{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:57:58Z","timestamp":1772769478077,"version":"3.50.1"},"reference-count":86,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT (Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia)","doi-asserted-by":"publisher","award":["PTDC\/SAUNUT\/30455\/2017"],"award-info":[{"award-number":["PTDC\/SAUNUT\/30455\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT (Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia)","doi-asserted-by":"publisher","award":["2021.05300.BD"],"award-info":[{"award-number":["2021.05300.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT (Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia)","doi-asserted-by":"publisher","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IPMA","award":["PTDC\/SAUNUT\/30455\/2017"],"award-info":[{"award-number":["PTDC\/SAUNUT\/30455\/2017"]}]},{"name":"IPMA","award":["2021.05300.BD"],"award-info":[{"award-number":["2021.05300.BD"]}]},{"name":"IPMA","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer\u2019s disease (AD). After ingestion, dietary DHA must cross the blood\u2013brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation\/food fortification intended neural enrichment in DHA. As it is rich in DHA, especially its phospholipids (PL), Atlantic mackerel (Scomber scombrus, caught in Spring\/2022) was used as a raw material. The polar lipids fraction was separated and hydrolysed with Rhizomucor miehei lipase, to enzymatically convert phosphatidylcholine (PC) into LPC. The fish (muscle and by-products) lipids fraction was used for total lipids (TL) content, lipid classes (LC) and fatty acid (FA) profile evaluation, whilst polar lipids extracts were studied for LC production and FA analysis. Muscle TL ranged between 1.45 and 4.64 g\/100 g (WW), while by-products accounted for 7.56-8.96 g\/100 g, with the highest contents being found in March. However, PL were more abundant in muscle (22.46\u201332.20% of TL). For polar lipids extracts, PL represented 50.79% of TL, among which PC corresponded to 57.76% and phosphatidylethanolamine to 42.24%. After hydrolysis, nearly half of this PC was converted into LPC. When compared to the initial PC, DHA relative content (33.6% of total FA) was significantly higher after hydrolysis: 55.6% in PC and 73.6% in LPC. Such extract, obtained from this undervalued species, may represent a promising strategy to increase DHA uptake into brain cells while allowing this species to upgrade.<\/jats:p>","DOI":"10.3390\/md22030116","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:59:19Z","timestamp":1709186359000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain"],"prefix":"10.3390","volume":"22","author":[{"given":"Romina","family":"Gomes","sequence":"first","affiliation":[{"name":"Division of Aquaculture, Upgrading and Bioprospection (DivAV), Portuguese Institute for the Sea and Atmosphere (IPMA, I.P.), Avenida Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"MEtRICs\/Departamento de Qu\u00edmica, NOVA School of Science and Technology|FCTNOVA, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"In\u00eas","family":"Mendes","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Upgrading and Bioprospection (DivAV), Portuguese Institute for the Sea and Atmosphere (IPMA, I.P.), Avenida Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Barreiro School of Technology, Polytechnic Institute of Setubal, Rua Am\u00e9rico da Silva Marinho, 2839-001 Lavradio, Portugal"}]},{"given":"Maria Paula","family":"Duarte","sequence":"additional","affiliation":[{"name":"MEtRICs\/Departamento de Qu\u00edmica, NOVA School of Science and Technology|FCTNOVA, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"Narcisa M.","family":"Bandarra","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Upgrading and Bioprospection (DivAV), Portuguese Institute for the Sea and Atmosphere (IPMA, I.P.), Avenida Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-2397","authenticated-orcid":false,"given":"Ana","family":"Gomes-Bispo","sequence":"additional","affiliation":[{"name":"Division of Aquaculture, Upgrading and Bioprospection (DivAV), Portuguese Institute for the Sea and Atmosphere (IPMA, I.P.), Avenida Alfredo Magalh\u00e3es Ramalho, 6, 1495-165 Alg\u00e9s, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wong, L.R., Wong, P., and Ho, P.C. 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