{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:56:03Z","timestamp":1770710163702,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: People with Parkinson\u2019s disease (PD) may be at risk of having bad periodontal status. A consistent periodontal examination is critical to investigate how it impacts on PD quality of life. We aimed to assess the periodontal status of people with PD, and its association with quality of life and self-perceived xerostomia. Materials and Methods: To this end, from February to March 2020, we consecutively enrolled 28 PD individuals, and motor and non-motor symptoms of PD were assessed using the Movement Disorder Society Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS). We performed full-mouth periodontal examination and gathered information on self-perceived quality of life in PD, oral health impact profile (OHIP-14) and xerostomia. Results: The prevalence of periodontitis was 75.0% and most cases were identified as severe (46.4%). Upper extremity rigidity, hand posture and kinetic tremors were significantly correlated with worse periodontal status. PDQ-8 showed to be correlated with self-perceived oral health-related quality of life and xerostomia levels. Conclusions: This group of people with PD had a high prevalence of periodontitis. Deteriorated levels of the upper extremities in advanced stages of PD were associated with worse periodontal status and hygiene habits. Quality of life in PD appears to be associated with self-perceived OHRQoL and xerostomia.<\/jats:p>","DOI":"10.3390\/medicina56080383","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:15:38Z","timestamp":1596111338000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Parkinson\u2019s Disease, Periodontitis and Patient-Related Outcomes: A Cross-Sectional Study"],"prefix":"10.3390","volume":"56","author":[{"given":"Patr\u00edcia","family":"Lyra","sequence":"first","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-260X","authenticated-orcid":false,"given":"Vanessa","family":"Machado","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"},{"name":"Periodontology Department, Clinical Research Unit (CRU), CiiEM, Egas Moniz, CRL, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-5936","authenticated-orcid":false,"given":"Lu\u00eds","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"Quantitative Methods for Health Research Unit (MQIS), CiiEM, Egas Moniz, CRL, 2829-511 Caparica, Portugal"}]},{"given":"Josefa","family":"Domingos","sequence":"additional","affiliation":[{"name":"Laboratory of Motor Behavior, Sport and Health Department, Faculty of Human Kinetics, University of Lisbon, 1495-751 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-3129","authenticated-orcid":false,"given":"Catarina","family":"Godinho","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4077","authenticated-orcid":false,"given":"Jos\u00e9 Jo\u00e3o","family":"Mendes","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-8263","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"},{"name":"Periodontology Department, Clinical Research Unit (CRU), CiiEM, Egas Moniz, CRL, 2829-511 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJM2003ra020003","article-title":"Alzheimer\u2019s Disease and Parkinson\u2019s Disease","volume":"348","author":"Nussbaum","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"5","author":"Breteler","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural. Transm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Elbaz","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm.2165","article-title":"Missing pieces in the Parkinson\u2019s disease puzzle","volume":"16","author":"Obeso","year":"2010","journal-title":"Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: A polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/JPER.18-0157","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification","volume":"89","author":"Caton","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global Burden of Severe Periodontitis in 1990\u20132010","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/jcpe.12732","article-title":"Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action","volume":"44","author":"Tonetti","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/prd.12135","article-title":"Aging, inflammation, immunity and periodontal disease","volume":"72","author":"Ebersole","year":"2016","journal-title":"Periodontol. 2000"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/jcpe.12881","article-title":"Ageing effects on humoral immune responses in chronic periodontitis","volume":"45","author":"Ebersole","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jcpe.12517","article-title":"Are periodontal diseases really silent? A systematic review of their effect on quality of life","volume":"43","author":"Buset","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00784-019-03188-1","article-title":"The impact of nonsurgical periodontal treatment on oral health-related quality of life: A systematic review and meta-analysis","volume":"24","author":"Botelho","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: A two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: A systematic review and meta-analysis","volume":"116","author":"Suvan","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: Consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hussain, S.B., Botelho, J., Machado, V., Zehra, S.A., Mendes, J.J., Ciurtin, C., Orlandi, M., and Aiuto, F.D. (2020). Is there a bidirectional association between rheumatoid arthritis and periodontitis? A systematic review and meta-analysis. Semin. Arthritis Rheum., 5.","DOI":"10.1016\/j.semarthrit.2020.01.009"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1038\/s41598-019-52116-6","article-title":"Study of Periodontal Health in Almada-Seixal (SoPHiAS): A cross-sectional study in the Lisbon Metropolitan Area","volume":"9","author":"Botelho","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2188\/jea.14.143","article-title":"Oral Health Conditions in Patients with Parkinson\u2019s Disease","volume":"14","author":"Nakayama","year":"2004","journal-title":"J. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1754-4505.2009.00075.x","article-title":"Dental health of patients with Parkinson\u2019s disease in Iceland","volume":"29","author":"Sveinsson","year":"2009","journal-title":"Spec. Care Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jocn.2008.12.027","article-title":"Increased frequencies of caries, periodontal disease and tooth loss in patients with Parkinson\u2019s disease","volume":"16","author":"Hanaoka","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"ref_23","first-page":"1","article-title":"Oral Health of Parkinson\u2019s Disease Patients: A Case-Control Study","volume":"2018","author":"Marinus","year":"2018","journal-title":"Parkinsons Dis."},{"key":"ref_24","first-page":"145","article-title":"Partial recording protocols performance on the assessment of periodontitis severity and extent: Bias magnitudes, sensibility, and specificity","volume":"59","author":"Machado","year":"2018","journal-title":"Rev. Port. Estomatol. Med. Dent. Cir. Maxilofac."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e3647","DOI":"10.7717\/peerj.3647","article-title":"Periodontal inflammatory disease is associated with the risk of Parkinson\u2019s disease: A population-based retrospective matched-cohort study","volume":"5","author":"Chen","year":"2017","journal-title":"PeerJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2471\/BLT.07.045120","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies","volume":"85","author":"Altman","year":"2007","journal-title":"Bull. World Health Organ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: Onset, progression, and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/08870449708406741","article-title":"The PDQ-8: Development and validation of a short-form parkinson\u2019s disease questionnaire","volume":"12","author":"Jenkinson","year":"1997","journal-title":"Psychol. Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.20344\/amp.8202","article-title":"Reliability and Validity of 39-Item Parkinson\u2019s Disease Questionnaire and Parkinson\u2019s Disease Quality of Life Questionnaire","volume":"30","author":"Vieira","year":"2017","journal-title":"Acta Med. Port."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","article-title":"The Plaque Control Record","volume":"43","author":"Drake","year":"1972","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-051X.1975.tb01734.x","article-title":"Periodontal treatment of multi rooted teeth. Results after 5 years","volume":"2","author":"Hamp","year":"1975","journal-title":"J. Clin. Periodontol."},{"key":"ref_34","first-page":"S149","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"45","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.15309\/17psd180208","article-title":"Oral Health-Related Quality of Life: Portuguese Linguistic and Cultural Adaptation of Ohip-14","volume":"18","author":"Afonso","year":"2017","journal-title":"Psicol. Sa\u00fade Doen\u00e7a"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-0528.1997.tb00941.x","article-title":"Derivation and validation of a short-form oral health impact profile","volume":"25","author":"Slade","year":"1997","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/ger.12313","article-title":"Validity and reliability of a Portuguese version of the Summated Xerostomia Inventory-5","volume":"35","author":"Thomson","year":"2018","journal-title":"Gerodontology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e5258","DOI":"10.7717\/peerj.5258","article-title":"Prevalence and extent of chronic periodontitis and its risk factors in a Portuguese subpopulation: A retrospective cross-sectional study and analysis of Clinical Attachment Loss","volume":"6","author":"Machado","year":"2018","journal-title":"PeerJ"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Botelho, J., Machado, V., Proen\u00e7a, L., Oliveira, M.J., Cavacas, M.A., Amaro, L., \u00c1guas, A., and Mendes, J.J. (2020). Perceived xerostomia, stress and periodontal status impact on elderly oral health-related quality of life: Findings from a cross-sectional survey. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-01183-7"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1601-5037.2008.00336.x","article-title":"The efficacy of dental floss in addition to a toothbrush on plaque and parameters of gingival inflammation: A systematic review","volume":"6","author":"Berchier","year":"2008","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Worthington, H.V., MacDonald, L., Poklepovic Pericic, T., Sambunjak, D., Johnson, T.M., Imai, P., and Clarkson, J.E. (2019). Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries. Cochrane Database Syst. Rev., 4.","DOI":"10.1002\/14651858.CD012018.pub2"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1902\/jop.2000.71.10.1528","article-title":"Van Der Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients","volume":"71","author":"Loos","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-051X.2007.01173.x","article-title":"A systematic review and meta-analyses on C-reactive protein in relation to periodontitis","volume":"35","author":"Paraskevas","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dioguardi, M., Crincoli, V., Laino, L., Alovisi, M., Sovereto, D., Mastrangelo, F., Lo Russo, L., and Lo Muzio, L. (2020). The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer\u2019s Disease: A Systematic Review. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020495"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4784268","article-title":"Linking Neuroinflammation and Neurodegeneration in Parkinson\u2019s Disease","volume":"2018","author":"Gelders","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/ger.12188","article-title":"Parkinson\u2019s disease and periodontitis\u2014The missing link? A review","volume":"33","author":"Kaur","year":"2016","journal-title":"Gerodontology"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hashioka, S., Inoue, K., Miyaoka, T., Hayashida, M., Wake, R., Oh-Nishi, A., and Inagaki, M. (2019). The Possible Causal Link of Periodontitis to Neuropsychiatric Disorders: More Than Psychosocial Mechanisms. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153723"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/8\/383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:52:57Z","timestamp":1760176377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/8\/383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["medicina56080383"],"URL":"https:\/\/doi.org\/10.3390\/medicina56080383","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,30]]}}}