{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:39:01Z","timestamp":1762868341139,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for the Support of Research and Scientific and Technological Development of Maranh\u00e3o (FAPEMA).","award":["031\/2016"],"award-info":[{"award-number":["031\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Background: This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods: Ethyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. The solid Ehrlich tumor model was used for antitumor activity. Female Swiss mice were divided into groups (n = 10\/group) as follows: The negative control (CTL\u2212), treated with a phosphate buffered solution; the positive control (CTL+), treated with cyclophosphamide (25 mg\/kg); extract treatments at doses of 4, 20, and 100 mg\/kg; animals without tumors or treatments (Sham); and animals without tumors treated with an intermediate dose (EAE20). All treatments were performed intraperitoneally, daily, for 15 days. Subsequently, the animals were euthanized, and the tumor, lymphoid organs, and serum were used for immunological, histological, and biochemical parameter evaluations. Results: The extract was rich in meroterpenoids. All doses significantly reduced tumor size, and the 20 and 100 mg\/kg doses reduced tumor-associated inflammation and tumor necrosis. The extract also reduced the cellular infiltration of lymphoid organs and circulating TNF-\u03b1 levels. The extract did not induce weight loss or renal and hepatic toxic changes. Conclusions: These results indicate that P. purpurogenum exhibits immunomodulatory and antitumor properties in vivo. Thus, fungal fermentation is a valid biotechnological approach to the production of antitumor agents.<\/jats:p>","DOI":"10.3390\/md18110541","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T09:44:53Z","timestamp":1603964693000},"page":"541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Amanda Mara","family":"Teles","sequence":"first","affiliation":[{"name":"Laboratory for Culture Cell, Postgraduate Program in Biotechnology (RENORBIO), Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Leticia Prince Pereira","family":"Pontes","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Luis 65080-085, Maranh\u00e3o, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-5281","authenticated-orcid":false,"given":"Sulayne Janayna Ara\u00fajo","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Luis 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Ana Luiza","family":"Butarelli","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Luis 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Gabriel Xavier","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory for Culture Cell, Postgraduate Program in Biotechnology (RENORBIO), Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Flavia Raquel Fernandes","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Immunophisiology Laboratory, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Geusa Felipa","family":"de Barros Bezerra","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Carla Junqueira","family":"Moragas-Tellis","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products for Public Health, Institute of Pharmaceutical Techonology, Oswaldo Cruz Foundation, Rio de Janeiro 21041-000, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-2449","authenticated-orcid":false,"given":"Rui Miguel Gil da","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"},{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-1564","authenticated-orcid":false,"given":"Marcos Antonio Cust\u00f3dio Neto","family":"da Silva","sequence":"additional","affiliation":[{"name":"Post-graduation in Internal Medicine, State University of Campinas, Campinas 13083-887, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-6159","authenticated-orcid":false,"given":"Fernando","family":"Almeida-Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Anamotopathology, Postgraduate Program in Animal Science, State University of Maranh\u00e3o, S\u00e3o Luis 65055-310, Maranh\u00e3o, Brazil"},{"name":"Laboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-3765","authenticated-orcid":false,"given":"K\u00e1tia da","family":"Silva Calabrese","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-362X","authenticated-orcid":false,"given":"Ana Paula Silva","family":"Azevedo-Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Luis 65080-085, Maranh\u00e3o, Brazil"}]},{"given":"Maria do Desterro Soares Brand\u00e3o","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranh\u00e3o, Avenida dos Portugueses, 1966 Bacanga, S\u00e3o Lu\u00eds 65080-085, Maranh\u00e3o, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Teixeira, T.R., Santos, G.S.D., Armstrong, L., Colepicolo, P., and Debonsi, H.M. 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