{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:24:50Z","timestamp":1769070290815,"version":"3.49.0"},"reference-count":96,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04501\/2020 and POCI-01-0145-FEDER-007628"],"award-info":[{"award-number":["UIDB\/04501\/2020 and POCI-01-0145-FEDER-007628"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Compete2020 and FEDER","award":["CENTRO-01-0246-FEDER-000018"],"award-info":[{"award-number":["CENTRO-01-0246-FEDER-000018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Thyroid cancer\u2019s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.<\/jats:p>","DOI":"10.3390\/metabo12010053","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T23:06:15Z","timestamp":1641769575000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-8667","authenticated-orcid":false,"given":"Vanessa","family":"Neto","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, iBiMED\u2014Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-4913","authenticated-orcid":false,"given":"Sara","family":"Esteves-Ferreira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-5136","authenticated-orcid":false,"given":"Isabel","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"given":"M\u00e1rcia","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-0922","authenticated-orcid":false,"given":"Rosa","family":"Dantas","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-0666","authenticated-orcid":false,"given":"Id\u00e1lia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, iBiMED\u2014Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Joana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"given":"Teresa","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Baixo Vouga, CHBV\u2014Endocrinology Department, 3810-164 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-5821","authenticated-orcid":false,"given":"Alexandra","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, iBiMED\u2014Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"ref_1","first-page":"30","article-title":"Diagnosis and treatment of patients with thyroid cancer","volume":"8","author":"Nguyen","year":"2015","journal-title":"Am. 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