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University","award":["10.54499\/UIDP\/04292\/2020"],"award-info":[{"award-number":["10.54499\/UIDP\/04292\/2020"]}]},{"name":"Technological University of the Shannon RUN-EU European University","award":["10.54499\/UIDB\/04292\/2020"],"award-info":[{"award-number":["10.54499\/UIDB\/04292\/2020"]}]},{"name":"Technological University of the Shannon RUN-EU European University","award":["10.54499\/LA\/P\/0069\/2020"],"award-info":[{"award-number":["10.54499\/LA\/P\/0069\/2020"]}]},{"name":"Technological University of the Shannon RUN-EU European University","award":["EAPA 0032\/2022"],"award-info":[{"award-number":["EAPA 0032\/2022"]}]},{"name":"Technological University of the Shannon RUN-EU European University","award":["2023.06631.CEECIND"],"award-info":[{"award-number":["2023.06631.CEECIND"]}]},{"name":"Technological University of the Shannon RUN-EU European University","award":["LCF\/TR\/CI23\/56000027"],"award-info":[{"award-number":["LCF\/TR\/CI23\/56000027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to conventional organic solvents, offering advantages such as biodegradability, greater environmental and economic sustainability, low toxicity, and enhanced extraction selectivity. This review provides a comprehensive analysis of the principles, physicochemical properties, and applications of DESs\/NADESs to obtain bioactive compounds from marine organisms. Among the most recent works, it is possible to verify the success of NADESs to extract carrageenan from the seaweed Kappaphycus alvarezii; pigments from Palmaria palmata; and polyphenols and proteins from different brown seaweeds. NADESs have also shown high potential to extract other valuable compounds from marine by-products, such as chitin from crabs and shrimp shells, and also lipids and proteins from different fish species and protein rich extracts from tilapia viscera. The challenges for DESs\/NADESs use at industrial scale are also discussed, and success cases are revealed, highlighting their potential as game changers for extracting bioactive compounds from marine organisms and driving the development of innovative biotechnological products.<\/jats:p>","DOI":"10.3390\/md23050211","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:11:57Z","timestamp":1747372317000},"page":"211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4726-8122","authenticated-orcid":false,"given":"Sandro","family":"Amador","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier (ITQB), NOVA University of Lisbon, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"CENIMAT\/I3N, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Alice","family":"Martins","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre\/ARNET-Aquatic Research Network, ESTM, Polytechnic University of Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-2564","authenticated-orcid":false,"given":"Margarida","family":"Matias","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre\/ARNET-Aquatic Research Network, ESTM, Polytechnic University of Leiria, 2520-630 Peniche, Portugal"},{"name":"LIFE-Health and Bioscience Research Institute, Technological University of Shannon, Moylish Park, V94 E8YF Limerick, Ireland"}]},{"given":"Rui","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre\/ARNET-Aquatic Research Network, ESTM, Polytechnic University of Leiria, 2520-630 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-3111","authenticated-orcid":false,"given":"Susete","family":"Pinteus","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Centre\/ARNET-Aquatic Research Network, ESTM, Polytechnic University of Leiria, 2520-630 Peniche, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref_1","unstructured":"United Nations (2015). 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