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However, the diversity of the secondary metabolite biosynthetic gene clusters (SM-BGCs) in Aquimarina genomes indicates a far greater biosynthetic potential. In this study, nine representative Aquimarina strains were tested for antimicrobial activity against diverse human-pathogenic and marine microorganisms and subjected to metabolomic and genomic profiling. We found an inhibitory activity of most Aquimarina strains against Candida glabrata and marine Vibrio and Alphaproteobacteria species. Aquimarina sp. Aq135 and Aquimarina muelleri crude extracts showed particularly promising antimicrobial activities, amongst others against methicillin-resistant Staphylococcus\u00a0aureus. The metabolomic and functional genomic profiles of Aquimarina spp. followed similar patterns and were shaped by phylogeny. SM-BGC and metabolomics networks suggest the presence of novel polyketides and peptides, including cyclic depsipeptide-related compounds. Moreover, exploration of the \u2018Sponge Microbiome Project\u2019 dataset revealed that Aquimarina spp. possess low-abundance distributions worldwide across multiple marine biotopes. Our study emphasizes the relevance of this member of the microbial rare biosphere as a promising source of novel natural products. We predict that future metabologenomics studies of Aquimarina species will expand the spectrum of known secondary metabolites and bioactivities from marine ecosystems.<\/jats:p>","DOI":"10.3390\/md20070423","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T01:48:38Z","timestamp":1656467318000},"page":"423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Insights into the Antimicrobial Activities and Metabolomes of Aquimarina (Flavobacteriaceae, Bacteroidetes) Species from the Rare Marine Biosphere"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-0662","authenticated-orcid":false,"given":"Sandra Godinho","family":"Silva","sequence":"first","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-6013","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Paula","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"given":"Jos\u00e9 Paulo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-3579","authenticated-orcid":false,"given":"Dalila","family":"Mil-Homens","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-6174","authenticated-orcid":false,"given":"Miguel Cacho","family":"Teixeira","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-5787","authenticated-orcid":false,"given":"Ars\u00e9nio Mendes","family":"Fialho","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-4101","authenticated-orcid":false,"given":"Rodrigo","family":"Costa","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Bioengeneering Department, Instituto Superior T\u00e9cnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Centre of Marine Sciences, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-9192","authenticated-orcid":false,"given":"Tina","family":"Keller-Costa","sequence":"additional","affiliation":[{"name":"IBB\u2014Institute for Bioengineering and Biosciences and i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Av. 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