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natural compounds for skincare applications. A growing number of products now incorporate extracts or isolated compounds from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity for further research. Among these, Caulerpa prolifera (Forssk\u00e5l) J.V. Lamouroux has emerged as a promising candidate for cosmeceutical applications. This study provides the most comprehensive phytochemical assessment of C. prolifera to date, revealing its potential as a source of bioactive extracts and compounds. The analysis identified key components of its lipophilic profile, predominantly saturated and unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate\u2014an endocrine disruptor potentially biosynthesized or bioaccumulated by the algae. While the crude extract exhibited moderate tyrosinase inhibitory activity, its overall antioxidant capacity was limited. Fractionation of the extract, however, yielded subfractions with distinct bioactivities linked to changes in chemical composition. Notably, enhanced inhibitory activities against elastase and collagenase were observed in subfractions enriched with 1-octadecanol and only traces of phthalate. Conversely, antioxidant activity diminished with the loss of specific compounds such as \u03b2-sitosterol, erucic acid, nervonic acid, and lignoceric acid. This work advances the understanding of the relationship between the chemical composition of C. prolifera and its bioactivities, emphasizing its potential as a source of cosmeceutical ingredients, leading to a more comprehensive valorization of this macroalga.<\/jats:p>","DOI":"10.3390\/md23020083","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:20:52Z","timestamp":1739503252000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antiaging Potential of Lipophilic Extracts of Caulerpa prolifera"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-8505","authenticated-orcid":false,"given":"Gon\u00e7alo P.","family":"Rosa","sequence":"first","affiliation":[{"name":"University of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, Portugal"},{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-8913","authenticated-orcid":false,"given":"Maria Carmo","family":"Barreto","sequence":"additional","affiliation":[{"name":"University of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-2375","authenticated-orcid":false,"given":"Ana M. L.","family":"Seca","sequence":"additional","affiliation":[{"name":"University of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, Portugal"},{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Xu, H., Zheng, Y.-W., Liu, Q., Liu, L.-P., Luo, F.-L., Zhou, H.-C., Isoda, H., Ohkohchi, N., and Li, Y.-M. (2018). Reactive oxygen species in skin repair, regeneration, aging, and inflammation. Reactive Oxygen Species (ROS) in Living Cells, InTech.","DOI":"10.5772\/intechopen.72747"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e18239","DOI":"10.1016\/j.heliyon.2023.e18239","article-title":"Intrinsic and environmental basis of aging: A narrative review","volume":"9","author":"Navarro","year":"2023","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., and Park, K.-C. (2019). Molecular mechanisms of dermal aging and antiaging approaches. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092126"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Maldonado, E., Morales-Pison, S., Urbina, F., and Solari, A. (2023). Aging hallmarks and the role of oxidative stress. Antioxidants, 12.","DOI":"10.3390\/antiox12030651"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Papaccio, F., D\u2019arino, A., Caputo, S., and Bellei, B. (2022). Focus on the contribution of oxidative stress in skin aging. Antioxidants, 11.","DOI":"10.3390\/antiox11061121"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kathuria, D., Sharma, A., Verma, M., and Nayik, G.A. (2024). Bioprospecting of Natural Sources for Cosmeceuticals, Royal Society of Chemistry.","DOI":"10.1039\/9781837672288"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"He, X., Gao, X., Guo, Y., and Xie, W. (2024). Research progress on bioactive factors against skin aging. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073797"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bioana.2024.05.001","article-title":"Copper ions amplify the oxidative stress caused by calcium overload leading to apoptosis","volume":"1","author":"Liu","year":"2024","journal-title":"Biomed. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"594386","DOI":"10.1155\/2024\/5594386","article-title":"A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds","volume":"2024","author":"Tumilaar","year":"2024","journal-title":"J. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/derm.21923","article-title":"Hyaluronic acid: A key molecule in skin aging","volume":"4","author":"Papakonstantinou","year":"2012","journal-title":"Dermato-Endocrinology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zolghadri, S., Beygi, M., Mohammad, T.F., Alijanianzadeh, M., Pillaiyar, T., Garcia-Molina, P., Garcia-Canovas, F., Munoz-Munoz, J., and Saboury, A.A. (2023). Targeting tyrosinase in hyperpigmentation: Current status, limitations and future promises. Biochem. Pharmacol., 212.","DOI":"10.1016\/j.bcp.2023.115574"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Goyal, A., Sharma, A., Kaur, J., Kumari, S., Garg, M., Sindhu, R.K., Rahman, M.H., Akhtar, M.F., Tagde, P., and Najda, A. (2022). Bioactive-based cosmeceuticals: An update on emerging trends. Molecules, 27.","DOI":"10.3390\/molecules27030828"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chakdar, H., and Pabbi, S. (2017). Algal pigments for human health and cosmeceuticals. Algal Green Chemistry, Elsevier.","DOI":"10.1016\/B978-0-444-63784-0.00009-6"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Thiyagarasaiyar, K., Goh, B.-H., Jeon, Y.-J., and Yow, Y.-Y. (2020). Algae metabolites in cosmeceutical: An overview of current applications and challenges. Mar. Drugs, 18.","DOI":"10.3390\/md18060323"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11101-011-9214-4","article-title":"Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: A review","volume":"10","author":"Wijesinghe","year":"2011","journal-title":"Phytochem. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ruocco, N., Costantini, S., Guariniello, S., and Costantini, M. (2016). Polysaccharides from the marine environment with pharmacological, cosmeceutical and nutraceutical potential. Molecules, 21.","DOI":"10.3390\/molecules21050551"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jphotobiol.2016.06.027","article-title":"Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review","volume":"162","author":"Sanjeewa","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_18","unstructured":"Guiry, M.D., Guiry, G.M., and AlgaeBase (2024, March 21). World-wide electronic publication, National University of Ireland, Galway. 22 December 2020. Available online: https:\/\/www.algaebase.org."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1515\/bot-2018-0075","article-title":"First record of Caulerpa prolifera in the Azores (NE Atlantic)","volume":"62","author":"Cacabelos","year":"2019","journal-title":"Bot. Mar."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1021\/np0202529","article-title":"Acetylene sesquiterpenoid esters from the green alga Caulerpa prolifera","volume":"66","author":"Smyrniotopoulos","year":"2003","journal-title":"J. Nat. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jat.1127","article-title":"Prevention of Aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts","volume":"26","author":"Ahmed","year":"2006","journal-title":"J. Appl. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biopha.2009.03.005","article-title":"Biological activities of sulfated polysaccharides from tropical seaweeds","volume":"64","author":"Costa","year":"2010","journal-title":"Biomed. Pharmacother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1007\/s10811-020-02249-3","article-title":"Sulfated polysaccharides from green seaweed Caulerpa prolifera suppress fat accumulation","volume":"32","author":"Rocha","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10126-010-9303-1","article-title":"The sesquiterpene caulerpenyne from Caulerpa spp. is a lipoxygenase inhibitor","volume":"13","author":"Cengiz","year":"2011","journal-title":"Mar. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbpc.2006.08.001","article-title":"Enzymatic antioxidant response of a labrid fish Coris julis liver to environmental caulerpenyne","volume":"144","author":"Sureda","year":"2006","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.3390\/md11051553","article-title":"Spasmolytic Effect of caulerpine involves blockade of Ca2+ influx on guinea pig ileum","volume":"11","author":"Sousa","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1590\/S0102-695X2012005000072","article-title":"Caulerpin as a potential antiviral drug against Herpes simplex Virus Type 1","volume":"22","author":"Macedo","year":"2012","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/md7040689","article-title":"The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa","volume":"7","year":"2009","journal-title":"Mar. Drugs"},{"key":"ref_29","first-page":"1934578X0600100914","article-title":"Acetylenic aquatic anticancer agents and related compounds","volume":"1","author":"Dembitsky","year":"2006","journal-title":"Nat. Prod. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/BF01989878","article-title":"Furocaulerpin, a new acetylenic sesquiterpenoid from the green alga Caulerpa prolifera","volume":"37","author":"Fattorusso","year":"1981","journal-title":"Experientia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104392","DOI":"10.1016\/j.tifs.2024.104392","article-title":"Recent Advances in Squalene: Biological Activities, Sources, Extraction, and Delivery Systems","volume":"146","author":"Cheng","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_32","first-page":"367","article-title":"Seasonality of caulerpenyne content in native Caulerpa prolifera and invasive C. taxifolia and C. racemosa var","volume":"53","author":"Box","year":"2010","journal-title":"cylindracea in the Western Mediterranean sea. Bot. Mar."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.marenvres.2012.05.001","article-title":"Physiological response and photoacclimation capacity of Caulerpa prolifera (Forssk\u00e5l) J.V. Lamouroux and Cymodocea nodosa (Ucria) Ascherson meadows in the Mar Menor Lagoon (SE Spain)","volume":"79","author":"Korbee","year":"2012","journal-title":"Mar. Environ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yap, W.-F., Tay, V., Tan, S.-H., Yow, Y.-Y., and Chew, J. (2019). Decoding antioxidant and antibacterial potentials of malaysian green seaweeds: Caulerpa racemosa and Caulerpa lentillifera. Antibiotics, 8.","DOI":"10.3390\/antibiotics8030152"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1615\/InterJAlgae.v26.i1.20","article-title":"Effect of extraction method on the phytochemical composition, antioxidant and antimicrobial activities of Caulerpa prolifera (Forssk.) J.V. Lamour. (Chlorophyta) extract","volume":"26","author":"Chaabani","year":"2023","journal-title":"Int. J. Algae"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kurniawan, R., Nurkolis, F., Taslim, N.A., Subali, D., Surya, R., Gunawan, W.B., Alisaputra, D., Mayulu, N., Salindeho, N., and Kim, B. (2023). Carotenoids composition of green algae Caulerpa racemosa and their antidiabetic, anti-obesity, antioxidant, and anti-inflammatory properties. Molecules, 28.","DOI":"10.3390\/molecules28073267"},{"key":"ref_37","first-page":"100621","article-title":"Green seaweed Caulerpa racemosa\u2014Chemical constituents, cytotoxicity in breast cancer cells and molecular docking simulation","volume":"12","author":"Sanger","year":"2023","journal-title":"J. Agric. Food Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rosa, G.P., Peixoto, A.F., Barreto, M.C., Seca, A.M.L., and Pinto, D.C.G.A. (2022). Bio-Guided Optimization of Cystoseira Abies-Marina Cosmeceuticals Extraction by Advanced Technologies. Mar. Drugs, 21.","DOI":"10.3390\/md21010035"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Choosuwan, P., Praiboon, J., Boonpisuttinant, K., Klomjit, A., Muangmai, N., Ruangchuay, R., and Chirapart, A. (2023). Inhibitory effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on tyrosinase activity and \u03b1-MSH-induced melanogenesis in B16F10 melanoma cells. Life, 13.","DOI":"10.3390\/life13040934"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Castej\u00f3n, N., Thorarinsdottir, K.A., Einarsd\u00f3ttir, R., Kristbergsson, K., and Marteinsd\u00f3ttir, G. (2021). Exploring the potential of icelandic seaweeds extracts produced by aqueous pulsed electric fields-assisted extraction for cosmetic applications. Mar. Drugs, 19.","DOI":"10.3390\/md19120662"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kelm, G.R., and Wickett, R.R. (2017). The role of fatty acids in cosmetic technology. Fatty Acids, Elsevier.","DOI":"10.1016\/B978-0-12-809521-8.00012-X"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Baker, P., Huang, C., Radi, R., Moll, S.B., Jules, E., and Arbiser, J.L. (2023). Skin barrier function: The interplay of physical, chemical, and immunologic properties. Cells, 12.","DOI":"10.3390\/cells12232745"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15427","DOI":"10.1074\/jbc.M313701200","article-title":"Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: A new aspect of ubiquitin-proteasome function","volume":"279","author":"Ando","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12010-022-04143-9","article-title":"Chemical Composition and Tyrosinase Inhibitory Activities of Fatty Acids Obtained from Heterotrophic Microalgae, S","volume":"195","author":"Kose","year":"2023","journal-title":"limacinum and C. cohnii. Appl. Biochem. Biotechnol."},{"key":"ref_45","first-page":"7683","article-title":"Potential assessment of some micro- and macroalgal species for bioethanol and biodiesel production","volume":"46","author":"Ismail","year":"2024","journal-title":"Energy Sources Part A Recovery Util. Environ. Eff."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kamal, M., Abdel-Raouf, N., Alwutayd, K., AbdElgawad, H., Abdelhameed, M.S., Hammouda, O., and Elsayed, K.N.M. (2023). Seasonal changes in the biochemical composition of dominant macroalgal species along the egyptian red sea shore. Biology, 12.","DOI":"10.3390\/biology12030411"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Harwood, J.L. (2023). Polyunsaturated fatty acids: Conversion to lipid mediators, roles in inflammatory diseases and dietary sources. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108838"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Simonetto, M., Infante, M., Sacco, R.L., Rundek, T., and Della-Morte, D. (2019). A novel anti-inflammatory role of omega-3 pufas in prevention and treatment of atherosclerosis and vascular cognitive impairment and dementia. Nutrients, 11.","DOI":"10.3390\/nu11102279"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Czumaj, A., and \u015aledzi\u0144ski, T. (2020). Biological role of unsaturated fatty acid desaturases in health and disease. Nutrients, 12.","DOI":"10.3390\/nu12020356"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4161\/derm.3.1.13900","article-title":"An update on the role of the sebaceous gland in the pathogenesis of acne","volume":"3","author":"Makrantonaki","year":"2011","journal-title":"Dermato-Endocrinology"},{"key":"ref_51","first-page":"863","article-title":"Fatty acid composition and chilling resistance in the green alga Caulerpa prolifera (Forrskal) Lamouroux (Chlorophyta, Caulerpales)","volume":"39","author":"Terrados","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Djuricic, I., and Calder, P.C. (2021). Beneficial outcomes of Omega-6 and Omega-3 polyunsaturated fatty acids on human health: An update for 2021. Nutrients, 13.","DOI":"10.3390\/nu13072421"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lin, T.-K., Zhong, L., and Santiago, J. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010070"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs, D., Camera, E., P\u00f3liska, S., Cavallo, A., Maiellaro, M., Dull, K., Gruber, F., Zouboulis, C.C., Szegedi, A., and T\u00f6r\u0151csik, D. (2023). Linoleic acid induced changes in SZ95 sebocytes\u2014Comparison with palmitic acid and arachidonic acid. Nutrients, 15.","DOI":"10.3390\/nu15153315"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Latreille, J., Kesse-Guyot, E., Malvy, D., Andreeva, V., Galan, P., Tschachler, E., Hercberg, S., Guinot, C., and Ezzedine, K. (2012). Dietary monounsaturated fatty acids intake and risk of skin photoaging. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044490"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/156720109788680877","article-title":"Status of fatty acids as skin penetration enhancers\u2014A review","volume":"6","author":"Mittal","year":"2009","journal-title":"Curr. Drug Deliv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10753-020-01179-z","article-title":"Neophytadiene from Turbinaria Ornata suppresses LPS-induced inflammatory response in RAW 264.7 macrophages and Sprague Dawley rats","volume":"43","author":"Bhardwaj","year":"2020","journal-title":"Inflammation"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"DiNatale, L., Idkowiak-Baldys, J., Zhuang, Y., Gonzalez, A., Stephens, T.J., Jiang, L.I., Li, W., Basson, R., and Bayat, A. (2021). Novel rotational combination regimen of skin topicals improves facial photoaging: Efficacy demonstrated in double-blinded clinical trials and laboratory validation. Front. Med., 8.","DOI":"10.3389\/fmed.2021.724344"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/fcp.12049","article-title":"Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress","volume":"28","author":"Silva","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.fct.2009.11.012","article-title":"Fragrance material review on phytol","volume":"48","author":"McGinty","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rosa, G.P., Seca, A.M.L., Pinto, D.C.G.A., and Barreto, M.C. (2024). New phytol derivatives with increased cosmeceutical potential. Molecules, 29.","DOI":"10.3390\/molecules29204917"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhang, P., Liu, N., Xue, M., Zhang, M., Liu, W., Xu, C., Fan, Y., Meng, Y., Zhang, Q., and Zhou, Y. (2023). Anti-inflammatory and antioxidant properties of \u03b2-sitosterol in copper sulfate-induced inflammation in zebrafish Danio rerio. Antioxidants, 12.","DOI":"10.3390\/antiox12020391"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Khan, Z., Nath, N., Rauf, A., Emran, T.B., Mitra, S., Islam, F., Chandran, D., Barua, J., Khandaker, M.U., and Idris, A.M. (2022). Multifunctional roles and pharmacological potential of \u03b2-sitosterol: Emerging evidence toward clinical applications. Chem. Biol. Interact., 365.","DOI":"10.1016\/j.cbi.2022.110117"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1080\/00032719.2013.879658","article-title":"Mass spectral fragmentation pathways of phthalate esters by gas chromatography\u2013Tandem mass spectrometry","volume":"47","author":"Yin","year":"2014","journal-title":"Anal. Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106903","DOI":"10.1016\/j.envint.2021.106903","article-title":"Human health impacts of exposure to phthalate plasticizers: An overview of reviews","volume":"158","author":"Eales","year":"2022","journal-title":"Environ. Int."},{"key":"ref_67","first-page":"97","article-title":"Phthalates\u2014Widespread occurrence and the effect on male gametes. Part 1. general characteristics, sources and human exposure","volume":"67","year":"2016","journal-title":"Rocz. Pa\u0144stwowego Zak\u0142adu Hig."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Huang, L., Zhu, X., Zhou, S., Cheng, Z., Shi, K., Zhang, C., and Shao, H. (2021). Phthalic acid esters: Natural sources and biological activities. Toxins, 13.","DOI":"10.3390\/toxins13070495"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/acs.est.2c09426","article-title":"Air-sea exchange and atmospheric deposition of phthalate esters in the South China Sea","volume":"57","author":"Mi","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/17451000.2023.2173783","article-title":"Concentrations of phthalate esters on indian ocean silky sharks and their long-term dietary consumption risks","volume":"18","author":"Wang","year":"2022","journal-title":"Mar. Biol. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.marpolbul.2019.01.015","article-title":"Concentrations and distribution of phthalate esters in the seamount area of the tropical Western Pacific Ocean","volume":"140","author":"Zhang","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Pace, A., Vaglica, A., Maccotta, A., and Savoca, D. (2024). The origin of phthalates in algae: Biosynthesis and environmental bioaccumulation. Environments, 11.","DOI":"10.3390\/environments11040078"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/B:JAPH.0000047778.93467.af","article-title":"Biosorption of di(2-ethylhexyl)phthalate by seaweed biomass","volume":"16","author":"Chan","year":"2004","journal-title":"J. Appl. Phycol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"90887","DOI":"10.1007\/s11356-022-22142-5","article-title":"Uptake and photoinduced degradation of phthalic acid esters (PAEs) in Ulva lactuca highlight its potential application in environmental bioremediation","volume":"29","author":"Savoca","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Rowdhwal, S.S.S., and Chen, J. (2018). Toxic effects of di-2-ethylhexyl phthalate: An overview. BioMed Res. Int., 2018.","DOI":"10.1155\/2018\/1750368"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: When 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00244-018-0535-9","article-title":"Di-(2-ethylhexyl) phthalate exposure modulates antioxidant enzyme activity and gene expression in juvenile and adult Daphnia magna","volume":"75","author":"Wang","year":"2018","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"28800","DOI":"10.3390\/ijms161226131","article-title":"Possible mechanisms of di(2-ethylhexyl) phthalate-induced MMP-2 and MMP-9 expression in A7r5 rat vascular smooth muscle cells","volume":"16","author":"Shih","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s12640-022-00575-7","article-title":"Oleamide reduces mitochondrial dysfunction and toxicity in rat cortical slices through the combined action of cannabinoid receptors activation and induction of antioxidant activity","volume":"40","author":"Tinkov","year":"2022","journal-title":"Neurotox. Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chen, S., Wang, X., Wang, X., Zheng, W., He, S., Song, M., and Wang, H. (2022). The influence of syringic acid and erucic acid on the antioxidant properties of natural rubber: Experimental and molecular simulation investigations. Polymers, 14.","DOI":"10.3390\/polym14204254"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/1566524023666230509123536","article-title":"Erucic acid: A possible therapeutic agent for neurodegenerative diseases","volume":"24","author":"Goyal","year":"2024","journal-title":"Curr. Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5650\/jos.ess20262","article-title":"Protective effect of nervonic acid against 6-hydroxydopamine-induced oxidative stress in PC-12 Cells","volume":"70","author":"Umemoto","year":"2021","journal-title":"J. Oleo Sci."},{"key":"ref_83","unstructured":"Environmental Protection Agency (2020). Supporting Information for Low-Priority Substance 1-Octadecanol (CASRN 112-92-5) Final Designation, Environmental Protection Agency."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Prieto-Blanco, M.C., Fern\u00e1ndez-Amado, M., L\u00f3pez-Mah\u00eda, P., Muniategui-Lorenzo, S., and Prada-Rodr\u00edguez, D. (2018). Surfactants in cosmetics. Analysis of Cosmetic Products, Elsevier.","DOI":"10.1016\/B978-0-444-63508-2.00011-4"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10915818509078685","article-title":"Final report on the safety assessment of stearyl alcohol, oleyl alcohol, and octyl dodecanol","volume":"4","author":"Alcohol","year":"1985","journal-title":"J. Am. Coll. Toxicol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s10811-018-1447-9","article-title":"Comparative study by GC-MS and chemometrics on the chemical and nutritional profile of Fucus spiralis L. juvenile and mature life-cycle phases","volume":"30","author":"Seca","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved abts radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1021\/jf00093a019","article-title":"Role of ferritin as a lipid oxidation catalyst in muscle food","volume":"38","author":"Decker","year":"1990","journal-title":"J. Agric. Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1248\/bpb.26.352","article-title":"Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by .beta.-glucosidase in the presence of amino acids","volume":"26","author":"Ling","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-2006-957470","article-title":"The inhibitory components from Artocarpus incisus on melanin biosynthesis","volume":"64","author":"Shimizu","year":"1998","journal-title":"Planta Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/13880200903586286","article-title":"In Vitro anti-aging activities of Terminalia chebula gall extract","volume":"48","author":"Manosroi","year":"2010","journal-title":"Pharm. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Ndlovu, G., Fouche, G., Tselanyane, M., Cordier, W., and Steenkamp, V. (2013). In vitro determination of the anti-aging potential of four southern african medicinal plants. BMC Complement. Med. Ther., 13.","DOI":"10.1186\/1472-6882-13-304"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1172\/JCI102861","article-title":"Isolation and characterization of proteinase and collagenase from Cl. histolyticum 12","volume":"32","author":"Mandl","year":"1953","journal-title":"J. Clin. Investig."},{"key":"ref_95","unstructured":"R Core Team (2023). R: A Language and Environment for Statistical Computing, R foundation for statistical."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/2\/83\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:02Z","timestamp":1760027642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/2\/83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":95,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["md23020083"],"URL":"https:\/\/doi.org\/10.3390\/md23020083","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]}}}