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environments occupy more than 70% of the earth\u2019s surface, integrating very diverse habitats with specific characteristics. This heterogeneity of environments is reflected in the biochemical composition of the organisms that inhabit them. Marine organisms are a source of bioactive compounds, being increasingly studied due to their health-beneficial properties, such as antioxidant, anti-inflammatory, antibacterial, antiviral, or anticancer. In the last decades, marine fungi have stood out for their potential to produce compounds with therapeutic properties. The objective of this study was to determine the fatty acid profile of isolates from the fungi Emericellopsis cladophorae and Zalerion maritima and assess the anti-inflammatory, antioxidant, and antibacterial potential of their lipid extracts. The analysis of the fatty acid profile, using GC-MS, showed that E. cladophorae and Z. maritima possess high contents of polyunsaturated fatty acids, 50% and 34%, respectively, including the omega-3 fatty acid 18:3 n-3. Emericellopsis cladophorae and Z. maritima lipid extracts showed anti-inflammatory activity expressed by the capacity of their COX-2 inhibition which was 92% and 88% of inhibition at 200 \u00b5g lipid mL\u22121, respectively. Emericellopsis cladophorae lipid extracts showed a high percentage of inhibition of COX -2 activity even at low concentrations of lipids (54% of inhibition using 20 \u00b5g lipid mL\u22121), while a dose-dependent behaviour was observed in Z. maritima. The antioxidant activity assays of total lipid extracts demonstrated that the lipid extract from E. cladophorae did not show antioxidant activity, while Z. maritima gave an IC20 value of 116.6 \u00b1 6.2 \u00b5g mL\u22121 equivalent to 92.1 \u00b1 4.8 \u00b5mol Trolox g\u22121 of lipid extract in the DPPH\u2022 assay, and 101.3 \u00b1 14.4 \u00b5g mL\u22121 equivalent to 106.6 \u00b1 14.8 \u00b5mol Trolox g\u22121 of lipid extract in the ABTS\u2022+ assay. The lipid extract of both fungal species did not show antibacterial properties at the concentrations tested. This study is the first step in the biochemical characterization of these marine organisms and demonstrates the bioactive potential of lipid extracts from marine fungi for biotechnological applications.<\/jats:p>","DOI":"10.3390\/md21040199","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:37:28Z","timestamp":1679546248000},"page":"199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Lipid Extracts from the Marine Fungi Emericellopsis cladophorae and Zalerion maritima as a Source of Anti-Inflammatory, Antioxidant and Antibacterial Compounds"],"prefix":"10.3390","volume":"21","author":[{"given":"Mariana","family":"Abra\u00fal","sequence":"first","affiliation":[{"name":"ECOMARE\u2014Laboratory for Innovation and Sustainability of Marine Biological Resources, CESAM\u2014Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0117-2958","authenticated-orcid":false,"given":"Artur","family":"Alves","sequence":"additional","affiliation":[{"name":"CESAM\u2014Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-9757","authenticated-orcid":false,"given":"Sandra","family":"Hil\u00e1rio","sequence":"additional","affiliation":[{"name":"CESAM\u2014Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"T\u00e2nia","family":"Melo","sequence":"additional","affiliation":[{"name":"ECOMARE\u2014Laboratory for Innovation and Sustainability of Marine Biological Resources, CESAM\u2014Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-3885","authenticated-orcid":false,"given":"Tiago","family":"Conde","sequence":"additional","affiliation":[{"name":"ECOMARE\u2014Laboratory for Innovation and Sustainability of Marine Biological Resources, CESAM\u2014Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":false,"given":"Maria Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[{"name":"ECOMARE\u2014Laboratory for Innovation and Sustainability of Marine Biological Resources, CESAM\u2014Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-7913","authenticated-orcid":false,"given":"Felisa","family":"Rey","sequence":"additional","affiliation":[{"name":"ECOMARE\u2014Laboratory for Innovation and Sustainability of Marine Biological Resources, CESAM\u2014Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Mass Spectrometry Centre, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1751-7915.2010.00179.x","article-title":"Bioactive Compounds from Marine Bacteria and Fungi","volume":"3","author":"Debbab","year":"2010","journal-title":"Microb. 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