{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:58:24Z","timestamp":1773190704386,"version":"3.50.1"},"reference-count":136,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER\u2014Fundo Europeu de Desenvolvimento Regional","award":["POCI-01-0145-FEDER-030240"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030240"]}]},{"name":"FEDER\u2014Fundo Europeu de Desenvolvimento Regional","award":["PTDC\/OCE-ETA\/30240\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/30240\/2017"]}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-030240"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030240"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/OCE-ETA\/30240\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/30240\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine macroalgae are rich in bioactive compounds that can be applied in several fields, mainly food, cosmetics, and medicine. The health-promoting effects of bioactive compounds, such as polyphenols, polysaccharides, carotenoids, proteins, and fatty acids, have been increasingly explored, especially regarding their antioxidant activity and improvement in human health. To extract these valuable compounds, advanced technologies that include Supercritical-Fluid Extraction (SFE), Pressurised-Liquid Extraction (PLE), Ultrasound-Assisted Extraction (UAE), Microwave-Assisted Extraction (MAE), Enzyme-Assisted Extraction (EAE), Ultrasound-Microwave-Assisted Extraction (UMAE) and Liquefied Gas Extraction (LGE) have been assessed due to their notable advantages over the conventional methods (Solid\u2013Liquid and Soxhlet extraction). These advanced techniques are considerably influenced by different extraction parameters such as temperature, pressure, type of solvent, extraction time, solvent:solid material ratio, power (MAE, UAE, and UMAE), enzymes used (EAE), and factors related to the macroalgae matrix itself. Optimizing these process parameters for each method is critical to obtain better efficiency results for the targeted bioactive compounds. Macroalgae are natural sources with undeniable beneficial effects on human health. In this context, optimising the extraction techniques discussed in this review should prioritise exploiting these valuable resources\u2019 wide range of bioactive properties.<\/jats:p>","DOI":"10.3390\/md20110677","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T07:26:50Z","timestamp":1667114810000},"page":"677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":198,"title":["A Critical Comparison of the Advanced Extraction Techniques Applied to Obtain Health-Promoting Compounds from Seaweeds"],"prefix":"10.3390","volume":"20","author":[{"given":"Eva","family":"Quit\u00e9rio","sequence":"first","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas\/CISA, Escola Superior de Sa\u00fade\u2014Instituto Polit\u00e9cnico do Porto, Rua Doutor Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"given":"Clara","family":"Grosso","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Doutor Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-117X","authenticated-orcid":false,"given":"Ricardo","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas\/CISA, Escola Superior de Sa\u00fade\u2014Instituto Polit\u00e9cnico do Porto, Rua Doutor Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"},{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias, Universidade do Porto, R. do Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Doutor Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-9681","authenticated-orcid":false,"given":"Cristina","family":"Soares","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Doutor Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3390\/md9050803","article-title":"Neuroprotective Effects of Marine Algae","volume":"9","author":"Pangestuti","year":"2011","journal-title":"Mar. 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