{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:57:59Z","timestamp":1769752679170,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["2017 SGR 1546"],"award-info":[{"award-number":["2017 SGR 1546"]}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["FJCI-2015-26590"],"award-info":[{"award-number":["FJCI-2015-26590"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["18-00132S"],"award-info":[{"award-number":["18-00132S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["FA1403 POSITIVe"],"award-info":[{"award-number":["FA1403 POSITIVe"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Structural and Investment Funds","award":["VEKOP-2.3.3-15-2017-00022"],"award-info":[{"award-number":["VEKOP-2.3.3-15-2017-00022"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LISBOA-01-0145-FEDER-402-022125"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-402-022125"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.<\/jats:p>","DOI":"10.3390\/metabo8030046","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T11:13:45Z","timestamp":1535109225000},"page":"46","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interlaboratory Coverage Test on Plant Food Bioactive Compounds and Their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-8361","authenticated-orcid":false,"given":"Ville Mikael","family":"Koistinen","sequence":"first","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"}]},{"given":"Andreia","family":"Bento da Silva","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa (ITQB NOVA), Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"}]},{"given":"L\u00e1szl\u00f3","family":"Abrank\u00f3","sequence":"additional","affiliation":[{"name":"Alkalmazott Kemia Tsz, Elelmiszertudomanyi Kar, Szent Istv\u00e1n Egyetem, 29-43 Villanyi Street, 1118 Budapest, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-3189","authenticated-orcid":false,"given":"Dorrain","family":"Low","sequence":"additional","affiliation":[{"name":"INRA, Human Nutrition Unit, Universit\u00e9 Clermont Auvergne, F63000 Clermont-Ferrand, France"}]},{"given":"Rocio","family":"Garcia Villalba","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, CEBAS-CSIC, Campus Universitario de Espinardo, edf 25, 30100 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-1739","authenticated-orcid":false,"given":"Francisco","family":"Tom\u00e1s Barber\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, CEBAS-CSIC, Campus Universitario de Espinardo, edf 25, 30100 Murcia, Spain"}]},{"given":"Rikard","family":"Landberg","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden"}]},{"given":"Otto","family":"Savolainen","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-6480","authenticated-orcid":false,"given":"Inmaculada","family":"Alvarez-Acero","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 10, 28040 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-8507","authenticated-orcid":false,"given":"Sonia","family":"De Pascual-Teresa","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 10, 28040 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-925X","authenticated-orcid":false,"given":"Christof","family":"Van Poucke","sequence":"additional","affiliation":[{"name":"Technology and Food Science Department, Flanders Research Institute for Agriculture Fisheries and Food (ILVO), Brusselsesteenweg 370, B-9090 Melle, Belgium"}]},{"given":"Concei\u00e7\u00e3o","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa (ITQB NOVA), Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"}]},{"given":"Lucie","family":"Petr\u00e1skov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Biotransformation, Institute of Microbiology of the CAS, V\u00edde\u0148sk\u00e1 1083, CZ-142 20 Prague, Czechia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7714-5350","authenticated-orcid":false,"given":"Kate\u0159ina","family":"Valentov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Biotransformation, Institute of Microbiology of the CAS, V\u00edde\u0148sk\u00e1 1083, CZ-142 20 Prague, Czechia"}]},{"given":"Stephanie","family":"Durand","sequence":"additional","affiliation":[{"name":"INRA, Human Nutrition Unit, Universit\u00e9 Clermont Auvergne, F63000 Clermont-Ferrand, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-5589","authenticated-orcid":false,"given":"Wies\u0142aw","family":"Wiczkowski","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland"}]},{"given":"Dorota","family":"Szawara-Nowak","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-8833","authenticated-orcid":false,"given":"Ra\u00fal","family":"Gonz\u00e1lez-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s\/n, 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, 08028 Barcelona, Spain"}]},{"given":"Rafael","family":"Llorach","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s\/n, 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, 08028 Barcelona, Spain"}]},{"given":"Cristina","family":"Andr\u00e9s-Lacueva","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s\/n, 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, 08028 Barcelona, Spain"}]},{"given":"Anna-Marja","family":"Aura","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 VTT, Espoo, Finland"}]},{"given":"Tuulikki","family":"Sepp\u00e4nen-Laakso","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 VTT, Espoo, Finland"}]},{"given":"Kati","family":"Hanhineva","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"}]},{"given":"Claudine","family":"Manach","sequence":"additional","affiliation":[{"name":"INRA, Human Nutrition Unit, Universit\u00e9 Clermont Auvergne, F63000 Clermont-Ferrand, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-4634","authenticated-orcid":false,"given":"Maria Ros\u00e1rio","family":"Bronze","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa (ITQB NOVA), Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"Instituto de Biologia Experimental Tecnol\u00f3gica (iBET), Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon (FFULisboa), Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.tifs.2008.03.003","article-title":"Metabolomics: Applications to food science and nutrition research","volume":"19","author":"Wishart","year":"2008","journal-title":"Trends Food Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1021\/acs.jafc.6b03272","article-title":"Environmental Factors Correlated with the Metabolite Profile of Vitis vinifera cv. Pinot Noir Berry Skins along a European Latitudinal Gradient","volume":"64","author":"Castagna","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/elps.201800004","article-title":"Omics approaches for food authentication","volume":"39","author":"Creydt","year":"2018","journal-title":"Electrophoresis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12263-018-0603-9","article-title":"Validation of biomarkers of food intake-critical assessment of candidate biomarkers","volume":"13","author":"Dragsted","year":"2018","journal-title":"Genes Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/pca.1187","article-title":"An introduction to liquid chromatography\u2013mass spectrometry instrumentation applied in plant metabolomic analyses","volume":"21","author":"Allwood","year":"2010","journal-title":"Phytochem. Anal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/pmic.201000756","article-title":"MALDI-imaging mass spectrometry\u2014An emerging technique in plant biology","volume":"11","author":"Kaspar","year":"2011","journal-title":"Proteomics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-313X.2012.04902.x","article-title":"High-resolution plant metabolomics: From mass spectral features to metabolites and from whole-cell analysis to subcellular metabolite distributions","volume":"70","author":"Kueger","year":"2012","journal-title":"Plant J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jpba.2012.09.004","article-title":"Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography-mass spectrometry","volume":"72","author":"Wu","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1080\/10408398.2015.1016477","article-title":"Mass Spectrometry-based Analysis of Whole Grain Phytochemicals","volume":"57","author":"Koistinen","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.chroma.2015.11.077","article-title":"Recent advances and trends in the liquid-chromatography-mass spectrometry analysis of flavonoids","volume":"1430","author":"Venter","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11306-009-0168-0","article-title":"Mass-spectrometry-based metabolomics: Limitations and recommendations for future progress with particular focus on nutrition research","volume":"5","author":"Scalbert","year":"2009","journal-title":"Metabolomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nprot.2007.95","article-title":"Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry","volume":"2","author":"Moco","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.chroma.2013.01.012","article-title":"Analysis of food polyphenols by ultra high-performance liquid chromatography coupled to mass spectrometry: An overview","volume":"1292","author":"Motilva","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chroma.2005.11.054","article-title":"Chromatographic analysis of lignans","volume":"1112","author":"Smeds","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chroma.2016.08.027","article-title":"Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine","volume":"1464","author":"Feliciano","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0021-9673(01)00946-3","article-title":"Chromatographic analysis of plant sterols in foods and vegetable oils","volume":"935","author":"Abidi","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1021\/jf9043887","article-title":"Fast separation and determination of sterols in vegetable oils by ultraperformance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry detection","volume":"58","author":"Lliberia","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.trac.2013.12.011","article-title":"Review of methods for analysis of carotenoids","volume":"56","author":"Cepeda","year":"2014","journal-title":"Trends Anal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7258","DOI":"10.1016\/j.chroma.2009.07.058","article-title":"Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography\u2013tandem mass spectrometry","volume":"1216","author":"Monagas","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/rcm.3546","article-title":"Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography\/electrospray ionization tandem mass spectrometry with data-dependent acquisition","volume":"22","author":"Sang","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3945\/jn.113.187237","article-title":"The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates","volume":"144","author":"Hanhineva","year":"2014","journal-title":"J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2015.12.023","article-title":"A high-throughput method for liquid chromatography\u2013tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake","volume":"499","author":"Ross","year":"2016","journal-title":"Anal. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/elps.201100005","article-title":"Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry\u2013application to the detection of olive oil adulteration with seed oils","volume":"32","author":"Crego","year":"2011","journal-title":"Electrophoresis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1021\/jf2051569","article-title":"A versatile targeted metabolomics method for the rapid quantification of multiple classes of phenolics in fruits and beverages","volume":"60","author":"Vrhovsek","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3945\/ajcn.113.076133","article-title":"The food metabolome: A window over dietary exposure","volume":"99","author":"Scalbert","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MOL.0000000000000140","article-title":"Metabolomics as a tool in nutritional research","volume":"26","author":"Gibbons","year":"2015","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rangel-Huerta, O.D., and Gil, A. (2016). Nutrimetabolomics: An Update on Analytical Approaches to Investigate the Role of Plant-Based Foods and Their Bioactive Compounds in Non-Communicable Chronic Diseases. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122072"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11306-016-1082-x","article-title":"Untargeted metabolomics approach using UPLC-ESI-QTOF-MS to explore the metabolome of fresh-cut iceberg lettuce","volume":"12","author":"Garcia","year":"2016","journal-title":"Metabolomics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1038\/s41598-018-24149-w","article-title":"Metabolic profiling of sourdough fermented wheat and rye bread","volume":"8","author":"Koistinen","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1039\/C1MB05350G","article-title":"LC-MS-based metabolomics","volume":"8","author":"Zhou","year":"2012","journal-title":"Mol. BioSyst."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Valentov\u00e1, K., K\u00e1\u0148ov\u00e1, K., Di Meo, F., Pelantov\u00e1, H., Chambers, C.S., Rydlov\u00e1, L., Petr\u00e1skov\u00e1, L., K\u0159enkov\u00e1, A., Cva\u010dka, J., and Trouillas, P. (2017). Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112231"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.chroma.2006.01.019","article-title":"Analytical separation and detection methods for flavonoids","volume":"1112","author":"Out","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.foodchem.2007.05.081","article-title":"LC\u2013MS n analysis of the cis isomers of chlorogenic acids","volume":"106","author":"Clifford","year":"2008","journal-title":"Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.ftd.0000179845.53213.39","article-title":"METLIN: A metabolite mass spectral database","volume":"27","author":"Smith","year":"2005","journal-title":"Ther. Drug Monit."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1021\/ci025515j","article-title":"Application of associative neural networks for prediction of lipophilicity in ALOGPS 2.1 program","volume":"42","author":"Tetko","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: Data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/8\/3\/46\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:21:00Z","timestamp":1760196060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/8\/3\/46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,24]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["metabo8030046"],"URL":"https:\/\/doi.org\/10.3390\/metabo8030046","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,24]]}}}