{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:13:08Z","timestamp":1777669988461,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hibah Publikasi Terindeks Internasional (PUTI) Review Article Q1 Tahun Anggaran 2022","award":["NKB-741\/UN2.RST\/HKP.05.00\/2022"],"award-info":[{"award-number":["NKB-741\/UN2.RST\/HKP.05.00\/2022"]}]},{"name":"Hibah Publikasi Terindeks Internasional (PUTI) Review Article Q1 Tahun Anggaran 2022","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"Hibah Publikasi Terindeks Internasional (PUTI) Review Article Q1 Tahun Anggaran 2022","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"name":"FCT-Foundation for Science and Technology of Portugal","award":["NKB-741\/UN2.RST\/HKP.05.00\/2022"],"award-info":[{"award-number":["NKB-741\/UN2.RST\/HKP.05.00\/2022"]}]},{"name":"FCT-Foundation for Science and Technology of Portugal","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"FCT-Foundation for Science and Technology of Portugal","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The search for new antibiotics against drug-resistant microbes has been expanded to marine bacteria. Marine bacteria have been proven to be a prolific source of a myriad of novel compounds with potential biological activities. Therefore, this review highlights novel and bioactive compounds from marine bacteria reported during the period of January 2016 to December 2021. Published articles containing novel marine bacterial secondary metabolites that are active against drug-resistant pathogens were collected. Previously described compounds (prior to January 2016) are not included in this review. Unreported compounds during this period that exhibited activity against pathogenic microbes were discussed and compared in order to find the cue of the structure\u2013bioactivity relationship. The results showed that Streptomyces are the most studied bacteria with undescribed bioactive compounds, followed by other genera in the Actinobacteria. We have categorized the structures of the compounds in the present review into four groups, based on their biosynthetic origins, as polyketide derivatives, amino acid derivatives, terpenoids, as well as compounds with mixed origin. These compounds were active against one or more drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), vancomycin-resistant Enterococci (VRE), multidrug-resistant Mycobacterium tuberculosis (MDR-TB), and amphotericin B-resistant Candida albicans. In addition, some of the compounds also showed activity against biofilm formation of the test bacteria. Some previously undescribed compounds, isolated from marine-derived bacteria during this period, could have a good potential as lead compounds for the development of drug candidates to overcome multidrug-resistant pathogens.<\/jats:p>","DOI":"10.3390\/md21010050","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:29:57Z","timestamp":1673576997000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Secondary Metabolites from Marine-Derived Bacteria with Antibiotic and Antibiofilm Activities against Drug-Resistant Pathogens"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3467-6263","authenticated-orcid":false,"given":"Joko Tri","family":"Wibowo","sequence":"first","affiliation":[{"name":"Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), KST Soekarno Jl. Raya Bogor Km. 46, Cibinong 16911, Indonesia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-0501","authenticated-orcid":false,"given":"Asep","family":"Bayu","sequence":"additional","affiliation":[{"name":"Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), KST Soekarno Jl. Raya Bogor Km. 46, Cibinong 16911, Indonesia"}]},{"given":"Widya Dwi","family":"Aryati","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-9163","authenticated-orcid":false,"given":"Carla","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto and CIIMAR, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"given":"Arry","family":"Yanuar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia"},{"name":"National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok 16424, Indonesia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-1061","authenticated-orcid":false,"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[{"name":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-3293","authenticated-orcid":false,"given":"Masteria Yunovilsa","family":"Putra","sequence":"additional","affiliation":[{"name":"Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), KST Soekarno Jl. Raya Bogor Km. 46, Cibinong 16911, Indonesia"},{"name":"National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok 16424, Indonesia"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Murugaiyan, J., Kumar, P.A., Rao, G.S., Iskandar, K., Hawser, S., Hays, J.P., Mohsen, Y., Adukkadukkam, S., Awuah, W.A., and Jose, R.A.M. (2022). Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics. Antibiotics, 11.","DOI":"10.3390\/antibiotics11020200"},{"key":"ref_2","unstructured":"OECD (2018). Stemming the Superbug Tide, OECD Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijmm.2013.02.009","article-title":"Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions","volume":"303","author":"Cox","year":"2013","journal-title":"Int. J. Med. 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