{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:40:57Z","timestamp":1776415257700,"version":"3.51.2"},"reference-count":91,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1\u2019s precise function has not been fully elucidated but analysis of its interacting proteins will permit unraveling putative associations to specific cellular pathways and cellular processes. By assessing public databases it was possible to identify the LAP1 interactome, and this was curated. In total, 41 interactions were identified. Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1. Furthermore, by making use of the Ingenuity Pathways Analysis tool and submitting the LAP1 interactors, the top two canonical pathways were \u201cTelomerase signalling\u201d and \u201cTelomere Extension by Telomerase\u201d and the top functions \u201cCell Morphology\u201d, \u201cCellular Assembly and Organization\u201d and \u201cDNA Replication, Recombination, and Repair\u201d. Once again, putative LAP1 functions are reinforced but novel functions are emerging.<\/jats:p>","DOI":"10.3390\/membranes6010008","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T03:30:25Z","timestamp":1452915025000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features"],"prefix":"10.3390","volume":"6","author":[{"given":"Joana","family":"Serrano","sequence":"first","affiliation":[{"name":"Neuroscience and Signalling Laboratory, Department of Medical Sciences, Institute of Biomedicine\u2014iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-9874","authenticated-orcid":false,"given":"Odete","family":"Da Cruz e Silva","sequence":"additional","affiliation":[{"name":"Neuroscience and Signalling Laboratory, Department of Medical Sciences, Institute of Biomedicine\u2014iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-5797","authenticated-orcid":false,"given":"Sandra","family":"Rebelo","sequence":"additional","affiliation":[{"name":"Neuroscience and Signalling Laboratory, Department of Medical Sciences, Institute of Biomedicine\u2014iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.devcel.2009.10.016","article-title":"The Nuclear Envelope as a Signaling Node in Development and Disease","volume":"17","author":"Dauer","year":"2009","journal-title":"Dev. 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