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These compounds, including proteins, phenolics, polysaccharides, pigments, vitamins, and fatty acids, possess unique biological properties that are increasingly being explored in the field of nanotechnology across diverse sectors. Among marine-derived nanoparticles, promising applications have emerged in the biomedical and pharmaceutical fields, particularly metallic nanoparticles and polysaccharide-based drug delivery systems. This review provides a unique perspective on the integration of two research areas: the exploration of marine bioresources as bioactive compounds sources with nanotechnological methodologies to develop sustainable, safe, stable and functional marine-derived NPs. It highlights recent advancements in the green synthesis of MNPs and the formulation of drug delivery systems using marine polysaccharides. This review also describes the recent trends over the past ten years and discusses the major challenges and limitations associated with these approaches, including variability in biological sources, batch-to-batch inconsistency, mechanistic uncertainties, and difficulties in reproducibility and scalability. Furthermore, it emphasizes the need for standardized protocols and the integration of life cycle assessments (LCA) to evaluate environmental and economic viability for effective translating marine-derives nanoparticles from research to clinical applications.<\/jats:p>","DOI":"10.3390\/md23050207","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:31:49Z","timestamp":1747135909000},"page":"207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6359-6945","authenticated-orcid":false,"given":"Laura M.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-4031","authenticated-orcid":false,"given":"Catarina P.","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisboa, Portugal"},{"name":"Instituto de Biof\u00edsica e Engenharia Biom\u00e9dica (IBEB), Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-3006","authenticated-orcid":false,"given":"Rita","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Departamento de Engenharia Qu\u00edmica, Instituto Superior de Engenharia de Lisboa, 1959-007 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1021\/acsmedchemlett.8b00368","article-title":"Marine Natural Products in Medicinal Chemistry","volume":"9","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e24214","DOI":"10.7554\/eLife.24214","article-title":"Digitizing Mass Spectrometry Data to Explore the Chemical Diversity and Distribution of Marine Cyanobacteria and Algae","volume":"6","author":"Garg","year":"2017","journal-title":"eLife"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Qiu, Y., Chen, S., Yu, M., Shi, J., Liu, J., Li, X., Chen, J., Sun, X., Huang, G., and Zheng, C. (2024). Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity. Mar. Drugs, 22.","DOI":"10.3390\/md22100433"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lasalo, M., Jauffrais, T., Georgel, P., and Matsui, M. (2024). Marine Microorganism Molecules as Potential Anti-Inflammatory Therapeutics. Mar. Drugs, 22.","DOI":"10.3390\/md22090405"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Hotta, K., Deng, Y., Yuan, R., Quan, S., and Chen, X. (2021). Advances in Biosynthesis of Natural Products from Marine Microorganisms. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122551"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ebrahimi, B., Baroutian, S., Li, J., Zhang, B., Ying, T., and Lu, J. (2023). Combination of Marine Bioactive Compounds and Extracts for the Prevention and Treatment of Chronic Diseases. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1047026"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ghosh, S., Sarkar, T., Pati, S., Kari, Z.A., Edinur, H.A., and Chakraborty, R. (2022). Novel Bioactive Compounds from Marine Sources as a Tool for Functional Food Development. Front. Mar. Sci., 9.","DOI":"10.3389\/fmars.2022.832957"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.foodchem.2016.10.066","article-title":"Chemical Composition and Physicochemical Properties of Tropical Red Seaweed, Gracilaria changii","volume":"221","author":"Chan","year":"2017","journal-title":"Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Machado, M., Machado, S., Pimentel, F.B., Freitas, V., Alves, R.C., and Oliveira, M.B.P.P. (2020). Amino Acid Profile and Protein Quality Assessment of Macroalgae Produced in an Integrated Multi-Trophic Aquaculture System. Foods, 9.","DOI":"10.3390\/foods9101382"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s10811-021-02399-y","article-title":"\u03b2-Carotene Extraction from Dunaliella salina by Supercritical CO2","volume":"33","author":"Ludwig","year":"2021","journal-title":"J. Appl. Phycol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Garcia-Perez, P., Louren\u00e7o-Lopes, C., Silva, A., Pereira, A.G., Fraga-Corral, M., Zhao, C., Xiao, J., Simal-Gandara, J., and Prieto, M.A. (2022). Pigment Composition of Nine Brown Algae from the Iberian Northwestern Coastline: Influence of the Extraction Solvent. Mar. Drugs, 20.","DOI":"10.3390\/md20020113"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"126688","DOI":"10.1016\/j.foodchem.2020.126688","article-title":"Optimization of Phycobiliprotein Pigments Extraction from Red Algae Gracilaria gracilis for Substitution of Synthetic Food Colorants","volume":"321","author":"Pereira","year":"2020","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/md13041882","article-title":"Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice","volume":"13","author":"Huang","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s10811-018-1651-7","article-title":"Enzyme-Assisted Extraction of Nizamuddinia zanardinii for the Recovery of Sulfated Polysaccharides with Anticancer and Immune-Enhancing Activities","volume":"31","author":"Alboofetileh","year":"2019","journal-title":"J. Appl. Phycol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"116303","DOI":"10.1016\/j.carbpol.2020.116303","article-title":"Conception of Novel Blue Crab Chitosan Films Crosslinked with Different Saccharides via the Maillard Reaction with Improved Functional and Biological Properties","volume":"241","author":"Hamdi","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s10811-019-01816-7","article-title":"Phlorotannins from Fucales: Potential to Control Hyperglycemia and Diabetes-Related Vascular Complications","volume":"31","author":"Lopes","year":"2019","journal-title":"J. Appl. Phycol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5530\/pres.14.1.7","article-title":"Analysis of Bioactive Compounds from Different Algae Samples Extracted with Ultrasound: Characterizations, Phytochemical Contents and Antioxidant Potentials","volume":"14","author":"Wizi","year":"2021","journal-title":"Pharmacogn. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Barbosa, A.I., Coutinho, A.J., Costa Lima, S.A., and Reis, S. (2019). Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field. Mar. Drugs, 17.","DOI":"10.3390\/md17120654"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Macedo, M.W.F.S., Cunha, N.B.d., Carneiro, J.A., Costa, R.A.d., Alencar, S.A.d., Cardoso, M.H., Franco, O.L., and Dias, S.C. (2021). Marine Organisms as a Rich Source of Biologically Active Peptides. Front. Mar. Sci., 8.","DOI":"10.3389\/fmars.2021.667764"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.foodhyd.2017.08.002","article-title":"Chemical Characterization and Antioxidant Activity of Sulfated Polysaccharides from Navicula sp.","volume":"75","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102294","DOI":"10.1016\/j.algal.2021.102294","article-title":"Effects of Simultaneous Dual-Frequency Divergent Ultrasound-Assisted Extraction on the Structure, Thermal and Antioxidant Properties of Protein from Chlorella pyrenoidosa","volume":"56","author":"Lian","year":"2021","journal-title":"Algal Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envres.2019.02.016","article-title":"Beijing Urban Particulate Matter-Induced Injury and Inflammation in Human Lung Epithelial Cells and the Protective Effects of Fucosterol from Sargassum binderi (Sonder ex J. Agardh)","volume":"172","author":"Fernando","year":"2019","journal-title":"Environ. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2174\/092986710791556069","article-title":"Overview of Anticoagulant Activity of Sulfated Polysaccharides from Seaweeds in Relation to Their Structures, Focusing on Those of Green Seaweeds","volume":"17","author":"Ciancia","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijbiomac.2020.05.012","article-title":"Sulfated Polysaccharide from the Red Algae Gelidiella acerosa: Anticoagulant, Antiplatelet and Antithrombotic Effects","volume":"159","author":"Chagas","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/np900787p","article-title":"Pachycladins A\u2212E, Prostate Cancer Invasion and Migration Inhibitory Eunicellin-Based Diterpenoids from the Red Sea Soft Coral Cladiella pachyclados","volume":"73","author":"Hassan","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biopha.2016.11.131","article-title":"Sargassum Fusiforme Polysaccharides Inhibit VEGF-A-Related Angiogenesis and Proliferation of Lung Cancer in Vitro and in Vivo","volume":"85","author":"Chen","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3746\/pnf.2018.23.3.189","article-title":"Ustadi Antidiabetic Activity of Sargassum hystrix Extracts in Streptozotocin-Induced Diabetic Rats","volume":"23","author":"Gotama","year":"2018","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3945\/jn.114.200931","article-title":"The Green Algal Carotenoid Siphonaxanthin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and the Accumulation of Lipids in White Adipose Tissue of KK-Ay Mice","volume":"145","author":"Li","year":"2015","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijbiomac.2015.10.081","article-title":"Marine Polysaccharide-Based Nanomaterials as a Novel Source of Nanobiotechnological Applications","volume":"82","author":"Manivasagan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Jeong, G.-J., Khan, S., Tabassum, N., Khan, F., and Kim, Y.-M. (2022). Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles. Mar. Drugs, 20.","DOI":"10.3390\/md20080527"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M., and Rizzolio, F. (2020). The History of Nanoscience and Nanotechnology: From Chemical\u2013Physical Applications to Nanomedicine. Molecules, 25.","DOI":"10.3390\/molecules25010112"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Uzair, B., Liaqat, A., Iqbal, H., Menaa, B., Razzaq, A., Thiripuranathar, G., Rana, N.F., and Menaa, F. (2020). Green and Cost-Effective Synthesis of Metallic Nanoparticles by Algae: Safe Methods for Translational Medicine. Bioengineering, 7.","DOI":"10.3390\/bioengineering7040129"},{"key":"ref_33","first-page":"561","article-title":"Nanoparticles\u2014A Review","volume":"5","author":"Mohanraj","year":"2006","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.bjp.0707130","article-title":"Nanoparticles: Pharmacological and Toxicological Significance","volume":"150","author":"Medina","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rajput, V.D., Singh, A., Minkina, T., Rawat, S., Mandzhieva, S., Sushkova, S., Shuvaeva, V., Nazarenko, O., Rajput, P. (2021). Nano-Enabled Products: Challenges and Opportunities for Sustainable Agriculture. Plants, 10.","DOI":"10.3390\/plants10122727"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e16928","DOI":"10.1016\/j.heliyon.2023.e16928","article-title":"The Impact of Silver Nanoparticles on the Growth of Plants: The Agriculture Applications","volume":"9","author":"Khan","year":"2023","journal-title":"Heliyon"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/03601234.2019.1631098","article-title":"Microalgae Biosynthesis of Silver Nanoparticles for Application in the Control of Agricultural Pathogens","volume":"54","author":"Terra","year":"2019","journal-title":"J. Environ. Sci. Health Part B"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Premarathna, K.S.D., Lau, S.Y., Chiong, T., Show, P.-L., Vithanage, M., and Lam, M.K. (2024). Greening up the Fight against Emerging Contaminants: Algae-Based Nanoparticles for Water Remediation. Clean Technol. Environ. Policy.","DOI":"10.1007\/s10098-024-02862-7"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1039\/D4RA00343H","article-title":"Microalgae-Derived Co3O4 Nanomaterials for Catalytic CO Oxidation","volume":"14","author":"Sidorowicz","year":"2024","journal-title":"RSC Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.adna.2024.07.002","article-title":"Alginate-Based Nanocomposites for Food Preservation: Recent Progress Showcasing Heightened Material Properties and Functionalities","volume":"1","author":"Xie","year":"2024","journal-title":"Adv. Nanocompos."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104127","DOI":"10.1016\/j.tifs.2023.104127","article-title":"Microalgae with Active Biological Metal-Nanoparticles as a Novel Food. Biosynthesis, Characterization and Bioavailability Investigation\u2014Review","volume":"139","author":"Ruzik","year":"2023","journal-title":"Trends Food Sci. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Luksiene, Z. (2016). Nanoparticles and Their Potential Application as Antimicrobials in the Food Industry. Food Preservation, Academic Press.","DOI":"10.1016\/B978-0-12-804303-5.00016-X"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fytianos, G., Rahdar, A., and Kyzas, G.Z. (2020). Nanomaterials in Cosmetics: Recent Updates. Nanomaterials, 10.","DOI":"10.3390\/nano10050979"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejps.2017.03.026","article-title":"Development and Photoprotective Effect of a Sunscreen Containing the Antioxidants Spirulina and Dimethylmethoxy Chromanol on Sun-Induced Skin Damage","volume":"104","author":"Souza","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jiec.2021.06.012","article-title":"A Microlagal-Based Carbonaceous Sensor for Enzymatic Determination of Glucose in Blood Serum","volume":"101","author":"Jafari","year":"2021","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-chembioeng-062011-081040","article-title":"Nanocrystals for Electronics","volume":"3","author":"Panthani","year":"2012","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Khanna, P., Kaur, A., and Goyal, D. (2019). Algae-Based Metallic Nanoparticles: Synthesis, Characterization and Applications. J. Microbiol. Methods, 163.","DOI":"10.1016\/j.mimet.2019.105656"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Silva, C.O., Pinho, J.O., Lopes, J.M., Almeida, A.J., Gaspar, M.M., and Reis, C. (2019). Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11010022"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Menaa, F., Wijesinghe, U., Thiripuranathar, G., Althobaiti, N.A., Albalawi, A.E., Khan, B.A., and Menaa, B. (2021). Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?. Mar. Drugs, 19.","DOI":"10.3390\/md19090484"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1080\/10717544.2018.1501119","article-title":"The Challenges of Oral Drug Delivery via Nanocarriers","volume":"25","author":"Reinholz","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.addr.2019.07.010","article-title":"Nanocarrier-Based Systems for Targeted and Site Specific Therapeutic Delivery","volume":"144","author":"Majumder","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sidorowicz, A., Fais, G., Casula, M., Borselli, M., Giannaccare, G., Locci, A.M., Lai, N., Orr\u00f9, R., Cao, G., and Concas, A. (2023). Nanoparticles from Microalgae and Their Biomedical Applications. Mar. Drugs, 21.","DOI":"10.3390\/md21060352"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s10811-015-0715-1","article-title":"Algae as Crucial Organisms in Advancing Nanotechnology: A Systematic Review","volume":"28","author":"Sharma","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Alves, A., Sousa, E., Sousa, E., Kijjoa, A., Pinto, M., and Pinto, M. (2020). Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics. Molecules, 25.","DOI":"10.3390\/molecules25112536"},{"key":"ref_55","first-page":"101012","article-title":"Algae as a Source of Bionanofactory for the Synthesis of Ecofriendly Nanoparticles","volume":"22","author":"Riazunnisa","year":"2024","journal-title":"Environ. Nanotechnol. Monit. Manag."},{"key":"ref_56","unstructured":"(2024). Marine-Based Drug Market\u2014Innovations & Global Industry Trends, Future Market Insights."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"107871","DOI":"10.1016\/j.biotechadv.2021.107871","article-title":"Marine Drugs: Biology, Pipelines, Current and Future Prospects for Production","volume":"54","author":"Papon","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"ref_58","unstructured":"(2024). Algae Products Market Size & Share Analysis\u2014Growth Trends & Forecasts (2025\u20132030), Mordor Intelligence."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"202292-4","DOI":"10.15826\/chimtech.2022.9.2.S4","article-title":"Impact of Herbal Supplements Nowadays: An Overview","volume":"9","author":"Ramirez","year":"2022","journal-title":"Chim. Techno Acta"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mendes, M.C., Navalho, S., Ferreira, A., Paulino, C., Figueiredo, D., Silva, D., Gao, F., Gama, F., Bombo, G., and Jacinto, R. (2022). Algae as Food in Europe: An Overview of Species Diversity and Their Application\u2020. Foods, 11.","DOI":"10.3390\/foods11131871"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Hamidi, M., Safarzadeh Kozani, P., Safarzadeh Kozani, P., Pierre, G., Michaud, P., and Delattre, C. (2020). Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?. Mar. Drugs, 18.","DOI":"10.3390\/md18010028"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mourelle, M.L., G\u00f3mez, C.P., and Legido, J.L. (2017). The Potential Use of Marine Microalgae and Cyanobacteria in Cosmetics and Thalassotherapy. Cosmetics, 4.","DOI":"10.3390\/cosmetics4040046"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"112607","DOI":"10.1016\/j.fct.2021.112607","article-title":"An Integration Study of Microalgae Bioactive Retention: From Microalgae Biomass to Microalgae Bioactives Nanoparticle","volume":"158","author":"Cai","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"100169","DOI":"10.1016\/j.nexus.2022.100169","article-title":"Agriculture of Microalgae Chlorella Vulgaris for Polyunsaturated Fatty Acids (PUFAs) Production Employing Palm Oil Mill Effluents (POME) for Future Food, Wastewater, and Energy Nexus","volume":"9","author":"Kumaran","year":"2023","journal-title":"Energy Nexus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.13057\/biodiv\/d221215","article-title":"Biomass, Pigment Production, and Nutrient Uptake of Chlorella sp. Under Different Photoperiods","volume":"22","author":"Fakhri","year":"2021","journal-title":"Biodiversitas J. Biol. Divers."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pourkarimi, S., Hallajisani, A., Alizadehdakhel, A., Nouralishahi, A., and Golzary, A. (2020). Factors Affecting Production of Beta-Carotene from Dunaliella salina Microalgae. Biocatal. Agric. Biotechnol., 29.","DOI":"10.1016\/j.bcab.2020.101771"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3109\/13880209.2016.1153660","article-title":"Antioxidant and Cytotoxic Activity of Carotenes Produced by Dunaliella salina under Stress","volume":"54","author":"Singh","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"100070","DOI":"10.1016\/j.nexus.2022.100070","article-title":"Antioxidant and Phytonutrient Activities of Spirulina Platensis","volume":"6","author":"Kumar","year":"2022","journal-title":"Energy Nexus"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jocd.12665","article-title":"Antioxidant Properties Evaluation of Topical Astaxanthin Formulations as Anti-Aging Products","volume":"18","author":"Eren","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF01923559","article-title":"The Structure of Scytonemin, an Ultraviolet Sunscreen Pigment from the Sheaths of Cyanobacteria","volume":"49","author":"Proteau","year":"1993","journal-title":"Experientia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1039\/C8FO01834K","article-title":"Effect of Microalgae as Iron Supplements on Iron-Deficiency Anemia in Rats","volume":"10","author":"Gao","year":"2019","journal-title":"Food Funct."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Ganuza, E., Etomi, E.H., Olson, M., and Whisner, C.M. (2024). Omega-3 Eicosapentaenoic Polar-Lipid Rich Extract from Microalgae Nannochloropsis Decreases Plasma Triglycerides and Cholesterol in a Real-World Normolipidemic Supplement Consumer Population. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1293909"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12986-017-0218-y","article-title":"Markers of Neuroprotection of Combined EPA and DHA Provided by Fish Oil Are Higher than Those of EPA (Nannochloropsis) and DHA (Schizochytrium) from Microalgae Oils in Wistar Rats","volume":"14","author":"Lopes","year":"2017","journal-title":"Nutr. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s000110050256","article-title":"Antioxidant and Anti-Inflammatory Properties of C-Phycocyanin from Blue-Green Algae","volume":"47","author":"Romay","year":"1998","journal-title":"Inflamm. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/tvst.8.6.20","article-title":"Dietary Spirulina Supplementation Protects Visual Function from Photostress by Suppressing Retinal Neurodegeneration in Mice","volume":"8","author":"Okamoto","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/encyclopedia1010017","article-title":"Macroalgae","volume":"1","author":"Pereira","year":"2021","journal-title":"Encyclopedia"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Pe\u00f1alver, R., Lorenzo, J.M., Ros, G., Amarowicz, R., Pateiro, M., and Nieto, G. (2020). Seaweeds as a Functional Ingredient for a Healthy Diet. Mar. Drugs, 18.","DOI":"10.3390\/md18060301"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9104835","DOI":"10.1155\/2022\/9104835","article-title":"Bioactive Potential of Brown Algae","volume":"2022","author":"Remya","year":"2022","journal-title":"Adsorpt. Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-12-387669-0.00006-5","article-title":"Marine Algal Sources for Treating Bacterial Diseases","volume":"64","year":"2011","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Rosemary, T., Arulkumar, A., Paramasivam, S., Mondragon-Portocarrero, A., and Miranda, J.M. (2019). Biochemical, Micronutrient and Physicochemical Properties of the Dried Red Seaweeds Gracilaria edulis and Gracilaria corticata. Molecules, 24.","DOI":"10.3390\/molecules24122225"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1080\/10942912.2010.517341","article-title":"Determination of the Anti-Oxidative Capacity and Bioactive Compounds in Green Seaweed Ulva rigida C. Agardh","volume":"15","author":"Yildiz","year":"2012","journal-title":"Int. J. Food Prop."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Andr\u00e9, R., Guedes, L., Melo, R., Ascens\u00e3o, L., Pacheco, R., Vaz, P.D., and Serralheiro, M.L. (2020). Effect of Food Preparations on in Vitro Bioactivities and Chemical Components of Fucus vesiculosus. Foods, 9.","DOI":"10.3390\/foods9070955"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Andr\u00e9, R., Pacheco, R., Alves, A.C., Santos, H.M., Bourbon, M., and Serralheiro, M.L. (2023). The Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis. Foods, 12.","DOI":"10.20944\/preprints202305.2272.v1"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E.D., Pozharitskaya, O.N., Zakharov, D.V., Flisyuk, E.V., Terninko, I.I., Generalova, Y.E., Smekhova, I.E., and Shikov, A.N. (2022). The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region. Mar. Drugs, 20.","DOI":"10.3390\/md20030193"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, L., Oliveira, C., Li, Q., Ferreira, A.S., Nunes, C., Coimbra, M.A., Reis, R.L., Martins, A., Wang, C., and Silva, T.H. (2023). Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo. Mar. Drugs, 21.","DOI":"10.3390\/md21050302"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Leandro, A., Pereira, L., and Gon\u00e7alves, A.M.M. (2020). Diverse Applications of Marine Macroalgae. Mar. Drugs, 18.","DOI":"10.3390\/md18010017"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Deng, Z., Liu, Y., Wang, J., Wu, S., Geng, L., Sui, Z., and Zhang, Q. (2018). Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs). Mar. Drugs, 16.","DOI":"10.3390\/md16090299"},{"key":"ref_88","unstructured":"(2025, March 13). Seanol Science Center. Available online: https:\/\/seanolinstitute.org\/ssc\/about-us.html."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"115211","DOI":"10.1016\/j.carbpol.2019.115211","article-title":"Size-Dependent Whitening Activity of Enzyme-Degraded Fucoidan from Laminaria japonica","volume":"225","author":"Chen","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Xiang, X., Jiang, Q., Yang, H., Zhou, X., Chen, Y., Chen, H., Liu, S., and Chen, L. (2022). A Review on Shellfish Polysaccharides: Extraction, Characterization and Amelioration of Metabolic Syndrome. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.974860"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jare.2023.11.002","article-title":"Maximizing Crustaceans (Shrimp, Crab, and Lobster) by-Products Value for Optimum Valorization Practices: A Comparative Review of Their Active Ingredients, Extraction, Bioprocesses and Applications","volume":"57","author":"Zhang","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"115306","DOI":"10.1016\/j.envres.2023.115306","article-title":"A Review on Extraction of Polysaccharides from Crustacean Wastes and Their Environmental Applications","volume":"221","author":"Saravanan","year":"2023","journal-title":"Environ. Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Muthu, M., Gopal, J., Chun, S., Devadoss, A.J.P., Hasan, N., and Sivanesan, I. (2021). Crustacean Waste-Derived Chitosan: Antioxidant Properties and Future Perspective. Antioxidants, 10.","DOI":"10.3390\/antiox10020228"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1080\/10408398.2019.1602822","article-title":"The Effects of Chitosan Supplementation on Body Weight and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"60","author":"Huang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7324\/JAPS.2020.10506","article-title":"Characterization and Evaluation for Wound Healing of Chitosan Extracted from the Exoskeleton of Freshwater Crab Potamonautes niloticus","volume":"10","author":"Amer","year":"2020","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijbiomac.2020.02.243","article-title":"Extraction, Purification and Characterization of Sulphated Polysaccharide from Bellamya quadrata and Its Stabilization Roles on Atherosclerotic Plaque","volume":"152","author":"Xiong","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Guzm\u00e1n, E., Ortega, F., and Rubio, R.G. (2022). Chitosan: A Promising Multifunctional Cosmetic Ingredient for Skin and Hair Care. Cosmetics, 9.","DOI":"10.3390\/cosmetics9050099"},{"key":"ref_98","first-page":"11","article-title":"Chitosan as A Preservative for Fruits and Vegetables: A Review on Chemistry and Antimicrobial Properties","volume":"4","author":"Duan","year":"2019","journal-title":"J. Bioresour. Bioprod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.ijbiomac.2016.10.105","article-title":"Low Molecular Weight Chitosan Is an Effective Antifungal Agent against Botryosphaeria sp. and Preservative Agent for Pear (Pyrus) Fruits","volume":"95","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s43094-024-00644-y","article-title":"Exploration of Different Strategies of Nanoencapsulation of Bioactive Compounds and Their Ensuing Approaches","volume":"10","author":"Chowdhury","year":"2024","journal-title":"Futur. J. Pharm. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Mendes, C., Thirupathi, A., Corr\u00eaa, M.E.A.B., Gu, Y., and Silveira, P.C.L. (2022). The Use of Metallic Nanoparticles in Wound Healing: New Perspectives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315376"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12943-021-01346-2","article-title":"Delivery of Cancer Therapies by Synthetic and Bio-Inspired Nanovectors","volume":"20","author":"Briolay","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Khursheed, R., Dua, K., Vishwas, S., Gulati, M., Jha, N.K., Aldhafeeri, G.M., Alanazi, F.G., Goh, B.H., Gupta, G., and Paudel, K.R. (2022). Biomedical Applications of Metallic Nanoparticles in Cancer: Current Status and Future Perspectives. Biomed. Pharmacother., 150.","DOI":"10.1016\/j.biopha.2022.112951"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Nagime, P.V., and Chandak, V.S. (2024). A Comprehensive Review of Nanomaterials Synthesis: Physical, Chemical, and Biological Approaches and Emerging Challenges. Biocatal. Agric. Biotechnol., 62.","DOI":"10.1016\/j.bcab.2024.103458"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wang, C., Gao, X., Chen, Z., Chen, Y., and Chen, H. (2017). Preparation, Characterization and Application of Polysaccharide-Based Metallic Nanoparticles: A Review. Polymers, 9.","DOI":"10.3390\/polym9120689"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"133571","DOI":"10.1016\/j.chemosphere.2022.133571","article-title":"Prospects of Algae-Based Green Synthesis of Nanoparticles for Environmental Applications","volume":"293","author":"Khan","year":"2022","journal-title":"Chemosphere"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.partic.2021.12.005","article-title":"Facile Biogenic Selenium Nanoparticle Synthesis, Characterization and Effects on Oxidative Stress Generated by UV in Microalgae","volume":"70","author":"Dinc","year":"2022","journal-title":"Particuology"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Joudeh, N., and Linke, D. (2022). Nanoparticle Classification, Physicochemical Properties, Characterization, and Applications: A Comprehensive Review for Biologists. J. Nanobiotechnology, 20.","DOI":"10.1186\/s12951-022-01477-8"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8013850","DOI":"10.1155\/2017\/8013850","article-title":"A Review of Current Research into the Biogenic Synthesis of Metal and Metal Oxide Nanoparticles via Marine Algae and Seagrasses","volume":"2017","author":"Fawcett","year":"2017","journal-title":"J. Nanosci."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Araya-Castro, K., Chao, T.-C., Dur\u00e1n-Vinet, B., Cisternas, C., Ciudad, G., and Rubilar, O. (2021). Green Synthesis of Copper Oxide Nanoparticles Using Protein Fractions from an Aqueous Extract of Brown Algae Macrocystis pyrifera. Processes, 9.","DOI":"10.3390\/pr9010078"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Mahmood Ansari, S., Saquib, Q., De Matteis, V., Awad Alwathnani, H., Ali Alharbi, S., and Ali Al-Khedhairy, A. (2021). Marine Macroalgae Display Bioreductant Efficacy for Fabricating Metallic Nanoparticles: Intra\/Extracellular Mechanism and Potential Biomedical Applications. Bioinorg. Chem. Appl., 2021.","DOI":"10.1155\/2021\/5985377"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Venkatesan, J., Kim, S.-K., and Shim, M.S. (2016). Antimicrobial, Antioxidant, and Anticancer Activities of Biosynthesized Silver Nanoparticles Using Marine Algae Ecklonia cava. Nanomaterials, 6.","DOI":"10.3390\/nano6120235"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"116547","DOI":"10.1016\/j.carbpol.2020.116547","article-title":"Synthesis of Bioactive Silver Nanoparticles Using Alginate, Fucoidan and Laminaran from Brown Algae as a Reducing and Stabilizing Agent","volume":"245","author":"Yugay","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Alprol, A.E., Mansour, A.T., El-Beltagi, H.S., and Ashour, M. (2023). Algal Extracts for Green Synthesis of Zinc Oxide Nanoparticles: Promising Approach for Algae Bioremediation. Materials, 16.","DOI":"10.3390\/ma16072819"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"123431","DOI":"10.1016\/j.jhazmat.2020.123431","article-title":"Microalgal Biosorption of Heavy Metals: A Comprehensive Bibliometric Review","volume":"402","author":"Ubando","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"9342","DOI":"10.1039\/c0jm01735c","article-title":"Nano-Gold Biosynthesis by Silica-Encapsulated Micro-Algae: A \u201cLiving\u201d Bio-Hybrid Material","volume":"20","author":"Sicard","year":"2010","journal-title":"J. Mater. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10811-014-0355-x","article-title":"Biosynthesis of Monodisperse Gold Nanoparticles by Green Alga Rhizoclonium and Associated Biochemical Changes","volume":"27","author":"Parial","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"19459","DOI":"10.1007\/s11356-017-9772-0","article-title":"Biosynthesis of Silver Nanoparticles from Spirulina Microalgae and Its Antibacterial Activity","volume":"24","author":"Muthusamy","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.colsurfb.2017.02.020","article-title":"Green Synthesis of Gold Nanoparticles Using Brown Algae Cystoseira Baccata: Its Activity in Colon Cancer Cells","volume":"153","author":"Lastra","year":"2017","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s13204-014-0341-2","article-title":"Green Synthesis of Silver Nanoparticles Using Marine Algae Caulerpa racemosa and Their Antibacterial Activity against Some Human Pathogens","volume":"5","author":"Kathiraven","year":"2014","journal-title":"Appl. Nanosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"57765","DOI":"10.1007\/s11356-024-34967-3","article-title":"Optimization of Brilliant Blue R Photocatalytic Degradation by Silver Nanoparticles Synthesized Using Chlorella vulgaris","volume":"31","author":"Sidorowicz","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"106831","DOI":"10.1016\/j.jwpe.2024.106831","article-title":"Novel Experimental and Theoretical Study on the Synthesis and Use of Microalgae-Derived Silver Nanomaterials for Water Purification","volume":"69","author":"Sidorowicz","year":"2025","journal-title":"J. Water Process. Eng."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"126625","DOI":"10.1016\/j.jhazmat.2021.126625","article-title":"Algae-Mediated Biosystems for Metallic Nanoparticle Production: From Synthetic Mechanisms to Aquatic Environmental Applications","volume":"420","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"102389","DOI":"10.1016\/j.mtchem.2024.102389","article-title":"Green Synthesis of Silver Nanoparticles by Algae: Advancements, Challenges and Sustainable Prospects","volume":"42","author":"Teh","year":"2024","journal-title":"Mater. Today Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10661-017-6033-0","article-title":"Eco-Friendly Synthesis of Silver Nanoparticles Using Green Algae (Caulerpa serrulata): Reaction Optimization, Catalytic and Antibacterial Activities","volume":"189","author":"Aboelfetoh","year":"2017","journal-title":"Environ. Monit. Assess."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.procbio.2019.10.027","article-title":"Antibiofilm and Antimicrobial Activities of Green Synthesized Silver Nanoparticles Using Marine Red Algae Gelidium corneum","volume":"89","year":"2020","journal-title":"Process. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Alprol, A.E., Mansour, A.T., Abdelwahab, A.M., and Ashour, M. (2023). Advances in Green Synthesis of Metal Oxide Nanoparticles by Marine Algae for Wastewater Treatment by Adsorption and Photocatalysis Techniques. Catalysts, 13.","DOI":"10.3390\/catal13050888"},{"key":"ref_128","first-page":"020004","article-title":"Limitations and Possibilities of Green Synthesis and Long-Term Stability of Colloidal Ag Nanoparticles","volume":"1918","year":"2017","journal-title":"AIP Conf. Proc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s12668-020-00776-4","article-title":"Green Synthesis of Gold Nanoparticles Obtained from Algae Sargassum cymosum: Optimization, Characterization and Stability","volume":"10","author":"Costa","year":"2020","journal-title":"Bionanoscience"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.2147\/IJN.S423171","article-title":"How Synthesis of Algal Nanoparticles Affects Cancer Therapy?\u2014A Complete Review of the Literature","volume":"18","author":"Alkafaas","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Chugh, D., Viswamalya, V.S., and Das, B. (2021). Green Synthesis of Silver Nanoparticles with Algae and the Importance of Capping Agents in the Process. J. Genet. Eng. Biotechnol., 19.","DOI":"10.1186\/s43141-021-00228-w"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Rahman, A., Kumar, S., Bafana, A., Dahoumane, S.A., and Jeffryes, C. (2019). Biosynthetic Conversion of Ag+ to Highly Stable Ag0 Nanoparticles by Wild Type and Cell Wall Deficient Strains of Chlamydomonas reinhardtii. Molecules, 24.","DOI":"10.3390\/molecules24010098"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Moholkar, D.N., Havaldar, D.V., Potadar, R.S., and Pawar, K.D. (2021). Optimization of Biogenic Synthesis of Colloidal Metal Nanoparticles. Colloids\u2014Types, Preparation and Applications, IntechOpen.","DOI":"10.5772\/intechopen.94853"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00449-016-1616-7","article-title":"Caulerpa racemosa: A Marine Green Alga for Eco-Friendly Synthesis of Silver Nanoparticles and Its Catalytic Degradation of Methylene Blue","volume":"39","author":"Edison","year":"2016","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Nagarajan, S., and Arumugam Kuppusamy, K. (2013). Extracellular Synthesis of Zinc Oxide Nanoparticle Using Seaweeds of Gulf of Mannar, India. J. Nanobiotechnol., 11.","DOI":"10.1186\/1477-3155-11-39"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/C1NR11188D","article-title":"Gold Nanoparticles: Preparation, Properties, and Applications in Bionanotechnology","volume":"4","author":"Yeh","year":"2012","journal-title":"Nanoscale"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"101560","DOI":"10.1016\/j.jksus.2021.101560","article-title":"Gold Nanoparticles: Synthesis Properties and Applications","volume":"33","author":"Hammami","year":"2021","journal-title":"J. King Saud Univ.-Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cis.2013.12.011","article-title":"Microbial Synthesis of Gold Nanoparticles: Current Status and Future Prospects","volume":"209","author":"Shedbalkar","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Duman, H., Akda\u015f\u00e7i, E., Eker, F., Bechelany, M., and Karav, S. (2024). Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects. Nanomaterials, 14.","DOI":"10.20944\/preprints202410.1889.v1"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"100327","DOI":"10.1016\/j.talo.2024.100327","article-title":"Gold Nanoparticles (AuNPs): A Versatile Material for Biosensor Application","volume":"9","author":"Kumalasari","year":"2024","journal-title":"Talanta Open"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Chiang, M.C., Yang, Y.P., Nicol, C.J.B., and Wang, C.J. (2024). Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042360"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Amaral, M., Charmier, A.J., Afonso, R.A., Catarino, J., Fa\u00edsca, P., Carvalho, L., Ascens\u00e3o, L., Coelho, J.M.P., Manuela Gaspar, M., and Reis, C.P. (2021). Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward. Cancers, 13.","DOI":"10.3390\/cancers13061242"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Tabassum, N., Khan, F., Kang, M.-G., Jo, D.-M., Cho, K.-J., and Kim, Y.-M. (2023). Inhibition of Polymicrobial Biofilms of Candida albicans\u2013Staphylococcus aureus\/Streptococcus mutans by Fucoidan\u2013Gold Nanoparticles. Mar. Drugs, 21.","DOI":"10.3390\/md21020123"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3906\/biy-2010-64","article-title":"Synthesis of Intracellular and Extracellular Gold Nanoparticles with a Green Machine and Its Antifungal Activity","volume":"45","year":"2021","journal-title":"Turk. J. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jddst.2019.02.023","article-title":"Green Synthesis of Gold Nanoparticles from Dunaliella salina, Its Characterization and in Vitro Anticancer Activity on Breast Cancer Cell Line","volume":"51","author":"Singh","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ballesteros, N., Diego-Gonz\u00e1lez, L., Lastra-Valdor, M., Grimaldi, M., Cavazza, A., Bigi, F., Rodr\u00edguez-Arg\u00fcelles, M.C., and Sim\u00f3n-V\u00e1zquez, R. (2022). Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts. Mar. Drugs, 20.","DOI":"10.3390\/md20030182"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ballesteros, N., Maietta, I., Rey-M\u00e9ndez, R., Rodr\u00edguez-Arg\u00fcelles, M.C., Lastra-Valdor, M., Cavazza, A., Grimaldi, M., Bigi, F., and Sim\u00f3n-V\u00e1zquez, R. (2023). Gold Nanoparticles Synthesized by an Aqueous Extract of Codium tomentosum as Potential Antitumoral Enhancers of Gemcitabine. Mar. Drugs, 21.","DOI":"10.3390\/md21010020"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.saa.2012.09.024","article-title":"Sargassum myriocystum Mediated Biosynthesis of Gold Nanoparticles","volume":"99","author":"Karthick","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.saa.2012.08.081","article-title":"Biosynthesis of Antibacterial Gold Nanoparticles Using Brown Alga, Stoechospermum Marginatum (K\u00fctzing)","volume":"99","author":"Parthiban","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Ballesteros, N., Fernandes, M., Machado, R., Sampaio, P., Gomes, A.C., Cavazza, A., Bigi, F., and Rodr\u00edguez-Arg\u00fcelles, M.C. (2023). Valorisation of the Invasive Macroalgae Undaria pinnatifida (Harvey) Suringar for the Green Synthesis of Gold and Silver Nanoparticles with Antimicrobial and Antioxidant Potential. Mar. Drugs, 21.","DOI":"10.3390\/md21070397"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Zhang, X.F., Liu, Z.G., Shen, W., and Gurunathan, S. (2016). Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091534"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Rudi, L., Cepoi, L., Chiriac, T., Djur, S., Valuta, A., and Miscu, V. (2024). Effects of Silver Nanoparticles on the Red Microalga Porphyridium purpureum CNMN-AR-02, Cultivated on Two Nutrient Media. Mar. Drugs, 22.","DOI":"10.3390\/md22050208"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Duman, H., Eker, F., Akda\u015f\u00e7i, E., Witkowska, A.M., Bechelany, M., and Karav, S. (2024). Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties. Nanomaterials, 14.","DOI":"10.3390\/nano14181527"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12645-023-00243-1","article-title":"Synthesis and Characterization of Silver Nanoparticles Loaded with Carboplatin as a Potential Antimicrobial and Cancer Therapy","volume":"15","year":"2024","journal-title":"Cancer Nanotechnol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13204-015-0426-6","article-title":"Green Synthesis of Silver Nanoparticles: Characterization and Determination of Antibacterial Potency","volume":"6","author":"Annamalai","year":"2016","journal-title":"Appl. Nanosci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Mbanga, O., Cukrowska, E., and Gulumian, M. (2023). A Comparative Study of the Biodurability and Persistence of Gold, Silver and Titanium Dioxide Nanoparticles Using the Continuous Flow through System. Nanomaterials, 13.","DOI":"10.21203\/rs.3.rs-2462642\/v1"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Mikhailova, E.O. (2024). Green Silver Nanoparticles: An Antibacterial Mechanism. Antibiotics, 14.","DOI":"10.3390\/antibiotics14010005"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s43393-023-00173-4","article-title":"Chlorella Minutissima-Assisted Silver Nanoparticles Synthesis and Evaluation of Its Antibacterial Activity","volume":"4","author":"Kumar","year":"2024","journal-title":"Syst. Microbiol. Biomanuf."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"El-Naggar, N.E.-A., Hussein, M.H., Shaaban-Dessuuki, S.A., and Dalal, S.R. (2020). Production, Extraction and Characterization of Chlorella vulgaris Soluble Polysaccharides and Their Applications in AgNPs Biosynthesis and Biostimulation of Plant Growth. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-59945-w"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/09603123.2022.2163987","article-title":"Synthesis of Silver and Copper Nanoparticle Using Spirulina platensis and Evaluation of Their Anticancer Activity","volume":"34","author":"Doman","year":"2024","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jscs.2014.10.004","article-title":"Sustainable Synthesis of Silver Nanoparticles Using Macroalgae Spirogyra varians and Analysis of Their Antibacterial Activity","volume":"20","author":"Salari","year":"2016","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"WA, F. (2016). Green Biosynthesis of Silver Nanoparticles Using Marine Red Algae Acanthophora Specifera and Its Antibacterial Activity. J. Nanomed. Nanotechnol.","DOI":"10.4172\/2157-7439.1000409"},{"key":"ref_163","first-page":"710","article-title":"In Vitro Anticancer Activity of Silver Nanoparticles Synthesized Using the Extract of Gelidiella sp.","volume":"4","author":"Bhimba","year":"2012","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Hamouda, R.A., and Aljohani, E.S. (2024). Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect. Mar. Drugs, 22.","DOI":"10.3390\/md22040154"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Hamouda, R.A., Almaghrabi, F.Q., Alharbi, O.M., Al-Harbi, A.D.M., Alsulami, R.M., and Alhumairi, A.M. (2024). Antifungal Activities of Biogenic Silver Nanoparticles Mediated by Marine Algae: In Vitro and In Vivo Insights of Coating Tomato Fruit to Protect against Penicillium italicum Blue Mold. Mar. Drugs, 22.","DOI":"10.3390\/md22050225"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Ahmed, Y., Hussain, J., and Asif, S. (2020). Green Synthesis of Copper Oxide and Cobalt Oxide Nanoparticles Using Spinacia Oleracea Leaf Extract. engrXiv.","DOI":"10.31224\/osf.io\/75fa6"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Pasparakis, G. (2022). Recent Developments in the Use of Gold and Silver Nanoparticles in Biomedicine. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 14.","DOI":"10.1002\/wnan.1817"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Sim\u00f5es, M.F., Ottoni, C.A., and Antunes, A. (2020). Biogenic Metal Nanoparticles: A New Approach to Detect Life on Mars?. Life, 10.","DOI":"10.3390\/life10030028"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.addr.2008.03.018","article-title":"Magnetic Nanoparticles in MR Imaging and Drug Delivery","volume":"60","author":"Sun","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_170","first-page":"100231","article-title":"Magnetic Nanosystem a Tool for Targeted Delivery and Diagnostic Application: Current Challenges and Recent Advancement","volume":"7","author":"Rarokar","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"18179","DOI":"10.1039\/D1RA02149D","article-title":"Copper as an Antimicrobial Agent: Recent Advances","volume":"11","author":"Salah","year":"2021","journal-title":"RSC Adv."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s11671-018-2532-3","article-title":"Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes","volume":"13","author":"Siddiqi","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"El-Belely, E.F., Farag, M.M.S., Said, H.A., Amin, A.S., Azab, E., Gobouri, A.A., and Fouda, A. (2021). Green Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) Using Arthrospira platensis (Class: Cyanophyceae) and Evaluation of Their Biomedical Activities. Nanomaterials, 11.","DOI":"10.3390\/nano11010095"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Fais, G., Sidorowicz, A., Perra, G., Dess\u00ec, D., Loy, F., Lai, N., Follesa, P., Orr\u00f9, R., Cao, G., and Concas, A. (2024). Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells. Mar. Drugs, 22.","DOI":"10.3390\/md22120549"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Taghizadeh, S.-M., Lal, N., Ebrahiminezhad, A., Moeini, F., Seifan, M., Ghasemi, Y., and Berenjian, A. (2020). Green and Economic Fabrication of Zinc Oxide (ZnO) Nanorods as a Broadband UV Blocker and Antimicrobial Agent. Nanomaterials, 10.","DOI":"10.3390\/nano10030530"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Sidorowicz, A., Margarita, V., Fais, G., Pantaleo, A., Manca, A., Concas, A., Rappelli, P., Fiori, P.L., and Cao, G. (2022). Characterization of Nanomaterials Synthesized from Spirulina Platensis Extract and Their Potential Antifungal Activity. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0274753"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s13204-013-0233-x","article-title":"Biosynthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanoparticles (CONPs) Produced Using Brown Alga Extract (Bifurcaria bifurcata)","volume":"4","author":"Abboud","year":"2014","journal-title":"Appl. Nanosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s12010-014-1225-3","article-title":"Microwave-Mediated Extracellular Synthesis of Metallic Silver and Zinc Oxide Nanoparticles Using Macro-Algae (Gracilaria edulis) Extracts and Its Anticancer Activity Against Human PC3 Cell Lines","volume":"174","author":"Priyadharshini","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Dikshit, P.K., Kumar, J., Das, A.K., Sadhu, S., Sharma, S., Singh, S., Gupta, P.K., and Kim, B.S. (2021). Green Synthesis of Metallic Na-noparticles: Applications and Limitations. Catalysts, 11.","DOI":"10.3390\/catal11080902"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Chaudhary, R., Nawaz, K., Khan, A.K., Hano, C., Abbasi, B.H., and Anjum, S. (2020). An Overview of the Algae-mediated Biosynthesis of Nanoparticles and Their Biomedical Applications. Biomolecules, 10.","DOI":"10.3390\/biom10111498"},{"key":"ref_181","first-page":"100500","article-title":"Recent Advances in Green Synthesized Nanoparticles: From Production to Application","volume":"24","author":"Kazemi","year":"2023","journal-title":"Mater. Today Sustain."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"G\u00e4rtner, G., Stoyneva-G\u00e4rtner, M., and Uzunov, B. (2021). Algal Toxic Compounds and Their Aeroterrestrial, Airborne and Other Extremophilic Producers with Attention to Soil and Plant Contamination: A Review. Toxins, 13.","DOI":"10.3390\/toxins13050322"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.3390\/ijms160510389","article-title":"Subcellular Sequestration and Impact of Heavy Metals on the Ultrastructure and Physiology of the Multicellular Freshwater Alga Desmidium swartzii","volume":"16","author":"Andosch","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Vijayaram, S., Ring\u00f8, E., Ghafarifarsani, H., Hoseinifar, S.H., Ahani, S., and Chou, C.-C. (2024). Use of Algae in Aquaculture: A Review. Fishes, 9.","DOI":"10.3390\/fishes9020063"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Nizam, N.U.M., Hanafiah, M.M., and Woon, K.S. (2021). A Content Review of Life Cycle Assessment of Nanomaterials: Current Practices, Challenges, and Future Prospects. Nanomaterials, 11.","DOI":"10.3390\/nano11123324"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.3390\/md13052967","article-title":"Marine Polysaccharides from Algae with Potential Biomedical Applications","volume":"13","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1080\/87559129.2023.2212055","article-title":"A Review on Seaweeds and Seaweed-Derived Polysaccharides: Nutrition, Chemistry, Bioactivities, and Applications","volume":"40","author":"Xie","year":"2024","journal-title":"Food Rev. Int."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.lfs.2010.03.010","article-title":"Fucoidan, a Sulfated Polysaccharide, Inhibits Adipogenesis through the Mitogen-Activated Protein Kinase Pathway in 3T3-L1 Preadipocytes","volume":"86","author":"Kim","year":"2010","journal-title":"Life Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10811-007-9291-3","article-title":"Purification and Characterization of a N-Acetylglucosaminidase Produced by Talaromyces emersonii during Growth on Algal Fucoidan","volume":"20","author":"Murray","year":"2008","journal-title":"J. Appl. Phycol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Citkowska, A., Szekalska, M., and Winnicka, K. (2019). Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms. Mar. Drugs, 17.","DOI":"10.3390\/md17080458"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"100707","DOI":"10.1016\/j.clet.2023.100707","article-title":"Technology Comparison for Sequential Extraction of Fucoidan and Sodium Alginate from Ascophyllum nodosum Using a Glycerol and Choline Chloride Solvent","volume":"18","author":"James","year":"2024","journal-title":"Clean. Eng. Technol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"102795","DOI":"10.1016\/j.algal.2022.102795","article-title":"Enzyme-Assisted Extraction of Fucoidan from Kjellmaniella crassifolia Based on Kinetic Study of Enzymatic Hydrolysis of Algal Cellulose","volume":"66","author":"Tang","year":"2022","journal-title":"Algal Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.3390\/md11082982","article-title":"The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells","volume":"11","author":"Boo","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/1534735417692097","article-title":"An Exploratory Study on the Anti-Inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients","volume":"17","author":"Takahashi","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10311-017-0670-y","article-title":"Chitosan Nanoparticles Preparation and Applications","volume":"16","author":"Divya","year":"2018","journal-title":"Environ. Chem. Lett."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Jha, R., and Mayanovic, R.A. (2023). A Review of the Preparation, Characterization, and Applications of Chitosan Nanoparticles in Nanomedicine. Nanomaterials, 13.","DOI":"10.3390\/nano13081302"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1021\/acsomega.0c01903","article-title":"Extraction, Characterization, and Antimicrobial Activity of Chitosan from Horse Mussel Modiolus modiolus","volume":"5","author":"Varma","year":"2020","journal-title":"ACS Omega"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"170","DOI":"10.14202\/vetworld.2017.170-175","article-title":"Extraction of Chitosan and its Oligomers from Shrimp Shell Waste, Their Characterization and Antimicrobial Effect","volume":"10","author":"Varun","year":"2017","journal-title":"Vet. World"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e1431085","DOI":"10.1080\/2162402X.2018.1431085","article-title":"The Natural Product chitosan Enhances the Anti-Tumor Activity of Natural Killer Cells by Activating Dendritic Cells","volume":"7","author":"Li","year":"2018","journal-title":"OncoImmunology"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"7658052","DOI":"10.1155\/2019\/7658052","article-title":"Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics","volume":"2019","author":"Jiang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2100809","DOI":"10.1002\/admi.202100809","article-title":"An Up-to-Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications","volume":"8","author":"Dodero","year":"2021","journal-title":"Adv. Mater. Interfaces"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.2174\/1381612825666190425163424","article-title":"Alginate Nanoparticles for Drug Delivery and Targeting","volume":"25","author":"Severino","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"102951","DOI":"10.1016\/j.algal.2022.102951","article-title":"An Assessment of Physical and Chemical Conditions in Alginate Extraction from Two Cultivated Brown Algal Species in Norway: Alaria esculenta and Saccharina latissima","volume":"69","author":"Langeng","year":"2023","journal-title":"Algal Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cej.2013.10.024","article-title":"Chromium Biosorption Using the Residue of Alginate Extraction from Sargassum filipendula","volume":"237","author":"Bertagnolli","year":"2014","journal-title":"Chem. Eng. J."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Lukova, P., Kokova, V., Baldzhieva, A., Murdjeva, M., Katsarov, P., Delattre, C., and Apostolova, E. (2024). Alginate from Ericaria crinita Possesses Antioxidant Activity and Attenuates Systemic Inflammation via Downregulation of Pro-Inflammatory Cytokines. Mar. Drugs, 22.","DOI":"10.3390\/md22110482"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Acevedo, S., Covarrubias, A.A., Haeger, P., Pancetti, F., Tala, F., and de la Fuente-Ortega, E. (2024). Alginate Oligosaccharides Protect Gastric Epithelial Cells against Oxidative Stress Damage through Induction of the Nrf2 Pathway. Antioxidants, 13.","DOI":"10.3390\/antiox13050618"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Sun, Y., Ma, X., and Hu, H. (2021). Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems. Mar. Drugs, 19.","DOI":"10.3390\/md19060345"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"102953","DOI":"10.1016\/j.cis.2023.102953","article-title":"Polysaccharide-Based Nanoassemblies: From Synthesis Methodologies and Industrial Applications to Future Prospects","volume":"318","author":"Bushra","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Hoang, N.H., Thanh, T.L., Sangpueak, R., Treekoon, J., Saengchan, C., Thepbandit, W., Papathoti, N.K., Kamkaew, A., and Buensanteai, N. (2022). Chitosan Nanoparticles-Based Ionic Gelation Method: A Promising Candidate for Plant Disease Management. Polymers, 14.","DOI":"10.3390\/polym14040662"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1039\/D1TB00628B","article-title":"Polysaccharide Nanoparticles: From Fabrication to Applications","volume":"9","author":"Plucinski","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Van Bavel, N., Issler, T., Pang, L., Anikovskiy, M., and Prenner, E.J. (2023). A Simple Method for Synthesis of Chitosan Nanoparticles with Ionic Gelation and Homogenization. Molecules, 28.","DOI":"10.3390\/molecules28114328"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Venkatesan, J., Singh, S.K., Anil, S., Kim, S.-K., and Shim, M.S. (2018). Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating. Molecules, 23.","DOI":"10.3390\/molecules23061429"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jccs.201190121","article-title":"Chitosan\/Fucoidan pH Sensitive Nanoparticles for Oral Delivery System","volume":"58","author":"Huang","year":"2011","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.foodhyd.2015.02.006","article-title":"O-carboxymethyl Chitosan\/Fucoidan Nanoparticles Increase Cellular Curcumin Uptake","volume":"53","author":"Huang","year":"2016","journal-title":"Food Hydrocoll."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s11814-013-0243-0","article-title":"Polyelectrolyte Complexes of Chitosan Self-Assembled with Fucoidan: An Optimum Condition to Prepare their Nanoparticles and Their Characteristics","volume":"31","author":"Lee","year":"2014","journal-title":"Korean J. Chem. Eng."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijbiomac.2022.07.068","article-title":"Fucoidan-Based Nanoparticles: Preparations and Applications","volume":"217","author":"Venkatesan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Wardani, G., Nugraha, J., Kurnijasanti, R., Mustafa, M.R., and Sudjarwo, S.A. (2023). Molecular Mechanism of Fucoidan Nanoparticles as Protector on Endothelial Cell Dysfunction in Diabetic Rats\u2019 Aortas. Nutrients, 15.","DOI":"10.3390\/nu15030568"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Chiang, C.-S., Huang, B.-J., Chen, J.-Y., Chieng, W.W., Lim, S.H., Lee, W., Shyu, W.-C., and Jeng, L.-B. (2021). Fucoidan-Based Nanoparticles with Inherently Therapeutic Efficacy for Cancer Treatment. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13121986"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.carbpol.2013.02.018","article-title":"Doxorubicin Loading Fucoidan Acetate Nanoparticles for Immune and Chemotherapy in Cancer Treatment","volume":"94","author":"Lee","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Guadarrama-Escobar, O.R., Serrano-Casta\u00f1eda, P., Anguiano-Almaz\u00e1n, E., V\u00e1zquez-Dur\u00e1n, A., Pe\u00f1a-Ju\u00e1rez, M.C., Vera-Graziano, R., Morales-Florido, M.I., Rodriguez-Perez, B., Rodriguez-Cruz, I.M., and Miranda-Calder\u00f3n, J.E. (2023). Chitosan Nanoparticles as Oral Drug Carriers. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054289"},{"key":"ref_221","first-page":"1238","article-title":"Gene Therapy Based on Interleukin-12 Loaded Chitosan Nanoparticles in a Mouse Model of Fibrosarcoma","volume":"19","author":"Lotfipour","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"119763","DOI":"10.1016\/j.ijpharm.2020.119763","article-title":"Chitosan Nanoparticles for Oral Photothermally Enhanced Photodynamic Therapy of Colon Cancer","volume":"589","author":"Chen","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"119161","DOI":"10.1016\/j.ijpharm.2020.119161","article-title":"Radioprotective Effect of Self-Assembled Low Molecular Weight Fucoidan\u2013Chitosan Nanoparticles","volume":"579","author":"Wu","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Barbosa, A.I., Costa Lima, S.A., and Reis, S. (2019). Application of pH-Responsive Fucoidan\/Chitosan Nanoparticles to Improve Oral Quercetin Delivery. Molecules, 24.","DOI":"10.3390\/molecules24020346"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.ijbiomac.2021.04.045","article-title":"Curcumin-Laden Dual-Targeting Fucoidan\/Chitosan Nanocarriers for Inhibiting Brain Inflammation via Intranasal Delivery","volume":"181","author":"Don","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"120548","DOI":"10.1016\/j.ijpharm.2021.120548","article-title":"Fucoidan\/Chitosan Nanoparticles Functionalized with Anti-ErbB-2 Target Breast Cancer Cells and Impair Tumor Growth in Vivo","volume":"600","author":"Oliveira","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10965-014-0415-6","article-title":"Preparing, Characterizing, and Evaluating Chitosan\/Fucoidan Nanoparticles as Oral Delivery Carriers","volume":"21","author":"Huang","year":"2014","journal-title":"J. Polym. Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.3390\/md12084379","article-title":"Preparation and Characterization of Antioxidant Nanoparticles Composed of Chitosan and Fucoidan for Antibiotics Delivery","volume":"12","author":"Huang","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijbiomac.2020.04.233","article-title":"Mucoadhesive and pH Responsive Fucoidan-Chitosan Nanoparticles for the Oral Delivery of Methotrexate","volume":"158","author":"Coutinho","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Van Bavel, N., Lewrenz, A.-M., Issler, T., Pang, L., Anikovskiy, M., and Prenner, E.J. (2023). Synthesis of Alginate Nanoparticles Using Hydrolyzed and Enzyme-Digested Alginate Using the Ionic Gelation and Water-in-Oil Emulsion Method. Polymers, 15.","DOI":"10.3390\/polym15051319"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.eurpolymj.2018.04.032","article-title":"Bioadhesive Polymeric Nanoparticles as Strategy to Improve the Treatment of Yeast Infections in Oral Cavity: In-Vitro and Ex-Vivo Studies","volume":"104","author":"Roque","year":"2018","journal-title":"Eur. Polym. J."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"110933","DOI":"10.1016\/j.msec.2020.110933","article-title":"Multifunctional Alginate Nanoparticles Containing Nitric Oxide Donor and Silver Nanoparticles for Biomedical Applications","volume":"112","author":"Urzedo","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"119013","DOI":"10.1016\/j.carbpol.2021.119013","article-title":"Review on Design Strategies and Considerations of Polysaccharide-Based Smart Drug Delivery Systems for Cancer Therapy","volume":"279","author":"Meng","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Xu, S.-Y., Huang, X., and Cheong, K.-L. (2017). Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities. Mar. Drugs, 15.","DOI":"10.3390\/md15120388"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1039\/D2NH00214K","article-title":"Polysaccharide-Based Nanocomposites for Biomedical Applications: A Critical Review","volume":"7","author":"Shokrani","year":"2022","journal-title":"Nanoscale Horiz."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Yu, H., Wu, W., Lin, X., and Feng, Y. (2020). Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.601246"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Jesus, S., Marques, A.P., Duarte, A., Soares, E., Costa, J.P., Cola\u00e7o, M., Schmutz, M., Som, C., Borchard, G., and Wick, P. (2020). Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility. Front. Bioeng. 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