{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:19:55Z","timestamp":1773818395825,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00674\/202o"],"award-info":[{"award-number":["UIDB\/00674\/202o"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/116895\/2016"],"award-info":[{"award-number":["SFRH\/BD\/116895\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/117426\/2016"],"award-info":[{"award-number":["SFRH\/BD\/117426\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MAdeira 14-20","award":["M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000008"]}]},{"name":"ARDITI - Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["M1420-01-0145-FEDER-000005"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The innovation of the new psychoactive substances (NPS) market requires the rapid identification of new substances that can be a risk to public health, in order to reduce the damage from their use. Twelve seized products suspected to contain illicit substances were analyzed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), gas chromatography coupled to mass spectrometry (GC-MS), and nuclear magnetic resonance spectroscopy (NMR). Synthetic cathinones (SCat) were found in all products, either as a single component or in mixtures. Infrared spectra of all products were consistent with the molecular structure of SCat, showing an intense absorption band at 1700\u20131674 cm\u22121, corresponding to the carbonyl stretching, a medium\/strong peak at 1605\u20131580 cm\u22121, indicating stretching vibrations in the aromatic ring (C=C) and bands with relative low intensity at frequencies near 2700\u20132400 cm\u22121, corresponding to an amine salt. It was possible to identify a total of eight cathinone derivatives by GC-MS and NMR analysis: 4\u2032-methyl-\u03b1-pyrrolidinohexanophenone (MPHP), \u03b1-pyrrolidinohexanophenone (\u03b1-PHP), 3-fluoromethcathinone (3-FMC), methedrone, methylone, buphedrone, N-ethylcathinone, and pentedrone. Among the adulterants found in these samples, caffeine was the most frequently detected substance, followed by ethylphenidate. These results highlight the prevalence of SCat in seized materials of the Portuguese market. Reference standards are usually required for confirmation, but when reference materials are not available, the combination of complementary techniques is fundamental for a rapid and an unequivocal identification of such substances.<\/jats:p>","DOI":"10.3390\/metabo11030144","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T20:55:44Z","timestamp":1614459344000},"page":"144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-6686","authenticated-orcid":false,"given":"Jo\u00e3o L.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-6032","authenticated-orcid":false,"given":"Vera L.","family":"Alves","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal"}]},{"given":"Joselin","family":"Aguiar","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal"}]},{"given":"Maria J.","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pol\u00edcia Cient\u00edfica da Pol\u00edcia Judici\u00e1ria, Novo edif\u00edcio-sede da Pol\u00edcia Judici\u00e1ria, Rua Gomes Freire, 1169-007 Lisboa, Portugal"}]},{"given":"Helena M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Medicina Legal e Ci\u00eancias Forenses, I.P., Polo das Ci\u00eancias de Sa\u00fade (Polo III), Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal"},{"name":"Faculdade de Ci\u00eancias Exatas e da Engenharia, Campus da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/10408444.2019.1679087","article-title":"Synthetic cathinones: An evolving class of new psychoactive substances","volume":"49","author":"Alves","year":"2019","journal-title":"Crit. 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