{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:17:10Z","timestamp":1767824230100,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.<\/jats:p>","DOI":"10.3390\/md9050852","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T11:42:42Z","timestamp":1305286962000},"page":"852-862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines"],"prefix":"10.3390","volume":"9","author":[{"given":"David M.","family":"Pereira","sequence":"first","affiliation":[{"name":"REQUIMTE\/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Jose","family":"Cheel","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic"},{"name":"Department of Research and Development, CPN s.r.o., Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic"}]},{"given":"Carlos","family":"Areche","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Chile, Casilla 653, Santiago, Chile"}]},{"given":"Aurelio","family":"San-Martin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Chile, Casilla 653, Santiago, Chile"}]},{"given":"Juana","family":"Rovirosa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Chile, Casilla 653, Santiago, Chile"}]},{"given":"Luis R.","family":"Silva","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-4396","authenticated-orcid":false,"given":"Patricia","family":"Valentao","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9764-3920","authenticated-orcid":false,"given":"Paula B.","family":"Andrade","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. 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