{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:03:03Z","timestamp":1765357383188,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union","award":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"],"award-info":[{"award-number":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"]}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Foundation for Science and Technology","doi-asserted-by":"publisher","award":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"],"award-info":[{"award-number":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CRESC Algarve 2020","award":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"],"award-info":[{"award-number":["101003376","730984","UIDB\/04326\/2020","UIDP\/04326\/2020","LA\/P\/0101\/2020","EMBRC.PT ALG-01-0145-FEDER-022121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Tetrodotoxin (TTX) and its analogues are naturally occurring toxins historically responsible for human poisoning fatalities in Eastern Asia. It is typically linked to the consumption of pufferfish and, to a lesser extent, marine gastropods and crabs. In the scope of a comprehensive project to understand the prevalence of emergent toxins in edible marine organisms, we report, for the first time, the detection of TTX analogues in the soft tissues of edible crabs, the European fiddler crab (Afruca tangeri) and green crab (Carcinus maenas), harvested in southern Portugal. No TTX was detected in the analyzed samples. However, three TTX analogues were detected\u2014an unknown TTX epimer, deoxyTTX, and trideoxyTTX. These three analogues were found in the European fiddler crab while only trideoxyTTX was found in the green crab, suggesting that the accumulation of TTX analogues might be influenced by the crabs\u2019 different feeding ecology. These results highlight the need to widely monitor TTX and its analogues in edible marine species in order to provide adequate information to the European Food Safety Authority and to protect consumers.<\/jats:p>","DOI":"10.3390\/md21060320","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T02:00:19Z","timestamp":1685066419000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Vectors of TTX Analogues in the North Atlantic Coast: The Edible Crabs Afruca tangeri and Carcinus maenas"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-7163","authenticated-orcid":false,"given":"Sandra","family":"Lage","sequence":"first","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"given":"Felicitas","family":"ten Brink","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"},{"name":"Energy and Environment Institute, School of Environmental Sciences, University of Hull, Hull HU6 7RX, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-6468","authenticated-orcid":false,"given":"Adelino V. M.","family":"Can\u00e1rio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"given":"Jos\u00e9 P.","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref_1","first-page":"1688","article-title":"Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane","volume":"289","author":"Sugimoto","year":"1999","journal-title":"J. Pharmacol. Exp. 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