{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:41:15Z","timestamp":1773312075291,"version":"3.50.1"},"reference-count":175,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3\u03b2,7\u03b1-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC50) values between 1\u20135 \u00b5M against several cell lines.<\/jats:p>","DOI":"10.3390\/md16110410","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T10:51:01Z","timestamp":1540551061000},"page":"410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-9135","authenticated-orcid":false,"given":"Djenisa H. A.","family":"Rocha","sequence":"first","affiliation":[{"name":"Department of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-2375","authenticated-orcid":false,"given":"Ana M. L.","family":"Seca","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"},{"name":"cE3c-Centre for Ecology, Evolution and Environmental Changes, Azorean Biodiversity Group & Faculty of Sciences and Technology, University of Azores, Rua M\u00e3e de Deus, 9501-321 Ponta Delgada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA-Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"ref_1","unstructured":"IARC, International Agency for Research on Cancer, World Health Organization (2018, September 14). Press Release n\u00ba 263, 12 September 2018. Available online: http:\/\/gco.iarc.fr\/today\/home."},{"key":"ref_2","unstructured":"Stewart, B.W., and Wild, C.P. (2014). Transitions in human development and the global cancer burden. World Cancer Report 2014, International Agency for Research on Cancer."},{"key":"ref_3","unstructured":"(2018, June 30). WCRFI, World Cancer Research Fund International. 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