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This condition affects millions of individuals worldwide and is linked to a variety of consequences, including cardiovascular disease, neuropathy, nephropathy, and retinopathy. Diabetes therapy now focuses on controlling blood glucose levels through lifestyle changes, oral medicines, and insulin injections. However, these therapies have limits and may not successfully prevent or treat diabetic problems. Several marine-derived chemicals have previously demonstrated promising findings as possible antidiabetic medicines in preclinical investigations. Peptides, polyphenols, and polysaccharides extracted from seaweeds, sponges, and other marine species are among them. As a result, marine natural products have the potential to be a rich source of innovative multitargeted medications for diabetes prevention and treatment, as well as associated complications. Future research should focus on the chemical variety of marine creatures as well as the mechanisms of action of marine-derived chemicals in order to find new antidiabetic medicines and maximize their therapeutic potential. Based on preclinical investigations, this review focuses on the next step for seaweed applications as potential multitargeted medicines for diabetes, highlighting the bioactivities of seaweeds in the prevention and treatment of this illness.<\/jats:p>","DOI":"10.3390\/md22040168","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:07:46Z","timestamp":1712729266000},"page":"168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-221X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Cotas","sequence":"first","affiliation":[{"name":"Marine Resources, Conservation and Technology, Marine Algae Lab, CFE\u2014Centre for Functional Ecology: Science for People & Planet, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"given":"Silvia","family":"Lomartire","sequence":"additional","affiliation":[{"name":"Marine Resources, Conservation and Technology, Marine Algae Lab, CFE\u2014Centre for Functional Ecology: Science for People & Planet, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0619","authenticated-orcid":false,"given":"Leonel","family":"Pereira","sequence":"additional","affiliation":[{"name":"Marine Resources, Conservation and Technology, Marine Algae Lab, CFE\u2014Centre for Functional Ecology: Science for People & Planet, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-6648","authenticated-orcid":false,"given":"Ana","family":"Valado","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro\u2014SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal"},{"name":"Research Centre for Natural Resources, Environment and Society\u2014CERNAS, Escola Superior Agr\u00e1ria de Coimbra Bencanta, 3045-601 Coimbra, Portugal"}]},{"given":"Jo\u00e3o Carlos","family":"Marques","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre\/ARNET-Aquatic Research Network, Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-7183","authenticated-orcid":false,"given":"Ana M. M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Marine Resources, Conservation and Technology, Marine Algae Lab, CFE\u2014Centre for Functional Ecology: Science for People & Planet, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5001\/omj.2017.34","article-title":"Diabetes Mellitus: A Local and Global Public Health Emergency!","volume":"32","year":"2017","journal-title":"Oman Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rachdaoui, N. (2020). Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051770"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Piliponien\u0117, L., Veli\u010dkien\u0117, D., and Kreg\u017edyt\u0117, R. (2021). Microvascular Complications, Peripheral Artery Disease and Mortality in Patients with Type 2 Diabetes Mellitus, in Two Counties of Southern Lithuania over 13 Years: Analysis Using a Cohort Database of the National Health Insurance. Medicina, 57.","DOI":"10.3390\/medicina57121380"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lauritano, C., and Ianora, A. (2016). Marine Organisms with Anti-Diabetes Properties. Mar. Drugs, 14.","DOI":"10.3390\/md14120220"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lomartire, S., and Gon\u00e7alves, A.M.M. (2022). An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications. Mar. Drugs, 20.","DOI":"10.3390\/md20020141"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2017.12.001","article-title":"Bioactive Compounds from Marine Macroalgae and Their Hypoglycemic Benefits","volume":"72","author":"Zhao","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kim, E., Cui, J., Kang, I., Zhang, G., and Lee, Y. (2021). Potential Antidiabetic Effects of Seaweed Extracts by Upregulating Glucose Utilization and Alleviating Inflammation in C2C12 Myotubes. Int. J. Environ. Res. Public. Health, 18.","DOI":"10.3390\/ijerph18031367"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lu, L.W., and Chen, J.-H. (2022). Seaweeds as Ingredients to Lower Glycemic Potency of Cereal Foods Synergistically\u2014A Perspective. Foods, 11.","DOI":"10.3390\/foods11050714"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1230218","DOI":"10.1155\/2020\/1230218","article-title":"Antidiabetic Potential of Marine Brown Algae\u2014A Mini Review","volume":"2020","author":"Gunathilaka","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Karuppusamy, S., Rajauria, G., Fitzpatrick, S., Lyons, H., McMahon, H., Curtin, J., Tiwari, B.K., and O\u2019Donnell, C. (2022). Biological Properties and Health-Promoting Functions of Laminarin: A Comprehensive Review of Preclinical and Clinical Studies. Mar. Drugs, 20.","DOI":"10.3390\/md20120772"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"El-Beltagi, H.S., Mohamed, A.A., Mohamed, H.I., Ramadan, K.M.A., Barqawi, A.A., and Mansour, A.T. (2022). Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review. Mar. Drugs, 20.","DOI":"10.3390\/md20060342"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Biris-Dorhoi, E.-S., Michiu, D., Pop, C.R., Rotar, A.M., Tofana, M., Pop, O.L., Socaci, S.A., and Farcas, A.C. (2020). Macroalgae\u2014A Sustainable Source of Chemical Compounds with Biological Activities. Nutrients, 12.","DOI":"10.3390\/nu12103085"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bocanegra, A., Macho-Gonz\u00e1lez, A., Garcimart\u00edn, A., Bened\u00ed, J., and S\u00e1nchez-Muniz, F.J. (2021). Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083816"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lomartire, S., Marques, J.C., and Gon\u00e7alves, A.M.M. (2021). An Overview to the Health Benefits of Seaweeds Consumption. Mar. Drugs, 19.","DOI":"10.3390\/md19060341"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pe\u00f1alver, R., Lorenzo, J.M., Ros, G., Amarowicz, R., Pateiro, M., and Nieto, G. (2020). Seaweeds as a Functional Ingredient for a Healthy Diet. Mar. Drugs, 18.","DOI":"10.3390\/md18060301"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.crcon.2021.04.002","article-title":"Macroalgae-Derived Rare Sugars: Applications and Catalytic Synthesis","volume":"4","author":"Bayu","year":"2021","journal-title":"Carbon. Resour. Convers."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbacli.2016.02.001","article-title":"Glycogen Metabolism in Humans","volume":"5","year":"2016","journal-title":"BBA Clin."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"van Laar, A., Grootaert, C., Rajkovic, A., Desmet, T., Beerens, K., and Van Camp, J. (2023). Rare Sugar Metabolism and Impact on Insulin Sensitivity along the Gut\u2013Liver\u2013Muscle Axis In Vitro. Nutrients, 15.","DOI":"10.3390\/nu15071593"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00217-015-2437-7","article-title":"Sugar Alcohols\u2014Their Role in the Modern World of Sweeteners: A Review","volume":"241","author":"Grembecka","year":"2015","journal-title":"Eur. Food Res. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shannon, E., Conlon, M., and Hayes, M. (2021). Seaweed Components as Potential Modulators of the Gut Microbiota. Mar. Drugs, 19.","DOI":"10.3390\/md19070358"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S2213-8587(14)70225-6","article-title":"Iodine Deficiency and Thyroid Disorders","volume":"3","author":"Zimmermann","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Collins, K., Fitzgerald, G., Stanton, C., and Ross, R. (2016). Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases. Mar. Drugs, 14.","DOI":"10.3390\/md14030060"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1192\/bjp.bp.112.114793","article-title":"Dietary Patterns and Suicide in Japanese Adults: The Japan Public Health Center-Based Prospective Study","volume":"203","author":"Nanri","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5551\/jat.6866","article-title":"Lifestyle and Cardiovascular Disease in Japan","volume":"18","author":"Iso","year":"2011","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/jmf.2008.0151","article-title":"Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds","volume":"12","author":"Bocanegra","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijgfs.2018.09.002","article-title":"World Cuisine of Seaweeds: Science Meets Gastronomy","volume":"14","author":"Mouritsen","year":"2018","journal-title":"Int. J. Gastron. Food Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF02859049","article-title":"Edible Seaweeds of China and Their Place in the Chinese Diet","volume":"41","author":"Bangmei","year":"1987","journal-title":"Econ. Bot."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Peng, J., Min, S., Qing, P., and Yang, M. (2021). The Impacts of Urbanization and Dietary Knowledge on Seaweed Consumption in China. Foods, 10.","DOI":"10.3390\/foods10061373"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Miyake, Y., Tanaka, K., Okubo, H., Sasaki, S., and Arakawa, M. (2014). Seaweed Consumption and Prevalence of Depressive Symptoms during Pregnancy in Japan: Baseline Data from the Kyushu Okinawa Maternal and Child Health Study. BMC Pregnancy Childbirth, 14.","DOI":"10.1186\/1471-2393-14-301"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1021\/ed077p984","article-title":"Discovery and Early Uses of Iodine","volume":"77","author":"Rosenfeld","year":"2000","journal-title":"J. Chem. Educ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ifset.2016.02.005","article-title":"Identification and Characterization of Phenolic Antioxidant Compounds from Brown Irish Seaweed Himanthalia elongata Using LC-DAD\u2013ESI-MS\/MS","volume":"37","author":"Rajauria","year":"2016","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10811-012-9931-0","article-title":"The Consumption of Seaweed as a Protective Factor in the Etiology of Breast Cancer: Proof of Principle","volume":"25","author":"Teas","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_33","first-page":"81","article-title":"Effects of Fucoidan from Fucus Vesiculosus in Reducing Symptoms of Osteoarthritis: A Randomized Placebo-Controlled Trial","volume":"10","author":"Fitton","year":"2016","journal-title":"Biologics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1753-4887.2007.tb00278.x","article-title":"Nutritional Value of Edible Seaweeds","volume":"65","author":"MacArtain","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MAJ.0b013e318065c3a1","article-title":"The Prevalence of Metabolic Syndrome in Various Populations","volume":"333","author":"Kolovou","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.diabres.2003.12.007","article-title":"Prevalence of the Metabolic Syndrome among 40,698 Korean Metropolitan Subjects","volume":"65","author":"Lee","year":"2004","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ije\/dyh032","article-title":"The Metabolic Syndrome and Associated Lifestyle Factors among South Korean Adults","volume":"33","author":"Park","year":"2004","journal-title":"Int. J. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0929-6646(09)60161-3","article-title":"Prevalence of Obesity and Metabolic Syndrome in Taiwan","volume":"105","author":"Hwang","year":"2006","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3177\/jnsv.56.13","article-title":"Algae Consumption and Risk of Type 2 Diabetes: Korean National Health and Nutrition Examination Survey in 2005","volume":"56","author":"LEE","year":"2010","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_40","first-page":"292","article-title":"Time Trend of Obesity, the Metabolic Syndrome and Related Dietary Pattern in Taiwan: From NAHSIT 1993\u20131996 to NAHSIT 2005\u20132008","volume":"20","author":"Yeh","year":"2011","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2152\/jmi.61.291","article-title":"Effects of the Intake of Undaria pinnatifida (Wakame) and its Sporophylls (Mekabu) on Postprandial Glucose and Insulin Metabolism","volume":"61","author":"Tanemura","year":"2014","journal-title":"J. Med. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cca.2014.10.042","article-title":"Association between Flavonoid Intake and Diabetes Risk among the Koreans","volume":"439","author":"Yeon","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.fitote.2012.04.027","article-title":"Fucoidan Regulate Blood Glucose Homeostasis in C57BL\/KSJ M+\/+db and C57BL\/KSJ Db\/Db Mice","volume":"83","author":"Kim","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nutres.2012.04.003","article-title":"Fucoidan from the Sporophyll of Undaria pinnatifida Suppresses Adipocyte Differentiation by Inhibition of Inflammation-Related Cytokines in 3T3-L1 Cells","volume":"32","author":"Kim","year":"2012","journal-title":"Nutr. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/mol.113.085100","article-title":"Low Molecular Weight Fucoidan Improves Endoplasmic Reticulum Stress-Reduced Insulin Sensitivity through AMP-Activated Protein Kinase Activation in L6 Myotubes and Restores Lipid Homeostasis in a Mouse Model of Type 2 Diabetes","volume":"84","author":"Jeong","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.carbpol.2013.02.076","article-title":"Hypoglycemic Property of Acidic Polysaccharide Extracted from Saccharina japonica and Its Potential Mechanism","volume":"95","author":"Wang","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/fsn3.3100","article-title":"The Anti-obesity and Anti-diabetic Effects of the Edible Seaweed Gloiopeltis furcata (Postels et Ruprecht) J. Agardh in Mice Fed a High-fat Diet","volume":"11","author":"Murakami","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.marpolbul.2014.04.032","article-title":"Possible Change in Distribution of Seaweed, Sargassum Horneri, in Northeast Asia under A2 Scenario of Global Warming and Consequent Effect on Some Fish","volume":"85","author":"Komatsu","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.carbpol.2017.08.043","article-title":"Structure, Enzymatic Transformation, Anticancer Activity of Fucoidan and Sulphated Fucooligosaccharides from Sargassum horneri","volume":"175","author":"Silchenko","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopha.2018.12.001","article-title":"Differential Modulation of Immune Response and Cytokine Profiles of Sargassum horneri Ethanol Extract in Murine Spleen with or without Concanavalin A Stimulation","volume":"110","author":"Herath","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3390\/md12020851","article-title":"Fucoidan as a Marine Anticancer Agent in Preclinical Development","volume":"12","author":"Kwak","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Luthuli, S., Wu, S., Cheng, Y., Zheng, X., Wu, M., and Tong, H. (2019). Therapeutic Effects of Fucoidan: A Review on Recent Studies. Mar. Drugs, 17.","DOI":"10.3390\/md17090487"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Murakami, S., Hirazawa, C., Ohya, T., Yoshikawa, R., Mizutani, T., Ma, N., Moriyama, M., Ito, T., and Matsuzaki, C. (2021). The Edible Brown Seaweed Sargassum horneri (Turner) C. Agardh Ameliorates High-Fat Diet-Induced Obesity, Diabetes, and Hepatic Steatosis in Mice. Nutrients, 13.","DOI":"10.3390\/nu13020551"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10811-016-0974-5","article-title":"Algae as Nutritional and Functional Food Sources: Revisiting Our Understanding","volume":"29","author":"Wells","year":"2017","journal-title":"J. Appl. Phycol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4305148","DOI":"10.1155\/2019\/4305148","article-title":"A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem","volume":"2019","author":"Sachithanandam","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., and Song, S. (2019). Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies. Mar. Drugs, 17.","DOI":"10.3390\/md17030183"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"135295","DOI":"10.1016\/j.foodchem.2022.135295","article-title":"Algal Nutraceuticals: A Perspective on Metabolic Diversity, Current Food Applications, and Prospects in the Field of Metabolomics","volume":"409","author":"Cassani","year":"2023","journal-title":"Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pereira, L., and Valado, A. (2023). Algae-Derived Natural Products in Diabetes and Its Complications\u2014Current Advances and Future Prospects. Life, 13.","DOI":"10.20944\/preprints202307.0722.v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2165\/00003495-200565030-00005","article-title":"Oral Antidiabetic Agents","volume":"65","author":"Krentz","year":"2005","journal-title":"Drugs"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Abo-Shady, A.M., Gheda, S.F., Ismail, G.A., Cotas, J., Pereira, L., and Abdel-Karim, O.H. (2023). Antioxidant and Antidiabetic Activity of Algae. Life, 13.","DOI":"10.3390\/life13020460"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/biologics2010008","article-title":"Therapeutic Role of Antimicrobial Peptides in Diabetes Mellitus","volume":"2","author":"Depta","year":"2022","journal-title":"Biologics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.3390\/md13116838","article-title":"Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods","volume":"13","author":"Cardoso","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ismail, M.M., Alotaibi, B.S., and EL-Sheekh, M.M. (2020). Therapeutic Uses of Red Macroalgae. Molecules, 25.","DOI":"10.3390\/molecules25194411"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ganesan, K., and Xu, B. (2019). Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides. Molecules, 24.","DOI":"10.3390\/molecules24142556"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1080\/10408398.2021.2024130","article-title":"Antidiabetic Potential of Seaweed and Their Bioactive Compounds: A Review of Developments in Last Decade","volume":"63","author":"Agarwal","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tifs.2020.01.019","article-title":"Recent Updates on Bioaccessibility of Phytonutrients","volume":"97","author":"Thakur","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_67","unstructured":"Alegr\u00eda, A., Garcia-Llatas, G., and Cilla, A. (2015). The Impact of Food Bioactives on Health, Springer International Publishing."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Monteiro, P., Lomartire, S., Cotas, J., Pacheco, D., Marques, J.C., Pereira, L., and Gon\u00e7alves, A.M.M. (2021). Seaweeds as a Fermentation Substrate: A Challenge for the Food Processing Industry. Processes, 9.","DOI":"10.3390\/pr9111953"},{"key":"ref_69","unstructured":"Satoor, S.N., Patil, D.P., Kristensen, H.D., Joglekar, M.V., Shouche, Y., and Hardikar, A.A. (2014). Mouse Genetics: Methods and Protocols, Humana Press."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.3390\/md13085447","article-title":"Potential Bioactive Compounds from Seaweed for Diabetes Management","volume":"13","author":"Sharifuddin","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Guzm\u00e1n, M., Rodr\u00edguez-Nogales, A., Algieri, F., and G\u00e1lvez, J. (2018). Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders. Mar. Drugs, 16.","DOI":"10.3390\/md16080250"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/01652176.2022.2061744","article-title":"Antioxidant Effects of Seaweeds and Their Active Compounds on Animal Health and Production\u2014A Review","volume":"42","author":"Michalak","year":"2022","journal-title":"Vet. Q."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s10811-022-02839-3","article-title":"Anti-Hyperglycemic and Antioxidant Effect of Fucoidan Extract from Lessonia Trabeculata in Alloxan-Induced Diabetes Rats","volume":"34","author":"Abdala","year":"2022","journal-title":"J. Appl. Phycol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Shin, D., Shim, S.R., Wu, Y., Hong, G., Jeon, H., Kim, C.-G., and Lee, K.J. (2023). How Do Brown Seaweeds Work on Biomarkers of Dyslipidemia? A Systematic Review with Meta-Analysis and Meta-Regression. Mar. Drugs, 21.","DOI":"10.3390\/md21040220"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/nutraceuticals2040032","article-title":"Bioactivity of Carrageenans in Metabolic Syndrome and Cardiovascular Diseases","volume":"2","author":"Valado","year":"2022","journal-title":"Nutraceuticals"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.foodchem.2018.07.142","article-title":"Inhibition of \u03b1-Glucosidase Activity by Selected Edible Seaweeds and Fucoxanthin","volume":"270","author":"Zaharudin","year":"2019","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13099-022-00512-1","article-title":"Effect of Crude Polysaccharide from Seaweed, Dictyopteris divaricata (CDDP) on Gut Microbiota Restoration and Anti-Diabetic Activity in Streptozotocin (STZ)-Induced T1DM Mice","volume":"14","author":"Siddiqui","year":"2022","journal-title":"Gut Pathog."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Liyanage, N.M., Nagahawatta, D.P., Jayawardena, T.U., and Jeon, Y.-J. (2023). The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease. Life, 13.","DOI":"10.3390\/life13041026"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lin, H.-T.V., Tsou, Y.-C., Chen, Y.-T., Lu, W.-J., and Hwang, P.-A. (2017). Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes. Mar. Drugs, 15.","DOI":"10.3390\/md15040113"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12986-019-0392-1","article-title":"Fucoidan Prevent Murine Autoimmune Diabetes via Suppression TLR4-Signaling Pathways, Regulation DC\/Treg Induced Immune Tolerance and Improving Gut Microecology","volume":"16","author":"Xue","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"102642","DOI":"10.1016\/j.algal.2022.102642","article-title":"Preparation, Characterization, Radical Scavenging Property and Antidiabetic Potential of Laminarioligosaccharides Derived from Laminarin","volume":"63","author":"Jayapala","year":"2022","journal-title":"Algal Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/1750-3841.14011","article-title":"Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties","volume":"83","author":"Admassu","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Nyakundi, B.B., and Yang, J. (2023). Uses of Papaya Leaf and Seaweed Supplementations for Controlling Glucose Homeostasis in Diabetes. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076846"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Giuntini, E.B., Sard\u00e1, F.A.H., and de Menezes, E.W. (2022). The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives. Foods, 11.","DOI":"10.3390\/foods11233934"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"112738","DOI":"10.1016\/j.lwt.2021.112738","article-title":"Identification and In Silico Study of a Novel Dipeptidyl Peptidase IV Inhibitory Peptide Derived from Green Seaweed Ulva Spp. Hydrolysates","volume":"154","author":"Cian","year":"2022","journal-title":"LWT"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s10811-013-0017-4","article-title":"In Vitro Assessment of the Cardioprotective, Anti-Diabetic and Antioxidant Potential of Palmaria palmata Protein Hydrolysates","volume":"25","author":"Harnedy","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.foodchem.2014.09.083","article-title":"Purification and Identification of Dipeptidyl Peptidase (DPP) IV Inhibitory Peptides from the Macroalga Palmaria palmata","volume":"172","author":"Harnedy","year":"2015","journal-title":"Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"104101","DOI":"10.1016\/j.jff.2020.104101","article-title":"Twice Daily Oral Administration of Palmaria palmata Protein Hydrolysate Reduces Food Intake in Streptozotocin Induced Diabetic Mice, Improving Glycaemic Control and Lipid Profiles","volume":"73","author":"McLaughlin","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1007\/s00394-021-02583-3","article-title":"Macroalgal Protein Hydrolysates from Palmaria palmata Influence the \u2018Incretin Effect\u2019 In Vitro via DPP-4 Inhibition and Upregulation of Insulin, GLP-1 and GIP Secretion","volume":"60","author":"McLaughlin","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1080\/14786419.2022.2025802","article-title":"Sulfated Galactofucan from Seaweed Padina tetrastromatica Attenuates Proteolytic Enzyme Dipeptidyl-Peptidase-4: A Potential Anti-Hyperglycemic Lead","volume":"36","author":"Antony","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lomartire, S., and Gon\u00e7alves, A.M.M. (2022). Novel Technologies for Seaweed Polysaccharides Extraction and Their Use in Food with Therapeutically Applications\u2014A Review. Foods, 11.","DOI":"10.3390\/foods11172654"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Gabbia, D., and De Martin, S. (2020). Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases. Molecules, 25.","DOI":"10.3390\/molecules25184182"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tifs.2020.01.020","article-title":"Therapeutic Potential of Algal Natural Products against Metabolic Syndrome: A Review of Recent Developments","volume":"97","author":"Fernando","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11101-021-09773-1","article-title":"A Review of Alpha-Glucosidase Inhibitors from Plants as Potential Candidates for the Treatment of Type-2 Diabetes","volume":"21","author":"Dirir","year":"2022","journal-title":"Phytochem. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kashtoh, H., and Baek, K.-H. (2022). Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes. Plants, 11.","DOI":"10.3390\/plants11202722"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"126646","DOI":"10.1016\/j.foodchem.2020.126646","article-title":"Comparative Assessment of Nutritional Composition, Polyphenol Profile, Antidiabetic and Antioxidative Properties of Selected Edible Wild Plant Species of Bangladesh","volume":"320","author":"Alam","year":"2020","journal-title":"Food Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111738","DOI":"10.1016\/j.fct.2020.111738","article-title":"An Overview on the Role of Bioactive \u03b1-Glucosidase Inhibitors in Ameliorating Diabetic Complications","volume":"145","author":"Hossain","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Pradhan, B., Nayak, R., Patra, S., Jit, B.P., Ragusa, A., and Jena, M. (2020). Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review. Molecules, 26.","DOI":"10.3390\/molecules26010037"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Echave, J., Otero, P., Garcia-Oliveira, P., Munekata, P.E.S., Pateiro, M., Lorenzo, J.M., Simal-Gandara, J., and Prieto, M.A. (2022). Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives. Antioxidants, 11.","DOI":"10.3390\/antiox11010176"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"694362","DOI":"10.3389\/fnut.2021.694362","article-title":"Anti-Diabetic Potential of a Stigmasterol From the Seaweed Gelidium spinosum and Its Application in the Formulation of Nanoemulsion Conjugate for the Development of Functional Biscuits","volume":"8","author":"Poulose","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.3390\/md13085358","article-title":"Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota","volume":"13","author":"Cian","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Meinita, M.D.N., Harwanto, D., and Choi, J.-S. (2022). Seaweed Exhibits Therapeutic Properties against Chronic Diseases: An Overview. Appl. Sci., 12.","DOI":"10.3390\/app12052638"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Salehi, B., Sharifi-Rad, J., Seca, A.M., Pinto, D.C., Michalak, I., Trincone, A., Mishra, A.P., Nigam, M., Zam, W., and Martins, N. (2019). Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications. Molecules, 24.","DOI":"10.3390\/molecules24224182"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/phycology2020012","article-title":"Seaweeds as a Source of Functional Proteins","volume":"2","author":"Thiviya","year":"2022","journal-title":"Phycology"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Baghel, R.S., Choudhary, B., Pandey, S., Pathak, P.K., Patel, M.K., and Mishra, A. (2023). Rehashing Our Insight of Seaweeds as a Potential Source of Foods, Nutraceuticals, and Pharmaceuticals. Foods, 12.","DOI":"10.3390\/foods12193642"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.foodchem.2013.04.123","article-title":"The \u03b1-Amylase and \u03b1-Glucosidase Inhibitory Effects of Irish Seaweed Extracts","volume":"141","author":"Lordan","year":"2013","journal-title":"Food Chem."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Gazali, M., Jolanda, O., Husni, A., Majid, F.A.A., and Syafitri, R. (2023). In Vitro \u03b1-Amylase and \u03b1-Glucosidase Inhibitory Activity of Green Seaweed Halimeda tuna Extract from the Coast of Lhok Bubon, Aceh. Plants, 12.","DOI":"10.3390\/plants12020393"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Cheong, K.-L., Yu, B., Chen, J., and Zhong, S. (2022). A Comprehensive Review of the Cardioprotective Effect of Marine Algae Polysaccharide on the Gut Microbiota. Foods, 11.","DOI":"10.3390\/foods11223550"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Yang, Y., Liang, M., Ouyang, D., Tong, H., Wu, M., and Su, L. (2022). Research Progress on the Protective Effect of Brown Algae-Derived Polysaccharides on Metabolic Diseases and Intestinal Barrier Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810784"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Lopes, G., Andrade, P., and Valent\u00e3o, P. (2016). Phlorotannins: Towards New Pharmacological Interventions for Diabetes Mellitus Type 2. Molecules, 22.","DOI":"10.3390\/molecules22010056"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Vijaykrishnaraj, M., and Wang, K. (2021). Dietary Natural Products as a Potential Inhibitor towards Advanced Glycation End Products and Hyperglycemic Complications: A Phytotherapy Approaches. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112336"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","article-title":"The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives","volume":"14","author":"Tsalamandris","year":"2019","journal-title":"Eur. Cardiol. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Pereira, L., and Valado, A. (2021). The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases. Mar. Drugs, 19.","DOI":"10.3390\/md19030128"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Sanjeewa, K.K.A., Herath, K.H.I.N.M., Yang, H.-W., Choi, C.S., and Jeon, Y.-J. (2021). Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Mar. Drugs, 19.","DOI":"10.3390\/md19120678"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Cotas, J., Lomartire, S., Gon\u00e7alves, A.M.M., and Pereira, L. (2024). From Ocean to Medicine: Harnessing Seaweed\u2019s Potential for Drug Development. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020797"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Mabate, B., Daub, C.D., Malgas, S., Edkins, A.L., and Pletschke, B.I. (2021). Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy. Mar. Drugs, 19.","DOI":"10.3390\/md19010030"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zheng, H., Zhao, Y., and Guo, L. (2022). A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins. Mar. Drugs, 20.","DOI":"10.3390\/md20120742"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"014","DOI":"10.33160\/yam.2019.03.003","article-title":"A Randomized Placebo-Controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity","volume":"62","author":"Sakai","year":"2019","journal-title":"Yonago Acta Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4162\/nrp.2008.2.2.62","article-title":"Effects of Seaweed Supplementation on Blood Glucose Concentration, Lipid Profile, and Antioxidant Enzyme Activities in Patients with Type 2 Diabetes Mellitus","volume":"2","author":"Kim","year":"2008","journal-title":"Nutr. Res. Pract."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/nutrit\/nuy066","article-title":"Risks and Benefits of Consuming Edible Seaweeds","volume":"77","author":"Cherry","year":"2019","journal-title":"Nutr. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.3390\/md13095920","article-title":"Therapies from Fucoidan: An Update","volume":"13","author":"Fitton","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000512971","article-title":"Iodine, Seaweed, and the Thyroid","volume":"10","author":"Smyth","year":"2021","journal-title":"Eur. Thyroid. J."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Rosa, G.P., Tavares, W.R., Sousa, P.M.C., Pag\u00e8s, A.K., Seca, A.M.L., and Pinto, D.C.G.A. (2019). Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials. Mar. Drugs, 18.","DOI":"10.3390\/md18010008"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"740054","DOI":"10.3389\/fmars.2021.740054","article-title":"Edible Seaweeds: A Potential Novel Source of Bioactive Metabolites and Nutraceuticals with Human Health Benefits","volume":"8","author":"Choudhary","year":"2021","journal-title":"Front. Mar. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Martins, M., Silva, R., MM Pinto, M., and Sousa, E. (2020). Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer\u2019s Disease. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090242"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"837649","DOI":"10.3389\/fnagi.2022.837649","article-title":"Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer\u2019s Disease","volume":"14","author":"Gong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Bhuyan, P.P., Nayak, R., Patra, S., Abdulabbas, H.S., Jena, M., and Pradhan, B. (2023). Seaweed-Derived Sulfated Polysaccharides; The New Age Chemopreventives: A Comprehensive Review. Cancers, 15.","DOI":"10.3390\/cancers15030715"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Cotas, J., Leandro, A., Monteiro, P., Pacheco, D., Figueirinha, A., Gon\u00e7alves, A.M.M., da Silva, G.J., and Pereira, L. (2020). Seaweed Phenolics: From Extraction to Applications. Mar. Drugs, 18.","DOI":"10.3390\/md18080384"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s10811-022-02749-4","article-title":"Phlorotannins\u2013Bioactivity and Extraction Perspectives","volume":"34","author":"Kumar","year":"2022","journal-title":"J. Appl. Phycol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/md9071273","article-title":"Bromophenols in Marine Algae and Their Bioactivities","volume":"9","author":"Liu","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Dai, R., Sun, Y., Su, R., and Gao, H. (2022). Anti-Alzheimer\u2019s Disease Potential of Traditional Chinese Medicinal Herbs as Inhibitors of BACE1 and AChE Enzymes. Biomed. Pharmacother., 154.","DOI":"10.1016\/j.biopha.2022.113576"},{"key":"ref_132","unstructured":"Monteiro, P., Cotas, J., Pacheco, D., Figueirinha, A., da Silva, G.J., Pereira, L., and Gon\u00e7alves, A.M.M. (2022). Sustainable Global Resources of Seaweeds Volume 2, Springer International Publishing."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Unnikrishnan, P.S., Animish, A., Madhumitha, G., Suthindhiran, K., and Jayasri, M.A. (2022). Bioactivity Guided Study for the Isolation and Identification of Antidiabetic Compounds from Edible Seaweed\u2014Ulva Reticulata. Molecules, 27.","DOI":"10.3390\/molecules27248827"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Matos, G.S., Pereira, S.G., Genisheva, Z.A., Gomes, A.M., Teixeira, J.A., and Rocha, C.M.R. (2021). Advances in Extraction Methods to Recover Added-Value Compounds from Seaweeds: Sustainability and Functionality. Foods, 10.","DOI":"10.3390\/foods10030516"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Freitas, M.V., In\u00e1cio, L.G., Ruas, A., Silva, I.A., Mouga, T., Pereira, L., and Afonso, C. (2022). Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal. Appl. Sci., 13.","DOI":"10.3390\/app13010157"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fmars.2019.00107","article-title":"The Environmental Risks Associated with the Development of Seaweed Farming in Europe\u2014Prioritizing Key Knowledge Gaps","volume":"6","author":"Campbell","year":"2019","journal-title":"Front. Mar. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"792923","DOI":"10.3389\/fnut.2021.792923","article-title":"Increasing Seaweed Consumption in the Netherlands and Portugal and the Consequences for the Intake of Iodine, Sodium, and Exposure to Chemical Contaminants: A Risk-Benefit Study","volume":"8","author":"Vellinga","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1080\/10408398.2020.1844637","article-title":"Minerals in Edible Seaweed: Health Benefits and Food Safety Issues","volume":"62","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"103357","DOI":"10.1016\/j.algal.2023.103357","article-title":"Seaweed: Nutritional and Gastronomic Perspective. A Review","volume":"77","author":"Salido","year":"2024","journal-title":"Algal Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"111013","DOI":"10.1016\/j.fct.2019.111013","article-title":"Bioactive Compounds in Seaweeds: An Overview of Their Biological Properties and Safety","volume":"135","author":"Rengasamy","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Coelho, M., Duarte, A.P., Pinto, S., Botelho, H.M., Reis, C.P., Serralheiro, M.L., and Pacheco, R. (2023). Edible Seaweeds Extracts: Characterization and Functional Properties for Health Conditions. Antioxidants, 12.","DOI":"10.3390\/antiox12030684"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Poza, S., Leandro, A., Cotas, C., Cotas, J., Marques, J.C., Pereira, L., and Gon\u00e7alves, A.M.M. (2020). The Evolution Road of Seaweed Aquaculture: Cultivation Technologies and the Industry 4.0. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17186528"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/jpy.12326","article-title":"Prospects and Challenges for Industrial Production of Seaweed Bioactives","volume":"51","author":"Hafting","year":"2015","journal-title":"J. Phycol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Quit\u00e9rio, E., Grosso, C., Ferraz, R., Delerue-Matos, C., and Soares, C. (2022). A Critical Comparison of the Advanced Extraction Techniques Applied to Obtain Health-Promoting Compounds from Seaweeds. Mar. Drugs, 20.","DOI":"10.3390\/md20110677"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1080\/10408398.2021.1969534","article-title":"Seaweed Polysaccharides: Emerging Extraction Technologies, Chemical Modifications and Bioactive Properties","volume":"63","author":"Otero","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phytochem.2013.12.003","article-title":"Alpha-Amylase and Alpha-Glucosidase Inhibition Is Differentially Modulated by Fucoidan Obtained from Fucus Vesiculosus and Ascophyllum Nodosum","volume":"98","author":"Kim","year":"2014","journal-title":"Phytochemistry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.lwt.2015.06.050","article-title":"Aqueous Extracts and Suspensions of Restructured Pork Formulated with Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis Distinctly Affect the In Vitro \u03b1-Glucosidase Activity and Glucose Diffusion","volume":"64","author":"Bastida","year":"2015","journal-title":"LWT-Food Sci. 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