{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T04:12:26Z","timestamp":1774152746387,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>The amount of cheese whey generated from the production of speciality sheep and goat cheese is significantly growing due to the acclaimed nutritional and medicinal benefits of the milk from these species. However, most of the cheese whey generated has no applications, thus giving rise to environmental problems. This work focuses on the study of the performance of the nanofiltration process for recovering the permeates of ultrafiltration from sheep and goat cheese whey. Nanofiltration experiments were carried out with membranes of nanofiltration (NF) in total recirculation and concentration modes, at 25 \u00b0C. Nanofiltration of the ultrafiltration permeates from sheep cheese whey was done at a pressure of 3.0 \u00d7 106 Pa and a circulation velocity of 1.42 m\u00b7s\u22121, until a volume concentration factor (VCF) of 2.5. Nanofiltration of the permeates from ultrafiltration of goat cheese whey was performed at a pressure of 2.0 \u00d7 106 Pa and a circulation velocity of 0.94 m\u00b7s\u22121, until a VCF of 2.0. From the results, it was concluded that osmotic pressure was the most important factor affecting the performance of the process. In both cases, the final permeates had a much lower organic load and its future use in the process of cheese making should be evaluated.<\/jats:p>","DOI":"10.3390\/membranes8040114","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T11:23:27Z","timestamp":1542799407000},"page":"114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Contribution for the Valorisation of Sheep and Goat Cheese Whey through Nanofiltration"],"prefix":"10.3390","volume":"8","author":[{"given":"Ant\u00f3nia","family":"Macedo","sequence":"first","affiliation":[{"name":"Escola Superior Agr\u00e1ria, Polytechnic Institute of Beja, Rua Pedro Soares, Ap. 6158, 7801-908 Beja, Portugal"},{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"}]},{"given":"Joana","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Instituto Superior de Agronomia, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"}]},{"given":"Elizabeth","family":"Duarte","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"},{"name":"Instituto Superior de Agronomia, University of Lisbon, Tapada da Ajuda, 1349-017 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mollea, C., Marmo, L., and Bosco, F. (2013). Valorisation of cheese whey, a by-product from the dairy industry. Food Industry, InTech.","DOI":"10.5772\/53159"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.biotechadv.2010.02.002","article-title":"Fermentation of lactose to bio-ethanol by yeasts as part of integrated solutions for the valorisation of cheese whey","volume":"28","author":"Teixeira","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.desal.2011.05.055","article-title":"Concentration and purification of whey proteins by ultrafiltration","volume":"278","author":"Baldasso","year":"2011","journal-title":"Desalination"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0022029904000482","article-title":"Effect of protein concentration, pH, lactose content and pasteurization on thermal gelation of acid caprine whey protein concentrates","volume":"72","author":"Almeida","year":"2005","journal-title":"J. Dairy Res."},{"key":"ref_5","unstructured":"Pulina, G., Mil\u00e0n Sendra, M.J., Lavin, M.P., Theodoridis, A., Morin, E., and Capote, J. (2017). New opportunities for dairy sheep and goats (oral presentation). Small Ruminant Symposium, Proceedings of the American Dairy Science Association (ADSA) Animal Meeting, Pitsburgh, PA, USA, 25\u201328 June 2017, University Autonoma of Barcelona."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.smallrumres.2011.09.040","article-title":"Bioactive components of ovine and caprine cheese whey","volume":"101","author":"Ramos","year":"2011","journal-title":"Small Rumin. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.smallrumres.2006.09.013","article-title":"Physico-chemical characteristics of goat and sheep milk","volume":"68","author":"Park","year":"2007","journal-title":"Small Rumin. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1753-4887.2010.00281.x","article-title":"Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: A systematic review of the literature","volume":"68","author":"Alexander","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_9","unstructured":"Macedo, A. (2005). Application of membrane technologies in the valuation of by-products resulting from the manufacture of Serpa cheese. Final Progress Report of the Agro Project No. 327. (Program Agro, Ministry of Agriculture and Fisheries of Portugal), Instituto Polit\u00e9cnico de Beja."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0958-6946(02)00070-5","article-title":"Valorization of by-products from ovine cheese manufacture: Clarification by thermocalcic precipitation\/microfiltration before ultrafiltration","volume":"12","author":"Pereira","year":"2002","journal-title":"Int. Dairy J."},{"key":"ref_11","first-page":"1097","article-title":"Production of infant formula analogs by membrane fractionation of caprine milk: Effect of temperature treatment on membrane performance","volume":"2","author":"Maduko","year":"2011","journal-title":"J. Food Nutr. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.desal.2007.10.046","article-title":"Analysis of separation and fouling behaviour during nanofiltration of dairy ultrafiltration permeates","volume":"236","author":"Rice","year":"2009","journal-title":"Desalination"},{"key":"ref_13","unstructured":"Garem, A., and Jeantet, R. (1995). Fouling occurring in nanofiltration of dairy products. Fouling and Cleaning in Pressure Driven Membrane Processes, International Dairy Federation. Special Issue 9504."},{"key":"ref_14","unstructured":"Walstra, P., Geurts, T.J., Noomen, A., Jellema, A., and van Bokel, M.A.J.S. (2001). Ciencia de la Leche y Tecnologia de los Produtos L\u00e1cteos, Editorial Acribia, S.A."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mulder, M. (1996). Basic Principles of Membrane Technology, Kluwer Academic Publishers. [2nd ed.].","DOI":"10.1007\/978-94-009-1766-8"},{"key":"ref_16","unstructured":"Pouliot, Y., and Jelen, P. (1995). Pretreatments of dairy fluids to minimize long-term membrane fouling. Fouling and Cleaning in Pressure Driven Membrane Processes, International Dairy Federation. Special Issue 9504."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.memsci.2011.07.012","article-title":"The role of concentration polarization in ultrafiltration of ovine cheese whey","volume":"381","author":"Macedo","year":"2011","journal-title":"J. Membr. Sci."},{"key":"ref_18","unstructured":"(1986). Portuguese Standard NP 675. Milk and dry milk. Determination of Lactose Concentration."},{"key":"ref_19","unstructured":"Cunliffe, P. (1990). AOAC Official Methods of Analysis. Solids (Total) in milk, IDF-ISO-AOAC method I. Official Methods of Analysis of AOAC International, AOAC Official Methods of Analysis."},{"key":"ref_20","unstructured":"(1991). Portuguese Standard NP 1986. Milk. Determination of Crude Protein."},{"key":"ref_21","first-page":"281","article-title":"Direct and indirect determination of true protein content of milk by Kjeldahl analysis: Collaborative study","volume":"73","author":"Barbano","year":"1991","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"ref_22","unstructured":"Rice, E.W., Clesceri, L.S., Baird, R.B., and Eaton, A.D. (2012). Suspended solids. Standard Methods for Examination of Water and Wastewater, American Public Health Association. [22nd ed.]."},{"key":"ref_23","unstructured":"Rice, E.W., Clesceri, L.S., Baird, R.B., and Eaton, A.D. (2012). Determination of oil and grease. Standard Methods for Examination of Water and Wastewater, American Public Health Association. [22nd ed.]."},{"key":"ref_24","unstructured":"Gon\u00e7alves, M.L. (1983). Determination of sodium and potassium in milk. An\u00e1lise de Solu\u00e7\u00f5es, Funda\u00e7\u00e3o Calouste Gulbenkian."},{"key":"ref_25","unstructured":"Gon\u00e7alves, M.L. (1983). Determination of calcium and magnesium in milk. An\u00e1lise de Solu\u00e7\u00f5es, Funda\u00e7\u00e3o Calouste Gulbenkian."},{"key":"ref_26","unstructured":"(1983). Portuguese Standard NP 471. Milk. Determination of Chloride in Milk."},{"key":"ref_27","unstructured":"Rice, E.W., Clesceri, L.S., Baird, R.B., and Eaton, A.D. (2012). Phosphate. Standard Methods for Examination of Water and Wastewater, American Public Health Association. [22nd ed.]."},{"key":"ref_28","unstructured":"Rice, E.W., Clesceri, L.S., Baird, R.B., and Eaton, A.D. (2012). Chemical Oxygen Demand\u2013Section 5220. Standard Methods for Examination of Water and Wastewater, American Public Health Association. [22nd ed.]."},{"key":"ref_29","unstructured":"Rice, E.W., Clesceri, L.S., Baird, R.B., and Eaton, A.D. (2012). Oxygen Demand (biological)\u2013Section 5210. Standard Methods for Examination of Water and Wastewater, American Public Health Association. [22nd ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cheryan, M. (1998). Ultrafiltration and Microfiltration Handbook, CRC Press. [2nd ed.].","DOI":"10.1201\/9781482278743"},{"key":"ref_31","unstructured":"Montgomery, D.C., and Runger, G.C. (1994). Applied Statistics and Probability for Enginneers, John Wiley & Sons, Inc."},{"key":"ref_32","unstructured":"Marshall, D., and Dauphin, G. (1995). Physicochemical aspects of membrane fouling by dairy fluids. Fouling and Cleaning in Pressure Driven Membrane Processes, International Dairy Federation. Special Issue 9504."},{"key":"ref_33","first-page":"1","article-title":"Possibilities of whey utilisation","volume":"2","author":"Lisak","year":"2014","journal-title":"J. Nutr. Food Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0958-6946(02)00070-5","article-title":"Valorization of by-products from ovine cheese manufacture: Clarification by thermocalcic precipitation\/microfiltration before ultrafiltration","volume":"12","author":"Pereira","year":"2002","journal-title":"Int. Dairy J."},{"key":"ref_35","unstructured":"Macedo, A. (2010). Fracionation of Ovine Whey by Membrane Technology and Study of Possible Applications of the Concentrates Produced. [Ph.D. Thesis, Lisbon University-Instituto Superior de Agronomia]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.memsci.2005.04.046","article-title":"The role of membrane charge on nanofiltration performance","volume":"265","author":"Teixeira","year":"2005","journal-title":"J. Membr. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2166\/wst.2005.0716","article-title":"Reduction of wastewaters and valorisation of by-products from \u201cSerpa\u201d cheese manufacture using nanofiltration","volume":"52","author":"Magueijo","year":"2005","journal-title":"Water Sci. Technol."},{"key":"ref_38","first-page":"657","article-title":"Effect of various pretreatments on the ultrafiltration of sweet cheese whey about 55 \u00b0C","volume":"36","author":"Hiddink","year":"1981","journal-title":"Milchwissenschaft"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0376-7388(96)00127-5","article-title":"Effect of solution chemistry on the surface charge of polymeric reverse osmosis and nanofiltration membranes","volume":"119","author":"Childress","year":"1996","journal-title":"J. Membr. Sci."}],"container-title":["Membranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0375\/8\/4\/114\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:30:57Z","timestamp":1760196657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0375\/8\/4\/114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["membranes8040114"],"URL":"https:\/\/doi.org\/10.3390\/membranes8040114","relation":{},"ISSN":["2077-0375"],"issn-type":[{"value":"2077-0375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]}}}