{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:22:05Z","timestamp":1772810525663,"version":"3.50.1"},"reference-count":78,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education (Poland)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Lipid extracts from the microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis have great potential to prevent ultraviolet A (UVA)-induced metabolic disorders. Therefore, the aim of this study has been to analyze their cytoprotective effect, focused on maintaining intracellular redox balance and inflammation in UVA-irradiated skin fibroblasts, at the proteome level. The above lipid extracts reversed the suppression of the antioxidant response caused by UVA radiation, which was more visible in the case of C. amblystomatis. Modulations of interactions between heme oxygenase-1 and matrix metalloproteinase 1\/Parkinson\u2019s disease protein 7\/transcript1-\u03b1\/\u03b2, as well as thioredoxin and migration inhibitory factor\/Parkinson\u2019s disease protein 7\/calnexin\/ATPase p97, created key molecular signaling underlying their cytoprotective actions. Moreover, they reduced pro-inflammatory processes in the control group but they also showed the potential to regulate the cellular inflammatory response by changing inflammasome signaling associated with the changes in the caspase-1 interaction area, including heat shock proteins HSP90, HSPA8, and vimentin. Therefore, lipid extracts from N. oceanica and C. amblystomatis protect skin fibroblast metabolism from UVA-induced damage by restoring the redox balance and regulating inflammatory signaling pathways. Thus, those extracts have proven to have great potential to be used in cosmetic or cosmeceutical products to protect the skin against the effects of solar radiation. However, the possibility of their use requires the evaluation of their effects at the skin level in in vivo and clinical studies.<\/jats:p>","DOI":"10.3390\/md22110509","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:34:11Z","timestamp":1731324851000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7509-4297","authenticated-orcid":false,"given":"Sinemyiz","family":"Atalay Ekiner","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-1346","authenticated-orcid":false,"given":"Agnieszka","family":"G\u0119gotek","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-7675","authenticated-orcid":false,"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":false,"given":"Maria Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-7139","authenticated-orcid":false,"given":"El\u017cbieta","family":"Skrzydlewska","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV Radiation and the Skin","volume":"14","author":"Jarrett","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kong, J., Hu, X.-M., Cai, W.-W., Wang, Y.-M., Chi, C.-F., and Wang, B. (2023). Bioactive Peptides from Skipjack Tuna Cardiac Arterial Bulbs (II): Protective Function on UVB-Irradiated HaCaT Cells through Antioxidant and Anti-Apoptotic Mechanisms. Mar. Drugs, 21.","DOI":"10.3390\/md21020105"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/JD9.0000000000000144","article-title":"Ultraviolet Induced Skin Inflammation","volume":"4","author":"Zhao","year":"2021","journal-title":"Int. J. Dermatol. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s42764-020-00009-8","article-title":"Mechanisms of UV-induced mutations and skin cancer","volume":"1","author":"Pfeifer","year":"2020","journal-title":"Genome Instab Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e71052","DOI":"10.7554\/eLife.71052","article-title":"Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage","volume":"10","author":"Rognoni","year":"2021","journal-title":"eLife"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-319-56017-5_2","article-title":"Ultraviolet Light Induced Generation of Reactive Oxygen Species","volume":"Volume 996","author":"Cockrell","year":"2017","journal-title":"Ultraviolet Light in Human Health, Diseases and Environment"},{"key":"ref_8","first-page":"3216415","article-title":"Natural Exogenous Antioxidant Defense against Changes in Human Skin Fibroblast Proteome Disturbed by UVA Radiation","volume":"2020","author":"Domingues","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"tkac005","DOI":"10.1093\/burnst\/tkac005","article-title":"Roles of the fibroblast growth factor signal transduction system in tissue injury repair","volume":"10","author":"Chen","year":"2022","journal-title":"Burn. Trauma"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Knoedler, S., Broichhausen, S., Guo, R., Dai, R., Knoedler, L., Kauke-Navarro, M., Diatta, F., Pomahac, B., Machens, H.-G., and Jiang, D. (2023). Fibroblasts\u2013the cellular choreographers of wound healing. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1233800"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"He, Y.-L., Liu, Y., Lin, L., Mo, Y., Li, H., Zhou, C., Hong, P., and Qian, Z.-J. (2024). Antioxidant peptide ETT from Isochrysis zhanjiangensis attenuate skin aging by maintaining homeostasis and promoting collagen generation. Algal Res., 82.","DOI":"10.1016\/j.algal.2024.103615"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cai, W.-W., Hu, X.-M., Wang, Y.-M., Chi, C.-F., and Wang, B. (2022). Bioactive Peptides from Skipjack Tuna Cardiac Arterial Bulbs: Preparation, Identification, Antioxidant Activity, and Stability against Thermal, pH, and Simulated Gastrointestinal Digestion Treatments. Mar. Drugs, 20.","DOI":"10.3390\/md20100626"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhang, S.-Y., Zhao, Y.-Q., Wang, Y.-M., Yang, X.-R., Chi, C.-F., and Wang, B. (2022). Gelatins and antioxidant peptides from Skipjack tuna (Katsuwonus pelamis) skins: Purification, characterization, and cytoprotection on ultraviolet-A injured human skin fibroblasts. Food Biosci., 50.","DOI":"10.1016\/j.fbio.2022.102138"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105101","DOI":"10.1016\/j.jff.2022.105101","article-title":"The protective effect of collagen peptides from bigeye tuna (Thunnus obesus) skin and bone to attenuate UVB-induced photoaging via MAPK and TGF-\u03b2 signaling pathways","volume":"93","author":"Fu","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Wang, Y.-M., Qiu, Y.-T., Chi, C.-F., Luo, H.-Y., and Wang, B. (2022). Gelatin From Cartilage of Siberian Sturgeon (Acipenser baerii): Preparation, Characterization, and Protective Function on Ultraviolet-A-Injured Human Skin Fibroblasts. Front. Mar. Sci., 9.","DOI":"10.3389\/fmars.2022.925407"},{"key":"ref_16","first-page":"1","article-title":"Lipidomic assessment of the impact of Nannochloropsis oceanica microalga lipid extract on human skin keratinocytes exposed to chronic UVB radiation","volume":"13","author":"Conde","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Conde, T., Neves, B., Couto, D., Melo, T., Lopes, D., Pais, R., Batista, J., Cardoso, H., Silva, J.L., and Domingues, P. (2023). Polar Lipids of Marine Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Mitigate the LPS-Induced Pro-Inflammatory Response in Macrophages. Mar. Drugs, 21.","DOI":"10.3390\/md21120629"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Correia, N., Pereira, H., Schulze, P.S.C., Costa, M.M., Santo, G.E., Guerra, I., Trov\u00e3o, M., Barros, A., Cardoso, H., and Silva, J.L. (2023). Heterotrophic and Photoautotrophic Media Optimization Using Response Surface Methodology for the Novel Microalga Chlorococcum amblystomatis. Appl. Sci., 13.","DOI":"10.3390\/app13042089"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.7717\/peerj.1879","article-title":"Chlorophyll enhances oxidative stress tolerance inCaenorhabditis elegansand extends its lifespan","volume":"4","author":"Wang","year":"2016","journal-title":"PeerJ"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Stasiewicz, A., Conde, T., G\u0119gotek, A., Domingues, M.R., Domingues, P., and Skrzydlewska, E. (2023). Prevention of UVB Induced Metabolic Changes in Epidermal Cells by Lipid Extract from Microalgae Nannochloropsis oceanica. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411302"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"45517","DOI":"10.18632\/oncotarget.17268","article-title":"Inhibitory effect of ethanol extract of Nannochloropsis oceanica on lipopolysaccharide-induced neuroinflammation, oxidative stress, amyloidogenesis and memory impairment","volume":"8","author":"Choi","year":"2017","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-83455-y","article-title":"Polar lipidomic profile shows Chlorococcum amblystomatis as a promising source of value-added lipids","volume":"11","author":"Conde","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Stasiewicz, A., Conde, T., Domingues, M.D.R., Domingues, P., Biernacki, M., and Skrzydlewska, E. (2024). Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts. Antioxidants, 13.","DOI":"10.3390\/antiox13030276"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.nrl.2021.10.003","article-title":"Relationship between inflammation and oxidative stress and its effect on multiple sclerosis","volume":"39","author":"Ortiz","year":"2024","journal-title":"Neurologia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid Med. Cell. Longev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome activation and regulation: Toward a better understanding of complex mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Discov."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"216354","DOI":"10.1016\/j.canlet.2023.216354","article-title":"The tumour-promoting role of protein homeostasis: Implications for cancer immunotherapy","volume":"573","author":"Liang","year":"2023","journal-title":"Cancer Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress","volume":"6","author":"Miguel","year":"2015","journal-title":"Redox Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.2174\/0929867325666180510124558","article-title":"Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target","volume":"26","author":"Infantino","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yi, Y.-S. (2023). Inflammation, Inflammatory Diseases, and Inflammasomes. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119224"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_32","first-page":"57","article-title":"Impact of climate change on non-communicable diseases caused by altered UV radiation","volume":"8","author":"Baldermann","year":"2023","journal-title":"J. Health Monit."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ekiner, S.A., G\u0119gotek, A., and Skrzydlewska, E. (2024). Inflammasome activity regulation by PUFA metabolites. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1452749"},{"key":"ref_34","first-page":"60","article-title":"Protein lipidation in health and disease: Molecular basis, physiological function and pathological implication. Signal Transduct","volume":"9","author":"Yuan","year":"2024","journal-title":"Target. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling\u2013from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2018","journal-title":"FEBS J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1002\/mco2.261","article-title":"Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications","volume":"4","author":"Zhong","year":"2023","journal-title":"Medcomm"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: Cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Consoli, V., Sorrenti, V., Grosso, S., and Vanella, L. (2021). Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions. Biomolecules, 11.","DOI":"10.3390\/biom11040589"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lan, Y.-W., Chen, W.-R., Chang, G.R.-L., Chen, Y.-C., Chong, K.-Y., Chuang, K.-C., Kao, Y.-T., Chen, M.-S., and Chen, C.-M. (2024). Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation. Cell Biosci., 14.","DOI":"10.1186\/s13578-024-01200-0"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhang, B., Xie, S., Su, Z., Song, S., Xu, H., Chen, G., Cao, W., Yin, S., Gao, Q., and Wang, H. (2016). Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling. Sci. Rep., 6.","DOI":"10.1038\/srep21132"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Toro, A., Ruiz, M.S., Lage-Vickers, S., Sanchis, P., Sabater, A., Pascual, G., Seniuk, R., Cascardo, F., Ledesma-Bazan, S., and Vilicich, F. (2022). A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?. Antioxidants, 11.","DOI":"10.3390\/antiox11020276"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Velasquez, M., O\u2019sullivan, C., Brockett, R., Mikels-Vigdal, A., Mikaelian, I., Smith, V., and Greenstein, A.E. (2023). Characterization of Active MMP9 in Chronic Inflammatory Diseases Using a Novel Anti-MMP9 Antibody. Antibodies, 12.","DOI":"10.3390\/antib12010009"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lippai, R., Veres-Sz\u00e9kely, A., Sziksz, E., Iwakura, Y., Pap, D., Rokonay, R., Szebeni, B., Lotz, G., B\u00e9res, N.J., and Cseh, \u00c1. (2021). Immunomodulatory role of Parkinson\u2019s disease 7 in inflammatory bowel disease. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-93671-1"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/icb.2014.51","article-title":"STAT1 plays a role in TLR signal transduction and inflammatory responses","volume":"92","author":"Luu","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Xue, N., Liu, Y., Jin, J., Ji, M., and Chen, X. (2022). Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136941"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Vuji\u0107, T., Schvartz, D., Furlani, I.L., Meister, I., Gonz\u00e1lez-Ruiz, V., Rudaz, S., and Sanchez, J.-C. (2022). Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. Cells, 11.","DOI":"10.3390\/cells11233926"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1515\/chem-2019-0041","article-title":"Dynamic Changes in MMP1 and TIMP1 in the Antifibrotic Process of Dahuang Zhechong Pill in Rats with Liver Fibrosis","volume":"17","author":"Lin","year":"2019","journal-title":"Open Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0891-5849(00)00463-9","article-title":"Adaptive antioxidant response protects dermal fibroblasts from UVA-induced phototoxicity","volume":"30","author":"Meewes","year":"2001","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0006-291X(03)01430-X","article-title":"UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes","volume":"308","author":"Steinbrenner","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rousset, F., Nguyen, M.V.C., Grange, L., Morel, F., and Lardy, B. (2013). Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066478"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12935-024-03248-x","article-title":"Peroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression","volume":"24","author":"Chua","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_53","unstructured":"(2020). The Role of Matrix Metalloproteinases in Wound Healing. Int. J. Pharm. Res., 12, 4391."},{"key":"ref_54","first-page":"4787202","article-title":"PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease","volume":"2020","author":"Pap","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.redox.2014.01.017","article-title":"Molecular chaperones and proteostasis regulation during redox imbalance","volume":"2","author":"Niforou","year":"2014","journal-title":"Redox Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1523\/JNEUROSCI.0682-22.2022","article-title":"STAT1 Contributes to Microglial\/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury","volume":"42","author":"Zhao","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Hoang, K.N.L., Anstee, J.E., and Arnold, J.N. (2021). The Diverse Roles of Heme Oxygenase-1 in Tumor Progression. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.658315"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1158\/1078-0432.CCR-11-3225","article-title":"Molecular Pathways: Interferon\/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth","volume":"18","author":"Khodarev","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.18632\/aging.202505","article-title":"Macrophage migration inhibitory factor activates the inflammatory response in joint capsule fibroblasts following post-traumatic joint contracture","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging"},{"key":"ref_60","first-page":"e98410","article-title":"Calnexin is necessary for T cell transmigration into the central nervous system","volume":"3","author":"Jung","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"19558","DOI":"10.1074\/jbc.M114.630061","article-title":"The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-\u03baB Signaling via Partial Degradation of the NF-\u03baB Subunit p100","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.molcel.2023.03.030","article-title":"Chaperone-directed ribosome repair after oxidative damage","volume":"83","author":"Yang","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/imm.13267","article-title":"Inhibition of the NLRP3 inflammasome by HSP90 inhibitors","volume":"162","author":"Nizami","year":"2021","journal-title":"Immunology"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Bonam, S.R., Ruff, M., and Muller, S. (2019). HSPA8\/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates. Cells, 8.","DOI":"10.3390\/cells8080849"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1038\/ncomms7574","article-title":"Vimentin regulates activation of the NLRP3 inflammasome","volume":"6","author":"Rogel","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-50206-z","article-title":"Heterotrophy as a tool to overcome the long and costly autotrophic scale-up process for large scale production of microalgae","volume":"9","author":"Barros","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102718","DOI":"10.1016\/j.algal.2022.102718","article-title":"Effects of outdoor and indoor cultivation on the polar lipid composition and antioxidant activity of Nannochloropsis oceanica and Nannochloropsis limnetica: A lipidomics perspective","volume":"64","author":"Couto","year":"2022","journal-title":"Algal Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1039\/D2FO00275B","article-title":"Seventeen novel angiotensin converting enzyme (ACE) inhibitory peptides from the protein hydrolysate ofMytilus edulis: Isolation, identification, molecular docking study, and protective function on HUVECs","volume":"13","author":"Suo","year":"2022","journal-title":"Food Funct."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0076-6879(05)05003-2","article-title":"In-solution digestion of proteins for mass spectrometry","volume":"405","author":"Medzihradszky","year":"2005","journal-title":"Methods Enzymol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jpba.2018.03.068","article-title":"Proteomic plasma profile of psoriatic patients","volume":"155","author":"Domingues","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chong, J., Wishart, D.S., and Xia, J. (2019). Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis. Curr. Protoc. Bioinform., 68.","DOI":"10.1002\/cpbi.86"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: Protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1021\/acs.jproteome.2c00651","article-title":"Cytoscape stringApp 2.0: Analysis and Visualization of Heterogeneous Biological Networks","volume":"22","author":"Doncheva","year":"2022","journal-title":"J. Proteome Res."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/11\/509\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:29:47Z","timestamp":1760113787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/11\/509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":78,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["md22110509"],"URL":"https:\/\/doi.org\/10.3390\/md22110509","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]}}}