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program","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"COST (European Cooperation in Science and Technology) program","award":["PTDC\/MED-FAR\/3492\/2021"],"award-info":[{"award-number":["PTDC\/MED-FAR\/3492\/2021"]}]},{"name":"COST (European Cooperation in Science and Technology) program","award":["LCF\/PR\/HR21\/52410028"],"award-info":[{"award-number":["LCF\/PR\/HR21\/52410028"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PTDC\/MED-FAR\/3492\/2021"],"award-info":[{"award-number":["PTDC\/MED-FAR\/3492\/2021"]}]},{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["LCF\/PR\/HR21\/52410028"],"award-info":[{"award-number":["LCF\/PR\/HR21\/52410028"]}]},{"name":"La Caixa Foundation","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"La Caixa Foundation","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]},{"name":"La Caixa Foundation","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"La Caixa Foundation","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"La Caixa Foundation","award":["PTDC\/MED-FAR\/3492\/2021"],"award-info":[{"award-number":["PTDC\/MED-FAR\/3492\/2021"]}]},{"name":"La Caixa Foundation","award":["LCF\/PR\/HR21\/52410028"],"award-info":[{"award-number":["LCF\/PR\/HR21\/52410028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine sponges are highly efficient in removing organic pollutants and their cultivation, adjacent to fish farms, is increasingly considered as a strategy for improving seawater quality. Moreover, these invertebrates produce a plethora of bioactive metabolites, which could translate into an extra profit for the aquaculture sector. Here, we investigated the chemical profile and bioactivity of two Mediterranean species (i.e., Agelas oroides and Sarcotragus foetidus) and we assessed whether cultivated sponges differed substantially from their wild counterparts. Metabolomic analysis of crude sponge extracts revealed species-specific chemical patterns, with A. oroides and S. foetidus dominated by alkaloids and lipids, respectively. More importantly, farmed and wild explants of each species demonstrated similar chemical fingerprints, with the majority of the metabolites showing modest differences on a sponge mass-normalized basis. Furthermore, farmed sponge extracts presented similar or slightly lower antibacterial activity against methicillin-resistant Staphylococcus aureus, compared to the extracts resulting from wild sponges. Anticancer assays against human colorectal carcinoma cells (HCT-116) revealed marginally active extracts from both wild and farmed S. foetidus populations. Our study highlights that, besides mitigating organic pollution in fish aquaculture, sponge farming can serve as a valuable resource of biomolecules, with promising potential in pharmaceutical and biomedical applications.<\/jats:p>","DOI":"10.3390\/md21120612","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:35:06Z","timestamp":1701056106000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative Chemical Profiling and Antimicrobial\/Anticancer Evaluation of Extracts from Farmed versus Wild Agelas oroides and Sarcotragus foetidus Sponges"],"prefix":"10.3390","volume":"21","author":[{"given":"Despoina","family":"Varamogianni-Mamatsi","sequence":"first","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"},{"name":"School of Chemical and Environmental Engineering, Technical University of Crete, 73100 Chania, Greece"},{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Chemistry and Life Sciences Departments, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4378-5173","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Nunes","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Associated Laboratory for Green Chemistry, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-0781","authenticated-orcid":false,"given":"Vanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Thekla I.","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"}]},{"given":"Eirini","family":"Kagiampaki","sequence":"additional","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"}]},{"given":"Emmanouela","family":"Vernadou","sequence":"additional","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4102-9331","authenticated-orcid":false,"given":"Thanos","family":"Dailianis","sequence":"additional","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-0302","authenticated-orcid":false,"given":"Nicolas","family":"Kalogerakis","sequence":"additional","affiliation":[{"name":"School of Chemical and Environmental Engineering, Technical University of Crete, 73100 Chania, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-1151","authenticated-orcid":false,"given":"Lu\u00eds C.","family":"Branco","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Associated Laboratory for Green Chemistry, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4829-754X","authenticated-orcid":false,"given":"Cec\u00edlia M. P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4533-7531","authenticated-orcid":false,"given":"Rita G.","family":"Sobral","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Chemistry and Life Sciences Departments, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-1170","authenticated-orcid":false,"given":"Susana P.","family":"Gaud\u00eancio","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Chemistry and Life Sciences Departments, NOVA School of Science and Technology, NOVA University of Lisbon, Campus Caparica, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-4290","authenticated-orcid":false,"given":"Manolis","family":"Mandalakis","sequence":"additional","affiliation":[{"name":"Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, 71500 Heraklion Crete, Greece"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100620","DOI":"10.1016\/j.gfs.2022.100620","article-title":"Aquaculture: The missing contributor in the food security agenda","volume":"32","author":"Garlock","year":"2022","journal-title":"Glob. 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