{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:41:02Z","timestamp":1775680862819,"version":"3.50.1"},"reference-count":17,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A new compound maleimide-5-oxime was isolated, together with 3,4- dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.<\/jats:p>","DOI":"10.3390\/md502040","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:03:57Z","timestamp":1224939837000},"page":"40-51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand"],"prefix":"10.3390","volume":"5","author":[{"given":"Rawiwan","family":"Wattanadilok","sequence":"first","affiliation":[{"name":"Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand"}]},{"given":"Pichan","family":"Sawangwong","sequence":"additional","affiliation":[{"name":"Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand"}]},{"given":"C\u00e1tia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Madalena","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Eugenia","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Artur","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade de Aveiro, 4810-1933 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-1061","authenticated-orcid":false,"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2007,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/1385272802666220130083412","article-title":"Antifungal metabolites from marine sponges","volume":"2","author":"Li","year":"1998","journal-title":"Curr Org Chem"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"i5","DOI":"10.1093\/jac\/dki218","article-title":"Changing patterns and trends in systematic fungal 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