{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:36:47Z","timestamp":1777505807611,"version":"3.51.4"},"reference-count":80,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007621"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007621"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/CVT-WEL\/5207\/2014"],"award-info":[{"award-number":["PTDC\/CVT-WEL\/5207\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-029540"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029540"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/114995\/2016"],"award-info":[{"award-number":["SFRH\/BD\/114995\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/114942\/2016"],"award-info":[{"award-number":["SFRH\/BPD\/114942\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/114959\/2016"],"award-info":[{"award-number":["SFRH\/BPD\/114959\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine algae are recognised sources of bioactive compounds that have attracted great interest as nutritional supplements for aquaculture fish. Intensive rearing conditions often expose fish to husbandry-related stressors, rendering fish more susceptible to disease and reducing production yields. The present work evaluated the potential of two marine algae extracts (Fucus vesiculosus and Nannochloropsis gaditana) as nutritional supplements to mitigate stress effects in meagre (Argyrosomus regius) exposed to an acute handling stress (AS). A plant-based diet was used as a control, and three other diets were prepared, which were similar to the control diet but supplemented with 1% of each algal extract or a combination of the two extracts (0.5% each). The effects of supplemented diets on stress biomarkers, antioxidant enzyme activities, and immune response were analysed in fish exposed to AS after 4 weeks of feeding. Supplemented diets did not affect growth performance but the inclusion of F. vesiculosus promoted higher feed efficiency, as compared to the control group. Dietary algal extracts supplementation reduced plasma glucose levels, increased white blood cell counts, and reduced the expression of pro-inflammatory genes when compared with the control. N. gaditana supplementation led to a reduction in hepatic antioxidant enzyme activity and glutathione levels, while F. vesiculosus supplementation increased muscle glutathione reductase activity and reduced lipid peroxidation. These findings support the potential of algal extracts as nutraceuticals in aquafeeds to enhance the ability of fish to cope with husbandry-related stressful conditions and ultimately improve fish health and welfare.<\/jats:p>","DOI":"10.3390\/md19110598","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:22:02Z","timestamp":1634862122000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional Feeds to Tackle Meagre (Argyrosomus regius) Stress: Physiological Responses under Acute Stressful Handling Conditions"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-8575","authenticated-orcid":false,"given":"Marta","family":"Monteiro","sequence":"first","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-6507","authenticated-orcid":false,"given":"Carla","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]},{"given":"Filipe","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"}]},{"given":"Carolina","family":"Castro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"}]},{"given":"Filipa","family":"Fontinha","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-8364","authenticated-orcid":false,"given":"In\u00eas","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"}]},{"given":"Pedro","family":"Pous\u00e3o","sequence":"additional","affiliation":[{"name":"Portuguese Institute for Sea and Atmosphere (IPMA), Olh\u00e3o Pilot Aquaculture Station, Av. 5 de Outubro, s\/n, 8700-305 Olh\u00e3o, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-8963","authenticated-orcid":false,"given":"Elisabete","family":"Matos","sequence":"additional","affiliation":[{"name":"SORGAL, Oils and Feedd Society, S.A., Estrada Nacional 109 Lugar da Pardala, 3880-728 S\u00e3o Jo\u00e3o de Ovar, Portugal"},{"name":"B2E Blue Bioeconomy CoLab\u2014Colabrtive Laboratory, Av. Liberdade, s\/n, 4450-718 Le\u00e7a da Palmeira, Portugal"}]},{"given":"Patr\u00edcia","family":"D\u00edaz-Rosales","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Fish Immunology and Patology Group, Center for Animal Health Research (CISA, INIA), Carretera de Algete a El Casar, s\/n, 28130 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-836X","authenticated-orcid":false,"given":"Aires","family":"Oliva-Teles","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6248-0500","authenticated-orcid":false,"given":"Paula","family":"Enes","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]},{"given":"Ana","family":"Couto","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Departament of Biology, Faculty of Ci\u00eancias, University of Porto, Rua do Campo Alegre, Building FC4, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"The effect of dietary fucoidan on growth, immune functions, blood characteristics and oxidative stress resistance of juvenile red sea bream, Pagrus major","volume":"45","author":"Sony","year":"2018","journal-title":"Fish Physiol. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10811-016-0903-7","article-title":"The dietary effect of ulvan from Ulva clathrata on hematological-immunological parameters and growth of tilapia (Oreochromis niloticus)","volume":"29","year":"2017","journal-title":"J. Appl. 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