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In this study a commercially available pharmaceutical-grade fucoidan extracted from Fucus vesiculosus, FE, was characterized and its anti-inflammatory potential was investigated. Fucose was the main monosaccharide (90 mol%) present in the studied FE, followed by uronic acids, galactose, and xylose that were present at similar values (3.8\u20132.4 mol%). FE showed a molecular weight of 70 kDa and a sulfate content of around 10%. The expression of cytokines by mouse bone-marrow-derived macrophages (BMDMs) revealed that the addition of FE upregulated the expression of CD206 and IL-10 by about 28 and 22 fold, respectively, in respect to control. This was corroborated in a stimulated pro-inflammatory situation, with the higher expression (60 fold) of iNOS being almost completely reversed by the addition of FE. FE was also capable of reverse LPS-caused inflammation in an in vivo mouse model, including by reducing macrophage activation by LPS from 41% of positive CD11C to 9% upon fucoidan injection. Taken together, the potential of FE as an anti-inflammatory agent was validated, both in vitro and in vivo.<\/jats:p>","DOI":"10.3390\/md21050302","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:04:05Z","timestamp":1684289045000},"page":"302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo"],"prefix":"10.3390","volume":"21","author":[{"given":"Lingzhi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529000, China"}]},{"given":"Catarina","family":"Oliveira","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 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Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115691","DOI":"10.1016\/j.carbpol.2019.115691","article-title":"Immunomodulatory properties of photopolymerizable fucoidan and carrageenans","volume":"230","author":"Amin","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.fct.2011.04.020","article-title":"Anti-inflammatory effects of fucoidan through inhibition of NF-\u03baB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells","volume":"49","author":"Park","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_16","first-page":"205","article-title":"Anti-inflammatory activity of fucoidan with blocking NF-\u03baB and STAT1 in human keratinocytes cells","volume":"21","author":"Ryu","year":"2015","journal-title":"Nat. Prod. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ifset.2016.04.014","article-title":"A cold water extract of Fucus vesiculosus inhibits lipopolysaccharide (LPS) induced pro-inflammatory responses in the porcine colon ex-vivo model","volume":"37","author":"Bahar","year":"2016","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pozharitskaya, O., Obluchinskaya, E., and Shikov, A. (2020). Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea. Mar. Drugs, 18.","DOI":"10.3390\/md18050275"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E., Pozharitskaya, O., and Shikov, A. (2022). In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds. Mar. Drugs, 20.","DOI":"10.3390\/md20100606"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/MPA.0b013e3182a63b9d","article-title":"Protective effects of fucoidan, a P- and L-selectin inhibitor, in murine acute pancreatitis","volume":"43","author":"Carvalho","year":"2014","journal-title":"Pancreas"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/glycob\/cwm014","article-title":"A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds","volume":"17","author":"Cumashi","year":"2007","journal-title":"Glycobiology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lean, Q.Y., Eri, R., Fitton, J., Patel, R., and G\u00fcven, N. (2015). Fucoidan Extracts Ameliorate Acute Colitis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128453"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E., Pozharitskaya, O., Flisyuk, E., and Shikov, A. (2021). Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties. Mar. Drugs, 19.","DOI":"10.3390\/md19110643"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"556312","DOI":"10.3389\/fpls.2020.556312","article-title":"A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae","volume":"11","author":"Ponce","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.carbpol.2011.06.006","article-title":"Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed","volume":"86","author":"Mussatto","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E., Pozharitskaya, O., Zakharov, D., Flisyuk, E., Terninko, I., Generalova, Y., Smekhova, I., and Shikov, A. (2022). The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region. Mar. Drugs, 20.","DOI":"10.3390\/md20030193"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbm4.10058","article-title":"Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics","volume":"2","author":"Ng","year":"2018","journal-title":"Jbmr Plus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.fct.2011.05.022","article-title":"Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia\u2013reperfusion injury in rats via regulating the inflammation response","volume":"49","author":"Li","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_29","first-page":"695","article-title":"Pro- versus anti-inflammatory cytokines: Myth or reality","volume":"47","author":"Cavaillon","year":"2001","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand Fr.)"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/187152809787582507","article-title":"The IL-12 family of cytokines in infection, inflammation and autoimmune disorders","volume":"8","author":"Gee","year":"2009","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/wound.2019.1032","article-title":"The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis","volume":"9","author":"Steen","year":"2020","journal-title":"Adv. Wound Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"18750","DOI":"10.1038\/s41598-019-55289-2","article-title":"Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia","volume":"9","author":"Tsuchiya","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Nielsen, M.C., Hvidbjerg Gantzel, R., Cl\u00e0ria, J., Trebicka, J., M\u00f8ller, H.J., and Gr\u00f8nb\u00e6k, H. (2020). Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure. Cells, 9.","DOI":"10.3390\/cells9051175"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.carbpol.2012.03.056","article-title":"Molecular characteristics and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava","volume":"89","author":"Lee","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.pa.35.040195.003255","article-title":"Macrophages and inflammatory mediators in tissue injury","volume":"35","author":"Laskin","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2174\/1566524043359908","article-title":"The role of iNOS in chronic inflammatory processes in vivo: Is it damage-promoting, protective, or active at all?","volume":"4","author":"Suschek","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1440-1681.2009.05314.x","article-title":"Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia","volume":"37","author":"Cui","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ijbiomac.2020.04.012","article-title":"In vitro and in vivo anti-inflammatory activities of a fucose-rich fucoidan isolated from Saccharina japonica","volume":"156","author":"Ni","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"32033","DOI":"10.3402\/fnr.v60.32033","article-title":"Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells","volume":"60","author":"Hwang","year":"2016","journal-title":"Food Nutr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-319-54090-0_7","article-title":"F4\/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen","volume":"62","year":"2017","journal-title":"Results Probl. Cell Differ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1084\/jem.20042307","article-title":"The macrophage F4\/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance","volume":"201","author":"Lin","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/mi.2015.65","article-title":"CD11c+ monocyte\/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23","volume":"9","author":"Arnold","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zayed, A., El-Aasr, M., Ibrahim, A., and Ulber, R. (2020). Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties. Mar. Drugs, 18.","DOI":"10.3390\/md18110571"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0144-8617(02)00006-1","article-title":"Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea","volume":"49","author":"Melo","year":"2002","journal-title":"Carbohydr. Polym."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114962","DOI":"10.1016\/j.carbpol.2019.06.001","article-title":"Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides","volume":"222","author":"Pandeirada","year":"2019","journal-title":"Carbohydr. Polym."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/21\/5\/302\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:35Z","timestamp":1760124995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/21\/5\/302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["md21050302"],"URL":"https:\/\/doi.org\/10.3390\/md21050302","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}