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Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and\/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.<\/jats:p>","DOI":"10.3390\/metabo11120799","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T05:42:10Z","timestamp":1638250930000},"page":"799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Pesticides and Male Fertility: A Dangerous Crosstalk"],"prefix":"10.3390","volume":"11","author":[{"given":"S\u00edlvia","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"QOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Sara C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"QOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary Research in Biomedicine, Department of Anatomy, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-5152","authenticated-orcid":false,"given":"Vicente","family":"Seco-Rovira","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, University of Murcia, 30100 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"QOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary Research in Biomedicine, Department of Anatomy, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7869","authenticated-orcid":false,"given":"Maria de Lourdes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.reprotox.2008.05.062","article-title":"Pesticides and fertility: An epidemiological study in northeast Italy and review of the literature","volume":"26","author":"Clementi","year":"2008","journal-title":"Reprod. 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