{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:14:51Z","timestamp":1768868091069,"version":"3.49.0"},"reference-count":74,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Functional Ecology Strategic Project","award":["UIDB\/04004\/2025"],"award-info":[{"award-number":["UIDB\/04004\/2025"]}]},{"name":"Center for Functional Ecology Strategic Project","award":["UIDP\/04004\/2025"],"award-info":[{"award-number":["UIDP\/04004\/2025"]}]},{"name":"TERRA Associate Laboratory","award":["LA\/P\/0092\/2020"],"award-info":[{"award-number":["LA\/P\/0092\/2020"]}]},{"name":"Research Center for Natural Resources, Environment and Society\u2014CERNAS","award":["UIDB\/00681"],"award-info":[{"award-number":["UIDB\/00681"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Seaweed represents a diverse group of marine organisms rich in bioactive compounds that have attracted interest for their potential relevance in neurological research. Recent studies highlight their ability to modulate neuroinflammation, oxidative stress, synaptic plasticity, and pathways implicated in neurodegeneration in preclinical models. Extracts from brown, red, and green algae contain polysaccharides, polyphenols, carotenoids, and fatty acids that exhibit neuroprotective, antioxidant, and anti-inflammatory activities in vitro and in vivo, although these findings remain limited to experimental systems. This review synthesizes current evidence on the neurological activities of seaweed-derived compounds, emphasizing mechanistic findings while clearly distinguishing between experimental observations and unvalidated clinical implications. Challenges related to bioavailability, pharmacokinetics, safety, and clinical translation are discussed, alongside considerations for future research. Evidence in humans remains scarce and indirect, and no seaweed-derived compound has demonstrated neuroprotection or disease-modifying effects in clinical settings.<\/jats:p>","DOI":"10.3390\/md24010031","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:11:21Z","timestamp":1767870681000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurological Benefits of Seaweed-Derived Compounds"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0619","authenticated-orcid":false,"given":"Leonel","family":"Pereira","sequence":"first","affiliation":[{"name":"Centre for Functional Ecology (CFE), Marine Resources, Conservation and Technology, Marine Algae Lab, Associate Laboratory TERRA, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-6648","authenticated-orcid":false,"given":"Ana","family":"Valado","sequence":"additional","affiliation":[{"name":"Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"},{"name":"H&TRC\u2014Health & Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, Rua 5 de Outubro, 3045-043 Coimbra, Portugal"},{"name":"Research Center for Natural Resources, Environment and Society (CERNAS), Polytechnic University of Coimbra, Bencanta, 3045-601 Coimbra, Portugal"},{"name":"MARE\u2014Marine and Environmental Sciences Centre\/ARNET\u2014Aquatic Research Network, University of Coimbra, 3000-456 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cadar, E., Popescu, A., Dragan, A.-M.-L., Pesterau, A.-M., Pascale, C., Anuta, V., Prasacu, I., Velescu, B.S., Tomescu, C.L., and Bogdan-Andreescu, C.F. (2025). Bioactive compounds of marine algae and their potential health and nutraceutical applications: A review. Mar. 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