"Global sodium consumption and death from cardiovascular causes","volume":"371","author":"Mozaffarian","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2174\/138527281807140515154116","article-title":"Bioproducts from seaweeds: A review with special focus on the iberian peninsula","volume":"18","author":"Cardoso","year":"2014","journal-title":"Curr. Org. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Catarino, M., Silva, A., and Cardoso, S. (2018). Phycochemical constituents and biological activities of Fucus spp.. Mar. Drugs, 16.","DOI":"10.3390\/md16080249"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1002\/jsfa.8798","article-title":"Chemical characterization of 21 species of marine macroalgae common in Norwegian waters: Benefits of and limitations to their potential use in food and feed","volume":"98","author":"Biancarosa","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_12","unstructured":"(2017, July 06). World Health Organisation WHO | Arsenic. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs372\/en\/#.WV5hlWgAVaM.mendeley."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1007\/s10811-017-1343-8","article-title":"Biomass soaking treatments to reduce potentially undesirable compounds in the edible seaweeds sugar kelp (Saccharina latissima) and winged kelp (Alaria esculenta) and health risk estimation for human consumption","volume":"30","author":"Marfaing","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1007\/s10811-017-1074-x","article-title":"Biochemical composition, nutritional value, and antioxidant properties of seven seaweed species from the Madeira Archipelago","volume":"29","author":"Nunes","year":"2017","journal-title":"J. Appl. Phycol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.foodchem.2009.10.028","article-title":"Lipid, fatty acid, protein, amino acid and ash contents in four Brazilian red algae species","volume":"120","author":"Gressler","year":"2010","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s10811-017-1310-4","article-title":"Influence of sea grapes (Caulerpa racemosa) supplementation on physical, functional, and anti-oxidant properties of semi-sweet biscuits","volume":"30","author":"Kumar","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s10811-015-0546-0","article-title":"Seasonal variations in the amino acid profile and protein nutritional value of Saccharina latissima cultivated in a commercial IMTA system","volume":"27","author":"Marinho","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s10811-014-0249-y","article-title":"Ecophysiological characteristics of Porphyra spp. (Bangiophyceae, Rhodophyta): Seasonal and latitudinal variations in northern-central Chile","volume":"26","author":"Tala","year":"2014","journal-title":"J. Appl. Phycol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.foodchem.2014.06.016","article-title":"Changes in total nitrogen and amino acid composition of New Zealand Undaria pinnatifida with growth, location and plant parts","volume":"186","author":"Zhou","year":"2015","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10499-007-9142-x","article-title":"Cultivation of Chondrus canaliculatus (C. Agardh) Greville (Gigartinales, Rhodophyta) in controlled environments","volume":"16","author":"Edding","year":"2008","journal-title":"Aquac. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aquaculture.2010.12.036","article-title":"IMTA with Gracilaria vermiculophylla: Productivity and nutrient removal performance of the seaweed in a land-based pilot scale system","volume":"312","author":"Abreu","year":"2011","journal-title":"Aquaculture"},{"key":"ref_22","unstructured":"Lobban, C.S., and Harrison, P.J. (1997). Seaweed Ecology and Physiology, Cambridge University Press."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Santos, S.C.R., Ungureanu, G., Volf, I., Boaventura, R.A.R., and Botelho, C.M.S. (2018). Macroalgae Biomass as Sorbent for Metal Ions. Biomass as Renewable Raw Material to Obtain Bioproducts of High-Tech Value, WoodHead Publishing.","DOI":"10.1016\/B978-0-444-63774-1.00003-X"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Antunes, W.M., Luna, A.S., Henriques, C.A., and Da Costa, A.C.A. (2003). An evaluation of copper biosorption by a brown seaweed under optimized conditions. Electron. J. Biotechnol., 6.","DOI":"10.2225\/vol6-issue3-fulltext-5"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.chemosphere.2006.03.002","article-title":"A comparative study on metal sorption by brown seaweed","volume":"65","author":"Tsui","year":"2006","journal-title":"Chemosphere"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-4203(00)00096-7","article-title":"Seasonal variability in the kinetics of Cu, Pb, Cd and Hg accumulation by macroalgae","volume":"74","author":"Vasconcelos","year":"2001","journal-title":"Mar. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.foodchem.2011.03.114","article-title":"Chemical composition and functional properties of Ulva lactuca seaweed collected in Tunisia","volume":"128","author":"Yaich","year":"2011","journal-title":"Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10811-008-9390-9","article-title":"Determination of the chemical composition of ulvan, a cell wall polysaccharide from Ulva spp. (Ulvales, Chlorophyta) by FT-IR and chemometrics","volume":"21","author":"Robic","year":"2009","journal-title":"J. Appl. Phycol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/bip.21195","article-title":"Ultrastructure of ulvan: A polysaccharide from green seaweeds","volume":"91","author":"Robic","year":"2009","journal-title":"Biopolymers"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Paradossi, G., Cavalieri, F., Pizzoferrato, L., and Liquori, A.M. (1999). A physico-chemical study on the polysaccharide ulvan from hot water extraction of the macroalga Ulva. Int. J. Biol. Macromol., 309\u2013315.","DOI":"10.1016\/S0141-8130(99)00049-5"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.foodchem.2014.09.030","article-title":"A new HPLC method for the detection of iodine applied to natural samples of edible seaweeds and commercial seaweed food products","volume":"172","author":"Nitschke","year":"2015","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biombioe.2017.11.006","article-title":"Seasonal variation of elements composition and biomethane in brown macroalgae","volume":"109","author":"Ometto","year":"2018","journal-title":"Biomass Bioenergy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e12845","DOI":"10.1111\/jfpp.12845","article-title":"Seaweed as an Ingredient for Nutritional Improvement of Fish Jerky: Seaweed for Nutritional Improvement of Fish Jerky","volume":"41","author":"Hanjabam","year":"2017","journal-title":"J. Food Process. Preserv."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lorenzo, J., Agreg\u00e1n, R., Munekata, P., Franco, D., Carballo, J., \u015eahin, S., Lacomba, R., and Barba, F. (2017). Proximate composition and nutritional value of three macroalgae: Ascophyllum nodosum, fucus vesiculosus and bifurcaria bifurcata. Mar. Drugs, 15.","DOI":"10.3390\/md15110360"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s10811-016-0839-y","article-title":"Tracing seaweeds as mineral sources for farm-animals","volume":"28","author":"Cabrita","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.microc.2012.10.003","article-title":"Study of cooking on the bioavailability of As, Co, Cr, Cu, Fe, Ni, Se and Zn from edible seaweed","volume":"108","year":"2013","journal-title":"Microchem. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.foodres.2017.11.015","article-title":"Composition and bioaccessibility of elements in green seaweeds from fish pond aquaculture","volume":"105","author":"Afonso","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jfca.2008.10.021","article-title":"Trace elements determination in edible seaweeds by an optimized and validated ICP-MS method","volume":"22","year":"2009","journal-title":"J. Food Compos. Anal."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/aoc.590040318","article-title":"Determination of arsenic and other elemental abundances in marine macro-algae by photon activation analysis","volume":"4","author":"Suzuki","year":"1990","journal-title":"Appl. Organomet. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10967-012-1713-2","article-title":"Estimation of total as well as bioaccessible levels and average daily dietary intake of iodine from Japanese edible seaweeds by epithermal neutron activation analysis","volume":"294","author":"Fukushima","year":"2012","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10967-009-0240-2","article-title":"Vanadium levels in marine organisms of Onagawa Bay in Japan","volume":"282","author":"Fukushima","year":"2009","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.microc.2017.05.001","article-title":"Direct analysis of marine macroalgae for determination of macro minerals by energy dispersive X-ray fluorescence","volume":"134","author":"Brito","year":"2017","journal-title":"Microchem. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.sab.2017.03.009","article-title":"Seasonal determination of trace and ultra-trace content in Macrocystis pyrifera from San Jorge Gulf (Patagonia) by Total Reflection X-ray Fluorescence","volume":"131","author":"Salomone","year":"2017","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Neto, R., Mar\u00e7al, C., Queir\u00f3s, A., Abreu, H., Silva, A., and Cardoso, S. (2018). Screening of Ulva rigida, Gracilaria sp., Fucus vesiculosus and Saccharina latissima as functional ingredients. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102987"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jfca.2010.03.015","article-title":"Validation of an ICP-OES method for macro and trace element determination in Laminaria and Porphyra seaweeds from four different countries","volume":"23","year":"2010","journal-title":"J. Food Compos. Anal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/15287394.2015.1113598","article-title":"Essential and toxic elements in seaweeds for human consumption","volume":"79","author":"Desideri","year":"2016","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jfca.2015.06.008","article-title":"Mineral nutrient content and iron bioavailability in common and Hawaiian seaweeds assessed by an in vitro digestion\/Caco-2 cell model","volume":"43","author":"Flores","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.foodres.2016.08.007","article-title":"Health-promoting ingredients from four selected Azorean macroalgae","volume":"89","author":"Paiva","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.aca.2007.07.030","article-title":"Development of a new sample pre-treatment procedure based on pressurized liquid extraction for the determination of metals in edible seaweed","volume":"598","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"H1031","DOI":"10.1152\/ajpheart.00899.2011","article-title":"How NaCl raises blood pressure: A new paradigm for the pathogenesis of salt-dependent hypertension","volume":"302","author":"Blaustein","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/MOL.0b013e3282f33ccc","article-title":"Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes","volume":"19","author":"Bo","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_52","first-page":"157","article-title":"Valuable biomolecules from nine north atlantic red macroalgae: Amino acids, fatty acids, carotenoids, minerals and metals","volume":"07","author":"Parjikolaei","year":"2016","journal-title":"Nat. Resour."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2215\/CJN.09750913","article-title":"Renal control of calcium, phosphate, and magnesium homeostasis","volume":"10","author":"Blaine","year":"2015","journal-title":"Clin. J. Am. Soci. Nephrol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.22358\/jafs\/73886\/2004","article-title":"Magnesium increases calcium absorption mediated by transcellular transport in small intestine of goats and rats","volume":"13","author":"Kozakai","year":"2004","journal-title":"J. Anim. Feed Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/aob\/mcu096","article-title":"Chemical and enzymatic fractionation of cell walls from Fucales: Insights into the structure of the extracellular matrix of brown algae","volume":"114","author":"Kervarec","year":"2014","journal-title":"Ann. Bot."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10811-014-0327-1","article-title":"The seasonal variation in the chemical composition of the kelp species Laminaria digitata, Laminaria hyperborea, Saccharina latissima and Alaria esculenta","volume":"27","author":"Schiener","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biortech.2010.06.152","article-title":"Seasonal variation in the chemical composition of the bioenergy feedstock Laminaria digitata for thermochemical conversion","volume":"102","author":"Adams","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/B978-0-12-387669-0.00029-6","article-title":"Seaweed Minerals as Nutraceuticals","volume":"Volume 64","year":"2011","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Osredkar, J. (2011). Copper and Zinc, biological role and significance of Copper\/Zinc imbalance. J. Clin. Toxicol.","DOI":"10.4172\/2161-0495.S3-001"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.marpolbul.2008.11.021","article-title":"Baseline metal concentrations in marine algae from S\u00e3o Miguel (Azores) under different ecological conditions\u2014Urban proximity and shallow water hydrothermal activity","volume":"58","author":"Wallenstein","year":"2009","journal-title":"Mar. Pollut. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s10811-011-9737-5","article-title":"Biostimulant activity of brown seaweed species from Strangford Lough: Compositional analyses of polysaccharides and bioassay of extracts using mung bean (Vigno mungo L.) and pak choi (Brassica rapa chinensis L.)","volume":"24","author":"Sharma","year":"2012","journal-title":"J. Appl. Phycol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jfca.2014.11.010","article-title":"Mineral and trace element concentrations in seaweeds from the sub-Antarctic ecoregion of Magallanes (Chile)","volume":"39","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1021\/jf0721500","article-title":"Nutritional and toxicological importance of macro, trace, and ultra-trace elements in algae food products","volume":"55","author":"Dawczynski","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0048-9697(00)00467-8","article-title":"Elemental and radioactive analysis of commercially available seaweed","volume":"255","year":"2000","journal-title":"Sci. Total Environ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.foodchem.2010.07.117","article-title":"Bioavailability study using an in-vitro method of iodine and bromine in edible seaweed","volume":"124","year":"2011","journal-title":"Food Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0269-7491(01)00322-0","article-title":"Seasonal variation and background levels of heavy metals in two green seaweeds","volume":"119","author":"Villares","year":"2002","journal-title":"Environ. Pollut."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jsfa.3836","article-title":"Composition, nutritional aspects and effect on serum parameters of marine algae Ulva rigida","volume":"90","author":"Taboada","year":"2009","journal-title":"J. Sci. Food Agric."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.foodchem.2012.02.165","article-title":"Trace metals in marine foodstuff: Bioavailability estimation and effect of major food constituents","volume":"134","year":"2012","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0045-6535(01)00292-2","article-title":"Heavy metal contamination in the seaweeds of the Venice lagoon","volume":"47","author":"Caliceti","year":"2002","journal-title":"Chemosphere"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1007\/s10811-016-0842-3","article-title":"Biorefinery of the green seaweed Ulva lactuca to produce animal feed, chemicals and biofuels","volume":"28","author":"Bikker","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1002\/jsfa.6681","article-title":"Characterization of protein, lipid and mineral contents in common Norwegian seaweeds and evaluation of their potential as food and feed: Biochemical composition of marine macroalgae","volume":"94","author":"Maehre","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jmarsys.2008.10.010","article-title":"Heavy metals in edible seaweeds commercialised for human consumption","volume":"75","author":"Besada","year":"2009","journal-title":"J. Mar. Syst."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chemosphere.2017.01.064","article-title":"Metals in edible seaweed","volume":"173","author":"Rubio","year":"2017","journal-title":"Chemosphere"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1023\/A:1008168631508","article-title":"Seasonal accumulation of metals by red alga Gracilaria verrucosa (Huds.) Papens. from Thermaikos Gulf, Greece","volume":"11","author":"Malea","year":"1999","journal-title":"J. Appl. Phycol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.foodchem.2014.04.119","article-title":"Edible Azorean macroalgae as source of rich nutrients with impact on human health","volume":"164","author":"Paiva","year":"2014","journal-title":"Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ecolind.2016.03.041","article-title":"Seaweed Alaria esculenta as a biomonitor species of metal contamination in Aughinish Bay (Ireland)","volume":"69","author":"Reis","year":"2016","journal-title":"Ecol. Indic."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4217\/OPR.2004.26.2.121","article-title":"Metal Concentrations in some Brown Seaweeds from Kongsfjorden on Spitsbergen, Svalbard Islands","volume":"26","author":"Ahn","year":"2004","journal-title":"Ocean Polar Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1515\/bot-2012-0114","article-title":"Seasonal variations in concentrations of macro- and micronutrients in three species of brown seaweed","volume":"56","author":"Villares","year":"2013","journal-title":"Bot. Mar."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.3168\/jds.2015-10810","article-title":"Short communication: Iodine concentrations in serum, milk, and tears after feeding Ascophyllum nodosum to dairy cows\u2014A pilot study","volume":"99","author":"Sorge","year":"2016","journal-title":"J. Dairy Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.envres.2015.09.016","article-title":"Toxic elements and speciation in seafood samples from different contaminated sites in Europe","volume":"143","author":"Maulvault","year":"2015","journal-title":"Environ. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.aquaculture.2015.07.032","article-title":"Metal content of kelp (Laminaria digitata) co-cultivated with Atlantic salmon in an Integrated Multi-Trophic Aquaculture system","volume":"450","author":"Ratcliff","year":"2016","journal-title":"Aquaculture"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"25736","DOI":"10.1039\/C4RA03537B","article-title":"Methodology for quantitative determination of the carbohydrate composition of brown seaweeds (Laminariaceae)","volume":"4","author":"Manns","year":"2014","journal-title":"RSC Adv."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/01140671003619290","article-title":"Nutrient and heavy metal content of edible seaweeds in New Zealand","volume":"38","author":"Smith","year":"2010","journal-title":"N. Z. J. Crop. Hortic. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jfda.2014.01.014","article-title":"Analysis of iodine content in seaweed by GC-ECD and estimation of iodine intake","volume":"22","author":"Yeh","year":"2014","journal-title":"J. Food Drug Anal."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1073\/pnas.0709959105","article-title":"Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry","volume":"105","author":"Kupper","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s10811-013-0014-7","article-title":"On the human consumption of the red seaweed dulse (Palmaria palmata (L.) Weber & Mohr)","volume":"25","author":"Mouritsen","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1874372201004010108","article-title":"Suppression of Thyroid Function by Seaweed \u201cKombu\u201d (Laminaria japonica) Supplement seen in a patient with alopecia areata: A case report","volume":"4","author":"Inui","year":"2010","journal-title":"Open Dermatol. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1507\/endocrj.K08E-125","article-title":"Suppression of Thyroid Function during Ingestion of Seaweed \u201cKombu\u201d (Laminaria japonoca) in Normal Japanese Adults","volume":"55","author":"Miyai","year":"2008","journal-title":"Endocr. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jtemb.2008.03.001","article-title":"Iodine requirements and the risks and benefits of correcting iodine deficiency in populations","volume":"22","author":"Zimmermann","year":"2008","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2006.03.068","article-title":"Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells","volume":"402","author":"Jin","year":"2006","journal-title":"Neurosc. Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/07315724.2009.10718117","article-title":"The okinawan diet: Health implications of a low-Calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load","volume":"28","author":"Willcox","year":"2009","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_92","unstructured":"European Commission (2014, December 13). Commission Directive 2008\/100\/EC of October 28, 2008 Amending Council Directive 90\/496\/EEC on Nutrition Labelling for Foodstuffs as Regards Recommended Daily Allowances, Energy Conversion Factors, and Definitions. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=celex%3A32008L0100."},{"key":"ref_93","unstructured":"WHO (2012). Guideline: Sodium Intake for Adults and Children, World Health Organization."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1017\/S1751731113002474","article-title":"The use of seaweed from the Galician coast as a mineral supplement in organic dairy cattle","volume":"8","author":"Miranda","year":"2014","journal-title":"Animal"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/1082013217740000","article-title":"Nutritional and bioactive compounds of commercialized algae powders used as food supplements","volume":"24","author":"Castillejo","year":"2018","journal-title":"Food Sci. Technol. Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.meatsci.2009.04.014","article-title":"Low-fat frankfurters enriched with n-3 PUFA and edible seaweed: Effects of olive oil and chilled storage on physicochemical, sensory and microbial characteristics","volume":"83","author":"Cofrades","year":"2009","journal-title":"Meat Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.meatsci.2011.03.016","article-title":"Effect of cooking on the chemical composition of low-salt, low-fat Wakame\/olive oil added beef patties with special reference to fatty acid content","volume":"89","author":"Cofrades","year":"2011","journal-title":"Meat Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.meatsci.2007.11.010","article-title":"Influence of different types and proportions of added edible seaweeds on characteristics of low-salt gel\/emulsion meat systems","volume":"79","author":"Cofrades","year":"2008","journal-title":"Meat Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.meatsci.2010.11.014","article-title":"Quality characteristics of low-salt restructured poultry with microbial transglutaminase and seaweed","volume":"87","author":"Cofrades","year":"2011","journal-title":"Meat Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.meatsci.2009.05.014","article-title":"Design and nutritional properties of potential functional frankfurters based on lipid formulation, added seaweed and low salt content","volume":"83","author":"Cofrades","year":"2009","journal-title":"Meat Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.foodres.2010.03.005","article-title":"Frozen storage characteristics of low-salt and low-fat beef patties as affected by Wakame addition and replacing pork backfat with olive oil-in-water emulsion","volume":"43","author":"Cofrades","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.meatsci.2009.06.031","article-title":"Composition and antioxidant capacity of low-salt meat emulsion model systems containing edible seaweeds","volume":"83","author":"Bastida","year":"2009","journal-title":"Meat Sci."},{"key":"ref_103","unstructured":"National Research Council (US) Committee on Diet and Health (1989). Diet and Health: Implications for Reducing Chronic Disease Risk, National Academies Press."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1439-0396.2010.01065.x","article-title":"Effect of macroalgae enriched with microelements on egg quality parameters and mineral content of eggs, eggshell, blood, feathers and droppings: Macroalgae as mineral feed additives","volume":"95","author":"Michalak","year":"2011","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1439-0396.2002.00363.x","article-title":"Supplementation of algae to the diet of pigs: A new possibility to improve the iodine content in the meat","volume":"86","author":"He","year":"2002","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.foodres.2016.10.030","article-title":"Natural fortification of trout with dietary macroalgae and selenised-yeast increases the nutritional contribution in iodine and selenium","volume":"99","author":"Bandarra","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.aquaculture.2015.05.004","article-title":"Iodine enrichment of rainbow trout flesh by dietary supplementation with the red seaweed Gracilaria vermiculophylla","volume":"446","author":"Valente","year":"2015","journal-title":"Aquaculture"},{"key":"ref_108","first-page":"645","article-title":"Marine algae as natural source of iodine in the feeding of freshwater fish: A new possibility to improve iodine supply of man","volume":"154","author":"Schmid","year":"2003","journal-title":"Revue de M\u00e9decine V\u00e9t\u00e9rinaire (France)"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.aquaculture.2014.11.028","article-title":"Dietary macroalgae is a natural and effective tool to fortify gilthead seabream fillets with iodine: Effects on growth, sensory quality and nutritional value","volume":"437","author":"Colen","year":"2015","journal-title":"Aquaculture"},{"key":"ref_110","unstructured":"Brewer, V., Kussy, D., and Eckert, J. (2008). Calcium Fortification of Food Powders. (11\/893478), U.S. Patent."},{"key":"ref_111","unstructured":"Weipeng, U. (2017). Seaweed Soybean Milk Powder. (CN107410509A), China Patent."},{"key":"ref_112","unstructured":"Marigot Ltd. (2018, October 22). Available online: http:\/\/aquamin.com\/food-beverage\/adding-value\/."},{"key":"ref_113","first-page":"151","article-title":"The influence of algae addition on physicochemical properties of cottage cheese","volume":"60","author":"Lalic","year":"2005","journal-title":"Milchwiss. Milk Sci. Int."},{"key":"ref_114","first-page":"38","article-title":"Probiotic drinks containing iodine","volume":"6","author":"Koval","year":"2005","journal-title":"Molochnaya Promyshlennost"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Cofrades, S., Serdaro\u011flu, M., and Jim\u00e9nez-Colmenero, F. (2013). Design of healthier foods and beverages containing whole algae. Functional Ingredients from Algae for Foods and Nutraceuticals, Elsevier.","DOI":"10.1533\/9780857098689.4.609"},{"key":"ref_116","unstructured":"Shrestha, M., Woehlk, H., and Tchetseubu Saha, G. (2011). Studies on drying and comminution of young brown seaweed for manufacture of algae-enriched dairy products. Die Milchwirschaft, 332\u2013336."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/jsfa.3480","article-title":"Effect of feeding intact brown seaweed Ascophyllum nodosum on some digestive parameters and on iodine content in edible tissues in pigs","volume":"89","author":"Dierick","year":"2009","journal-title":"J. Sci. Food Agric."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1745-4603.2010.00268.x","article-title":"Textural changes in fresh egg noodles formulated with seaweed powder and full or partial replacement of cuttlefish paste: Textural changes in fresh egg noodles","volume":"42","author":"Chang","year":"2011","journal-title":"J. Texture Stud."},{"key":"ref_119","first-page":"152","article-title":"Studies on functional salt fortified with seaweed components","volume":"39","author":"Kim","year":"2007","journal-title":"Korean J. Food Sci. Technol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.algal.2016.03.018","article-title":"Seaweed salt from Ulva: A novel first step in a cascading biorefinery model","volume":"16","author":"Magnusson","year":"2016","journal-title":"Algal Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.talanta.2010.07.043","article-title":"Evaluation of an in vitro method to estimate trace elements bioavailability in edible seaweeds","volume":"82","year":"2010","journal-title":"Talanta"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.microc.2017.09.010","article-title":"Determination and in vitro bioaccessibility evaluation of Ca, Cu, Fe, K, Mg, Mn, Mo, Na, P and Zn in linseed and sesame","volume":"137","author":"Souza","year":"2018","journal-title":"Microchem. J."},{"key":"ref_123","unstructured":"Pereira, C.C., do Nascimento da Silva, E., de Souza, A.O., Vieira, M.A., Ribeiro, A.S., and Cadore, S. (2016). Evaluation of the bioaccessibility of minerals from blackberries, raspberries, blueberries and strawberries. J. Food Compos. Anal."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0924-2244(93)90091-N","article-title":"Seaweed in food products: Biochemical and nutritional aspects","volume":"4","author":"Mabeau","year":"1993","journal-title":"Trends Food Sci. Technol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0308-8146(01)00273-4","article-title":"Bioavailability of nutrients in rats fed on edible seaweeds, Nori (Porphyra tenera) and Wakame (Undaria pinnatifida), as a source of dietary fibre","volume":"76","author":"Urbano","year":"2002","journal-title":"Food Chem."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Debon, S.J.J., and Tester, R.F. (2001). In vitro binding of calcium, iron and zinc by non-starch polysaccharides. Food Chem.","DOI":"10.1016\/S0308-8146(00)00312-5"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/S0278-6915(03)00141-8","article-title":"Diets containing a high percentage of Nori or Konbu algae are well-accepted and efficiently utilised by growing rats but induce different degrees of histological changes in the liver and bowel","volume":"41","author":"Bocanegra","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1017\/S0007114507801085","article-title":"A Nori but not a Konbu, dietary supplement decreases the cholesterolaemia, liver fat infiltration and mineral bioavailability in hypercholesterolaemic growing Wistar rats","volume":"99","author":"Bocanegra","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/jf0493627","article-title":"Chemical Composition, Iron Bioavailability, and Antioxidant Activity of Kappaphycus alvarezzi (Doty)","volume":"53","author":"Fayaz","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.foodchem.2006.04.032","article-title":"Studies on use of Enteromorpha in snack food","volume":"101","author":"Mamatha","year":"2007","journal-title":"Food Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/jn\/137.12.2691","article-title":"High Iron Content and Bioavailability in Humans from Four Species of Marine Algae","volume":"137","author":"Pereira","year":"2007","journal-title":"J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fshw.2015.03.001","article-title":"Nutritional status and effect of seaweed chocolate on anemic adolescent girls","volume":"4","year":"2015","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Fang, Y., Al-Assaf, S., Phillips, G.O., Nishinari, K., Funami, T., and Williams, P.A. (2008). Binding behavior of calcium to polyuronates: Comparison of pectin with alginate. Carbohydr. Polym.","DOI":"10.1016\/j.carbpol.2007.08.021"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01771671","article-title":"Calcium bioavailability from heated oyster shell-seaweed calcium (active absorbable algae calcium) as assessed by urinary calcium excretion","volume":"14","author":"Fujita","year":"1996","journal-title":"J. Bone Miner. MeTable"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1021\/acs.jafc.7b02151","article-title":"Evaluation of Iodine Bioavailability in Seaweed Using in Vitro Methods","volume":"65","author":"Chiocchetti","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0308-8146(03)00276-0","article-title":"Binding of fluoride, bromide and iodide to bovine serum albumin, studied with ion-selective electrodes","volume":"84","author":"Ayranci","year":"2004","journal-title":"Food Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1017\/S0007114514001573","article-title":"Low-level seaweed supplementation improves iodine status in iodine-insufficient women","volume":"112","author":"Combet","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tifs.2014.02.002","article-title":"Role of processing on bioaccessibility of minerals: Influence of localization of minerals and anti-nutritional factors in the plant","volume":"37","author":"Raes","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.envpol.2005.12.007","article-title":"Distribution and relationships between selected chemical elements in green alga Enteromorpha sp. from the southern Baltic","volume":"143","author":"Szefer","year":"2006","journal-title":"Environ. Pollut."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biortech.2013.12.102","article-title":"Biosorption: Current perspectives on concept, definition and application","volume":"160","author":"Fomina","year":"2014","journal-title":"Bioresour. Technol."},{"key":"ref_141","unstructured":"(2018, July 15). Edible Seaweed-French & European Regulation. Available online: http:\/\/www.cybercolloids.net\/sites\/default\/files\/seaweed%20and%20regulation2014.pdf."},{"key":"ref_142","unstructured":"European Commission (2008). Commission Regulation (EC) No 629\/2008 of 2 July 2008 Amending Regulation (EC) No 1881\/2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs, European Commission."},{"key":"#cr-split#-ref_143.1","unstructured":"European Commission (2013). Commission Regulation"},{"key":"#cr-split#-ref_143.2","unstructured":"(EU) No 1275\/2013 of 6 December 2013 Amending Annex I to Directive 2002\/32\/EC of the European Parliament and of the Council as Regards Maximum Levels for Arsenic, Cadmium, Lead, Nitrites, Volatile Mustard Oil and Harmful Botanical Impurities, European Commission."},{"key":"ref_144","unstructured":"European Commission (2015). Commission Recommendation (EU) 2015\/1381 of 10 August 2015 on the Monitoring of Arsenic in Food, European Commission."},{"key":"ref_145","unstructured":"(2018, March 08). WHO Arsenic, Available online: https:\/\/www.fda.gov\/Food\/FoodborneIllnessContaminants\/Metals\/ucm280202.htm."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jenvman.2014.12.051","article-title":"Arsenic and antimony in water and wastewater: Overview of removal techniques with special reference to latest advances in adsorption","volume":"151","author":"Ungureanu","year":"2015","journal-title":"J. Environ. Manag."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/carcin\/23.8.1387","article-title":"Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors","volume":"23","author":"Wei","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_148","first-page":"1271","article-title":"Cancer Induction by an Organic Arsenic Compound, Dimethylarsinic Acid (Cacodylic Acid), in F344\/DuCrj Rats after Pretreatment with Five Carcinogens","volume":"55","author":"Vaniamolo","year":"1995","journal-title":"Cancer Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1289\/ehp.8832","article-title":"Increased Mortality from Lung Cancer and Bronchiectasis in Young Adultsafter Exposure to Arsenic in Utero and in Early Childhood","volume":"114","author":"Smith","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2004.04.008","article-title":"Arsenic exposure exacerbates atherosclerotic plaque formation and increases nitrotyrosine and leukotriene biosynthesis","volume":"201","author":"Bunderson","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10552-010-9503-z","article-title":"Lifetime exposure to arsenic in drinking water and bladder cancer: A population-based case\u2013control study in Michigan, USA","volume":"21","author":"Meliker","year":"2010","journal-title":"Cancer Causes Control"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.toxrep.2017.09.006","article-title":"Effect of arsenic acid withdrawal on hepatotoxicity and disruption of erythrocyte antioxidant defense system","volume":"4","author":"Oyagbemi","year":"2017","journal-title":"Toxicol. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1021\/jf0110250","article-title":"Heavy Metal, Total Arsenic, and Inorganic Arsenic Contents of Algae Food Products","volume":"50","author":"Almela","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.envint.2018.05.032","article-title":"Quantification and feed to food transfer of total and inorganic arsenic from a commercial seaweed feed","volume":"118","author":"Monagail","year":"2018","journal-title":"Environ. Int."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/oeh.2007.13.2.202","article-title":"Cadmium-induced Cancers in Animals and in Humans","volume":"13","author":"Huff","year":"2007","journal-title":"Int. J. Occup. Environ. Health"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1579\/0044-7447(2007)36[3:MEAHEI]2.0.CO;2","article-title":"Methylmercury Exposure and Health Effects in Humans: A Worldwide Concern","volume":"36","author":"Mergler","year":"2007","journal-title":"AMBIO J. Hum. Environ."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1289\/ehp.1408554","article-title":"Relation of Prenatal Methylmercury Exposure from Environmental Sources to Childhood IQ","volume":"123","author":"Jacobson","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1515\/jpm-2013-0349","article-title":"Mercury exposure in pregnancy: A review","volume":"42","author":"Solan","year":"2014","journal-title":"J. Perinat. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1289\/ehp.9303","article-title":"Dose\u2013Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data","volume":"115","author":"Axelrad","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1020170922049","article-title":"Biomonitoring of Metal Availability in the Southern Basin of the Lagoon of Venice (Italy) by Means of Macroalgae","volume":"140","author":"Favero","year":"2002","journal-title":"Water Air Soil Pollut."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1021\/jf034537i","article-title":"Estimation of arsenic bioaccessibility in edible seaweed by an in vitro digestion method","volume":"51","author":"Laparra","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1007\/s10811-016-0793-8","article-title":"Metals in Undaria pinnatifida (Harvey) Suringar and Sargassum muticum (Yendo) Fensholt edible seaweeds growing around Venice (Italy)","volume":"28","author":"Marzocchi","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodchem.2014.08.020","article-title":"Determination of toxic heavy metals and speciation of arsenic in seaweeds from South Korea","volume":"169","author":"Khan","year":"2015","journal-title":"Food Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.foodchem.2006.05.009","article-title":"Mineral composition of edible seaweed Porphyra vietnamensis","volume":"102","author":"Rao","year":"2007","journal-title":"Food Chem."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/16\/11\/400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:25:38Z","timestamp":1760196338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/16\/11\/400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":165,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11]]}},"alternative-id":["md16110400"],"URL":"https:\/\/doi.org\/10.3390\/md16110400","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]}}}