{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:58:24Z","timestamp":1776463104006,"version":"3.51.2"},"reference-count":65,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Unilever R&amp;D Netherlands","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Chemical communication is common among animals. In humans, the chemical basis of social communication has remained a black box, despite psychological and neural research showing distinctive physiological, behavioral, and neural consequences of body odors emitted during emotional states like fear and happiness. We used a multidisciplinary approach to examine whether molecular cues could be associated with an emotional state in the emitter. Our research revealed that the volatile molecules transmitting different emotions to perceivers also have objectively different chemical properties. Chemical analysis of underarm sweat collected from the same donors in fearful, happy, and emotionally neutral states was conducted using untargeted two-dimensional (GC\u00d7GC) coupled with time of flight (ToF) MS-based profiling. Based on the multivariate statistical analyses, we find that the pattern of chemical volatiles (N = 1655 peaks) associated with fearful state is clearly different from that associated with (pleasant) neutral state. Happy sweat is also significantly different from the other states, chemically, but shows a bipolar pattern of overlap with fearful as well as neutral state. Candidate chemical classes associated with emotional and neutral sweat have been identified, specifically, linear aldehydes, ketones, esters, and cyclic molecules (5 rings). This research constitutes a first step toward identifying the chemical fingerprints of emotion.<\/jats:p>","DOI":"10.3390\/metabo10030084","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:50:53Z","timestamp":1583135453000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Chemical Fingerprints of Emotional Body Odor"],"prefix":"10.3390","volume":"10","author":[{"given":"Monique A.M.","family":"Smeets","sequence":"first","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"},{"name":"Faculty of Social and Behavioural Sciences, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands"}]},{"given":"Egge A.E.","family":"Rosing","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Doris M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Ewoud","family":"van Velzen","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Jean H.","family":"Koek","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Cor","family":"Blonk","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Ilse","family":"Gortemaker","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands"}]},{"given":"Marloes B.","family":"Eidhof","sequence":"additional","affiliation":[{"name":"Faculty of Social and Behavioural Sciences, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands"}]},{"given":"Benyamin","family":"Markovitch","sequence":"additional","affiliation":[{"name":"Faculty of Social and Behavioural Sciences, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-3557","authenticated-orcid":false,"given":"Jasper","family":"de Groot","sequence":"additional","affiliation":[{"name":"Faculty of Social and Behavioural Sciences, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-5566","authenticated-orcid":false,"given":"G\u00fcn R.","family":"Semin","sequence":"additional","affiliation":[{"name":"Faculty of Social and Behavioural Sciences, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands"},{"name":"William James Center for Research, ISPA-Instituto Universit\u00e1rio, 1149-041 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1177\/0956797614566318","article-title":"A sniff of happiness","volume":"26","author":"Smeets","year":"2015","journal-title":"Psychol. 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