{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:16:34Z","timestamp":1765876594062,"version":"3.48.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER funds through the POCI-COMPETE 2020\u2014Operational Programme Competitiveness and Internationalisation in Axis I\u2014Strengthening research, technological development and innovation","award":["029114\u2014ProMETAB"],"award-info":[{"award-number":["029114\u2014ProMETAB"]}]},{"DOI":"10.13039\/501100001871","name":"National Funds by FCT-Foundation for Science and Technology, Portugal","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds by FCT-Foundation for Science and Technology, Portugal","doi-asserted-by":"publisher","award":["2021.07367.BD"],"award-info":[{"award-number":["2021.07367.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds by FCT-Foundation for Science and Technology, Portugal","doi-asserted-by":"publisher","award":["2021.07634.BD"],"award-info":[{"award-number":["2021.07634.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Associa\u00e7\u00e3o Portuguesa de Urologia\/Jaba Recordati"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Background: Periprostatic adipose tissue (PPAT) has been shown to play a significant role in prostate cancer (PCa) development and progression. This relationship is further exacerbated by obesity, as PPAT-secreted factors increase PCa aggressiveness and have also been implicated in chemotherapy resistance. Therefore, identifying the molecular mediators of PPAT\u2013prostate interorgan communication and the factors that disrupt this crosstalk is pivotal for better disease management. Obesogens, i.e., endocrine-disrupting chemicals that dysregulate adipose tissue towards an \u201cobese\u201d phenotype, have recently been implicated in disrupting this crosstalk, with an impact on prostate cell fate. Objectives: This study aimed to investigate whether obesogenic dysregulation of human PPAT secretory activity affects PCa cell viability and their response to docetaxel and cabazitaxel. Methods\/Results: Through ex vivo culture of human PPAT and conditioned medium assays, we demonstrated that exposure to the model obesogen tributyltin (TBT) induced an \u201cobese\u201d phenotype in human PPAT, characterised by adipocyte enlargement and increased secretion of leptin and C-C motif chemokine ligand 7. The TBT-treated PPAT secretome enhanced cell viability and decreased the sensitivity of PCa cells to taxanes. Conclusions: This study provides preliminary evidence that lays the groundwork for future investigations, dissecting the molecular pathways underpinning prostate carcinogenesis and resistance to chemotherapy induced by obesogen-dysregulated PPAT.<\/jats:p>","DOI":"10.3390\/medsci13040322","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T08:46:52Z","timestamp":1765874812000},"page":"322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces Their Sensitivity to Docetaxel and Cabazitaxel"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-5276","authenticated-orcid":false,"given":"Mariana","family":"Feij\u00f3","sequence":"first","affiliation":[{"name":"RISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marqu\u00eas d\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-4048","authenticated-orcid":false,"given":"Lara R. S.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marqu\u00eas d\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-4225","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Catarro","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laboratory of Drug-Toxicology, UBImedical, University of Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"given":"C\u00e1tia V.","family":"Vaz","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-3803","authenticated-orcid":false,"given":"Carlos","family":"Raba\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, Av. Bissaya Barreto, 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-1388","authenticated-orcid":false,"given":"Bruno J.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia de Coimbra Francisco Gentil, Av. Bissaya Barreto, 3000-075 Coimbra, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-8998","authenticated-orcid":false,"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laboratory of Drug-Toxicology, UBImedical, University of Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-4017","authenticated-orcid":false,"given":"Endre","family":"Kiss-Toth","sequence":"additional","affiliation":[{"name":"School of Medicine and Population Health, University of Sheffield, Sheffield S10 2RX, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-8360","authenticated-orcid":false,"given":"Sara","family":"Correia","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-488X","authenticated-orcid":false,"given":"S\u00edlvia","family":"Socorro","sequence":"additional","affiliation":[{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.coemr.2020.02.007","article-title":"Periprostatic adipose tissue: A heavy player in prostate cancer progression","volume":"10","author":"Manceau","year":"2020","journal-title":"Curr. Opin. Endocr. Metab. 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