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Several of their bioactivities have been demonstrated, such as anti-inflammatory, antioxidant, anticarcinogenic, antibacterial and antiviral behavior. However, there still lacks a clear definition regarding how these compounds exert their bioactive properties. Of all the bioactive compounds derived from marine macroalgae, attention has been focused on phenolic compounds, specifically in phlorotannins, due to their potential for biomedical applications. Phlorotannins are a diverse and wide group of phenolic compounds, with several structural variations based on the monomer phloroglucinol. Among the diverse phlorotannin structures, the eckol-family of phlorotannins demonstrates remarkable bioactivity, notably their anti-tumoral properties. However, the molecular mechanisms by which this activity is achieved remain elusive and sparse. This review focuses on the described molecular mechanisms of anti-tumoral effects by the eckol family of compounds and the future prospects of these molecules for potential application in oncology therapies.<\/jats:p>","DOI":"10.3390\/md20060387","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:25:12Z","timestamp":1654856712000},"page":"387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Call the Eckols: Present and Future Potential Cancer Therapies"],"prefix":"10.3390","volume":"20","author":[{"given":"Pedro","family":"Monteiro","sequence":"first","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Silvia","family":"Lomartire","sequence":"additional","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-221X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Cotas","sequence":"additional","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Jo\u00e3o C.","family":"Marques","sequence":"additional","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0619","authenticated-orcid":false,"given":"Leonel","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-7183","authenticated-orcid":false,"given":"Ana M. M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"University of Coimbra, MARE\u2014Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"},{"name":"Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The Human Tumor Microbiome Is Composed of Tumor Type\u2013Specific Intracellular Bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Front. 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