{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:54:12Z","timestamp":1760057652275,"version":"build-2065373602"},"reference-count":93,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the scope of project \u201cBLUE BIOECONOMY PACT\u201d","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]},{"name":"Next Generation EU European Fund","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]},{"name":"University of Aveiro, the Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT), and the Minist\u00e9rio da Ci\u00eancia Tecnologia e Ensino Superior (MCTES)","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]},{"name":"FCT through the Scientific Employment Stimulus Programme","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]},{"name":"FCT","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]},{"name":"ERA Chair BESIDE project financed by the European Union\u2019s Horizon 2020 research and innovation programme","award":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"],"award-info":[{"award-number":["C644915664-00000026","UIDB\/50017\/2020","UIDP\/50017\/2020","LA\/P\/0094\/2020","SFRH\/BD\/05303\/2021","951389"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Over the last decades, bioprospecting of tropical corals has revealed numerous bioactive compounds with potential for biotechnological applications. However, this search involves sampling in natural reefs, and this is currently hampered by multiple ethical and technological constraints. Living coral displays, research laboratories, and biobanks currently offer an opportunity to continue to unravel coral chemodiversity, acting as \u201cNoah\u2019s Arks\u201d that may continue to support the bioprospecting of molecules of interest. This issue is even more relevant if one considers that tropical coral reefs currently face unprecedent threats and irreversible losses that may impair the biodiscovery of molecules with potential for new products, processes, and services. Living coral displays provide controlled environments for studying corals and producing both known and new metabolites under varied conditions, and they are not prone to common bottlenecks associated with bioprospecting in natural coral reefs, such as loss of the source and replicability. Research laboratories may focus on a particular coral species or bioactive compound using corals that were cultured ex situ, although they may differ from wild conspecifics in metabolite production both in quantitative and qualitative terms. Biobanks collect and preserve coral specimens, tissues, cells, and\/or information (e.g., genes, associated microorganisms), which offers a plethora of data to support the study of bioactive compounds\u2019 mode of action without having to cope with issues related to access, standardization, and regulatory compliance. Bioprospecting in these settings faces several challenges and opportunities. On one hand, it is difficult to ensure the complexity of highly biodiverse ecosystems that shape the production and chemodiversity of corals. On the other hand, it is possible to maximize biomass production and fine tune the synthesis of metabolites of interest under highly controlled environments. Collaborative efforts are needed to overcome barriers and foster opportunities to fully harness the chemodiversity of tropical corals before in-depth knowledge of this pool of metabolites is irreversibly lost due to tropical coral reefs\u2019 degradation.<\/jats:p>","DOI":"10.3390\/md23020089","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:34:26Z","timestamp":1739943266000},"page":"89","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Living Coral Displays, Research Laboratories, and Biobanks as Important Reservoirs of Chemodiversity with Potential for Biodiscovery"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-9335","authenticated-orcid":false,"given":"Ricardo","family":"Calado","sequence":"first","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Miguel C.","family":"Leal","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-7700","authenticated-orcid":false,"given":"Ruben X. G.","family":"Silva","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-5105","authenticated-orcid":false,"given":"Mara","family":"Borba","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-5137","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Ferro","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Mariana","family":"Almeida","sequence":"additional","affiliation":[{"name":"CESAM, Departamento de Ambiente e Ordenamento, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-9283","authenticated-orcid":false,"given":"Diana","family":"Madeira","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM, Departamento de Biologia, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-289X","authenticated-orcid":false,"given":"Helena","family":"Vieira","sequence":"additional","affiliation":[{"name":"CESAM, Departamento de Ambiente e Ordenamento, Universidade de Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105382","DOI":"10.1016\/j.marpol.2022.105382","article-title":"Expert Opinions on Threats and Impacts in the Marine Environment","volume":"147","author":"Kvamsdal","year":"2023","journal-title":"Mar. 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