{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:08:52Z","timestamp":1773342532860,"version":"3.50.1"},"reference-count":75,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER\u2014Fundo Europeu de Desenvolvimento Regional funds","award":["POCI-01-0145-FEDER-030240"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030240"]}]},{"name":"FEDER\u2014Fundo Europeu de Desenvolvimento Regional funds","award":["PTDC\/OCE-ETA\/30240\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/30240\/2017"]}]},{"DOI":"10.13039\/501100001871","name":"Portuguese funds","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-030240"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030240"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese funds","doi-asserted-by":"publisher","award":["PTDC\/OCE-ETA\/30240\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/30240\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine macroalgae are excellent sources of bioactive compounds recognized by their pharmaceutical and biomedical potential. A subcritical water extraction (SWE) was applied to the macroalga Codium tomentosum, and the extract was used to prepare phytosomes. A Box\u2013Behnken design was applied to optimize the entrapment efficiency. These phytosomes were further modified with DSPE-PEG (2000)-maleimide and apolipoprotein E and characterized by dynamic light scattering, UV spectrophotometry, octanol\/water partition coefficient, differential scanning calorimetry, and Fourier transform infrared spectroscopy. As proof of concept, prototypes of functional food tailored to the elderly were produced. Yogurts were fortified with seaweed extract or phytosomes, and physicochemical properties and proximal composition (pH, acidity, syneresis, moisture, peroxides, proteins, total lipids, sugar content, ash, and mineral composition) were analyzed. The antioxidant and the inhibition capacity of two brain enzymes, cholinesterases (AChE and BuChE), involved in the pathogenesis of Alzheimer\u2019s disease, were also evaluated in the final prototypes. Despite their unappealing sensory characteristics, the results are promising for integrating marine extracts with potential neuroprotective effects into functional foods.<\/jats:p>","DOI":"10.3390\/md23040147","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T02:50:16Z","timestamp":1743389416000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimization of Nanoencapsulation of Codium tomentosum Extract and Its Potential Application in Yogurt Fortification"],"prefix":"10.3390","volume":"23","author":[{"given":"Micaela","family":"Costa","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-9681","authenticated-orcid":false,"given":"Cristina","family":"Soares","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-360X","authenticated-orcid":false,"given":"Aurora","family":"Silva","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"},{"name":"Department of Analytical Chemistry and Food Science, Nutrition and Food Group (NuFoG), Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)\u2014CITEXVI, Universidade de Vigo, 36310 Vigo, Spain"}]},{"given":"Maria F\u00e1tima","family":"Barroso","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-8905","authenticated-orcid":false,"given":"Pedro","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9907-9518","authenticated-orcid":false,"given":"Mariana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-6853","authenticated-orcid":false,"given":"Paula","family":"Gameiro","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Clara","family":"Grosso","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Han, Y., Kim, D.H., and Pack, S.P. (2024). Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives. Mar. Drugs, 22.","DOI":"10.3390\/md22110496"},{"key":"ref_2","unstructured":"Singh, S.K., and Maccioni, R. (2025). The Genetic Basis of Neurodegenerative Disorders: Implications in Alzheimer\u2019s Disease. A New Era in Alzheimer\u2019 s Research, Elsevier."},{"key":"ref_3","unstructured":"Alzheimer\u2019s Society (2021). Factsheet Risk Factors for Dementia, Alzheimer\u2019s Society."},{"key":"ref_4","unstructured":"NIH-NINDS (2025). Parkinson\u2019s Disease: Challenges, Progress, and Promise, National Institute of Neurological Disorders and Stroke, National Institutes of Health."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Biris-Dorhoi, E.-S., Michiu, D., Pop, C.R., Rotar, A.M., Tofana, M., Pop, O.L., Socaci, S.A., and Farcas, A.C. (2020). Macroalgae\u2014A Sustainable Source of Chemical Compounds with Biological Activities. Nutrients, 12.","DOI":"10.3390\/nu12103085"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Han, H.J., Park, S.K., Kang, J.Y., Kim, J.M., Yoo, S.K., Kim, D.-O., Kim, G.-H., and Heo, H.J. (2021). Mixture of Phlorotannin and Fucoidan from Ecklonia Cava Prevents the A\u03b2-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation. Mar. Drugs, 19.","DOI":"10.3390\/md19080434"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.foodres.2012.11.017","article-title":"Acetylcholinesterase Inhibitory Activity of Phlorotannins Isolated from the Brown Alga, Ecklonia Maxima (Osbeck) Papenfuss","volume":"54","author":"Kannan","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jia, C., Chai, J., Zhang, S., Sun, Y., He, L., Sang, Z., Chen, D., and Zheng, X. (2025). The Advancements of Marine Natural Products in the Treatment of Alzheimer\u2019s Disease: A Study Based on Cell and Animal Experiments. Mar. Drugs, 23.","DOI":"10.3390\/md23030091"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jpha.2021.06.001","article-title":"Pharmacokinetics, Distribution, and Excretion of Sodium Oligomannate, a Recently Approved Anti-Alzheimer\u2019s Disease Drug in China","volume":"12","author":"Lu","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Martins, B., Vieira, M., Delerue-Matos, C., Grosso, C., and Soares, C. (2022). Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar. Drugs, 20.","DOI":"10.3390\/md20060362"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-023-00700-w","article-title":"Sodium Oligomannate Alters Gut Microbiota, Reduces Cerebral Amyloidosis and Reactive Microglia in a Sex-Specific Manner","volume":"19","author":"Bosch","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pe\u00f1alver, R., Lorenzo, J.M., Ros, G., Amarowicz, R., Pateiro, M., and Nieto, G. (2020). Seaweeds as a Functional Ingredient for a Healthy Diet. Mar. Drugs, 18.","DOI":"10.3390\/md18060301"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Silva, J., Martins, A., Alves, C., Pinteus, S., Gaspar, H., Alfonso, A., and Pedrosa, R. (2020). Natural Approaches for Neurological Disorders\u2014The Neuroprotective Potential of Codium Tomentosum. Molecules, 25.","DOI":"10.3390\/molecules25225478"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Soares, C., Pa\u00edga, P., Marques, M., Neto, T., Carvalho, A.P., Paiva, A., Sim\u00f5es, P., Costa, L., Bernardo, A., and Fern\u00e1ndez, N. (2021). Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety. Processes, 9.","DOI":"10.3390\/pr9050893"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.phymed.2018.03.053","article-title":"Functionalized Liposomes and Phytosomes Loading Annona muricata L. Aqueous Extract: Potential Nanoshuttles for Brain-Delivery of Phenolic Compounds","volume":"42","author":"Mancini","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Toma, L., Deleanu, M., Sanda, G.M., Barb\u0103lat\u0103, T., Niculescu, L.\u015e., Sima, A.V., and Stancu, C.S. (2024). Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084162"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106453","DOI":"10.1016\/j.jfca.2024.106453","article-title":"Seaweed Bioactives Potential as Nutraceuticals and Functional Ingredients: A Review","volume":"133","author":"Matos","year":"2024","journal-title":"J. Food Compos. Anal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.foodres.2016.08.016","article-title":"Application of Seaweeds to Develop New Food Products with Enhanced Shelf-Life, Quality and Health-Related Beneficial Properties","volume":"99","author":"Roohinejad","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.foodres.2010.07.036","article-title":"Facts about the Formation of New Antioxidants in Natural Samples after Subcritical Water Extraction","volume":"43","author":"Plaza","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65825","DOI":"10.1039\/C6RA15769F","article-title":"Inhibition Effects of Maillard Reaction Products Derived from L-Cysteine and Glucose on Enzymatic Browning Catalyzed by Mushroom Tyrosinase and Characterization of Active Compounds by Partial Least Squares Regression Analysis","volume":"6","author":"Xu","year":"2016","journal-title":"RSC Adv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3136\/fstr.27.747","article-title":"Maillard Reaction Products Derived from Heat-Dried Green Tomato Increase Longevity and Neuroprotection in Caenorhabditis Elegans","volume":"27","author":"Bagoudou","year":"2021","journal-title":"Food Sci. Technol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhao, M., Zhang, B., and Deng, L. (2022). The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.859189"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"155589","DOI":"10.1016\/j.phymed.2024.155589","article-title":"Inhibition of Polyphenols on Maillard Reaction Products and Their Induction of Related Diseases: A Comprehensive Review","volume":"128","author":"Ye","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13098-020-00614-3","article-title":"Toxic AGEs (TAGE) Theory: A New Concept for Preventing the Development of Diseases Related to Lifestyle","volume":"12","author":"Takeuchi","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejps.2016.12.009","article-title":"Formulation and Characterization of an Apigenin-Phospholipid Phytosome (APLC) for Improved Solubility, in Vivo Bioavailability, and Antioxidant Potential","volume":"108","author":"Telange","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Deleanu, M., Toma, L., Sanda, G.M., Barb\u0103lat\u0103, T., Niculescu, L.\u015e., Sima, A.V., Deleanu, C., S\u0103c\u0103rescu, L., Suciu, A., and Alexandru, G. (2023). Formulation of Phytosomes with Extracts of Ginger Rhizomes and Rosehips with Improved Bioavailability, Antioxidant and Anti-Inflammatory Effects In Vivo. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041066"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Direito, R., Reis, C., Roque, L., Gon\u00e7alves, M., Sanches-Silva, A., Gaspar, M.M., Pinto, R., Rocha, J., Sepodes, B., and Ros\u00e1rio Bronze, M. (2019). Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11060296"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid Nanoparticles\u2500From Liposomes to MRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fbio.2016.07.006","article-title":"Nano-Phytosome as a Potential Food-Grade Delivery System","volume":"15","author":"Ghanbarzadeh","year":"2016","journal-title":"Food Biosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102851","DOI":"10.1016\/j.jddst.2021.102851","article-title":"Characterization and In Vitro Investigation of Antiscabietic Effect of Phytosomes Assimilating Quercetin and Naringenin Rich Fraction of Pistacia Integerrima Galls Extract against Sarcoptes Scabiei","volume":"67","author":"Kumar","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s13346-020-00822-4","article-title":"Phospholipid Complex-Loaded Self-Assembled Phytosomal Soft Nanoparticles: Evidence of Enhanced Solubility, Dissolution Rate, Ex Vivo Permeability, Oral Bioavailability, and Antioxidant Potential of Mangiferin","volume":"11","author":"Telange","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_32","first-page":"46","article-title":"Phosphatidylcholine Complex in Improving Oral Drug Delivery of Epicatechin: Preparation and Characterization","volume":"1","author":"Semalty","year":"2014","journal-title":"J. Drug Discov. Dev. Deliv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1007\/s10973-012-2448-6","article-title":"Chrysophanol\u2013Phospholipid Complex","volume":"111","author":"Singh","year":"2013","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Goh, K.K.T., Sarkar, A., and Singh, H. (2014). Milk Protein\u2013Polysaccharide Interactions. Milk Proteins, Elsevier.","DOI":"10.1016\/B978-0-12-405171-3.00013-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ifset.2016.07.031","article-title":"Seaweed Extracts as Potential Functional Ingredients in Yogurt","volume":"37","author":"Smyth","year":"2016","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Abdulqahar, F.W., El-Messery, T.M., Zaky, A.A., and El-Said, M.M. (2022). In Vitro Digestibility of Aucklandia Costus-Loaded Nanophytosomes and Their Use in Yoghurt as a Food Model. Food Biosci., 50.","DOI":"10.1016\/j.fbio.2022.102106"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.foodchem.2016.08.022","article-title":"Nano-Encapsulation of Fish Oil in Nano-Liposomes and Its Application in Fortification of Yogurt","volume":"216","author":"Ghorbanzade","year":"2017","journal-title":"Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zahid, H.F., Ranadheera, C.S., Fang, Z., and Ajlouni, S. (2022). Functional and Healthy Yogurts Fortified with Probiotics and Fruit Peel Powders. Fermentation, 8.","DOI":"10.3390\/fermentation8090469"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/ijfs.13298","article-title":"Seaweeds in Yogurt and Quark Supplementation: Influence of Five Dehydrated Edible Seaweeds on Sensory Characteristics","volume":"52","author":"Picon","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e15759","DOI":"10.1111\/jfpp.15759","article-title":"Development of Flavored Yoghurt Fortified with Microcapsules of Triple Omega 3-6-9 for Preventing Neurotoxicity Induced by Aluminum Chloride in Rats","volume":"45","author":"Ramadan","year":"2021","journal-title":"J. Food Process. Preserv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.26656\/fr.2017.5(S3).008","article-title":"Characterization of Caulerpa Racemosa Yogurt Processed Using Lactobacillus Bulgaricus and Streptococcus Thermophilus","volume":"5","author":"Dewi","year":"2021","journal-title":"Food Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101482","DOI":"10.1016\/j.fochx.2024.101482","article-title":"Recent Advances of Fermented Fruits: A Review on Strains, Fermentation Strategies, and Functional Activities","volume":"22","author":"Yuan","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s11947-021-02638-7","article-title":"Encapsulation of Sargassum Boveanum Algae Extract in Nano-Liposomes: Application in Functional Mayonnaise Production","volume":"14","author":"Savaghebi","year":"2021","journal-title":"Food Bioprocess Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.biotechadv.2013.03.011","article-title":"From Physiology to Systems Metabolic Engineering for the Production of Biochemicals by Lactic Acid Bacteria","volume":"31","author":"Gaspar","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_45","unstructured":"FAO, and WHO (2015). Codex Standard for Fermented Milks (CODEX STAN 243-2003) Milk and Milk Products, FAO."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Clarke, H.J., McCarthy, W.P., O\u2019Sullivan, M.G., Kerry, J.P., and Kilcawley, K.N. (2021). Oxidative Quality of Dairy Powders: Influencing Factors and Analysis. Foods, 10.","DOI":"10.3390\/foods10102315"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jfoodeng.2017.12.009","article-title":"Encapsulation of Food Waste Compounds in Soy Phosphatidylcholine Liposomes: Effect of Freeze-Drying, Storage Stability and Functional Aptitude","volume":"223","author":"Montero","year":"2018","journal-title":"J. Food Eng."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.foodres.2009.05.006","article-title":"Evaluation of Processed Cheese Fortified with Fish Oil Emulsion","volume":"42","author":"Ye","year":"2009","journal-title":"Food Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.lwt.2018.01.012","article-title":"Fortification of Set-Type Yoghurts with Elaeagnus angustifolia L. Flours: Effects on Physicochemical, Textural, and Microstructural Characteristics","volume":"90","author":"Demirci","year":"2018","journal-title":"LWT"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"G\u00f3rnicki, K., Choi\u0144ska, A., and Kaleta, A. (2020). Effect of Variety on Rehydration Characteristics of Dried Apples. Processes, 8.","DOI":"10.3390\/pr8111454"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Greis, M., Sainio, T., Katina, K., Nolden, A.A., Kinchla, A.J., Sepp\u00e4, L., and Partanen, R. (2022). Physicochemical Properties and Mouthfeel in Commercial Plant-Based Yogurts. Foods, 11.","DOI":"10.3390\/foods11070941"},{"key":"ref_52","first-page":"57","article-title":"Fruit Flavored Yogurt: Chemical, Functional and Rheological Properties","volume":"2","author":"Amal","year":"2016","journal-title":"Int. J. Environ. Agric. Res."},{"key":"ref_53","unstructured":"Pomin, V.H. (2011). A Review of the Nutrient Composition of Selected Edible Seaweeds. Seaweed: Ecology, Nutrient Composition and Medicinal Uses, Nova Science Publishers, Inc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1002\/fsn3.2430","article-title":"Quality, Physicochemical, and Textural Properties of Dairy Products Containing Fruits and Vegetables: A Review","volume":"9","author":"Salehi","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0308-8146(00)00146-1","article-title":"Influence of the Addition of Fruit on the Mineral Content of Yoghurts: Nutritional Assessment","volume":"71","year":"2000","journal-title":"Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.microc.2018.07.019","article-title":"Evaluation of the Mineral Content in Milk and Yogurt Types Using Chemometric Tools","volume":"143","author":"Souza","year":"2018","journal-title":"Microchem. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ifset.2011.07.004","article-title":"Recent Developments in the Application of Seaweeds or Seaweed Extracts as a Means for Enhancing the Safety and Quality Attributes of Foods","volume":"12","author":"Gupta","year":"2011","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"112385","DOI":"10.1016\/j.fct.2021.112385","article-title":"Seaweeds Rehydration and Boiling: Impact on Iodine, Sodium, Potassium, Selenium, and Total Arsenic Contents and Health Benefits for Consumption","volume":"155","author":"Correia","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s11947-011-0683-7","article-title":"Nanoemulsions for Food Applications: Development and Characterization","volume":"5","author":"Silva","year":"2012","journal-title":"Food Bioprocess Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.foodchem.2014.12.013","article-title":"Interactions of Polyphenols with Carbohydrates, Lipids and Proteins","volume":"175","author":"Jakobek","year":"2015","journal-title":"Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/phycology2020012","article-title":"Seaweeds as a Source of Functional Proteins","volume":"2","author":"Thiviya","year":"2022","journal-title":"Phycology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10927","DOI":"10.1039\/D4FO03671A","article-title":"Functional Yogurt: A Comprehensive Review of Its Nutritional Composition and Health Benefits","volume":"15","author":"Pannerchelvan","year":"2024","journal-title":"Food Funct."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wu, J., Lv, M., Shao, Z., Hungwe, M., Wang, J., Bai, X., Xie, J., Wang, Y., and Geng, W. (2021). Metabolism Characteristics of Lactic Acid Bacteria and the Expanding Applications in Food Industry. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.612285"},{"key":"ref_64","first-page":"28","article-title":"Top 10 Functional Food Trends: Reinventing Wellness","volume":"58","author":"Sloan","year":"2004","journal-title":"Food Technol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Baker, M.T., Lu, P., Parrella, J.A., and Leggette, H.R. (2022). Consumer Acceptance toward Functional Foods: A Scoping Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031217"},{"key":"ref_66","unstructured":"Research, G.V. (2025, March 03). Functional Foods Market Size & Trends Analysis Report, 2030. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/functional-food-market."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1007\/s13197-021-05146-w","article-title":"Physicochemical Analysis of Mango Flavored Yogurt Supplemented with Moringa Oleifera Leaf Powder","volume":"58","author":"Saeed","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"112093","DOI":"10.1016\/j.lwt.2021.112093","article-title":"Phytosomal Nanocarriers for Encapsulation and Delivery of Resveratrol- Preparation, Characterization, and Application in Mayonnaise","volume":"151","author":"Rabbani","year":"2021","journal-title":"LWT"},{"key":"#cr-split#-ref_69.1","unstructured":"(2011). European Parliament and Council of the European Union. Regulation"},{"key":"#cr-split#-ref_69.2","unstructured":"(EU) No 1169\/2011 of the European Parliament and of the Council of 25 October 2011 on the provision of food information to consumers. Off. J. Eur. Union, L 304, 18-63."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.foodchem.2011.07.123","article-title":"Lipid Content of Frozen Fish: Comparison of Different Extraction Methods and Variability during Freezing Storage","volume":"131","author":"Ramalhosa","year":"2012","journal-title":"Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2004.12.001","article-title":"Carbohydrate Analysis by a Phenol\u2013Sulfuric Acid Method in Microplate Format","volume":"339","author":"Masuko","year":"2005","journal-title":"Anal. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"125345","DOI":"10.1016\/j.foodchem.2019.125345","article-title":"Electrochemical Impedance Spectroscopy Characterization of Beverages","volume":"302","author":"Soares","year":"2020","journal-title":"Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ifset.2015.12.025","article-title":"Response Surface Evaluation of Microwave-Assisted Extraction Conditions for Lycium Barbarum Bioactive Compounds","volume":"33","author":"Mendes","year":"2016","journal-title":"Innov. Food Sci. Emerg. Technol."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/4\/147\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:05:01Z","timestamp":1760029501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/4\/147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["md23040147"],"URL":"https:\/\/doi.org\/10.3390\/md23040147","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}