{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:46:49Z","timestamp":1776930409996,"version":"3.51.2"},"reference-count":14,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T00:00:00Z","timestamp":1085443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, fine chemicals and agrochemicals. In recent years, a significant number of novel metabolites with potent pharmacological properties has been discovered from the marine organisms. Although there are only a few marine-derived products currently on the market, several robust new compounds derived from marine natural products are now in the clinical pipeline, with more clinical development. While the marine world offers an extremely rich resource for novel compounds, it also represents a great challenge that requires inputs from various scientific areas to bring the marine chemical diversity up to its therapeutic potential.<\/jats:p>","DOI":"10.3390\/md202073","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:03:57Z","timestamp":1224939837000},"page":"73-82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":196,"title":["Drugs and Cosmetics from the Sea"],"prefix":"10.3390","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-1061","authenticated-orcid":false,"given":"Anake","family":"Kijjoa","sequence":"first","affiliation":[{"name":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar and CIIMAR, Universidade do Porto, 4099-003 Porto, Portugal"}]},{"given":"Pichan","family":"Sawangwong","sequence":"additional","affiliation":[{"name":"Department of Aquatic Science, Faculty of Science, Burapha University, Bangsaen, 20131 Chonburi, Thailand"}]}],"member":"1968","published-online":{"date-parts":[[2004,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cart\u00e9, B. K. (1996). Biomedical Potential of Marine Natural Products. Biosciences, 271\u2013286.","DOI":"10.2307\/1312834"},{"key":"ref_2","first-page":"28","article-title":"Aquaculture, Marine Sciences and Oceanography: A Confluence Connection","volume":"13","author":"Halvorson","year":"1998","journal-title":"New Engl. J. Higher Ed. Econ. Dev"},{"key":"ref_3","unstructured":"Faulkner, D. J. (1995). Chemical Riches from the Ocean. Chem. Brit, 680\u2013684."},{"key":"ref_4","unstructured":"Lazarovici, P., Spira, M. E., and Zlotkin, Eliahu (1996). Biochemical Aspects of Marine Pharmacology, Alaken, Inc."},{"key":"ref_5","first-page":"275","article-title":"Fishing for Drugs from the Sea: Status and Strategies","volume":"16","author":"Beart","year":"1995","journal-title":"TiPS"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/np50055a001","article-title":"Didemnins and Tunichlorin: Novel Natural Products from the Marine Tunicate Trididemnum solidum","volume":"51","author":"Rinehart","year":"1988","journal-title":"J. Nat. Prod"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fusetani, N. (2000). Drugs From The Sea, Basel.","DOI":"10.1159\/isbn.978-3-318-00599-8"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Gunasekera, S. P., Gunasekera, M., Longley, R. E., and Schulte, G.K. (1990). J. Org. Chem, 55, 4912\u20134915.","DOI":"10.1021\/jo00303a029"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-1128(200001)20:1<1::AID-MED1>3.0.CO;2-A","article-title":"Antitumor Compounds from Tunicates","volume":"20","author":"Rinehart","year":"2000","journal-title":"Med. Res. Rev"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1021\/jm990241l","article-title":"Ecteinascidin 743: A Minor Groove Alkylator that Binds DNA Toward the Major Groove","volume":"42","author":"Hurley","year":"1999","journal-title":"J. Med. Chem"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1021\/ja00066a061","article-title":"Kahalide F, A Bioactive Depsipeptide from the Sacoglossan Mollusk Elisia refescens and the Green Alga Bryopsis sp","volume":"115","author":"Hamann","year":"1993","journal-title":"J. Am. Chem. Soc"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.4071055","article-title":"Peptide Neurotoxins from Fish-Hunting Cone Snails","volume":"230","author":"Oliveira","year":"1985","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/np50090a001","article-title":"Phospholipase A2 Inhibitors from Marine Organisms","volume":"55","author":"Potts","year":"1992","journal-title":"J. Nat. Prod"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rouhi, A. M. (1995). Supply Issues Complicate Trek of Chemicals from the Sea to Market. C&EN, 42\u201344.","DOI":"10.1021\/cen-v073n047.p042"}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/2\/2\/73\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:26:13Z","timestamp":1760221573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/2\/2\/73"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,25]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,6]]}},"alternative-id":["md202073"],"URL":"https:\/\/doi.org\/10.3390\/md202073","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,25]]}}}